Putative GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania major

UniProt:

Q4Q7G9_LEIMA

TriTrypDb:

LmjF.30.1350 , LMJLV39_300020100 , LMJSD75_300019800

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7G9

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	5
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.532
CLV_C14_Caspase3-7	236	240	PF00656	0.706
CLV_C14_Caspase3-7	457	461	PF00656	0.388
CLV_NRD_NRD_1	124	126	PF00675	0.466
CLV_NRD_NRD_1	349	351	PF00675	0.348
CLV_NRD_NRD_1	533	535	PF00675	0.436
CLV_PCSK_KEX2_1	123	125	PF00082	0.471
CLV_PCSK_KEX2_1	533	535	PF00082	0.388
CLV_PCSK_KEX2_1	600	602	PF00082	0.530
CLV_PCSK_KEX2_1	70	72	PF00082	0.409
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.530
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.388
CLV_PCSK_SKI1_1	117	121	PF00082	0.335
CLV_PCSK_SKI1_1	374	378	PF00082	0.312
CLV_PCSK_SKI1_1	513	517	PF00082	0.312
DEG_APCC_DBOX_1	157	165	PF00400	0.633
DEG_MDM2_SWIB_1	502	510	PF02201	0.312
DEG_SCF_FBW7_1	47	54	PF00400	0.610
DEG_SCF_TRCP1_1	149	154	PF00400	0.474
DOC_AGCK_PIF_1	499	504	PF00069	0.312
DOC_CKS1_1	28	33	PF01111	0.579
DOC_CYCLIN_RxL_1	371	380	PF00134	0.312
DOC_MAPK_gen_1	70	78	PF00069	0.441
DOC_MAPK_HePTP_8	487	499	PF00069	0.340
DOC_MAPK_MEF2A_6	255	263	PF00069	0.559
DOC_MAPK_MEF2A_6	490	499	PF00069	0.340
DOC_PP1_RVXF_1	372	378	PF00149	0.312
DOC_PP1_RVXF_1	85	92	PF00149	0.370
DOC_PP2B_LxvP_1	246	249	PF13499	0.596
DOC_PP2B_LxvP_1	26	29	PF13499	0.811
DOC_PP2B_LxvP_1	395	398	PF13499	0.312
DOC_PP4_FxxP_1	295	298	PF00568	0.581
DOC_USP7_MATH_1	14	18	PF00917	0.648
DOC_USP7_MATH_1	241	245	PF00917	0.714
DOC_USP7_MATH_1	257	261	PF00917	0.693
DOC_USP7_MATH_1	265	269	PF00917	0.609
DOC_USP7_MATH_1	274	278	PF00917	0.558
DOC_USP7_MATH_1	318	322	PF00917	0.682
DOC_USP7_MATH_1	354	358	PF00917	0.312
DOC_USP7_MATH_1	40	44	PF00917	0.592
DOC_USP7_MATH_1	410	414	PF00917	0.291
DOC_USP7_MATH_1	62	66	PF00917	0.573
DOC_USP7_MATH_2	572	578	PF00917	0.491
DOC_USP7_UBL2_3	347	351	PF12436	0.388
DOC_WW_Pin1_4	244	249	PF00397	0.812
DOC_WW_Pin1_4	255	260	PF00397	0.630
DOC_WW_Pin1_4	27	32	PF00397	0.773
DOC_WW_Pin1_4	36	41	PF00397	0.621
DOC_WW_Pin1_4	42	47	PF00397	0.573
DOC_WW_Pin1_4	49	54	PF00397	0.542
LIG_14-3-3_CanoR_1	117	122	PF00244	0.410
LIG_14-3-3_CanoR_1	158	162	PF00244	0.567
LIG_14-3-3_CanoR_1	217	223	PF00244	0.565
LIG_14-3-3_CanoR_1	273	280	PF00244	0.702
LIG_14-3-3_CanoR_1	33	41	PF00244	0.613
LIG_14-3-3_CanoR_1	4	12	PF00244	0.679
LIG_14-3-3_CanoR_1	533	538	PF00244	0.388
LIG_APCC_ABBA_1	495	500	PF00400	0.340
LIG_BRCT_BRCA1_1	276	280	PF00533	0.588
LIG_BRCT_BRCA1_1	585	589	PF00533	0.357
LIG_CtBP_PxDLS_1	207	211	PF00389	0.620
LIG_deltaCOP1_diTrp_1	101	110	PF00928	0.342
LIG_eIF4E_1	541	547	PF01652	0.312
