Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7H6_LEIMA

TriTrypDb:

LmjF.30.1270 , LMJLV39_300019300 , LMJSD75_300019000

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.634
CLV_C14_Caspase3-7	597	601	PF00656	0.604
CLV_NRD_NRD_1	15	17	PF00675	0.477
CLV_NRD_NRD_1	269	271	PF00675	0.427
CLV_NRD_NRD_1	344	346	PF00675	0.479
CLV_NRD_NRD_1	386	388	PF00675	0.435
CLV_NRD_NRD_1	402	404	PF00675	0.451
CLV_NRD_NRD_1	659	661	PF00675	0.643
CLV_NRD_NRD_1	681	683	PF00675	0.576
CLV_NRD_NRD_1	81	83	PF00675	0.404
CLV_PCSK_KEX2_1	15	17	PF00082	0.477
CLV_PCSK_KEX2_1	269	271	PF00082	0.427
CLV_PCSK_KEX2_1	344	346	PF00082	0.479
CLV_PCSK_KEX2_1	385	387	PF00082	0.514
CLV_PCSK_KEX2_1	402	404	PF00082	0.457
CLV_PCSK_KEX2_1	658	660	PF00082	0.635
CLV_PCSK_KEX2_1	681	683	PF00082	0.576
CLV_PCSK_SKI1_1	15	19	PF00082	0.447
CLV_PCSK_SKI1_1	230	234	PF00082	0.612
CLV_PCSK_SKI1_1	262	266	PF00082	0.604
CLV_PCSK_SKI1_1	301	305	PF00082	0.441
CLV_PCSK_SKI1_1	371	375	PF00082	0.415
CLV_PCSK_SKI1_1	386	390	PF00082	0.464
CLV_PCSK_SKI1_1	403	407	PF00082	0.408
CLV_PCSK_SKI1_1	607	611	PF00082	0.670
CLV_PCSK_SKI1_1	636	640	PF00082	0.484
CLV_Separin_Metazoa	180	184	PF03568	0.418
CLV_Separin_Metazoa	667	671	PF03568	0.595
DEG_APCC_DBOX_1	136	144	PF00400	0.389
DEG_APCC_DBOX_1	268	276	PF00400	0.520
DEG_APCC_DBOX_1	402	410	PF00400	0.414
DEG_APCC_DBOX_1	516	524	PF00400	0.576
DOC_CYCLIN_RxL_1	298	306	PF00134	0.427
DOC_MAPK_RevD_3	68	83	PF00069	0.473
DOC_MIT_MIM_1	431	440	PF04212	0.398
DOC_PP2B_LxvP_1	48	51	PF13499	0.443
DOC_USP7_MATH_1	194	198	PF00917	0.707
DOC_USP7_MATH_1	199	203	PF00917	0.692
DOC_USP7_MATH_1	308	312	PF00917	0.488
DOC_USP7_MATH_1	315	319	PF00917	0.534
DOC_USP7_MATH_1	507	511	PF00917	0.588
DOC_USP7_MATH_1	66	70	PF00917	0.654
DOC_WW_Pin1_4	104	109	PF00397	0.517
DOC_WW_Pin1_4	210	215	PF00397	0.725
DOC_WW_Pin1_4	222	227	PF00397	0.658
DOC_WW_Pin1_4	233	238	PF00397	0.505
DOC_WW_Pin1_4	26	31	PF00397	0.569
DOC_WW_Pin1_4	598	603	PF00397	0.602
DOC_WW_Pin1_4	607	612	PF00397	0.520
DOC_WW_Pin1_4	669	674	PF00397	0.655
LIG_14-3-3_CanoR_1	209	213	PF00244	0.585
LIG_14-3-3_CanoR_1	262	267	PF00244	0.489
LIG_14-3-3_CanoR_1	386	396	PF00244	0.542
LIG_14-3-3_CanoR_1	531	541	PF00244	0.470
LIG_Actin_WH2_2	33	49	PF00022	0.466
LIG_APCC_ABBA_1	592	597	PF00400	0.611
LIG_BIR_III_4	559	563	PF00653	0.783
LIG_BRCT_BRCA1_1	217	221	PF00533	0.770
LIG_CaM_IQ_9	279	295	PF13499	0.490
LIG_Clathr_ClatBox_1	437	441	PF01394	0.403
LIG_EH1_1	42	50	PF00400	0.414
LIG_eIF4E_1	633	639	PF01652	0.554
LIG_FHA_1	108	114	PF00498	0.475
