JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7I4_LEIMA

TriTrypDb:

LmjF.30.1190 , LMJLV39_300018400 , LMJSD75_300018000

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.582
CLV_C14_Caspase3-7	505	509	PF00656	0.375
CLV_NRD_NRD_1	280	282	PF00675	0.695
CLV_NRD_NRD_1	317	319	PF00675	0.496
CLV_NRD_NRD_1	376	378	PF00675	0.290
CLV_NRD_NRD_1	593	595	PF00675	0.465
CLV_NRD_NRD_1	602	604	PF00675	0.394
CLV_PCSK_KEX2_1	280	282	PF00082	0.695
CLV_PCSK_KEX2_1	317	319	PF00082	0.496
CLV_PCSK_KEX2_1	376	378	PF00082	0.290
CLV_PCSK_KEX2_1	470	472	PF00082	0.389
CLV_PCSK_KEX2_1	595	597	PF00082	0.463
CLV_PCSK_KEX2_1	602	604	PF00082	0.424
CLV_PCSK_KEX2_1	619	621	PF00082	0.467
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.389
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.444
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.511
CLV_PCSK_PC7_1	591	597	PF00082	0.443
CLV_PCSK_SKI1_1	403	407	PF00082	0.389
CLV_PCSK_SKI1_1	439	443	PF00082	0.389
CLV_PCSK_SKI1_1	470	474	PF00082	0.389
DEG_APCC_DBOX_1	221	229	PF00400	0.643
DEG_MDM2_SWIB_1	74	82	PF02201	0.552
DOC_CDC14_PxL_1	27	35	PF14671	0.432
DOC_CKS1_1	14	19	PF01111	0.448
DOC_CYCLIN_RxL_1	199	207	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	572	578	PF00134	0.318
DOC_MAPK_gen_1	317	323	PF00069	0.488
DOC_MAPK_gen_1	602	613	PF00069	0.475
DOC_MAPK_MEF2A_6	193	201	PF00069	0.647
DOC_MAPK_MEF2A_6	606	615	PF00069	0.489
DOC_PP2B_LxvP_1	221	224	PF13499	0.665
DOC_PP2B_LxvP_1	28	31	PF13499	0.441
DOC_PP2B_LxvP_1	474	477	PF13499	0.360
DOC_PP2B_LxvP_1	58	61	PF13499	0.566
DOC_PP2B_LxvP_1	613	616	PF13499	0.542
DOC_PP2B_PxIxI_1	60	66	PF00149	0.559
DOC_PP4_FxxP_1	220	223	PF00568	0.657
DOC_SPAK_OSR1_1	116	120	PF12202	0.625
DOC_USP7_MATH_1	111	115	PF00917	0.572
DOC_USP7_MATH_1	141	145	PF00917	0.482
DOC_USP7_MATH_1	179	183	PF00917	0.630
DOC_USP7_MATH_1	445	449	PF00917	0.389
DOC_USP7_MATH_1	511	515	PF00917	0.389
DOC_WW_Pin1_4	13	18	PF00397	0.449
DOC_WW_Pin1_4	145	150	PF00397	0.629
DOC_WW_Pin1_4	2	7	PF00397	0.638
DOC_WW_Pin1_4	447	452	PF00397	0.389
DOC_WW_Pin1_4	571	576	PF00397	0.321
LIG_14-3-3_CanoR_1	123	130	PF00244	0.486
LIG_14-3-3_CanoR_1	237	245	PF00244	0.717
LIG_14-3-3_CanoR_1	318	324	PF00244	0.488
LIG_14-3-3_CanoR_1	377	386	PF00244	0.363
LIG_14-3-3_CanoR_1	408	416	PF00244	0.383
LIG_14-3-3_CanoR_1	471	475	PF00244	0.389
LIG_14-3-3_CanoR_1	94	102	PF00244	0.647
LIG_APCC_ABBA_1	236	241	PF00400	0.661
LIG_BRCT_BRCA1_1	113	117	PF00533	0.552
LIG_deltaCOP1_diTrp_1	344	352	PF00928	0.389
LIG_deltaCOP1_diTrp_1	38	44	PF00928	0.555
LIG_FHA_1	14	20	PF00498	0.555
LIG_FHA_1	196	202	PF00498	0.645
LIG_FHA_1	248	254	PF00498	0.630
LIG_FHA_1	277	283	PF00498	0.625
LIG_FHA_1	287	293	PF00498	0.589
