Putative N-acyl-L-amino acid amidohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amidohydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q7G6_LEIMA

TriTrypDb:

LmjF.30.1380 , LMJLV39_300020400 , LMJSD75_300020100

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7G6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004046	aminoacylase activity	5	7
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.175
CLV_NRD_NRD_1	153	155	PF00675	0.318
CLV_PCSK_SKI1_1	60	64	PF00082	0.317
CLV_PCSK_SKI1_1	87	91	PF00082	0.257
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.249
DOC_MAPK_MEF2A_6	159	166	PF00069	0.249
DOC_MAPK_RevD_3	142	155	PF00069	0.249
DOC_USP7_MATH_1	162	166	PF00917	0.249
DOC_USP7_MATH_1	20	24	PF00917	0.312
DOC_USP7_MATH_1	219	223	PF00917	0.175
DOC_USP7_MATH_1	284	288	PF00917	0.382
DOC_USP7_UBL2_3	22	26	PF12436	0.194
DOC_WW_Pin1_4	127	132	PF00397	0.249
DOC_WW_Pin1_4	92	97	PF00397	0.363
LIG_BIR_III_2	9	13	PF00653	0.295
LIG_BRCT_BRCA1_1	295	299	PF00533	0.362
LIG_BRCT_BRCA1_1	57	61	PF00533	0.249
LIG_FHA_1	100	106	PF00498	0.249
LIG_FHA_1	128	134	PF00498	0.373
LIG_FHA_1	139	145	PF00498	0.301
LIG_FHA_1	236	242	PF00498	0.383
LIG_FHA_1	36	42	PF00498	0.317
LIG_Integrin_RGD_1	124	126	PF01839	0.175
LIG_LIR_Nem_3	115	120	PF02991	0.329
LIG_LIR_Nem_3	265	270	PF02991	0.364
LIG_PDZ_Class_2	318	323	PF00595	0.519
LIG_SH2_CRK	318	322	PF00017	0.312
LIG_SH2_GRB2like	318	321	PF00017	0.311
LIG_SH2_SRC	113	116	PF00017	0.175
LIG_SH2_SRC	318	321	PF00017	0.311
LIG_SH2_STAP1	113	117	PF00017	0.249
LIG_SH2_STAP1	318	322	PF00017	0.506
LIG_SH2_STAT5	316	319	PF00017	0.290
LIG_SH3_3	254	260	PF00018	0.249
LIG_SUMO_SIM_par_1	162	168	PF11976	0.317
MOD_CDK_SPK_2	92	97	PF00069	0.249
MOD_CK1_1	165	171	PF00069	0.356
MOD_CK1_1	173	179	PF00069	0.305
MOD_CK1_1	222	228	PF00069	0.175
MOD_GlcNHglycan	250	253	PF01048	0.357
MOD_GlcNHglycan	265	270	PF01048	0.249
MOD_GlcNHglycan	42	45	PF01048	0.249
MOD_GSK3_1	109	116	PF00069	0.357
MOD_GSK3_1	164	171	PF00069	0.307
MOD_GSK3_1	218	225	PF00069	0.254
MOD_GSK3_1	280	287	PF00069	0.338
MOD_N-GLC_1	109	114	PF02516	0.249
MOD_NEK2_1	293	298	PF00069	0.406
MOD_NEK2_1	40	45	PF00069	0.249
MOD_NEK2_2	113	118	PF00069	0.347
MOD_PIKK_1	20	26	PF00454	0.350
MOD_PIKK_1	284	290	PF00454	0.249
MOD_Plk_1	109	115	PF00069	0.389
MOD_Plk_1	222	228	PF00069	0.345
MOD_Plk_1	265	271	PF00069	0.249
MOD_Plk_1	301	307	PF00069	0.323
MOD_ProDKin_1	127	133	PF00069	0.249
MOD_ProDKin_1	92	98	PF00069	0.363
MOD_SUMO_rev_2	251	260	PF00179	0.249
TRG_ENDOCYTIC_2	318	321	PF00928	0.311
TRG_ER_diArg_1	121	124	PF00400	0.240
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N6	Leptomonas seymouri	38%	80%
A0A0N0P327	Leptomonas seymouri	24%	84%
A0A0N1IJE8	Leptomonas seymouri	48%	100%
A0A1X0NW20	Trypanosomatidae	43%	98%
A0A1X0NW36	Trypanosomatidae	45%	84%
A0A1X0NWQ6	Trypanosomatidae	42%	93%
A0A3Q8IBS0	Leishmania donovani	41%	81%
A0A3Q8IIH2	Leishmania donovani	37%	80%
A0A3Q8IJC1	Leishmania donovani	92%	73%
A0A3S7WW66	Leishmania donovani	41%	82%
A0A422NTL2	Trypanosoma rangeli	37%	100%
A0A422NTM4	Trypanosoma rangeli	44%	79%
A0AHD2	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	29%	87%
A0RHZ2	Bacillus thuringiensis (strain Al Hakam)	28%	86%
A2RI06	Lactococcus lactis subsp. cremoris (strain MG1363)	30%	86%
A3CQT4	Streptococcus sanguinis (strain SK36)	26%	86%
A4HJ93	Leishmania braziliensis	37%	80%
A4HZ10	Leishmania infantum	41%	81%
A4I5G9	Leishmania infantum	92%	73%
A4I6N7	Leishmania infantum	37%	80%
A4I6N8	Leishmania infantum	38%	80%
A4ILT6	Geobacillus thermodenitrificans (strain NG80-2)	31%	86%