LIG_FHA_1	158	164	PF00498	0.610
LIG_FHA_1	302	308	PF00498	0.674
LIG_FHA_1	409	415	PF00498	0.312
LIG_FHA_1	419	425	PF00498	0.317
LIG_FHA_1	435	441	PF00498	0.452
LIG_FHA_1	449	455	PF00498	0.227
LIG_FHA_1	516	522	PF00498	0.312
LIG_FHA_1	571	577	PF00498	0.480
LIG_FHA_1	59	65	PF00498	0.509
LIG_FHA_2	188	194	PF00498	0.530
LIG_FHA_2	455	461	PF00498	0.388
LIG_LIR_Apic_2	293	298	PF02991	0.540
LIG_LIR_Gen_1	140	148	PF02991	0.415
LIG_LIR_Gen_1	422	433	PF02991	0.340
LIG_LIR_Gen_1	559	568	PF02991	0.474
LIG_LIR_LC3C_4	394	397	PF02991	0.312
LIG_LIR_Nem_3	101	106	PF02991	0.333
LIG_LIR_Nem_3	127	131	PF02991	0.371
LIG_LIR_Nem_3	134	139	PF02991	0.414
LIG_LIR_Nem_3	140	144	PF02991	0.284
LIG_LIR_Nem_3	422	428	PF02991	0.340
LIG_LIR_Nem_3	559	564	PF02991	0.485
LIG_Pex14_1	449	453	PF04695	0.312
LIG_Pex14_2	425	429	PF04695	0.340
LIG_Pex14_2	502	506	PF04695	0.312
LIG_SH2_CRK	488	492	PF00017	0.352
LIG_SH2_PTP2	561	564	PF00017	0.402
LIG_SH2_SRC	131	134	PF00017	0.390
LIG_SH2_STAP1	100	104	PF00017	0.332
LIG_SH2_STAP1	128	132	PF00017	0.356
LIG_SH2_STAP1	420	424	PF00017	0.388
LIG_SH2_STAP1	595	599	PF00017	0.388
LIG_SH2_STAT5	131	134	PF00017	0.389
LIG_SH2_STAT5	362	365	PF00017	0.312
LIG_SH2_STAT5	388	391	PF00017	0.312
LIG_SH2_STAT5	420	423	PF00017	0.312
LIG_SH2_STAT5	453	456	PF00017	0.343
LIG_SH2_STAT5	462	465	PF00017	0.335
LIG_SH2_STAT5	527	530	PF00017	0.312
LIG_SH2_STAT5	541	544	PF00017	0.303
LIG_SH2_STAT5	561	564	PF00017	0.450
LIG_SH3_3	170	176	PF00018	0.601
LIG_SH3_3	25	31	PF00018	0.636
LIG_SH3_3	261	267	PF00018	0.593
LIG_SH3_3	294	300	PF00018	0.666
LIG_SH3_3	479	485	PF00018	0.291
LIG_SUMO_SIM_anti_2	559	566	PF11976	0.410
LIG_TRAF2_1	529	532	PF00917	0.291
LIG_TRAF2_2	248	253	PF00917	0.573
LIG_WW_1	485	488	PF00397	0.312
LIG_WW_2	297	300	PF00397	0.619
LIG_WW_3	30	34	PF00397	0.547
MOD_CDK_SPxK_1	27	33	PF00069	0.544
MOD_CDK_SPxxK_3	42	49	PF00069	0.691
MOD_CK1_1	177	183	PF00069	0.709
MOD_CK1_1	244	250	PF00069	0.724
MOD_CK1_1	268	274	PF00069	0.629
MOD_CK1_1	290	296	PF00069	0.786
MOD_CK1_1	333	339	PF00069	0.545
MOD_CK1_1	432	438	PF00069	0.454
MOD_CK1_1	6	12	PF00069	0.710
MOD_CK2_1	410	416	PF00069	0.312
MOD_CK2_1	526	532	PF00069	0.291
MOD_CK2_1	601	607	PF00069	0.553
MOD_DYRK1A_RPxSP_1	255	259	PF00069	0.562
MOD_GlcNHglycan	149	152	PF01048	0.494
MOD_GlcNHglycan	176	179	PF01048	0.664
MOD_GlcNHglycan	218	221	PF01048	0.788
MOD_GlcNHglycan	235	238	PF01048	0.620
MOD_GlcNHglycan	250	253	PF01048	0.581
MOD_GlcNHglycan	255	258	PF01048	0.622
MOD_GlcNHglycan	274	277	PF01048	0.587
MOD_GlcNHglycan	320	323	PF01048	0.681
MOD_GlcNHglycan	332	335	PF01048	0.607
MOD_GlcNHglycan	356	359	PF01048	0.312
MOD_GlcNHglycan	431	434	PF01048	0.389
MOD_GlcNHglycan	6	9	PF01048	0.752
MOD_GlcNHglycan	64	67	PF01048	0.540
