Class i nuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

class i nuclease-like protein

Species:

Leishmania major

UniProt:

Q4Q7F8_LEIMA

TriTrypDb:

LmjF.30.1470 , LMJLV39_300021500 , LMJSD75_300021200

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q7F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7F8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006259	DNA metabolic process	4	5
GO:0006308	DNA catabolic process	5	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0009057	macromolecule catabolic process	4	5
GO:0009987	cellular process	1	5
GO:0019439	aromatic compound catabolic process	4	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034655	nucleobase-containing compound catabolic process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044248	cellular catabolic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044265	obsolete cellular macromolecule catabolic process	4	5
GO:0044270	cellular nitrogen compound catabolic process	4	5
GO:0046483	heterocycle metabolic process	3	5
GO:0046700	heterocycle catabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901361	organic cyclic compound catabolic process	4	5
GO:1901575	organic substance catabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004519	endonuclease activity	5	5
GO:0005488	binding	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.675
CLV_PCSK_FUR_1	134	138	PF00082	0.483
CLV_PCSK_FUR_1	175	179	PF00082	0.622
CLV_PCSK_KEX2_1	136	138	PF00082	0.483
CLV_PCSK_KEX2_1	177	179	PF00082	0.619
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.483
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.619
CLV_PCSK_SKI1_1	6	10	PF00082	0.528
CLV_PCSK_SKI1_1	74	78	PF00082	0.604
DEG_SCF_FBW7_1	119	126	PF00400	0.675
DOC_AGCK_PIF_2	59	64	PF00069	0.583
DOC_MAPK_DCC_7	3	13	PF00069	0.729
DOC_MAPK_gen_1	25	35	PF00069	0.475
DOC_MAPK_gen_1	3	13	PF00069	0.729
DOC_MAPK_MEF2A_6	25	33	PF00069	0.282
DOC_MAPK_MEF2A_6	6	13	PF00069	0.725
DOC_MAPK_NFAT4_5	6	14	PF00069	0.725
DOC_USP7_MATH_1	12	16	PF00917	0.715
DOC_WW_Pin1_4	119	124	PF00397	0.683
LIG_14-3-3_CanoR_1	142	146	PF00244	0.683
LIG_14-3-3_CterR_2	175	180	PF00244	0.829
LIG_APCC_ABBA_1	103	108	PF00400	0.683
LIG_BRCT_BRCA1_1	108	112	PF00533	0.683
LIG_eIF4E_1	148	154	PF01652	0.683
LIG_FHA_2	124	130	PF00498	0.675
LIG_FHA_2	89	95	PF00498	0.683
LIG_FHA_2	96	102	PF00498	0.595
LIG_LIR_Apic_2	88	93	PF02991	0.683
LIG_LIR_Gen_1	15	23	PF02991	0.710
LIG_LIR_Gen_1	38	49	PF02991	0.489
LIG_LIR_Gen_1	60	67	PF02991	0.583
LIG_LIR_Nem_3	116	121	PF02991	0.683
LIG_LIR_Nem_3	15	20	PF02991	0.721
LIG_LIR_Nem_3	38	44	PF02991	0.538
LIG_LIR_Nem_3	51	57	PF02991	0.339
LIG_LIR_Nem_3	60	65	PF02991	0.425
LIG_LYPXL_yS_3	118	121	PF13949	0.683
LIG_NRBOX	149	155	PF00104	0.683
LIG_Pex14_2	55	59	PF04695	0.583
LIG_Pex14_2	73	77	PF04695	0.584
LIG_SH2_CRK	62	66	PF00017	0.458
LIG_SH2_PTP2	39	42	PF00017	0.550
LIG_SH2_PTP2	43	46	PF00017	0.551
LIG_SH2_PTP2	47	50	PF00017	0.475
LIG_SH2_SRC	39	42	PF00017	0.542
LIG_SH2_SRC	47	50	PF00017	0.413
LIG_SH2_STAT5	131	134	PF00017	0.683
LIG_SH2_STAT5	152	155	PF00017	0.683
LIG_SH2_STAT5	17	20	PF00017	0.731
LIG_SH2_STAT5	39	42	PF00017	0.543
LIG_SH2_STAT5	43	46	PF00017	0.515
LIG_SH2_STAT5	47	50	PF00017	0.403
LIG_SH2_STAT5	54	57	PF00017	0.316
LIG_SH2_STAT5	90	93	PF00017	0.683
LIG_SH3_3	156	162	PF00018	0.788
LIG_SH3_3	31	37	PF00018	0.430
LIG_SUMO_SIM_anti_2	98	104	PF11976	0.683
LIG_SUMO_SIM_par_1	101	109	PF11976	0.683
LIG_SUMO_SIM_par_1	9	15	PF11976	0.721
LIG_TYR_ITSM	114	121	PF00017	0.683
MOD_CK2_1	88	94	PF00069	0.683
MOD_GlcNHglycan	14	17	PF01048	0.559
MOD_GlcNHglycan	59	62	PF01048	0.583
MOD_GSK3_1	119	126	PF00069	0.675
MOD_N-GLC_1	114	119	PF02516	0.483
MOD_NEK2_1	86	91	PF00069	0.675
MOD_OFUCOSY	45	52	PF10250	0.363
MOD_PKA_2	141	147	PF00069	0.683
MOD_Plk_1	106	112	PF00069	0.683
MOD_Plk_1	114	120	PF00069	0.583
MOD_Plk_1	164	170	PF00069	0.809
MOD_Plk_2-3	164	170	PF00069	0.809
MOD_Plk_2-3	88	94	PF00069	0.683
MOD_Plk_4	35	41	PF00069	0.491
MOD_ProDKin_1	119	125	PF00069	0.683
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.683
TRG_ENDOCYTIC_2	118	121	PF00928	0.683
TRG_ENDOCYTIC_2	17	20	PF00928	0.745
TRG_ENDOCYTIC_2	39	42	PF00928	0.523
TRG_ENDOCYTIC_2	43	46	PF00928	0.500
TRG_ENDOCYTIC_2	47	50	PF00928	0.412
TRG_ENDOCYTIC_2	54	57	PF00928	0.290
TRG_ENDOCYTIC_2	62	65	PF00928	0.269
TRG_NES_CRM1_1	94	108	PF08389	0.683
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4Q7F5	Leishmania major	100%	100%
Q4Q7F6	Leishmania major	100%	100%
Q4Q7F7	Leishmania major	98%	100%