LIG_FHA_1	263	269	PF00498	0.529
LIG_FHA_1	311	317	PF00498	0.501
LIG_FHA_1	355	361	PF00498	0.444
LIG_FHA_1	533	539	PF00498	0.554
LIG_FHA_1	572	578	PF00498	0.607
LIG_FHA_1	689	695	PF00498	0.436
LIG_FHA_2	388	394	PF00498	0.403
LIG_FHA_2	426	432	PF00498	0.473
LIG_FHA_2	509	515	PF00498	0.582
LIG_FHA_2	534	540	PF00498	0.559
LIG_FHA_2	55	61	PF00498	0.590
LIG_LIR_Gen_1	31	41	PF02991	0.353
LIG_LIR_LC3C_4	435	439	PF02991	0.324
LIG_LIR_Nem_3	31	36	PF02991	0.372
LIG_LIR_Nem_3	634	638	PF02991	0.536
LIG_NRBOX	625	631	PF00104	0.549
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.499
LIG_PCNA_yPIPBox_3	490	503	PF02747	0.466
LIG_PCNA_yPIPBox_3	6	14	PF02747	0.360
LIG_PCNA_yPIPBox_3	616	630	PF02747	0.573
LIG_PCNA_yPIPBox_3	679	693	PF02747	0.570
LIG_PTB_Apo_2	260	267	PF02174	0.530
LIG_PTB_Phospho_1	260	266	PF10480	0.531
LIG_SH2_CRK	300	304	PF00017	0.428
LIG_SH2_CRK	635	639	PF00017	0.467
LIG_SH2_STAP1	96	100	PF00017	0.461
LIG_SH3_3	193	199	PF00018	0.699
LIG_SH3_3	20	26	PF00018	0.578
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.422
LIG_SUMO_SIM_anti_2	663	670	PF11976	0.517
LIG_SUMO_SIM_par_1	149	154	PF11976	0.335
LIG_SUMO_SIM_par_1	311	318	PF11976	0.386
LIG_SUMO_SIM_par_1	435	441	PF11976	0.513
LIG_SUMO_SIM_par_1	469	475	PF11976	0.584
LIG_TRAF2_1	167	170	PF00917	0.508
LIG_TRAF2_1	2	5	PF00917	0.504
LIG_TRAF2_1	253	256	PF00917	0.607
LIG_TRAF2_1	390	393	PF00917	0.497
LIG_TRAF2_1	583	586	PF00917	0.610
LIG_TRFH_1	185	189	PF08558	0.463
MOD_CDK_SPxxK_3	598	605	PF00069	0.604
MOD_CDK_SPxxK_3	607	614	PF00069	0.469
MOD_CK1_1	202	208	PF00069	0.638
MOD_CK1_1	238	244	PF00069	0.652
MOD_CK1_1	461	467	PF00069	0.495
MOD_CK1_1	53	59	PF00069	0.551
MOD_CK1_1	580	586	PF00069	0.765
MOD_CK1_1	675	681	PF00069	0.494
MOD_CK2_1	325	331	PF00069	0.580
MOD_CK2_1	387	393	PF00069	0.423
MOD_CK2_1	425	431	PF00069	0.474
MOD_CK2_1	533	539	PF00069	0.577
MOD_CK2_1	54	60	PF00069	0.602
MOD_CK2_1	580	586	PF00069	0.757
MOD_GlcNHglycan	128	131	PF01048	0.643
MOD_GlcNHglycan	153	156	PF01048	0.347
MOD_GlcNHglycan	201	204	PF01048	0.604
MOD_GlcNHglycan	218	221	PF01048	0.758
MOD_GlcNHglycan	310	313	PF01048	0.518
MOD_GlcNHglycan	317	320	PF01048	0.597
MOD_GlcNHglycan	550	553	PF01048	0.588
MOD_GlcNHglycan	559	563	PF01048	0.625
MOD_GlcNHglycan	571	574	PF01048	0.571
MOD_GlcNHglycan	582	585	PF01048	0.700
MOD_GSK3_1	100	107	PF00069	0.541
MOD_GSK3_1	158	165	PF00069	0.519
MOD_GSK3_1	310	317	PF00069	0.630
MOD_GSK3_1	333	340	PF00069	0.620
MOD_GSK3_1	361	368	PF00069	0.513
MOD_GSK3_1	50	57	PF00069	0.573
