Putative ATP-binding cassette protein subfamily H,member 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily H, member 3, putative

Species:

Leishmania major

UniProt:

Q4Q7H1_LEIMA

TriTrypDb:

LmjF.30.1330 , LMJLV39_300019900 , LMJSD75_300019600

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7H1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005215	transporter activity	1	2
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0015399	primary active transmembrane transporter activity	4	2
GO:0017076	purine nucleotide binding	4	12
GO:0022804	active transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	2
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.475
CLV_NRD_NRD_1	27	29	PF00675	0.350
CLV_NRD_NRD_1	53	55	PF00675	0.310
CLV_NRD_NRD_1	82	84	PF00675	0.348
CLV_PCSK_KEX2_1	148	150	PF00082	0.607
CLV_PCSK_KEX2_1	208	210	PF00082	0.461
CLV_PCSK_KEX2_1	273	275	PF00082	0.391
CLV_PCSK_KEX2_1	337	339	PF00082	0.268
CLV_PCSK_KEX2_1	52	54	PF00082	0.320
CLV_PCSK_KEX2_1	82	84	PF00082	0.465
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.607
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.420
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.391
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.234
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.317
CLV_PCSK_SKI1_1	222	226	PF00082	0.333
CLV_PCSK_SKI1_1	237	241	PF00082	0.246
CLV_PCSK_SKI1_1	258	262	PF00082	0.261
CLV_PCSK_SKI1_1	303	307	PF00082	0.350
CLV_PCSK_SKI1_1	380	384	PF00082	0.330
CLV_PCSK_SKI1_1	83	87	PF00082	0.393
CLV_Separin_Metazoa	87	91	PF03568	0.398
DEG_APCC_DBOX_1	82	90	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.430
DEG_SPOP_SBC_1	171	175	PF00917	0.594
DOC_MAPK_gen_1	208	214	PF00069	0.355
DOC_MAPK_gen_1	273	281	PF00069	0.391
DOC_MAPK_gen_1	312	322	PF00069	0.280
DOC_MAPK_gen_1	337	345	PF00069	0.261
DOC_MAPK_gen_1	82	88	PF00069	0.317
DOC_MAPK_HePTP_8	126	138	PF00069	0.418
DOC_MAPK_MEF2A_6	129	138	PF00069	0.418
DOC_MAPK_MEF2A_6	315	324	PF00069	0.286
DOC_MAPK_MEF2A_6	337	345	PF00069	0.275
DOC_MAPK_NFAT4_5	338	346	PF00069	0.280
DOC_PP1_RVXF_1	122	129	PF00149	0.501
DOC_PP1_RVXF_1	224	231	PF00149	0.350
DOC_PP2B_LxvP_1	134	137	PF13499	0.403
DOC_PP2B_LxvP_1	36	39	PF13499	0.302
DOC_USP7_MATH_1	160	164	PF00917	0.722
DOC_USP7_MATH_1	283	287	PF00917	0.258
DOC_USP7_MATH_1	431	435	PF00917	0.352
DOC_USP7_UBL2_3	129	133	PF12436	0.357
DOC_USP7_UBL2_3	222	226	PF12436	0.318
DOC_WW_Pin1_4	173	178	PF00397	0.612
DOC_WW_Pin1_4	18	23	PF00397	0.419
LIG_14-3-3_CanoR_1	366	370	PF00244	0.364
LIG_14-3-3_CanoR_1	380	385	PF00244	0.236
LIG_14-3-3_CanoR_1	416	424	PF00244	0.469
LIG_14-3-3_CanoR_1	82	86	PF00244	0.344
LIG_Clathr_ClatBox_1	117	121	PF01394	0.474
LIG_CSL_BTD_1	5	8	PF09270	0.453
LIG_DLG_GKlike_1	264	271	PF00625	0.367
LIG_eIF4E_1	364	370	PF01652	0.498
LIG_FHA_1	113	119	PF00498	0.332
LIG_FHA_1	133	139	PF00498	0.210
LIG_FHA_1	356	362	PF00498	0.318
LIG_FHA_1	64	70	PF00498	0.479
LIG_FHA_2	357	363	PF00498	0.324
LIG_FHA_2	73	79	PF00498	0.317
LIG_FHA_2	82	88	PF00498	0.330
LIG_HP1_1	350	354	PF01393	0.280
LIG_LIR_Gen_1	229	238	PF02991	0.340
LIG_LIR_Gen_1	290	300	PF02991	0.365
LIG_LIR_Gen_1	395	404	PF02991	0.269
LIG_LIR_Nem_3	104	110	PF02991	0.256
LIG_LIR_Nem_3	127	131	PF02991	0.339
LIG_LIR_Nem_3	223	228	PF02991	0.357
LIG_LIR_Nem_3	229	233	PF02991	0.284
LIG_LIR_Nem_3	290	295	PF02991	0.391
LIG_LIR_Nem_3	388	394	PF02991	0.308
LIG_LIR_Nem_3	395	400	PF02991	0.313
LIG_NRBOX	341	347	PF00104	0.305
