RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4Q7I1_LEIMA

TriTrypDb:

LmjF.30.1230 , LMJLV39_300018800 , LMJSD75_300018500

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I1

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	11
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	11
GO:0072344	rescue of stalled ribosome	6	11
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0005488	binding	1	5
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043022	ribosome binding	4	2
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0044877	protein-containing complex binding	2	2
GO:0046872	metal ion binding	4	5
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.293
CLV_NRD_NRD_1	103	105	PF00675	0.566
CLV_NRD_NRD_1	360	362	PF00675	0.655
CLV_NRD_NRD_1	546	548	PF00675	0.565
CLV_NRD_NRD_1	590	592	PF00675	0.623
CLV_NRD_NRD_1	73	75	PF00675	0.404
CLV_PCSK_KEX2_1	103	105	PF00082	0.566
CLV_PCSK_KEX2_1	213	215	PF00082	0.547
CLV_PCSK_KEX2_1	360	362	PF00082	0.653
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.547
CLV_PCSK_SKI1_1	104	108	PF00082	0.490
CLV_PCSK_SKI1_1	173	177	PF00082	0.351
CLV_PCSK_SKI1_1	592	596	PF00082	0.624
CLV_PCSK_SKI1_1	597	601	PF00082	0.583
CLV_PCSK_SKI1_1	75	79	PF00082	0.335
DEG_APCC_KENBOX_2	351	355	PF00400	0.659
DEG_SPOP_SBC_1	404	408	PF00917	0.674
DOC_CKS1_1	669	674	PF01111	0.575
DOC_MAPK_gen_1	74	82	PF00069	0.349
DOC_PP4_FxxP_1	497	500	PF00568	0.520
DOC_USP7_MATH_1	134	138	PF00917	0.403
DOC_USP7_MATH_1	310	314	PF00917	0.582
DOC_USP7_MATH_1	319	323	PF00917	0.633
DOC_USP7_MATH_1	325	329	PF00917	0.629
DOC_USP7_MATH_1	405	409	PF00917	0.656
DOC_USP7_MATH_1	422	426	PF00917	0.656
DOC_USP7_MATH_1	567	571	PF00917	0.547
DOC_USP7_MATH_1	626	630	PF00917	0.723
DOC_USP7_MATH_1	635	639	PF00917	0.622
DOC_USP7_MATH_1	642	646	PF00917	0.651
DOC_USP7_MATH_1	661	665	PF00917	0.477
DOC_USP7_MATH_1	673	677	PF00917	0.604
DOC_WW_Pin1_4	115	120	PF00397	0.466
DOC_WW_Pin1_4	22	27	PF00397	0.535
DOC_WW_Pin1_4	300	305	PF00397	0.619
DOC_WW_Pin1_4	320	325	PF00397	0.607
DOC_WW_Pin1_4	461	466	PF00397	0.548
DOC_WW_Pin1_4	578	583	PF00397	0.756
DOC_WW_Pin1_4	584	589	PF00397	0.660
DOC_WW_Pin1_4	668	673	PF00397	0.710
DOC_WW_Pin1_4	678	683	PF00397	0.690
LIG_14-3-3_CanoR_1	103	112	PF00244	0.519
LIG_14-3-3_CanoR_1	200	204	PF00244	0.539
LIG_14-3-3_CanoR_1	240	246	PF00244	0.494
LIG_14-3-3_CanoR_1	419	428	PF00244	0.674
LIG_14-3-3_CanoR_1	463	469	PF00244	0.508
LIG_14-3-3_CanoR_1	61	66	PF00244	0.404
LIG_Actin_WH2_2	98	115	PF00022	0.434
LIG_AP2alpha_2	145	147	PF02296	0.486
LIG_APCC_ABBA_1	24	29	PF00400	0.498
