Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q7G4_LEIMA

TriTrypDb:

LmjF.30.1400 , LMJLV39_300020600 , LMJSD75_300020300

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

Q4Q7G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.628
CLV_C14_Caspase3-7	184	188	PF00656	0.498
CLV_C14_Caspase3-7	417	421	PF00656	0.371
CLV_NRD_NRD_1	270	272	PF00675	0.328
CLV_PCSK_KEX2_1	270	272	PF00082	0.328
CLV_PCSK_KEX2_1	388	390	PF00082	0.380
CLV_PCSK_KEX2_1	464	466	PF00082	0.440
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.380
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.429
CLV_PCSK_SKI1_1	245	249	PF00082	0.476
CLV_PCSK_SKI1_1	428	432	PF00082	0.414
CLV_PCSK_SKI1_1	529	533	PF00082	0.342
DEG_Kelch_Keap1_1	511	516	PF01344	0.431
DEG_SPOP_SBC_1	319	323	PF00917	0.446
DOC_ANK_TNKS_1	127	134	PF00023	0.530
DOC_PP4_FxxP_1	10	13	PF00568	0.600
DOC_PP4_FxxP_1	532	535	PF00568	0.351
DOC_USP7_MATH_1	185	189	PF00917	0.455
DOC_USP7_MATH_1	200	204	PF00917	0.653
DOC_USP7_MATH_1	220	224	PF00917	0.632
DOC_USP7_MATH_1	319	323	PF00917	0.488
DOC_USP7_MATH_1	41	45	PF00917	0.823
DOC_USP7_MATH_1	49	53	PF00917	0.617
DOC_USP7_MATH_1	533	537	PF00917	0.399
DOC_USP7_MATH_1	94	98	PF00917	0.751
DOC_WW_Pin1_4	131	136	PF00397	0.569
DOC_WW_Pin1_4	146	151	PF00397	0.617
DOC_WW_Pin1_4	206	211	PF00397	0.582
DOC_WW_Pin1_4	34	39	PF00397	0.560
DOC_WW_Pin1_4	445	450	PF00397	0.407
DOC_WW_Pin1_4	531	536	PF00397	0.333
DOC_WW_Pin1_4	57	62	PF00397	0.604
DOC_WW_Pin1_4	89	94	PF00397	0.757
LIG_14-3-3_CanoR_1	138	145	PF00244	0.701
LIG_14-3-3_CanoR_1	166	172	PF00244	0.476
LIG_14-3-3_CanoR_1	199	206	PF00244	0.457
LIG_14-3-3_CanoR_1	213	220	PF00244	0.611
LIG_14-3-3_CanoR_1	265	273	PF00244	0.528
LIG_14-3-3_CanoR_1	422	431	PF00244	0.484
LIG_14-3-3_CanoR_1	5	11	PF00244	0.562
LIG_14-3-3_CanoR_1	50	54	PF00244	0.707
LIG_14-3-3_CanoR_1	55	61	PF00244	0.657
LIG_14-3-3_CanoR_1	91	97	PF00244	0.614
LIG_APCC_ABBA_1	406	411	PF00400	0.427
LIG_BIR_III_4	420	424	PF00653	0.415
LIG_Clathr_ClatBox_1	190	194	PF01394	0.313
LIG_deltaCOP1_diTrp_1	259	266	PF00928	0.432
LIG_FHA_1	132	138	PF00498	0.591
LIG_FHA_1	256	262	PF00498	0.463
LIG_FHA_1	29	35	PF00498	0.605
LIG_FHA_1	300	306	PF00498	0.474
LIG_FHA_1	325	331	PF00498	0.467
LIG_FHA_1	358	364	PF00498	0.507
LIG_FHA_1	368	374	PF00498	0.488
LIG_FHA_1	512	518	PF00498	0.545
LIG_FHA_1	62	68	PF00498	0.639
LIG_FHA_2	241	247	PF00498	0.359
LIG_FHA_2	415	421	PF00498	0.325
LIG_FHA_2	480	486	PF00498	0.378
LIG_Integrin_isoDGR_2	504	506	PF01839	0.449
LIG_LIR_Apic_2	169	175	PF02991	0.413
LIG_LIR_Apic_2	530	535	PF02991	0.346
LIG_LIR_Apic_2	9	13	PF02991	0.595
LIG_LIR_Gen_1	353	363	PF02991	0.464
LIG_LIR_Nem_3	119	125	PF02991	0.625
LIG_LIR_Nem_3	353	358	PF02991	0.464
LIG_PCNA_PIPBox_1	244	253	PF02747	0.457
LIG_SH2_CRK	122	126	PF00017	0.537
LIG_SH2_STAP1	324	328	PF00017	0.432
LIG_SH2_STAP1	489	493	PF00017	0.496
LIG_SH2_STAP1	519	523	PF00017	0.374
LIG_SH2_STAT5	251	254	PF00017	0.283
LIG_SH3_1	172	178	PF00018	0.499
LIG_SH3_3	172	178	PF00018	0.443
LIG_SH3_3	192	198	PF00018	0.473
LIG_SH3_3	431	437	PF00018	0.326
LIG_SH3_3	449	455	PF00018	0.488
LIG_SH3_3	77	83	PF00018	0.657
LIG_SH3_4	428	435	PF00018	0.402
LIG_SUMO_SIM_par_1	453	459	PF11976	0.387
LIG_UBA3_1	517	522	PF00899	0.337
LIG_WRC_WIRS_1	440	445	PF05994	0.450