LIG_FHA_1	338	344	PF00498	0.338
LIG_FHA_1	40	46	PF00498	0.565
LIG_FHA_1	563	569	PF00498	0.389
LIG_FHA_1	99	105	PF00498	0.700
LIG_FHA_2	33	39	PF00498	0.510
LIG_FHA_2	349	355	PF00498	0.389
LIG_FHA_2	390	396	PF00498	0.389
LIG_FHA_2	429	435	PF00498	0.389
LIG_FHA_2	503	509	PF00498	0.389
LIG_Integrin_isoDGR_2	166	168	PF01839	0.599
LIG_Integrin_isoDGR_2	369	371	PF01839	0.389
LIG_Integrin_RGD_1	506	508	PF01839	0.375
LIG_LIR_Apic_2	217	223	PF02991	0.642
LIG_LIR_Apic_2	329	333	PF02991	0.389
LIG_LIR_Apic_2	415	419	PF02991	0.527
LIG_LIR_Gen_1	114	125	PF02991	0.532
LIG_LIR_Gen_1	350	358	PF02991	0.389
LIG_LIR_Gen_1	38	45	PF02991	0.566
LIG_LIR_Gen_1	424	434	PF02991	0.389
LIG_LIR_Gen_1	437	445	PF02991	0.266
LIG_LIR_Gen_1	459	466	PF02991	0.389
LIG_LIR_Gen_1	553	562	PF02991	0.389
LIG_LIR_Nem_3	114	120	PF02991	0.549
LIG_LIR_Nem_3	240	245	PF02991	0.635
LIG_LIR_Nem_3	350	355	PF02991	0.469
LIG_LIR_Nem_3	38	44	PF02991	0.563
LIG_LIR_Nem_3	384	388	PF02991	0.396
LIG_LIR_Nem_3	423	429	PF02991	0.387
LIG_LIR_Nem_3	437	443	PF02991	0.258
LIG_LIR_Nem_3	459	465	PF02991	0.389
LIG_LIR_Nem_3	50	56	PF02991	0.431
LIG_LIR_Nem_3	553	559	PF02991	0.389
LIG_LIR_Nem_3	577	581	PF02991	0.439
LIG_LYPXL_SIV_4	61	69	PF13949	0.565
LIG_MYND_1	6	10	PF01753	0.613
LIG_Pex14_2	357	361	PF04695	0.425
LIG_Pex14_2	422	426	PF04695	0.389
LIG_Pex14_2	74	78	PF04695	0.551
LIG_REV1ctd_RIR_1	41	50	PF16727	0.558
LIG_SH2_CRK	416	420	PF00017	0.389
LIG_SH2_NCK_1	330	334	PF00017	0.389
LIG_SH2_NCK_1	388	392	PF00017	0.389
LIG_SH2_NCK_1	416	420	PF00017	0.389
LIG_SH2_PTP2	62	65	PF00017	0.554
LIG_SH2_SRC	27	30	PF00017	0.528
LIG_SH2_SRC	416	419	PF00017	0.360
LIG_SH2_SRC	62	65	PF00017	0.554
LIG_SH2_STAP1	80	84	PF00017	0.544
LIG_SH2_STAT5	203	206	PF00017	0.796
LIG_SH2_STAT5	213	216	PF00017	0.617
LIG_SH2_STAT5	23	26	PF00017	0.654
LIG_SH2_STAT5	27	30	PF00017	0.585
LIG_SH2_STAT5	385	388	PF00017	0.389
LIG_SH2_STAT5	399	402	PF00017	0.256
LIG_SH2_STAT5	421	424	PF00017	0.389
LIG_SH2_STAT5	62	65	PF00017	0.561
LIG_SH2_STAT5	80	83	PF00017	0.446
LIG_SH3_1	330	336	PF00018	0.389
LIG_SH3_3	11	17	PF00018	0.454
LIG_SH3_3	116	122	PF00018	0.492
LIG_SH3_3	191	197	PF00018	0.616
LIG_SH3_3	253	259	PF00018	0.628
LIG_SH3_3	295	301	PF00018	0.592
LIG_SH3_3	330	336	PF00018	0.389
LIG_SH3_3	476	482	PF00018	0.389
LIG_SH3_3	546	552	PF00018	0.301
LIG_SUMO_SIM_par_1	32	39	PF11976	0.510
LIG_SUMO_SIM_par_1	335	340	PF11976	0.527
LIG_SUMO_SIM_par_1	564	569	PF11976	0.389
LIG_TRAF2_1	185	188	PF00917	0.624
LIG_TYR_ITIM	201	206	PF00017	0.650
LIG_WRC_WIRS_1	71	76	PF05994	0.554
MOD_CDK_SPK_2	13	18	PF00069	0.573
MOD_CK1_1	158	164	PF00069	0.684
MOD_CK1_1	276	282	PF00069	0.609
MOD_CK1_1	428	434	PF00069	0.360
MOD_CK1_1	509	515	PF00069	0.389