LIG_PDZ_Class_3	436	441	PF00595	0.413
LIG_PTB_Apo_2	224	231	PF02174	0.339
LIG_REV1ctd_RIR_1	258	268	PF16727	0.305
LIG_SH2_SRC	374	377	PF00017	0.377
LIG_SH2_STAP1	102	106	PF00017	0.309
LIG_SH2_STAP1	141	145	PF00017	0.464
LIG_SH2_STAP1	276	280	PF00017	0.258
LIG_SH2_STAP1	374	378	PF00017	0.313
LIG_SH2_STAP1	386	390	PF00017	0.251
LIG_SH2_STAT3	141	144	PF00017	0.461
LIG_SH2_STAT5	68	71	PF00017	0.283
LIG_SH3_3	16	22	PF00018	0.349
LIG_SH3_3	174	180	PF00018	0.557
LIG_SH3_3	2	8	PF00018	0.423
LIG_SH3_5	137	141	PF00018	0.376
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.335
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.258
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.358
LIG_SUMO_SIM_par_1	318	323	PF11976	0.339
LIG_SUMO_SIM_par_1	347	356	PF11976	0.246
LIG_SUMO_SIM_par_1	399	405	PF11976	0.349
LIG_TYR_ITIM	219	224	PF00017	0.339
LIG_UBA3_1	251	258	PF00899	0.261
LIG_UBA3_1	341	349	PF00899	0.261
MOD_CK1_1	165	171	PF00069	0.686
MOD_CK1_1	173	179	PF00069	0.749
MOD_CK1_1	190	196	PF00069	0.575
MOD_CK2_1	308	314	PF00069	0.312
MOD_CK2_1	329	335	PF00069	0.246
MOD_CK2_1	45	51	PF00069	0.344
MOD_CK2_1	81	87	PF00069	0.499
MOD_Cter_Amidation	271	274	PF01082	0.395
MOD_DYRK1A_RPxSP_1	18	22	PF00069	0.517
MOD_GlcNHglycan	168	171	PF01048	0.727
MOD_GlcNHglycan	189	192	PF01048	0.643
MOD_GlcNHglycan	331	334	PF01048	0.248
MOD_GSK3_1	162	169	PF00069	0.651
MOD_GSK3_1	186	193	PF00069	0.559
MOD_GSK3_1	243	250	PF00069	0.305
MOD_GSK3_1	380	387	PF00069	0.323
MOD_N-GLC_1	226	231	PF02516	0.373
MOD_N-GLC_1	243	248	PF02516	0.183
MOD_NEK2_1	308	313	PF00069	0.312
MOD_NEK2_1	404	409	PF00069	0.339
MOD_NEK2_2	431	436	PF00069	0.203
MOD_PK_1	28	34	PF00069	0.439
MOD_PKA_1	28	34	PF00069	0.469
MOD_PKA_2	308	314	PF00069	0.285
MOD_PKA_2	365	371	PF00069	0.300
MOD_PKA_2	415	421	PF00069	0.458
MOD_PKA_2	81	87	PF00069	0.345
MOD_Plk_1	226	232	PF00069	0.324
MOD_Plk_1	374	380	PF00069	0.374
MOD_Plk_1	404	410	PF00069	0.517
MOD_Plk_2-3	356	362	PF00069	0.347
MOD_Plk_2-3	45	51	PF00069	0.357
MOD_Plk_2-3	72	78	PF00069	0.323
MOD_Plk_2-3	81	87	PF00069	0.331
MOD_Plk_4	195	201	PF00069	0.625
MOD_Plk_4	247	253	PF00069	0.260
MOD_Plk_4	266	272	PF00069	0.246
MOD_Plk_4	365	371	PF00069	0.303
MOD_Plk_4	380	386	PF00069	0.262
MOD_Plk_4	63	69	PF00069	0.363
MOD_ProDKin_1	173	179	PF00069	0.612
MOD_ProDKin_1	18	24	PF00069	0.422
MOD_SUMO_rev_2	121	131	PF00179	0.417
MOD_SUMO_rev_2	21	31	PF00179	0.516
MOD_SUMO_rev_2	332	339	PF00179	0.220
TRG_ENDOCYTIC_2	221	224	PF00928	0.348
TRG_ENDOCYTIC_2	276	279	PF00928	0.261
TRG_ER_diArg_1	53	55	PF00400	0.288
TRG_NES_CRM1_1	314	327	PF08389	0.305
TRG_PTS2	1	36	PF00400	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R4	Leptomonas seymouri	70%	84%
A0A0S4J6G0	Bodo saltans	51%	85%
A0A1X0P1Z8	Trypanosomatidae	55%	86%
A0A3R7K7R6	Trypanosoma rangeli	55%	88%
A0A3S7X391	Leishmania donovani	93%	100%
A4HI85	Leishmania braziliensis	79%	93%
A4I5G4	Leishmania infantum	93%	100%
C9ZQV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	85%
E9B0R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q5HCL3	Staphylococcus aureus (strain COL)	22%	77%
Q6G5Z1	Staphylococcus aureus (strain MSSA476)	22%	77%
Q6GDC0	Staphylococcus aureus (strain MRSA252)	21%	77%
Q7A342	Staphylococcus aureus (strain N315)	22%	77%
Q87G35	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	23%	76%
Q8NUH8	Staphylococcus aureus (strain MW2)	22%	77%
Q99QV7	Staphylococcus aureus (strain Mu50 / ATCC 700699)	22%	77%
V5BPK8	Trypanosoma cruzi	58%	94%