Small nuclear ribonucleoprotein E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein polypeptide e, putative

Species:

Leishmania major

UniProt:

Q4Q7I2_LEIMA

TriTrypDb:

LmjF.30.1205 , LMJLV39_300018600 , LMJSD75_300018300

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	9
GO:0005682	U5 snRNP	5	9
GO:0005685	U1 snRNP	5	9
GO:0005686	U2 snRNP	5	9
GO:0005687	U4 snRNP	5	9
GO:0005737	cytoplasm	2	9
GO:0030532	small nuclear ribonucleoprotein complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	9
GO:0071011	precatalytic spliceosome	4	2
GO:0097525	spliceosomal snRNP complex	4	9
GO:0097526	spliceosomal tri-snRNP complex	5	9
GO:0110165	cellular anatomical entity	1	9
GO:0120114	Sm-like protein family complex	2	9
GO:0140513	nuclear protein-containing complex	2	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

Q4Q7I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I2

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0022618	ribonucleoprotein complex assembly	6	9
GO:0043933	protein-containing complex organization	4	9
GO:0065003	protein-containing complex assembly	5	9
GO:0071826	ribonucleoprotein complex subunit organization	5	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	70	74	PF00082	0.259
DOC_CYCLIN_RxL_1	64	76	PF00134	0.464
DOC_MAPK_gen_1	64	73	PF00069	0.534
LIG_14-3-3_CanoR_1	61	67	PF00244	0.510
LIG_Actin_WH2_2	45	63	PF00022	0.451
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_FHA_1	10	16	PF00498	0.453
LIG_LIR_Gen_1	45	52	PF02991	0.459
LIG_LIR_Nem_3	45	50	PF02991	0.475
LIG_PDZ_Class_2	81	86	PF00595	0.531
LIG_SH2_STAP1	44	48	PF00017	0.459
LIG_SH3_3	27	33	PF00018	0.482
LIG_SH3_3	77	83	PF00018	0.500
MOD_CK1_1	2	8	PF00069	0.619
MOD_GlcNHglycan	1	4	PF01048	0.640
MOD_NEK2_1	60	65	PF00069	0.408
MOD_PKA_2	60	66	PF00069	0.408
TRG_ENDOCYTIC_2	44	47	PF00928	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE83	Leptomonas seymouri	86%	100%
A0A0S4KHT0	Bodo saltans	42%	99%
A0A3Q8IEV2	Leishmania donovani	97%	100%
A1XQR9	Sus scrofa	33%	93%
A4FUI2	Bos taurus	33%	93%
A4HI73	Leishmania braziliensis	88%	100%
A4I5F2	Leishmania infantum	98%	100%
A8XDT0	Caenorhabditis briggsae	39%	96%
C9ZQT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B0Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P62303	Gallus gallus	33%	93%
P62304	Homo sapiens	33%	93%
P62305	Mus musculus	33%	93%
Q12330	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	91%
Q7ZUG0	Danio rerio	33%	93%
Q9USZ3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q9VLV5	Drosophila melanogaster	38%	91%
Q9XTU6	Caenorhabditis elegans	39%	96%