MOD_CDK_SPxxK_3	131	138	PF00069	0.572
MOD_CDK_SPxxK_3	146	153	PF00069	0.614
MOD_CDK_SPxxK_3	206	213	PF00069	0.542
MOD_CK1_1	124	130	PF00069	0.607
MOD_CK1_1	141	147	PF00069	0.491
MOD_CK1_1	167	173	PF00069	0.483
MOD_CK1_1	221	227	PF00069	0.625
MOD_CK1_1	59	65	PF00069	0.619
MOD_CK1_1	92	98	PF00069	0.684
MOD_CK2_1	167	173	PF00069	0.527
MOD_CK2_1	240	246	PF00069	0.345
MOD_CK2_1	303	309	PF00069	0.444
MOD_CK2_1	353	359	PF00069	0.439
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.372
MOD_DYRK1A_RPxSP_1	57	61	PF00069	0.654
MOD_GlcNHglycan	104	107	PF01048	0.486
MOD_GlcNHglycan	140	143	PF01048	0.555
MOD_GlcNHglycan	145	148	PF01048	0.577
MOD_GlcNHglycan	202	205	PF01048	0.737
MOD_GlcNHglycan	215	218	PF01048	0.710
MOD_GlcNHglycan	220	223	PF01048	0.702
MOD_GlcNHglycan	230	233	PF01048	0.339
MOD_GlcNHglycan	273	276	PF01048	0.243
MOD_GlcNHglycan	345	348	PF01048	0.381
MOD_GlcNHglycan	363	366	PF01048	0.158
MOD_GlcNHglycan	425	428	PF01048	0.584
MOD_GlcNHglycan	452	455	PF01048	0.444
MOD_GlcNHglycan	499	502	PF01048	0.339
MOD_GlcNHglycan	96	99	PF01048	0.590
MOD_GSK3_1	15	22	PF00069	0.743
MOD_GSK3_1	161	168	PF00069	0.486
MOD_GSK3_1	179	186	PF00069	0.420
MOD_GSK3_1	218	225	PF00069	0.606
MOD_GSK3_1	251	258	PF00069	0.329
MOD_GSK3_1	26	33	PF00069	0.773
MOD_GSK3_1	299	306	PF00069	0.441
MOD_GSK3_1	314	321	PF00069	0.547
MOD_GSK3_1	353	360	PF00069	0.545
MOD_GSK3_1	57	64	PF00069	0.688
MOD_GSK3_1	81	88	PF00069	0.754
MOD_N-GLC_1	15	20	PF02516	0.542
MOD_N-GLC_1	6	11	PF02516	0.570
MOD_N-GLC_2	240	242	PF02516	0.280
MOD_NEK2_1	121	126	PF00069	0.618
MOD_NEK2_1	165	170	PF00069	0.489
MOD_NEK2_1	299	304	PF00069	0.457
MOD_NEK2_1	383	388	PF00069	0.427
MOD_NEK2_1	456	461	PF00069	0.465
MOD_NEK2_1	56	61	PF00069	0.755
MOD_NEK2_1	85	90	PF00069	0.620
MOD_NEK2_2	324	329	PF00069	0.432
MOD_PIKK_1	303	309	PF00454	0.432
MOD_PIKK_1	350	356	PF00454	0.498
MOD_PIKK_1	78	84	PF00454	0.567
MOD_PK_1	30	36	PF00069	0.634
MOD_PKA_2	165	171	PF00069	0.477
MOD_PKA_2	49	55	PF00069	0.641
MOD_PKA_2	56	62	PF00069	0.638
MOD_PKB_1	30	38	PF00069	0.539
MOD_Plk_1	324	330	PF00069	0.432
MOD_Plk_1	6	12	PF00069	0.539
MOD_Plk_4	167	173	PF00069	0.503
MOD_Plk_4	246	252	PF00069	0.447
MOD_Plk_4	414	420	PF00069	0.360
MOD_Plk_4	439	445	PF00069	0.475
MOD_Plk_4	533	539	PF00069	0.385
MOD_Plk_4	81	87	PF00069	0.608
MOD_ProDKin_1	131	137	PF00069	0.570
MOD_ProDKin_1	146	152	PF00069	0.614
MOD_ProDKin_1	206	212	PF00069	0.583
MOD_ProDKin_1	34	40	PF00069	0.560
MOD_ProDKin_1	445	451	PF00069	0.420
MOD_ProDKin_1	531	537	PF00069	0.332
MOD_ProDKin_1	57	63	PF00069	0.604
MOD_ProDKin_1	89	95	PF00069	0.756
MOD_SUMO_rev_2	274	281	PF00179	0.432
MOD_SUMO_rev_2	516	523	PF00179	0.337
TRG_DiLeu_BaEn_1	513	518	PF01217	0.386
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.396
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.405
TRG_ENDOCYTIC_2	122	125	PF00928	0.526
TRG_ER_diArg_1	270	272	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ0	Leptomonas seymouri	68%	100%
A0A1X0P1V8	Trypanosomatidae	55%	100%
A0A3Q8IHW0	Leishmania donovani	93%	100%
A0A3R7MF36	Trypanosoma rangeli	51%	100%
A4HI91	Leishmania braziliensis	79%	100%
A4I5H1	Leishmania infantum	94%	100%
C9ZQV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHD6	Leishmania major	25%	100%
V5BYY0	Trypanosoma cruzi	51%	100%