Putative U3 small nuclear ribonucleoprotein (SnRNP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nuclear ribonucleoprotein (snRNP), putative

Species:

Leishmania major

UniProt:

Q4Q7H4_LEIMA

TriTrypDb:

LmjF.30.1290 , LMJLV39_300019500 , LMJSD75_300019200

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	10
GO:0034457	Mpp10 complex	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

Q4Q7H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7H4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0019843	rRNA binding	5	12
GO:0030515	snoRNA binding	5	2
GO:0042134	rRNA primary transcript binding	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.254
CLV_NRD_NRD_1	14	16	PF00675	0.451
CLV_NRD_NRD_1	2	4	PF00675	0.464
CLV_NRD_NRD_1	27	29	PF00675	0.352
CLV_NRD_NRD_1	285	287	PF00675	0.444
CLV_NRD_NRD_1	8	10	PF00675	0.443
CLV_PCSK_KEX2_1	2	4	PF00082	0.464
CLV_PCSK_KEX2_1	284	286	PF00082	0.464
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.464
CLV_PCSK_SKI1_1	10	14	PF00082	0.461
CLV_PCSK_SKI1_1	200	204	PF00082	0.253
CLV_PCSK_SKI1_1	216	220	PF00082	0.241
CLV_PCSK_SKI1_1	258	262	PF00082	0.419
CLV_PCSK_SKI1_1	48	52	PF00082	0.506
CLV_PCSK_SKI1_1	54	58	PF00082	0.504
CLV_PCSK_SKI1_1	65	69	PF00082	0.552
DEG_APCC_DBOX_1	257	265	PF00400	0.496
DEG_APCC_KENBOX_2	129	133	PF00400	0.537
DEG_Nend_UBRbox_1	1	4	PF02207	0.489
DOC_CYCLIN_RxL_1	211	223	PF00134	0.462
DOC_MAPK_gen_1	113	121	PF00069	0.451
DOC_MAPK_gen_1	235	245	PF00069	0.454
DOC_MAPK_gen_1	47	53	PF00069	0.444
DOC_PP1_RVXF_1	214	221	PF00149	0.451
DOC_PP1_RVXF_1	94	101	PF00149	0.451
DOC_PP2B_LxvP_1	106	109	PF13499	0.458
DOC_PP4_FxxP_1	207	210	PF00568	0.450
DOC_USP7_MATH_1	212	216	PF00917	0.540
DOC_USP7_UBL2_3	236	240	PF12436	0.507
DOC_WW_Pin1_4	252	257	PF00397	0.455
DOC_WW_Pin1_4	37	42	PF00397	0.466
LIG_14-3-3_CanoR_1	116	122	PF00244	0.462
LIG_14-3-3_CanoR_1	2	6	PF00244	0.480
LIG_14-3-3_CanoR_1	216	221	PF00244	0.451
LIG_14-3-3_CanoR_1	230	235	PF00244	0.451
LIG_14-3-3_CanoR_1	65	75	PF00244	0.522
LIG_14-3-3_CanoR_1	91	100	PF00244	0.501
LIG_EH1_1	161	169	PF00400	0.462
LIG_FHA_1	132	138	PF00498	0.537
LIG_FHA_1	159	165	PF00498	0.537
LIG_FHA_1	269	275	PF00498	0.399
LIG_FHA_1	62	68	PF00498	0.512
LIG_FHA_2	176	182	PF00498	0.451
LIG_FHA_2	55	61	PF00498	0.466
LIG_FHA_2	6	12	PF00498	0.600
LIG_FHA_2	67	73	PF00498	0.433
LIG_LIR_Gen_1	131	139	PF02991	0.492
LIG_LIR_Gen_1	223	234	PF02991	0.455
LIG_LIR_Nem_3	131	136	PF02991	0.492
LIG_LIR_Nem_3	180	186	PF02991	0.468
LIG_LIR_Nem_3	223	229	PF02991	0.455
LIG_LIR_Nem_3	255	260	PF02991	0.512
LIG_LYPXL_SIV_4	256	264	PF13949	0.580
LIG_LYPXL_yS_3	183	186	PF13949	0.451
LIG_NBox_RRM_1	32	42	PF00076	0.464
LIG_PCNA_yPIPBox_3	113	125	PF02747	0.435
LIG_RPA_C_Fungi	86	98	PF08784	0.424
LIG_SH2_CRK	257	261	PF00017	0.458
LIG_SH2_GRB2like	278	281	PF00017	0.438
LIG_SH2_GRB2like	75	78	PF00017	0.543
LIG_SH2_NCK_1	75	79	PF00017	0.495
LIG_SH2_SRC	75	78	PF00017	0.543
LIG_SH2_STAP1	133	137	PF00017	0.338
LIG_SH2_STAT5	133	136	PF00017	0.451
LIG_SH2_STAT5	205	208	PF00017	0.360
LIG_SH3_3	152	158	PF00018	0.304
LIG_SH3_3	271	277	PF00018	0.415
LIG_SUMO_SIM_anti_2	134	142	PF11976	0.304
LIG_SUMO_SIM_par_1	134	142	PF11976	0.302
LIG_TRAF2_1	78	81	PF00917	0.642
LIG_TRFH_1	252	256	PF08558	0.424
LIG_TYR_ITSM	253	260	PF00017	0.389
LIG_WRC_WIRS_1	217	222	PF05994	0.304
LIG_WRC_WIRS_1	226	231	PF05994	0.304
MOD_CDK_SPxK_1	252	258	PF00069	0.310