A4VY21	Streptococcus suis (strain 05ZYH33)	29%	86%
A4W4B4	Streptococcus suis (strain 98HAH33)	29%	86%
A5VJ57	Limosilactobacillus reuteri (strain DSM 20016)	28%	85%
A7GS08	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	29%	86%
A7Z433	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	30%	86%
A8AUM0	Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)	27%	86%
A8FCN2	Bacillus pumilus (strain SAFR-032)	32%	86%
A8YUT2	Lactobacillus helveticus (strain DPC 4571)	28%	84%
A9VUE2	Bacillus mycoides (strain KBAB4)	28%	86%
B1I9G2	Streptococcus pneumoniae (strain Hungary19A-6)	26%	86%
B1MZM9	Leuconostoc citreum (strain KM20)	32%	83%
B1YJ90	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	31%	87%
B2G6M8	Limosilactobacillus reuteri (strain JCM 1112)	28%	85%
B2GC10	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	28%	84%
B2IN14	Streptococcus pneumoniae (strain CGSP14)	26%	86%
B3W7E6	Lacticaseibacillus casei (strain BL23)	29%	84%
B5E3A3	Streptococcus pneumoniae serotype 19F (strain G54)	26%	86%
B7GIC0	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	29%	85%
B7H6W7	Bacillus cereus (strain B4264)	28%	86%
B7HMV1	Bacillus cereus (strain AH187)	28%	86%
B7IVL7	Bacillus cereus (strain G9842)	28%	86%
B7JKV4	Bacillus cereus (strain AH820)	28%	86%
B8DEC3	Listeria monocytogenes serotype 4a (strain HCC23)	29%	87%
B8ZPL8	Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)	26%	86%
B9DVY6	Streptococcus uberis (strain ATCC BAA-854 / 0140J)	29%	86%
B9IW60	Bacillus cereus (strain Q1)	28%	86%
C0ZGH7	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)	29%	86%
C1CAS3	Streptococcus pneumoniae (strain 70585)	26%	86%
C1CH24	Streptococcus pneumoniae (strain JJA)	26%	86%
C1CN42	Streptococcus pneumoniae (strain P1031)	26%	86%
C1CTZ9	Streptococcus pneumoniae (strain Taiwan19F-14)	27%	86%
C1EPZ4	Bacillus cereus (strain 03BB102)	28%	86%
C1L1T3	Listeria monocytogenes serotype 4b (strain CLIP80459)	30%	87%
C3LI46	Bacillus anthracis (strain CDC 684 / NRRL 3495)	28%	86%
C3P6Y7	Bacillus anthracis (strain A0248)	28%	86%
C5D827	Geobacillus sp. (strain WCH70)	32%	86%
C9ZIL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	80%
D5E0A1	Priestia megaterium (strain ATCC 12872 / QMB1551)	28%	86%
E9AGU3	Leishmania infantum	41%	82%
E9AIM3	Leishmania braziliensis	41%	80%
E9AIM4	Leishmania braziliensis	40%	72%
E9AIM5	Leishmania braziliensis	41%	82%
E9AUV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	81%
E9AUV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	82%
E9AUV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	82%
E9B0R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B1R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	80%
O04373	Arabidopsis thaliana	36%	73%
O07598	Bacillus subtilis (strain 168)	35%	82%
O34916	Bacillus subtilis (strain 168)	32%	86%
O34980	Bacillus subtilis (strain 168)	36%	78%
O81641	Arabidopsis thaliana	32%	75%
P37112	Geobacillus stearothermophilus	42%	87%
P44765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	76%
P45493	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	29%	84%
P54955	Bacillus subtilis (strain 168)	38%	85%
P54968	Arabidopsis thaliana	32%	73%
P54969	Arabidopsis thaliana	35%	74%
P54970	Arabidopsis thaliana	34%	74%
P54983	Bacillus subtilis (strain 168)	27%	84%
P54984	Synechocystis sp. (strain PCC 6803 / Kazusa)	31%	82%
P55663	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	30%	80%
P58156	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	41%	82%
