Putative calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q7I0_LEIMA

TriTrypDb:

LmjF.30.1240 , LMJLV39_300018900 , LMJSD75_300018600

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q7I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7I0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005509	calcium ion binding	5	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	344	346	PF00675	0.606
CLV_NRD_NRD_1	352	354	PF00675	0.580
CLV_NRD_NRD_1	40	42	PF00675	0.475
CLV_NRD_NRD_1	434	436	PF00675	0.417
CLV_PCSK_KEX2_1	257	259	PF00082	0.443
CLV_PCSK_KEX2_1	352	354	PF00082	0.467
CLV_PCSK_KEX2_1	40	42	PF00082	0.478
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.448
CLV_PCSK_SKI1_1	165	169	PF00082	0.396
CLV_PCSK_SKI1_1	257	261	PF00082	0.536
CLV_PCSK_SKI1_1	353	357	PF00082	0.546
CLV_PCSK_SKI1_1	381	385	PF00082	0.485
CLV_PCSK_SKI1_1	437	441	PF00082	0.529
CLV_PCSK_SKI1_1	481	485	PF00082	0.413
CLV_PCSK_SKI1_1	87	91	PF00082	0.408
DEG_APCC_DBOX_1	380	388	PF00400	0.468
DEG_APCC_DBOX_1	86	94	PF00400	0.392
DOC_CDC14_PxL_1	64	72	PF14671	0.416
DOC_CYCLIN_RxL_1	84	92	PF00134	0.384
DOC_MAPK_gen_1	142	151	PF00069	0.434
DOC_MAPK_gen_1	257	266	PF00069	0.534
DOC_MAPK_gen_1	435	442	PF00069	0.522
DOC_MAPK_gen_1	481	489	PF00069	0.418
DOC_MAPK_gen_1	73	81	PF00069	0.462
DOC_MAPK_MEF2A_6	257	266	PF00069	0.481
DOC_PP1_SILK_1	523	528	PF00149	0.487
DOC_PP2B_LxvP_1	245	248	PF13499	0.594
DOC_PP2B_LxvP_1	297	300	PF13499	0.688
DOC_PP2B_PxIxI_1	332	338	PF00149	0.502
DOC_SPAK_OSR1_1	258	262	PF12202	0.532
DOC_SPAK_OSR1_1	76	80	PF12202	0.398
DOC_USP7_MATH_1	215	219	PF00917	0.673
DOC_USP7_UBL2_3	527	531	PF12436	0.483
DOC_WW_Pin1_4	8	13	PF00397	0.438
LIG_14-3-3_CanoR_1	345	354	PF00244	0.519
LIG_14-3-3_CanoR_1	62	67	PF00244	0.486
LIG_Actin_WH2_2	306	323	PF00022	0.501
LIG_APCC_ABBA_1	499	504	PF00400	0.416
LIG_BRCT_BRCA1_1	366	370	PF00533	0.429
LIG_BRCT_BRCA1_1	60	64	PF00533	0.419
LIG_EH1_1	236	244	PF00400	0.560
LIG_FHA_1	228	234	PF00498	0.576
LIG_FHA_1	271	277	PF00498	0.611
LIG_FHA_1	32	38	PF00498	0.467
LIG_FHA_1	402	408	PF00498	0.659
LIG_FHA_1	527	533	PF00498	0.536
LIG_FHA_2	453	459	PF00498	0.525
LIG_FHA_2	98	104	PF00498	0.525
LIG_Integrin_RGD_1	122	124	PF01839	0.476
LIG_Integrin_RGD_1	145	147	PF01839	0.484
LIG_LIR_Apic_2	204	209	PF02991	0.535
LIG_LIR_Apic_2	528	533	PF02991	0.546
LIG_LIR_Gen_1	135	143	PF02991	0.497
LIG_LIR_Gen_1	147	156	PF02991	0.411
LIG_LIR_Gen_1	419	427	PF02991	0.402
LIG_LIR_Gen_1	441	448	PF02991	0.427
LIG_LIR_Gen_1	61	71	PF02991	0.416
LIG_LIR_Nem_3	135	140	PF02991	0.518
LIG_LIR_Nem_3	147	151	PF02991	0.415
LIG_LIR_Nem_3	393	398	PF02991	0.481
LIG_LIR_Nem_3	419	423	PF02991	0.417
LIG_LIR_Nem_3	441	446	PF02991	0.448
LIG_LIR_Nem_3	503	508	PF02991	0.422
LIG_LIR_Nem_3	519	525	PF02991	0.447
LIG_LIR_Nem_3	61	67	PF02991	0.467
LIG_NRBOX	85	91	PF00104	0.384
LIG_Pex14_1	175	179	PF04695	0.444
LIG_Pex14_1	535	539	PF04695	0.606
LIG_Pex14_2	486	490	PF04695	0.421
LIG_PTB_Apo_2	186	193	PF02174	0.559
LIG_PTB_Phospho_1	186	192	PF10480	0.557
LIG_SH2_CRK	509	513	PF00017	0.456
LIG_SH2_GRB2like	508	511	PF00017	0.414
LIG_SH2_SRC	324	327	PF00017	0.538
LIG_SH2_STAP1	137	141	PF00017	0.604
LIG_SH2_STAP1	420	424	PF00017	0.393
LIG_SH2_STAP1	502	506	PF00017	0.413
LIG_SH2_STAT5	148	151	PF00017	0.501
LIG_SH2_STAT5	166	169	PF00017	0.276
LIG_SH2_STAT5	179	182	PF00017	0.403
LIG_SH2_STAT5	192	195	PF00017	0.457
LIG_SH2_STAT5	206	209	PF00017	0.441