MOD_CK1_1	574	580	PF00069	0.454
MOD_CK1_1	96	102	PF00069	0.659
MOD_CK2_1	32	38	PF00069	0.509
MOD_CK2_1	389	395	PF00069	0.389
MOD_CK2_1	529	535	PF00069	0.389
MOD_Cter_Amidation	374	377	PF01082	0.389
MOD_GlcNHglycan	130	133	PF01048	0.558
MOD_GlcNHglycan	206	209	PF01048	0.613
MOD_GlcNHglycan	275	278	PF01048	0.519
MOD_GlcNHglycan	380	383	PF01048	0.447
MOD_GlcNHglycan	446	450	PF01048	0.389
MOD_GlcNHglycan	466	469	PF01048	0.199
MOD_GlcNHglycan	511	514	PF01048	0.389
MOD_GlcNHglycan	531	534	PF01048	0.199
MOD_GlcNHglycan	552	555	PF01048	0.389
MOD_GSK3_1	128	135	PF00069	0.602
MOD_GSK3_1	141	148	PF00069	0.708
MOD_GSK3_1	151	158	PF00069	0.633
MOD_GSK3_1	272	279	PF00069	0.633
MOD_GSK3_1	32	39	PF00069	0.481
MOD_GSK3_1	447	454	PF00069	0.389
MOD_GSK3_1	502	509	PF00069	0.389
MOD_GSK3_1	562	569	PF00069	0.389
MOD_GSK3_1	70	77	PF00069	0.554
MOD_GSK3_1	93	100	PF00069	0.736
MOD_N-GLC_2	571	573	PF02516	0.420
MOD_NEK2_1	104	109	PF00069	0.611
MOD_NEK2_1	204	209	PF00069	0.643
MOD_NEK2_1	267	272	PF00069	0.632
MOD_NEK2_1	292	297	PF00069	0.720
MOD_NEK2_1	36	41	PF00069	0.509
MOD_NEK2_1	378	383	PF00069	0.389
MOD_NEK2_1	406	411	PF00069	0.484
MOD_NEK2_1	74	79	PF00069	0.558
MOD_NEK2_2	111	116	PF00069	0.568
MOD_NEK2_2	589	594	PF00069	0.501
MOD_NEK2_2	70	75	PF00069	0.551
MOD_PIKK_1	141	147	PF00454	0.565
MOD_PKA_1	470	476	PF00069	0.389
MOD_PKA_2	319	325	PF00069	0.482
MOD_PKA_2	348	354	PF00069	0.389
MOD_PKA_2	378	384	PF00069	0.389
MOD_PKA_2	407	413	PF00069	0.383
MOD_PKA_2	470	476	PF00069	0.389
MOD_PKA_2	74	80	PF00069	0.560
MOD_PKA_2	93	99	PF00069	0.664
MOD_PKB_1	504	512	PF00069	0.389
MOD_Plk_1	111	117	PF00069	0.629
MOD_Plk_1	158	164	PF00069	0.659
MOD_Plk_1	173	179	PF00069	0.602
MOD_Plk_1	589	595	PF00069	0.502
MOD_Plk_2-3	133	139	PF00069	0.561
MOD_Plk_2-3	32	38	PF00069	0.509
MOD_Plk_4	216	222	PF00069	0.641
MOD_Plk_4	470	476	PF00069	0.389
MOD_Plk_4	98	104	PF00069	0.705
MOD_ProDKin_1	13	19	PF00069	0.448
MOD_ProDKin_1	145	151	PF00069	0.631
MOD_ProDKin_1	2	8	PF00069	0.635
MOD_ProDKin_1	447	453	PF00069	0.389
MOD_ProDKin_1	571	577	PF00069	0.319
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.514
TRG_ENDOCYTIC_2	203	206	PF00928	0.650
TRG_ENDOCYTIC_2	27	30	PF00928	0.536
TRG_ENDOCYTIC_2	438	441	PF00928	0.389
TRG_ENDOCYTIC_2	62	65	PF00928	0.634
TRG_ER_diArg_1	280	282	PF00400	0.686
TRG_ER_diArg_1	317	319	PF00400	0.496
TRG_ER_diArg_1	376	378	PF00400	0.284
TRG_ER_diArg_1	503	506	PF00400	0.389
TRG_ER_diArg_1	593	596	PF00400	0.459
TRG_ER_diArg_1	601	603	PF00400	0.400
TRG_NLS_MonoExtN_4	591	598	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3C6	Leishmania donovani	93%	100%
A4I5F0	Leishmania infantum	93%	100%
E9B0P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%