Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7H0_LEIMA

TriTrypDb:

LmjF.30.1340 , LMJLV39_300020000 , LMJSD75_300019700

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q7H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.729
CLV_NRD_NRD_1	169	171	PF00675	0.623
CLV_NRD_NRD_1	44	46	PF00675	0.638
CLV_PCSK_KEX2_1	104	106	PF00082	0.526
CLV_PCSK_KEX2_1	168	170	PF00082	0.618
CLV_PCSK_KEX2_1	44	46	PF00082	0.593
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.625
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.651
CLV_PCSK_PC7_1	164	170	PF00082	0.638
CLV_PCSK_SKI1_1	152	156	PF00082	0.520
DEG_APCC_DBOX_1	151	159	PF00400	0.671
DEG_APCC_DBOX_1	168	176	PF00400	0.529
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.517
DOC_PP4_FxxP_1	227	230	PF00568	0.701
DOC_USP7_MATH_1	19	23	PF00917	0.529
DOC_USP7_MATH_1	231	235	PF00917	0.778
DOC_USP7_MATH_1	67	71	PF00917	0.692
DOC_USP7_UBL2_3	62	66	PF12436	0.645
DOC_WW_Pin1_4	178	183	PF00397	0.678
DOC_WW_Pin1_4	226	231	PF00397	0.737
DOC_WW_Pin1_4	263	268	PF00397	0.679
DOC_WW_Pin1_4	282	287	PF00397	0.770
LIG_14-3-3_CanoR_1	224	230	PF00244	0.693
LIG_FHA_1	128	134	PF00498	0.744
LIG_FHA_2	104	110	PF00498	0.606
LIG_FHA_2	117	123	PF00498	0.646
LIG_HCF-1_HBM_1	112	115	PF13415	0.437
LIG_LIR_Apic_2	225	230	PF02991	0.702
LIG_LIR_Gen_1	35	46	PF02991	0.547
LIG_LIR_Nem_3	35	41	PF02991	0.581
LIG_NRP_CendR_1	315	318	PF00754	0.699
LIG_SH2_STAP1	38	42	PF00017	0.585
LIG_SH2_STAT5	27	30	PF00017	0.526
LIG_SH3_3	234	240	PF00018	0.724
LIG_TRAF2_1	106	109	PF00917	0.599
LIG_TRAF2_1	199	202	PF00917	0.675
LIG_WW_2	240	243	PF00397	0.574
LIG_WW_3	219	223	PF00397	0.543
MOD_CDK_SPK_2	263	268	PF00069	0.727
MOD_CK1_1	134	140	PF00069	0.689
MOD_CK1_1	245	251	PF00069	0.727
MOD_CK1_1	253	259	PF00069	0.745
MOD_CK1_1	266	272	PF00069	0.704
MOD_CK1_1	290	296	PF00069	0.606
MOD_CK2_1	116	122	PF00069	0.581
MOD_CK2_1	208	214	PF00069	0.699
MOD_CK2_1	34	40	PF00069	0.559
MOD_CK2_1	97	103	PF00069	0.546
MOD_Cter_Amidation	315	318	PF01082	0.638
MOD_GlcNHglycan	244	247	PF01048	0.698
MOD_GlcNHglycan	252	255	PF01048	0.650
MOD_GlcNHglycan	257	260	PF01048	0.634
MOD_GlcNHglycan	268	271	PF01048	0.739
MOD_GlcNHglycan	273	277	PF01048	0.659
MOD_GlcNHglycan	289	292	PF01048	0.533
MOD_GlcNHglycan	308	311	PF01048	0.558
MOD_GlcNHglycan	99	102	PF01048	0.557
MOD_GSK3_1	127	134	PF00069	0.669
MOD_GSK3_1	222	229	PF00069	0.759
MOD_GSK3_1	250	257	PF00069	0.695
MOD_N-GLC_1	32	37	PF02516	0.592
MOD_N-GLC_2	184	186	PF02516	0.530
MOD_NEK2_1	306	311	PF00069	0.696
MOD_NEK2_1	32	37	PF00069	0.555
MOD_PIKK_1	103	109	PF00454	0.547
MOD_PKA_2	116	122	PF00069	0.438
MOD_PKA_2	225	231	PF00069	0.792
MOD_PKA_2	306	312	PF00069	0.661
MOD_PKA_2	97	103	PF00069	0.618
MOD_Plk_1	222	228	PF00069	0.712
MOD_Plk_2-3	210	216	PF00069	0.702
MOD_ProDKin_1	178	184	PF00069	0.678
MOD_ProDKin_1	226	232	PF00069	0.739
MOD_ProDKin_1	263	269	PF00069	0.680
MOD_ProDKin_1	282	288	PF00069	0.771
MOD_SUMO_for_1	175	178	PF00179	0.749
TRG_ENDOCYTIC_2	38	41	PF00928	0.584
TRG_ER_diArg_1	224	227	PF00400	0.714
TRG_ER_diArg_1	44	46	PF00400	0.649
TRG_ER_diLys_1	314	318	PF00400	0.716
TRG_NES_CRM1_1	138	151	PF08389	0.471
TRG_NLS_MonoCore_2	167	172	PF00514	0.652
TRG_NLS_MonoExtC_3	167	173	PF00514	0.650
TRG_NLS_MonoExtC_3	313	318	PF00514	0.728
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU5	Leptomonas seymouri	50%	100%
A0A3S7X3H3	Leishmania donovani	89%	100%
A0A422N7B9	Trypanosoma rangeli	31%	100%
A4HI86	Leishmania braziliensis	70%	100%
A4I5G5	Leishmania infantum	89%	100%
C9ZQV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B0R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BYY3	Trypanosoma cruzi	31%	79%