LIG_SH2_STAT5	232	235	PF00017	0.568
LIG_SH2_STAT5	324	327	PF00017	0.425
LIG_SH2_STAT5	426	429	PF00017	0.431
LIG_SH2_STAT5	502	505	PF00017	0.538
LIG_SH2_STAT5	54	57	PF00017	0.490
LIG_SH3_1	196	202	PF00018	0.482
LIG_SH3_3	196	202	PF00018	0.482
LIG_SH3_3	241	247	PF00018	0.579
LIG_SH3_3	403	409	PF00018	0.634
LIG_SUMO_SIM_anti_2	310	318	PF11976	0.376
LIG_SUMO_SIM_par_1	260	265	PF11976	0.526
LIG_SUMO_SIM_par_1	310	318	PF11976	0.512
LIG_SUMO_SIM_par_1	467	474	PF11976	0.461
LIG_TRAF2_1	27	30	PF00917	0.473
LIG_TRAF2_1	399	402	PF00917	0.577
LIG_TRAF2_1	409	412	PF00917	0.693
LIG_TRAF2_1	413	416	PF00917	0.615
LIG_TRFH_1	274	278	PF08558	0.610
LIG_TRFH_1	497	501	PF08558	0.423
LIG_UBA3_1	66	73	PF00899	0.414
MOD_CK1_1	135	141	PF00069	0.611
MOD_CK1_1	95	101	PF00069	0.491
MOD_CK2_1	24	30	PF00069	0.502
MOD_CK2_1	97	103	PF00069	0.494
MOD_Cter_Amidation	350	353	PF01082	0.509
MOD_GlcNHglycan	156	159	PF01048	0.581
MOD_GlcNHglycan	225	228	PF01048	0.719
MOD_GlcNHglycan	512	515	PF01048	0.432
MOD_GSK3_1	122	129	PF00069	0.669
MOD_GSK3_1	20	27	PF00069	0.536
MOD_GSK3_1	223	230	PF00069	0.701
MOD_GSK3_1	260	267	PF00069	0.456
MOD_GSK3_1	268	275	PF00069	0.475
MOD_GSK3_1	289	296	PF00069	0.629
MOD_GSK3_1	58	65	PF00069	0.522
MOD_GSK3_1	95	102	PF00069	0.580
MOD_LATS_1	268	274	PF00433	0.600
MOD_N-GLC_1	227	232	PF02516	0.609
MOD_N-GLC_1	282	287	PF02516	0.585
MOD_N-GLC_1	431	436	PF02516	0.502
MOD_N-GLC_1	452	457	PF02516	0.532
MOD_N-GLC_1	533	538	PF02516	0.601
MOD_NEK2_1	132	137	PF00069	0.532
MOD_NEK2_1	282	287	PF00069	0.616
MOD_NEK2_1	293	298	PF00069	0.547
MOD_NEK2_1	309	314	PF00069	0.414
MOD_NEK2_1	377	382	PF00069	0.516
MOD_NEK2_1	431	436	PF00069	0.502
MOD_NEK2_1	526	531	PF00069	0.505
MOD_NEK2_2	452	457	PF00069	0.532
MOD_NEK2_2	533	538	PF00069	0.579
MOD_PIKK_1	160	166	PF00454	0.480
MOD_PIKK_1	216	222	PF00454	0.502
MOD_PIKK_1	315	321	PF00454	0.498
MOD_PIKK_1	39	45	PF00454	0.432
MOD_PK_1	110	116	PF00069	0.505
MOD_PK_1	260	266	PF00069	0.528
MOD_PKA_1	345	351	PF00069	0.642
MOD_PKA_2	160	166	PF00069	0.561
MOD_PKA_2	364	370	PF00069	0.398
MOD_PKA_2	39	45	PF00069	0.465
MOD_PKB_1	108	116	PF00069	0.530
MOD_Plk_1	110	116	PF00069	0.530
MOD_Plk_1	132	138	PF00069	0.524
MOD_Plk_1	227	233	PF00069	0.568
MOD_Plk_1	264	270	PF00069	0.438
MOD_Plk_1	282	288	PF00069	0.568
MOD_Plk_1	309	315	PF00069	0.459
MOD_Plk_1	452	458	PF00069	0.528
MOD_Plk_1	533	539	PF00069	0.590
MOD_Plk_2-3	92	98	PF00069	0.424
MOD_Plk_4	132	138	PF00069	0.533
MOD_Plk_4	228	234	PF00069	0.488
MOD_Plk_4	289	295	PF00069	0.690
MOD_Plk_4	309	315	PF00069	0.284
MOD_Plk_4	390	396	PF00069	0.497
MOD_ProDKin_1	8	14	PF00069	0.442
TRG_DiLeu_BaEn_3	181	187	PF01217	0.526
TRG_DiLeu_BaEn_4	28	34	PF01217	0.475
TRG_DiLeu_BaEn_4	91	97	PF01217	0.418
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.446
TRG_ENDOCYTIC_2	137	140	PF00928	0.509
TRG_ENDOCYTIC_2	148	151	PF00928	0.407
TRG_ENDOCYTIC_2	192	195	PF00928	0.570
TRG_ENDOCYTIC_2	420	423	PF00928	0.398
TRG_ENDOCYTIC_2	502	505	PF00928	0.436
TRG_ENDOCYTIC_2	509	512	PF00928	0.438
TRG_ER_diArg_1	352	354	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ1	Leptomonas seymouri	77%	100%
A0A1X0P2M2	Trypanosomatidae	49%	100%
A0A3Q8IBX6	Leishmania donovani	88%	100%
A0A422P525	Trypanosoma rangeli	51%	100%
A4HI76	Leishmania braziliensis	88%	100%
A4I676	Leishmania infantum	88%	100%
E9B0Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
V5BU66	Trypanosoma cruzi	50%	100%