P80092	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	42%	82%
Q032G8	Lactococcus lactis subsp. cremoris (strain SK11)	30%	86%
Q03CW2	Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441)	29%	84%
Q03HT1	Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)	27%	84%
Q03IN1	Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)	27%	86%
Q03YE3	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	32%	84%
Q04FS2	Oenococcus oeni (strain ATCC BAA-331 / PSU-1)	29%	85%
Q04I78	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)	26%	86%
Q1WUQ7	Ligilactobacillus salivarius (strain UCC118)	28%	85%
Q2FH40	Staphylococcus aureus (strain USA300)	28%	84%
Q2FYN6	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	84%
Q2YY21	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	84%
Q49XK0	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	27%	84%
Q4L6A3	Staphylococcus haemolyticus (strain JCSC1435)	28%	84%
Q4Q6F0	Leishmania major	37%	100%
Q4QCM4	Leishmania major	42%	78%
Q4QCM5	Leishmania major	41%	82%
Q4QCM6	Leishmania major	42%	81%
Q5FKR0	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	28%	84%
Q5HG22	Staphylococcus aureus (strain COL)	28%	84%
Q5HPE4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	29%	84%
Q5L145	Geobacillus kaustophilus (strain HTA426)	31%	86%
Q5LXY3	Streptococcus thermophilus (strain CNRZ 1066)	27%	86%
Q5M2I5	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	27%	86%
Q5N8F2	Oryza sativa subsp. japonica	35%	71%
Q5WF94	Alkalihalobacillus clausii (strain KSM-K16)	31%	86%
Q635U8	Bacillus cereus (strain ZK / E33L)	28%	86%
Q65K84	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	30%	86%
Q6G9G3	Staphylococcus aureus (strain MSSA476)	28%	84%
Q6GH10	Staphylococcus aureus (strain MRSA252)	28%	84%
Q6HEI5	Bacillus thuringiensis subsp. konkukian (strain 97-27)	28%	86%
Q6LAN3	Listeria ivanovii	29%	87%
Q721F4	Listeria monocytogenes serotype 4b (strain F2365)	30%	87%
Q731Y6	Bacillus cereus (strain ATCC 10987 / NRS 248)	28%	86%
Q7A5P6	Staphylococcus aureus (strain N315)	28%	84%
Q7XUA8	Oryza sativa subsp. japonica	32%	76%
Q819J6	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	28%	86%
Q81MQ3	Bacillus anthracis	28%	86%
Q836H7	Enterococcus faecalis (strain ATCC 700802 / V583)	30%	85%
Q84XG9	Oryza sativa subsp. indica	32%	73%
Q851L5	Oryza sativa subsp. japonica	37%	77%
Q851L6	Oryza sativa subsp. japonica	36%	78%
Q88V24	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	30%	84%
Q8CSM6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	84%
Q8DN55	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	26%	86%
Q8DVY6	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	29%	86%
Q8ERA3	Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)	30%	87%
Q8GGD4	Corynebacterium striatum	31%	81%
Q8H3C7	Oryza sativa subsp. japonica	37%	73%
Q8H3C8	Oryza sativa subsp. japonica	36%	73%
Q8H3C9	Oryza sativa subsp. japonica	36%	71%
Q8NWS3	Staphylococcus aureus (strain MW2)	28%	84%
Q8S9S4	Oryza sativa subsp. japonica	32%	73%
Q8VYX0	Arabidopsis thaliana	29%	70%
Q8Y8A0	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	29%	87%
Q92D10	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	29%	87%
Q97NE7	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	26%	86%
Q99U87	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	84%
Q9CIS4	Lactococcus lactis subsp. lactis (strain IL1403)	30%	84%
Q9K9H9	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	31%	87%
Q9SWX9	Arabidopsis thaliana	36%	74%
V5BCV1	Trypanosoma cruzi	36%	100%
V5D8V4	Trypanosoma cruzi	36%	100%