MOD_GSK3_1	508	515	PF00069	0.586
MOD_N-GLC_1	262	267	PF02516	0.489
MOD_N-GLC_1	458	463	PF02516	0.510
MOD_N-GLC_1	464	469	PF02516	0.479
MOD_N-GLC_1	512	517	PF02516	0.589
MOD_N-GLC_2	85	87	PF02516	0.401
MOD_NEK2_1	101	106	PF00069	0.594
MOD_NEK2_1	208	213	PF00069	0.698
MOD_NEK2_1	216	221	PF00069	0.556
MOD_NEK2_1	310	315	PF00069	0.527
MOD_NEK2_1	458	463	PF00069	0.550
MOD_NEK2_1	548	553	PF00069	0.578
MOD_NEK2_1	558	563	PF00069	0.552
MOD_NEK2_1	631	636	PF00069	0.473
MOD_NEK2_1	688	693	PF00069	0.473
MOD_PIKK_1	107	113	PF00454	0.529
MOD_PIKK_1	31	37	PF00454	0.501
MOD_PIKK_1	362	368	PF00454	0.474
MOD_PIKK_1	425	431	PF00454	0.471
MOD_PKA_2	208	214	PF00069	0.650
MOD_PKA_2	484	490	PF00069	0.543
MOD_PKB_1	385	393	PF00069	0.538
MOD_Plk_1	262	268	PF00069	0.527
MOD_Plk_1	349	355	PF00069	0.456
MOD_Plk_1	458	464	PF00069	0.491
MOD_Plk_1	512	518	PF00069	0.585
MOD_Plk_1	577	583	PF00069	0.668
MOD_Plk_2-3	585	591	PF00069	0.792
MOD_Plk_4	224	230	PF00069	0.495
MOD_Plk_4	337	343	PF00069	0.536
MOD_Plk_4	577	583	PF00069	0.785
MOD_Plk_4	625	631	PF00069	0.439
MOD_Plk_4	642	648	PF00069	0.449
MOD_Plk_4	672	678	PF00069	0.574
MOD_Plk_4	688	694	PF00069	0.429
MOD_ProDKin_1	104	110	PF00069	0.509
MOD_ProDKin_1	210	216	PF00069	0.726
MOD_ProDKin_1	222	228	PF00069	0.659
MOD_ProDKin_1	233	239	PF00069	0.505
MOD_ProDKin_1	26	32	PF00069	0.565
MOD_ProDKin_1	598	604	PF00069	0.606
MOD_ProDKin_1	607	613	PF00069	0.514
MOD_ProDKin_1	669	675	PF00069	0.650
MOD_SUMO_for_1	397	400	PF00179	0.543
MOD_SUMO_rev_2	161	166	PF00179	0.420
MOD_SUMO_rev_2	289	295	PF00179	0.491
TRG_DiLeu_BaEn_3	663	669	PF01217	0.538
TRG_DiLeu_BaEn_4	585	591	PF01217	0.609
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.478
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.520
TRG_ENDOCYTIC_2	300	303	PF00928	0.404
TRG_ENDOCYTIC_2	635	638	PF00928	0.468
TRG_ER_diArg_1	14	16	PF00400	0.477
TRG_ER_diArg_1	268	270	PF00400	0.413
TRG_ER_diArg_1	384	387	PF00400	0.489
TRG_ER_diArg_1	658	660	PF00400	0.630
TRG_NES_CRM1_1	414	427	PF08389	0.560
TRG_NES_CRM1_1	431	445	PF08389	0.309
TRG_Pf-PMV_PEXEL_1	301	306	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	636	641	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P981	Leptomonas seymouri	57%	96%
A0A1X0P283	Trypanosomatidae	29%	100%
A0A3Q8IFR6	Leishmania donovani	93%	100%
A0A3R7NW91	Trypanosoma rangeli	30%	100%
A4HI80	Leishmania braziliensis	77%	100%
A4I5F9	Leishmania infantum	93%	100%
E9B0Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DQP9	Trypanosoma cruzi	33%	100%