N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7H8_LEIMA

TriTrypDb:

LmjF.30.1255 , LMJLV39_300019100 , LMJSD75_300018800

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7H8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7H8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016407	acetyltransferase activity	5	3
GO:0016740	transferase activity	2	4
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.567
CLV_C14_Caspase3-7	29	33	PF00656	0.511
CLV_NRD_NRD_1	184	186	PF00675	0.454
CLV_NRD_NRD_1	226	228	PF00675	0.312
CLV_NRD_NRD_1	272	274	PF00675	0.557
CLV_NRD_NRD_1	323	325	PF00675	0.356
CLV_NRD_NRD_1	330	332	PF00675	0.418
CLV_PCSK_KEX2_1	184	186	PF00082	0.454
CLV_PCSK_KEX2_1	225	227	PF00082	0.312
CLV_PCSK_KEX2_1	272	274	PF00082	0.544
CLV_PCSK_KEX2_1	276	278	PF00082	0.577
CLV_PCSK_KEX2_1	323	325	PF00082	0.356
CLV_PCSK_KEX2_1	330	332	PF00082	0.418
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.595
CLV_PCSK_PC7_1	272	278	PF00082	0.648
CLV_PCSK_SKI1_1	273	277	PF00082	0.606
CLV_TASPASE1	65	71	PF01112	0.512
DEG_APCC_DBOX_1	261	269	PF00400	0.459
DEG_APCC_DBOX_1	81	89	PF00400	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DOC_ANK_TNKS_1	207	214	PF00023	0.302
DOC_CYCLIN_RxL_1	320	329	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.547
DOC_MAPK_gen_1	79	88	PF00069	0.414
DOC_PP1_RVXF_1	321	328	PF00149	0.378
DOC_PP2B_LxvP_1	53	56	PF13499	0.554
DOC_USP7_MATH_1	106	110	PF00917	0.607
DOC_USP7_MATH_1	202	206	PF00917	0.340
DOC_USP7_MATH_1	275	279	PF00917	0.586
DOC_USP7_MATH_1	39	43	PF00917	0.774
DOC_USP7_MATH_1	78	82	PF00917	0.450
DOC_WW_Pin1_4	133	138	PF00397	0.290
DOC_WW_Pin1_4	172	177	PF00397	0.472
DOC_WW_Pin1_4	183	188	PF00397	0.300
DOC_WW_Pin1_4	198	203	PF00397	0.234
LIG_14-3-3_CanoR_1	108	118	PF00244	0.551
LIG_14-3-3_CanoR_1	170	176	PF00244	0.509
LIG_14-3-3_CanoR_1	227	233	PF00244	0.317
LIG_14-3-3_CanoR_1	96	104	PF00244	0.536
LIG_deltaCOP1_diTrp_1	69	74	PF00928	0.447
LIG_FHA_1	176	182	PF00498	0.304
LIG_FHA_1	233	239	PF00498	0.388
LIG_FHA_1	255	261	PF00498	0.401
LIG_FHA_1	9	15	PF00498	0.523
LIG_FHA_2	290	296	PF00498	0.538
LIG_LIR_Gen_1	212	222	PF02991	0.312
LIG_LIR_Gen_1	58	66	PF02991	0.475
LIG_LIR_Nem_3	212	217	PF02991	0.326
LIG_LIR_Nem_3	58	62	PF02991	0.437
LIG_LIR_Nem_3	71	77	PF02991	0.495
LIG_PDZ_Class_2	346	351	PF00595	0.349
LIG_Rb_LxCxE_1	235	254	PF01857	0.492
LIG_SH2_CRK	322	326	PF00017	0.385
LIG_SH2_NCK_1	34	38	PF00017	0.528
LIG_SH2_PTP2	214	217	PF00017	0.388
LIG_SH2_SRC	59	62	PF00017	0.476
LIG_SH2_STAT5	21	24	PF00017	0.415
LIG_SH2_STAT5	214	217	PF00017	0.312
LIG_SH2_STAT5	332	335	PF00017	0.490
LIG_SH2_STAT5	59	62	PF00017	0.525
LIG_SH3_3	216	222	PF00018	0.340
LIG_SUMO_SIM_anti_2	342	348	PF11976	0.349
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.480
LIG_TYR_ITIM	57	62	PF00017	0.403
MOD_CDK_SPK_2	133	138	PF00069	0.291
MOD_CK1_1	109	115	PF00069	0.584
MOD_CK1_1	121	127	PF00069	0.482
MOD_CK1_1	151	157	PF00069	0.357
MOD_CK1_1	172	178	PF00069	0.482
MOD_CK1_1	193	199	PF00069	0.366
MOD_CK1_1	42	48	PF00069	0.665
MOD_CK1_1	70	76	PF00069	0.439
MOD_CK2_1	303	309	PF00069	0.761
MOD_GlcNHglycan	122	126	PF01048	0.370
MOD_GlcNHglycan	153	156	PF01048	0.315
MOD_GlcNHglycan	171	174	PF01048	0.277
MOD_GlcNHglycan	192	195	PF01048	0.428
MOD_GlcNHglycan	41	44	PF01048	0.665
MOD_GlcNHglycan	97	100	PF01048	0.516
MOD_GSK3_1	100	107	PF00069	0.616
MOD_GSK3_1	109	116	PF00069	0.577
MOD_GSK3_1	196	203	PF00069	0.432
MOD_GSK3_1	228	235	PF00069	0.340
MOD_GSK3_1	264	271	PF00069	0.517
MOD_GSK3_1	39	46	PF00069	0.722
MOD_GSK3_1	6	13	PF00069	0.513
MOD_NEK2_1	148	153	PF00069	0.404
MOD_NEK2_1	268	273	PF00069	0.614
MOD_NEK2_2	16	21	PF00069	0.463
MOD_OFUCOSY	147	152	PF10250	0.340
MOD_PIKK_1	232	238	PF00454	0.319
MOD_PKA_2	169	175	PF00069	0.401
MOD_PKA_2	207	213	PF00069	0.412
MOD_PKA_2	78	84	PF00069	0.487
MOD_PKA_2	95	101	PF00069	0.507
MOD_Plk_1	121	127	PF00069	0.243
MOD_Plk_1	281	287	PF00069	0.595
MOD_Plk_1	70	76	PF00069	0.448
MOD_Plk_4	177	183	PF00069	0.400
MOD_Plk_4	228	234	PF00069	0.321
MOD_Plk_4	55	61	PF00069	0.515
MOD_ProDKin_1	133	139	PF00069	0.290
MOD_ProDKin_1	172	178	PF00069	0.472
MOD_ProDKin_1	183	189	PF00069	0.300
MOD_ProDKin_1	198	204	PF00069	0.234
TRG_ENDOCYTIC_2	214	217	PF00928	0.312
TRG_ENDOCYTIC_2	322	325	PF00928	0.382
TRG_ENDOCYTIC_2	59	62	PF00928	0.418
TRG_ER_diArg_1	224	227	PF00400	0.312
TRG_ER_diArg_1	291	294	PF00400	0.589
TRG_ER_diArg_1	322	324	PF00400	0.383
TRG_ER_diArg_1	330	332	PF00400	0.421
TRG_NES_CRM1_1	52	65	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W0	Leptomonas seymouri	43%	100%
A0A3S7X392	Leishmania donovani	90%	100%
A4HI78	Leishmania braziliensis	69%	96%
A4I5F7	Leishmania infantum	90%	100%
E9B0Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%