MOD_CK2_1	175	181	PF00069	0.304
MOD_CK2_1	31	37	PF00069	0.508
MOD_CK2_1	5	11	PF00069	0.600
MOD_Cter_Amidation	238	241	PF01082	0.424
MOD_GlcNHglycan	33	36	PF01048	0.544
MOD_GSK3_1	1	8	PF00069	0.617
MOD_GSK3_1	145	152	PF00069	0.304
MOD_GSK3_1	156	163	PF00069	0.300
MOD_GSK3_1	212	219	PF00069	0.298
MOD_GSK3_1	31	38	PF00069	0.520
MOD_GSK3_1	61	68	PF00069	0.483
MOD_GSK3_1	87	94	PF00069	0.292
MOD_N-GLC_1	117	122	PF02516	0.294
MOD_N-GLC_1	131	136	PF02516	0.367
MOD_N-GLC_1	189	194	PF02516	0.304
MOD_N-GLC_1	65	70	PF02516	0.566
MOD_N-GLC_1	91	96	PF02516	0.424
MOD_NEK2_1	1	6	PF00069	0.478
MOD_NEK2_1	139	144	PF00069	0.324
MOD_NEK2_1	149	154	PF00069	0.278
MOD_NEK2_1	86	91	PF00069	0.395
MOD_NEK2_2	117	122	PF00069	0.338
MOD_PIKK_1	139	145	PF00454	0.319
MOD_PIKK_1	91	97	PF00454	0.307
MOD_PKA_1	54	60	PF00069	0.445
MOD_PKA_2	1	7	PF00069	0.476
MOD_Plk_1	117	123	PF00069	0.282
MOD_Plk_1	212	218	PF00069	0.298
MOD_Plk_4	145	151	PF00069	0.319
MOD_ProDKin_1	252	258	PF00069	0.310
MOD_ProDKin_1	37	43	PF00069	0.463
MOD_SUMO_for_1	234	237	PF00179	0.424
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.348
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.479
TRG_ENDOCYTIC_2	133	136	PF00928	0.338
TRG_ENDOCYTIC_2	183	186	PF00928	0.304
TRG_ENDOCYTIC_2	257	260	PF00928	0.458
TRG_ER_diArg_1	1	3	PF00400	0.490
TRG_ER_diArg_1	285	287	PF00400	0.446
TRG_ER_diArg_1	6	9	PF00400	0.445
TRG_NLS_MonoCore_2	282	287	PF00514	0.448
TRG_NLS_MonoExtN_4	283	288	PF00514	0.444
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI1	Leptomonas seymouri	92%	100%
A0A0N1PE93	Leptomonas seymouri	34%	87%
A0A0S4IS82	Bodo saltans	77%	99%
A0A0S4JV56	Bodo saltans	35%	87%
A0A1X0P1W8	Trypanosomatidae	81%	100%
A0A1X0P3X9	Trypanosomatidae	35%	87%
A0A3S7X0F1	Leishmania donovani	35%	87%
A0A3S7X394	Leishmania donovani	99%	100%
A0A422NTE1	Trypanosoma rangeli	34%	87%
A0A422P551	Trypanosoma rangeli	80%	100%
A4HFG9	Leishmania braziliensis	34%	87%
A4HI82	Leishmania braziliensis	95%	100%
A4I2N1	Leishmania infantum	35%	87%
A4I5G1	Leishmania infantum	99%	100%
C9ZQU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
D0A5P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	87%
E9AD22	Leishmania major	35%	87%
E9AYU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9B0Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O13823	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
O14180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	94%
O62518	Caenorhabditis elegans	48%	99%
P38805	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	98%
P53941	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	99%
P54073	Caenorhabditis elegans	34%	75%
Q0VD01	Bos taurus	52%	99%
Q5PQR5	Rattus norvegicus	52%	99%
Q5R631	Pongo abelii	32%	83%
Q5R947	Pongo abelii	53%	99%
Q5RJS9	Rattus norvegicus	32%	83%
Q6BYD9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	100%
Q6C804	Yarrowia lipolytica (strain CLIB 122 / E 150)	43%	100%
Q6FNN7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q6IQU6	Danio rerio	30%	87%
Q755T8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	43%	100%
Q7TND5	Mus musculus	32%	83%
Q8AVP1	Xenopus laevis	32%	84%
Q8VHZ7	Mus musculus	52%	99%
Q96G21	Homo sapiens	53%	99%
Q9H9Y2	Homo sapiens	32%	83%
Q9HGL6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	98%
Q9VKB4	Drosophila melanogaster	31%	73%
V5B7H7	Trypanosoma cruzi	34%	87%
V5BYY7	Trypanosoma cruzi	82%	100%