LIG_BIR_II_1	1	5	PF00653	0.733
LIG_BRCT_BRCA1_1	387	391	PF00533	0.430
LIG_BRCT_BRCA1_1	422	426	PF00533	0.662
LIG_BRCT_BRCA1_1	664	668	PF00533	0.563
LIG_eIF4E_1	219	225	PF01652	0.364
LIG_EVH1_2	207	211	PF00568	0.438
LIG_FHA_1	130	136	PF00498	0.391
LIG_FHA_1	232	238	PF00498	0.427
LIG_FHA_1	393	399	PF00498	0.558
LIG_FHA_1	511	517	PF00498	0.385
LIG_FHA_1	533	539	PF00498	0.590
LIG_FHA_1	82	88	PF00498	0.405
LIG_LIR_Apic_2	130	134	PF02991	0.327
LIG_LIR_Apic_2	495	500	PF02991	0.516
LIG_LIR_Gen_1	145	153	PF02991	0.426
LIG_LIR_Gen_1	162	170	PF02991	0.338
LIG_LIR_Gen_1	336	343	PF02991	0.530
LIG_LIR_Gen_1	467	474	PF02991	0.570
LIG_LIR_Gen_1	486	497	PF02991	0.417
LIG_LIR_Nem_3	145	150	PF02991	0.441
LIG_LIR_Nem_3	162	168	PF02991	0.392
LIG_LIR_Nem_3	244	248	PF02991	0.367
LIG_LIR_Nem_3	336	340	PF02991	0.519
LIG_LIR_Nem_3	388	394	PF02991	0.417
LIG_LIR_Nem_3	467	471	PF02991	0.578
LIG_LIR_Nem_3	485	491	PF02991	0.422
LIG_LIR_Nem_3	693	699	PF02991	0.584
LIG_NRP_CendR_1	722	723	PF00754	0.732
LIG_PCNA_yPIPBox_3	519	527	PF02747	0.387
LIG_Pex14_1	139	143	PF04695	0.403
LIG_Pex14_2	243	247	PF04695	0.514
LIG_Pex14_2	337	341	PF04695	0.637
LIG_Pex14_2	503	507	PF04695	0.371
LIG_SH2_CRK	131	135	PF00017	0.347
LIG_SH2_CRK	489	493	PF00017	0.395
LIG_SH2_SRC	143	146	PF00017	0.486
LIG_SH2_STAP1	183	187	PF00017	0.415
LIG_SH2_STAP1	233	237	PF00017	0.487
LIG_SH2_STAP1	27	31	PF00017	0.437
LIG_SH2_STAP1	474	478	PF00017	0.479
LIG_SH2_STAP1	489	493	PF00017	0.474
LIG_SH2_STAT5	111	114	PF00017	0.497
LIG_SH2_STAT5	131	134	PF00017	0.322
LIG_SH2_STAT5	165	168	PF00017	0.337
LIG_SH2_STAT5	233	236	PF00017	0.502
LIG_SH2_STAT5	385	388	PF00017	0.446
LIG_SH2_STAT5	474	477	PF00017	0.526
LIG_SH2_STAT5	53	56	PF00017	0.339
LIG_SH3_3	370	376	PF00018	0.500
LIG_SH3_3	459	465	PF00018	0.630
LIG_SH3_3	580	586	PF00018	0.533
LIG_SH3_3	666	672	PF00018	0.675
LIG_SH3_3	676	682	PF00018	0.633
LIG_SH3_3	694	700	PF00018	0.507
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.558
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.485
LIG_SUMO_SIM_par_1	507	513	PF11976	0.353
LIG_TRAF2_1	375	378	PF00917	0.497
LIG_TRAF2_1	522	525	PF00917	0.500
LIG_TRAF2_1	541	544	PF00917	0.412
LIG_TRAF2_1	88	91	PF00917	0.523
LIG_TRAF2_1	95	98	PF00917	0.488
LIG_TRAF2_2	620	625	PF00917	0.724
LIG_TYR_ITIM	163	168	PF00017	0.314
MOD_CDK_SPxxK_3	584	591	PF00069	0.709
MOD_CK1_1	201	207	PF00069	0.498
MOD_CK1_1	25	31	PF00069	0.590
MOD_CK1_1	311	317	PF00069	0.603
MOD_CK1_1	397	403	PF00069	0.640
MOD_CK1_1	420	426	PF00069	0.664
MOD_CK1_1	464	470	PF00069	0.420
MOD_CK1_1	570	576	PF00069	0.719
MOD_CK1_1	578	584	PF00069	0.654
