Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q7I6_LEIMA

TriTrypDb:

LmjF.30.1170 , LMJLV39_300018200 , LMJSD75_300017800

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q7I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.757
CLV_NRD_NRD_1	112	114	PF00675	0.580
CLV_NRD_NRD_1	236	238	PF00675	0.517
CLV_NRD_NRD_1	326	328	PF00675	0.502
CLV_NRD_NRD_1	643	645	PF00675	0.434
CLV_PCSK_KEX2_1	20	22	PF00082	0.594
CLV_PCSK_KEX2_1	236	238	PF00082	0.442
CLV_PCSK_KEX2_1	325	327	PF00082	0.478
CLV_PCSK_KEX2_1	405	407	PF00082	0.508
CLV_PCSK_KEX2_1	575	577	PF00082	0.447
CLV_PCSK_KEX2_1	63	65	PF00082	0.591
CLV_PCSK_KEX2_1	676	678	PF00082	0.436
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.594
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.480
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.447
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.525
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.436
CLV_PCSK_SKI1_1	185	189	PF00082	0.530
CLV_PCSK_SKI1_1	326	330	PF00082	0.502
CLV_PCSK_SKI1_1	422	426	PF00082	0.529
CLV_PCSK_SKI1_1	562	566	PF00082	0.359
CLV_Separin_Metazoa	668	672	PF03568	0.739
DEG_APCC_DBOX_1	324	332	PF00400	0.695
DEG_APCC_KENBOX_2	180	184	PF00400	0.813
DEG_COP1_1	431	440	PF00400	0.685
DEG_SCF_FBW7_1	41	48	PF00400	0.705
DOC_CKS1_1	170	175	PF01111	0.675
DOC_CKS1_1	42	47	PF01111	0.839
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.610
DOC_MAPK_FxFP_2	548	551	PF00069	0.411
DOC_MAPK_gen_1	526	536	PF00069	0.414
DOC_MAPK_MEF2A_6	334	342	PF00069	0.737
DOC_MAPK_MEF2A_6	529	538	PF00069	0.346
DOC_PP1_RVXF_1	630	636	PF00149	0.650
DOC_PP2B_LxvP_1	435	438	PF13499	0.658
DOC_PP2B_LxvP_1	637	640	PF13499	0.667
DOC_PP4_FxxP_1	317	320	PF00568	0.592
DOC_PP4_FxxP_1	548	551	PF00568	0.411
DOC_USP7_MATH_1	159	163	PF00917	0.741
DOC_USP7_MATH_1	378	382	PF00917	0.734
DOC_USP7_MATH_1	387	391	PF00917	0.645
DOC_USP7_MATH_1	45	49	PF00917	0.822
DOC_USP7_MATH_1	65	69	PF00917	0.626
DOC_USP7_MATH_1	72	76	PF00917	0.790
DOC_USP7_MATH_1	82	86	PF00917	0.711
DOC_USP7_MATH_2	13	19	PF00917	0.706
DOC_USP7_UBL2_3	181	185	PF12436	0.752
DOC_USP7_UBL2_3	571	575	PF12436	0.546
DOC_WW_Pin1_4	169	174	PF00397	0.729
DOC_WW_Pin1_4	32	37	PF00397	0.765
DOC_WW_Pin1_4	41	46	PF00397	0.771
DOC_WW_Pin1_4	52	57	PF00397	0.672
DOC_WW_Pin1_4	9	14	PF00397	0.755
LIG_14-3-3_CanoR_1	21	29	PF00244	0.834
LIG_14-3-3_CanoR_1	267	272	PF00244	0.515
LIG_14-3-3_CanoR_1	409	413	PF00244	0.679
LIG_14-3-3_CanoR_1	429	437	PF00244	0.773
LIG_14-3-3_CanoR_1	514	518	PF00244	0.378
LIG_14-3-3_CanoR_1	54	60	PF00244	0.816
LIG_14-3-3_CanoR_1	562	570	PF00244	0.602
LIG_BIR_II_1	1	5	PF00653	0.826
LIG_BRCT_BRCA1_1	240	244	PF00533	0.690
LIG_BRCT_BRCA1_1	47	51	PF00533	0.737
LIG_BRCT_BRCA1_1	492	496	PF00533	0.512
LIG_BRCT_BRCA1_1	576	580	PF00533	0.667