MOD_GSK3_1	104	111	PF00069	0.348
MOD_GSK3_1	113	120	PF00069	0.415
MOD_GSK3_1	147	154	PF00069	0.506
MOD_GSK3_1	187	194	PF00069	0.751
MOD_GSK3_1	244	251	PF00069	0.633
MOD_GSK3_1	253	260	PF00069	0.681
MOD_GSK3_1	268	275	PF00069	0.546
MOD_GSK3_1	283	290	PF00069	0.552
MOD_GSK3_1	301	308	PF00069	0.544
MOD_GSK3_1	333	340	PF00069	0.506
MOD_GSK3_1	36	43	PF00069	0.645
MOD_GSK3_1	408	415	PF00069	0.334
MOD_GSK3_1	47	54	PF00069	0.529
MOD_GSK3_1	513	520	PF00069	0.312
MOD_GSK3_1	570	577	PF00069	0.428
MOD_GSK3_1	58	65	PF00069	0.622
MOD_N-GLC_1	233	238	PF02516	0.706
MOD_N-GLC_1	460	465	PF02516	0.388
MOD_NEK2_1	104	109	PF00069	0.348
MOD_NEK2_1	147	152	PF00069	0.499
MOD_NEK2_1	272	277	PF00069	0.650
MOD_NEK2_1	280	285	PF00069	0.605
MOD_NEK2_1	305	310	PF00069	0.566
MOD_NEK2_1	332	337	PF00069	0.532
MOD_NEK2_1	377	382	PF00069	0.312
MOD_NEK2_1	454	459	PF00069	0.388
MOD_NEK2_1	515	520	PF00069	0.312
MOD_NEK2_2	595	600	PF00069	0.422
MOD_NMyristoyl	1	7	PF02799	0.578
MOD_PIKK_1	208	214	PF00454	0.626
MOD_PIKK_1	241	247	PF00454	0.736
MOD_PIKK_1	434	440	PF00454	0.388
MOD_PIKK_1	515	521	PF00454	0.312
MOD_PIKK_1	549	555	PF00454	0.340
MOD_PK_1	533	539	PF00069	0.388
MOD_PK_1	77	83	PF00069	0.342
MOD_PKA_1	533	539	PF00069	0.388
MOD_PKA_1	600	606	PF00069	0.485
MOD_PKA_2	157	163	PF00069	0.566
MOD_PKA_2	216	222	PF00069	0.569
MOD_PKA_2	272	278	PF00069	0.679
MOD_PKA_2	3	9	PF00069	0.616
MOD_PKA_2	354	360	PF00069	0.312
MOD_PKA_2	533	539	PF00069	0.388
MOD_PKA_2	600	606	PF00069	0.533
MOD_Plk_1	192	198	PF00069	0.585
MOD_Plk_1	268	274	PF00069	0.536
MOD_Plk_1	595	601	PF00069	0.398
MOD_Plk_1	87	93	PF00069	0.369
MOD_Plk_2-3	574	580	PF00069	0.427
MOD_Plk_4	117	123	PF00069	0.460
MOD_Plk_4	179	185	PF00069	0.614
MOD_Plk_4	290	296	PF00069	0.586
MOD_Plk_4	333	339	PF00069	0.513
MOD_Plk_4	449	455	PF00069	0.329
MOD_Plk_4	468	474	PF00069	0.399
MOD_ProDKin_1	244	250	PF00069	0.812
MOD_ProDKin_1	255	261	PF00069	0.630
MOD_ProDKin_1	27	33	PF00069	0.776
MOD_ProDKin_1	36	42	PF00069	0.621
MOD_ProDKin_1	47	53	PF00069	0.513
TRG_DiLeu_BaEn_2	100	106	PF01217	0.332
TRG_DiLeu_BaEn_2	372	378	PF01217	0.312
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.316
TRG_ENDOCYTIC_2	136	139	PF00928	0.502
TRG_ENDOCYTIC_2	488	491	PF00928	0.331
TRG_ENDOCYTIC_2	561	564	PF00928	0.468
TRG_ER_diArg_1	122	125	PF00400	0.404
TRG_ER_diArg_1	227	230	PF00400	0.570
TRG_ER_diArg_1	533	535	PF00400	0.388
TRG_NES_CRM1_1	426	438	PF08389	0.254
TRG_NES_CRM1_1	580	592	PF08389	0.437
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K2	Leptomonas seymouri	57%	82%
A0A3Q8IE73	Leishmania donovani	91%	100%
A4HI87	Leishmania braziliensis	75%	84%
A4I5G6	Leishmania infantum	91%	100%
E9B0R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%