MOD_CK1_1	659	665	PF00069	0.641
MOD_CK2_1	85	91	PF00069	0.571
MOD_CK2_1	92	98	PF00069	0.580
MOD_Cter_Amidation	358	361	PF01082	0.640
MOD_Cter_Amidation	589	592	PF01082	0.560
MOD_GlcNHglycan	1	4	PF01048	0.597
MOD_GlcNHglycan	14	17	PF01048	0.531
MOD_GlcNHglycan	309	313	PF01048	0.634
MOD_GlcNHglycan	316	319	PF01048	0.626
MOD_GlcNHglycan	387	390	PF01048	0.579
MOD_GlcNHglycan	407	410	PF01048	0.742
MOD_GlcNHglycan	420	423	PF01048	0.453
MOD_GlcNHglycan	480	483	PF01048	0.402
MOD_GlcNHglycan	617	620	PF01048	0.736
MOD_GlcNHglycan	625	629	PF01048	0.510
MOD_GlcNHglycan	637	640	PF01048	0.573
MOD_GlcNHglycan	664	667	PF01048	0.617
MOD_GlcNHglycan	94	97	PF01048	0.512
MOD_GSK3_1	243	250	PF00069	0.439
MOD_GSK3_1	310	317	PF00069	0.508
MOD_GSK3_1	319	326	PF00069	0.676
MOD_GSK3_1	413	420	PF00069	0.709
MOD_GSK3_1	478	485	PF00069	0.493
MOD_GSK3_1	626	633	PF00069	0.685
MOD_GSK3_1	664	671	PF00069	0.660
MOD_GSK3_1	673	680	PF00069	0.577
MOD_GSK3_1	81	88	PF00069	0.433
MOD_LATS_1	470	476	PF00433	0.385
MOD_N-GLC_1	417	422	PF02516	0.723
MOD_N-GLC_1	578	583	PF02516	0.617
MOD_NEK2_1	243	248	PF00069	0.425
MOD_NEK2_1	394	399	PF00069	0.577
MOD_NEK2_1	478	483	PF00069	0.461
MOD_NEK2_1	613	618	PF00069	0.700
MOD_NEK2_2	51	56	PF00069	0.404
MOD_NEK2_2	642	647	PF00069	0.741
MOD_OFUCOSY	133	138	PF10250	0.394
MOD_OFUCOSY	50	55	PF10250	0.390
MOD_PIKK_1	532	538	PF00454	0.581
MOD_PIKK_1	75	81	PF00454	0.345
MOD_PKA_2	199	205	PF00069	0.518
MOD_PKA_2	418	424	PF00069	0.658
MOD_Plk_1	198	204	PF00069	0.477
MOD_Plk_1	692	698	PF00069	0.644
MOD_Plk_1	75	81	PF00069	0.361
MOD_Plk_2-3	269	275	PF00069	0.372
MOD_Plk_4	220	226	PF00069	0.577
MOD_Plk_4	664	670	PF00069	0.575
MOD_ProDKin_1	115	121	PF00069	0.461
MOD_ProDKin_1	22	28	PF00069	0.524
MOD_ProDKin_1	300	306	PF00069	0.622
MOD_ProDKin_1	320	326	PF00069	0.606
MOD_ProDKin_1	461	467	PF00069	0.544
MOD_ProDKin_1	578	584	PF00069	0.757
MOD_ProDKin_1	668	674	PF00069	0.711
MOD_ProDKin_1	678	684	PF00069	0.692
MOD_SUMO_rev_2	545	555	PF00179	0.529
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.347
TRG_ENDOCYTIC_2	165	168	PF00928	0.315
TRG_ENDOCYTIC_2	468	471	PF00928	0.453
TRG_ENDOCYTIC_2	488	491	PF00928	0.391
TRG_ER_diArg_1	102	104	PF00400	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA72	Leptomonas seymouri	65%	100%
A0A0S4KKN7	Bodo saltans	39%	100%
A0A1X0P1Y0	Trypanosomatidae	43%	100%
A0A3S7X380	Leishmania donovani	94%	100%
A0A422P542	Trypanosoma rangeli	41%	100%
A4HI75	Leishmania braziliensis	80%	100%
A4I5F4	Leishmania infantum	94%	100%
E9B0Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BYZ6	Trypanosoma cruzi	36%	100%