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.418
LIG_EH_1	134	138	PF12763	0.672
LIG_eIF4E_1	489	495	PF01652	0.411
LIG_FHA_1	169	175	PF00498	0.795
LIG_FHA_1	418	424	PF00498	0.704
LIG_FHA_1	447	453	PF00498	0.529
LIG_FHA_1	5	11	PF00498	0.682
LIG_FHA_2	195	201	PF00498	0.642
LIG_FHA_2	563	569	PF00498	0.546
LIG_GBD_Chelix_1	299	307	PF00786	0.430
LIG_Integrin_RGD_1	334	336	PF01839	0.568
LIG_LIR_Apic_2	516	520	PF02991	0.359
LIG_LIR_Gen_1	200	209	PF02991	0.634
LIG_LIR_Gen_1	292	303	PF02991	0.403
LIG_LIR_Gen_1	308	317	PF02991	0.333
LIG_LIR_Gen_1	493	504	PF02991	0.512
LIG_LIR_Nem_3	200	206	PF02991	0.615
LIG_LIR_Nem_3	292	298	PF02991	0.474
LIG_LIR_Nem_3	308	314	PF02991	0.278
LIG_LIR_Nem_3	439	445	PF02991	0.658
LIG_LIR_Nem_3	493	499	PF02991	0.479
LIG_LIR_Nem_3	541	545	PF02991	0.388
LIG_LIR_Nem_3	577	583	PF02991	0.664
LIG_LIR_Nem_3	616	622	PF02991	0.681
LIG_LIR_Nem_3	8	14	PF02991	0.786
LIG_LYPXL_S_1	280	284	PF13949	0.411
LIG_MLH1_MIPbox_1	492	496	PF16413	0.512
LIG_MLH1_MIPbox_1	576	580	PF16413	0.667
LIG_MYND_3	437	441	PF01753	0.666
LIG_PCNA_TLS_4	409	416	PF02747	0.633
LIG_Pex14_1	269	273	PF04695	0.411
LIG_Pex14_2	442	446	PF04695	0.652
LIG_Pex14_2	491	495	PF04695	0.512
LIG_SH2_CRK	203	207	PF00017	0.688
LIG_SH2_CRK	275	279	PF00017	0.411
LIG_SH2_CRK	503	507	PF00017	0.411
LIG_SH2_CRK	53	57	PF00017	0.674
LIG_SH2_CRK	532	536	PF00017	0.346
LIG_SH2_CRK	592	596	PF00017	0.619
LIG_SH2_GRB2like	592	595	PF00017	0.674
LIG_SH2_NCK_1	11	15	PF00017	0.782
LIG_SH2_NCK_1	203	207	PF00017	0.638
LIG_SH2_SRC	517	520	PF00017	0.394
LIG_SH2_SRC	530	533	PF00017	0.282
LIG_SH2_SRC	592	595	PF00017	0.674
LIG_SH2_STAP1	203	207	PF00017	0.638
LIG_SH2_STAP1	383	387	PF00017	0.748
LIG_SH2_STAP1	503	507	PF00017	0.512
LIG_SH2_STAP1	596	600	PF00017	0.611
LIG_SH2_STAP1	91	95	PF00017	0.777
LIG_SH2_STAT5	179	182	PF00017	0.717
LIG_SH2_STAT5	383	386	PF00017	0.753
LIG_SH2_STAT5	415	418	PF00017	0.708
LIG_SH2_STAT5	489	492	PF00017	0.411
LIG_SH2_STAT5	517	520	PF00017	0.394
LIG_SH2_STAT5	530	533	PF00017	0.257
LIG_SH2_STAT5	539	542	PF00017	0.339
LIG_SH2_STAT5	579	582	PF00017	0.661
LIG_SH3_3	130	136	PF00018	0.760
LIG_SH3_3	227	233	PF00018	0.680
LIG_SH3_3	260	266	PF00018	0.656
LIG_SH3_3	337	343	PF00018	0.694
LIG_SH3_3	39	45	PF00018	0.846
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.512
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.689
LIG_SUMO_SIM_par_1	55	60	PF11976	0.675
LIG_SxIP_EBH_1	185	199	PF03271	0.753
LIG_TRAF2_1	125	128	PF00917	0.684
LIG_TRAF2_1	198	201	PF00917	0.633
LIG_TRAF2_1	605	608	PF00917	0.718
LIG_TRAF2_1	640	643	PF00917	0.637
LIG_TRAF2_1	95	98	PF00917	0.706
LIG_TYR_ITIM	501	506	PF00017	0.411
LIG_WRC_WIRS_1	539	544	PF05994	0.411
MOD_CDK_SPxK_1	32	38	PF00069	0.642
MOD_CK1_1	145	151	PF00069	0.668
MOD_CK1_1	23	29	PF00069	0.790
MOD_CK1_1	305	311	PF00069	0.400
