Transmembrane protein 107

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein, putative

Species:

Leishmania major

UniProt:

Q4Q7I5_LEIMA

TriTrypDb:

LmjF.30.1180 , LMJLV39_300018300 , LMJSD75_300017900

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q7I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.446
CLV_PCSK_KEX2_1	12	14	PF00082	0.446
CLV_PCSK_SKI1_1	28	32	PF00082	0.373
CLV_PCSK_SKI1_1	75	79	PF00082	0.480
DEG_MDM2_SWIB_1	90	97	PF02201	0.313
DOC_CYCLIN_RxL_1	97	107	PF00134	0.480
DOC_MAPK_MEF2A_6	12	21	PF00069	0.692
DOC_PP1_RVXF_1	98	105	PF00149	0.480
DOC_SPAK_OSR1_1	103	107	PF12202	0.480
DOC_WW_Pin1_4	13	18	PF00397	0.529
LIG_14-3-3_CanoR_1	12	17	PF00244	0.628
LIG_14-3-3_CanoR_1	58	63	PF00244	0.351
LIG_Actin_WH2_2	89	105	PF00022	0.386
LIG_FHA_1	127	133	PF00498	0.322
LIG_FHA_1	14	20	PF00498	0.684
LIG_FHA_1	82	88	PF00498	0.331
LIG_FHA_2	145	151	PF00498	0.293
LIG_LIR_Gen_1	68	77	PF02991	0.319
LIG_LIR_Gen_1	84	93	PF02991	0.328
LIG_LIR_Nem_3	15	21	PF02991	0.637
LIG_LIR_Nem_3	68	74	PF02991	0.259
LIG_LIR_Nem_3	84	89	PF02991	0.328
LIG_Pex14_1	39	43	PF04695	0.331
LIG_Pex14_2	86	90	PF04695	0.279
LIG_SH2_PTP2	18	21	PF00017	0.524
LIG_SH2_PTP2	71	74	PF00017	0.280
LIG_SH2_STAT5	18	21	PF00017	0.653
LIG_SH2_STAT5	71	74	PF00017	0.293
LIG_SH3_3	14	20	PF00018	0.606
LIG_SH3_3	27	33	PF00018	0.395
LIG_SUMO_SIM_par_1	119	125	PF11976	0.386
MOD_CK2_1	144	150	PF00069	0.293
MOD_GSK3_1	122	129	PF00069	0.402
MOD_GSK3_1	140	147	PF00069	0.353
MOD_GSK3_1	150	157	PF00069	0.311
MOD_N-GLC_2	79	81	PF02516	0.331
MOD_NEK2_1	110	115	PF00069	0.350
MOD_NEK2_1	122	127	PF00069	0.371
MOD_NEK2_1	154	159	PF00069	0.371
MOD_NEK2_1	82	87	PF00069	0.325
MOD_PKA_1	12	18	PF00069	0.653
MOD_PKA_2	12	18	PF00069	0.611
MOD_PKA_2	50	56	PF00069	0.347
MOD_PKA_2	57	63	PF00069	0.325
MOD_Plk_4	154	160	PF00069	0.415
MOD_Plk_4	42	48	PF00069	0.455
MOD_Plk_4	82	88	PF00069	0.293
MOD_ProDKin_1	13	19	PF00069	0.529
TRG_DiLeu_BaEn_3	68	74	PF01217	0.200
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.647
TRG_ENDOCYTIC_2	18	21	PF00928	0.659
TRG_ENDOCYTIC_2	71	74	PF00928	0.275
TRG_ER_diArg_1	11	13	PF00400	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KEE0	Bodo saltans	39%	100%
A0A1X0P1Z3	Trypanosomatidae	51%	100%
A0A3R7MXG9	Trypanosoma rangeli	53%	100%
A0A3S7X379	Leishmania donovani	93%	100%
A4I5E9	Leishmania infantum	93%	100%
C9ZQT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B0P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%