MOD_CK1_1	381	387	PF00069	0.682
MOD_CK1_1	55	61	PF00069	0.686
MOD_CK2_1	172	178	PF00069	0.831
MOD_CK2_1	194	200	PF00069	0.555
MOD_CK2_1	562	568	PF00069	0.411
MOD_CK2_1	82	88	PF00069	0.784
MOD_CK2_1	9	15	PF00069	0.649
MOD_GlcNHglycan	108	111	PF01048	0.484
MOD_GlcNHglycan	144	147	PF01048	0.768
MOD_GlcNHglycan	150	153	PF01048	0.594
MOD_GlcNHglycan	161	164	PF01048	0.622
MOD_GlcNHglycan	174	177	PF01048	0.730
MOD_GlcNHglycan	26	29	PF01048	0.769
MOD_GlcNHglycan	304	307	PF01048	0.386
MOD_GlcNHglycan	373	376	PF01048	0.732
MOD_GlcNHglycan	380	383	PF01048	0.578
MOD_GlcNHglycan	389	392	PF01048	0.576
MOD_GlcNHglycan	47	50	PF01048	0.798
MOD_GlcNHglycan	88	91	PF01048	0.758
MOD_GSK3_1	140	147	PF00069	0.632
MOD_GSK3_1	168	175	PF00069	0.754
MOD_GSK3_1	20	27	PF00069	0.843
MOD_GSK3_1	228	235	PF00069	0.573
MOD_GSK3_1	404	411	PF00069	0.658
MOD_GSK3_1	41	48	PF00069	0.754
MOD_GSK3_1	82	89	PF00069	0.730
MOD_N-GLC_1	329	334	PF02516	0.637
MOD_N-GLC_1	378	383	PF02516	0.628
MOD_N-GLC_1	45	50	PF02516	0.739
MOD_N-GLC_2	479	481	PF02516	0.411
MOD_NEK2_1	188	193	PF00069	0.587
MOD_NEK2_1	238	243	PF00069	0.586
MOD_NEK2_1	446	451	PF00069	0.392
MOD_NEK2_1	490	495	PF00069	0.355
MOD_NEK2_1	57	62	PF00069	0.660
MOD_NEK2_1	86	91	PF00069	0.809
MOD_NEK2_2	82	87	PF00069	0.647
MOD_PIKK_1	584	590	PF00454	0.628
MOD_PIKK_1	65	71	PF00454	0.664
MOD_PKA_1	20	26	PF00069	0.756
MOD_PKA_1	405	411	PF00069	0.657
MOD_PKA_2	20	26	PF00069	0.839
MOD_PKA_2	405	411	PF00069	0.604
MOD_PKA_2	428	434	PF00069	0.734
MOD_PKA_2	513	519	PF00069	0.499
MOD_PKA_2	86	92	PF00069	0.796
MOD_Plk_1	378	384	PF00069	0.684
MOD_Plk_4	305	311	PF00069	0.415
MOD_Plk_4	397	403	PF00069	0.567
MOD_Plk_4	490	496	PF00069	0.355
MOD_Plk_4	513	519	PF00069	0.430
MOD_ProDKin_1	169	175	PF00069	0.667
MOD_ProDKin_1	32	38	PF00069	0.717
MOD_ProDKin_1	41	47	PF00069	0.728
MOD_ProDKin_1	52	58	PF00069	0.587
MOD_ProDKin_1	9	15	PF00069	0.704
MOD_SUMO_rev_2	219	227	PF00179	0.599
MOD_SUMO_rev_2	629	633	PF00179	0.559
MOD_SUMO_rev_2	642	647	PF00179	0.541
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.459
TRG_ENDOCYTIC_2	11	14	PF00928	0.741
TRG_ENDOCYTIC_2	203	206	PF00928	0.533
TRG_ENDOCYTIC_2	275	278	PF00928	0.411
TRG_ENDOCYTIC_2	281	284	PF00928	0.411
TRG_ENDOCYTIC_2	487	490	PF00928	0.411
TRG_ENDOCYTIC_2	503	506	PF00928	0.411
TRG_ENDOCYTIC_2	539	542	PF00928	0.411
TRG_ENDOCYTIC_2	592	595	PF00928	0.506
TRG_ENDOCYTIC_2	596	599	PF00928	0.475
TRG_ENDOCYTIC_2	619	622	PF00928	0.582
TRG_ER_diArg_1	236	238	PF00400	0.651
TRG_ER_diArg_1	324	327	PF00400	0.601
TRG_ER_diArg_1	456	459	PF00400	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P984	Leptomonas seymouri	62%	96%
A0A3Q8IHU7	Leishmania donovani	92%	100%
A4HI71	Leishmania braziliensis	79%	90%
A4I5E8	Leishmania infantum	93%	100%
E9B0P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%