Class i nuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

class i nuclease-like protein

Species:

Leishmania major

UniProt:

Q4Q7F6_LEIMA

TriTrypDb:

LmjF.30.1480 , LMJLV39_300021500 , LMJSD75_300021200

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q7F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7F6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006259	DNA metabolic process	4	5
GO:0006308	DNA catabolic process	5	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0009057	macromolecule catabolic process	4	5
GO:0009987	cellular process	1	5
GO:0019439	aromatic compound catabolic process	4	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034655	nucleobase-containing compound catabolic process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044248	cellular catabolic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044265	obsolete cellular macromolecule catabolic process	4	5
GO:0044270	cellular nitrogen compound catabolic process	4	5
GO:0046483	heterocycle metabolic process	3	5
GO:0046700	heterocycle catabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901361	organic cyclic compound catabolic process	4	5
GO:1901575	organic substance catabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004519	endonuclease activity	5	5
GO:0005488	binding	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.675
CLV_PCSK_FUR_1	129	133	PF00082	0.483
CLV_PCSK_FUR_1	170	174	PF00082	0.623
CLV_PCSK_KEX2_1	131	133	PF00082	0.483
CLV_PCSK_KEX2_1	172	174	PF00082	0.624
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.483
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.624
CLV_PCSK_SKI1_1	69	73	PF00082	0.600
DEG_SCF_FBW7_1	114	121	PF00400	0.675
DOC_AGCK_PIF_2	54	59	PF00069	0.583
DOC_MAPK_gen_1	26	35	PF00069	0.436
DOC_MAPK_MEF2A_6	28	37	PF00069	0.416
DOC_WW_Pin1_4	114	119	PF00397	0.683
LIG_14-3-3_CanoR_1	137	141	PF00244	0.683
LIG_14-3-3_CanoR_1	28	37	PF00244	0.298
LIG_14-3-3_CterR_2	170	175	PF00244	0.828
LIG_APCC_ABBA_1	98	103	PF00400	0.683
LIG_BRCT_BRCA1_1	103	107	PF00533	0.683
LIG_BRCT_BRCA1_1	16	20	PF00533	0.298
LIG_eIF4E_1	143	149	PF01652	0.683
LIG_FHA_2	119	125	PF00498	0.675
LIG_FHA_2	84	90	PF00498	0.683
LIG_FHA_2	91	97	PF00498	0.595
LIG_LIR_Apic_2	83	88	PF02991	0.683
LIG_LIR_Gen_1	31	42	PF02991	0.475
LIG_LIR_Gen_1	55	62	PF02991	0.583
LIG_LIR_Nem_3	111	116	PF02991	0.683
LIG_LIR_Nem_3	31	37	PF02991	0.529
LIG_LIR_Nem_3	46	52	PF02991	0.339
LIG_LIR_Nem_3	55	60	PF02991	0.425
LIG_LYPXL_yS_3	113	116	PF13949	0.683
LIG_NRBOX	144	150	PF00104	0.683
LIG_Pex14_2	50	54	PF04695	0.583
LIG_Pex14_2	68	72	PF04695	0.583
LIG_SH2_CRK	57	61	PF00017	0.458
LIG_SH2_NCK_1	30	34	PF00017	0.488
LIG_SH2_PTP2	34	37	PF00017	0.459
LIG_SH2_PTP2	40	43	PF00017	0.510
LIG_SH2_SRC	34	37	PF00017	0.454
LIG_SH2_SRC	40	43	PF00017	0.447
LIG_SH2_STAP1	30	34	PF00017	0.488
LIG_SH2_STAT5	126	129	PF00017	0.683
LIG_SH2_STAT5	147	150	PF00017	0.683
LIG_SH2_STAT5	30	33	PF00017	0.588
LIG_SH2_STAT5	34	37	PF00017	0.455
LIG_SH2_STAT5	40	43	PF00017	0.438
LIG_SH2_STAT5	44	47	PF00017	0.368
LIG_SH2_STAT5	49	52	PF00017	0.316
LIG_SH2_STAT5	85	88	PF00017	0.683
LIG_SH3_3	151	157	PF00018	0.770
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.683
LIG_SUMO_SIM_par_1	96	104	PF11976	0.683
LIG_TYR_ITSM	109	116	PF00017	0.683
MOD_CK1_1	4	10	PF00069	0.648
MOD_CK2_1	83	89	PF00069	0.683
MOD_GlcNHglycan	14	17	PF01048	0.495
MOD_GlcNHglycan	54	57	PF01048	0.583
MOD_GSK3_1	114	121	PF00069	0.675
MOD_N-GLC_1	109	114	PF02516	0.483
MOD_NEK2_1	81	86	PF00069	0.675
MOD_PKA_2	136	142	PF00069	0.683
MOD_PKB_1	26	34	PF00069	0.298
MOD_Plk_1	101	107	PF00069	0.683
MOD_Plk_1	109	115	PF00069	0.583
MOD_Plk_1	159	165	PF00069	0.770
MOD_Plk_2-3	159	165	PF00069	0.770
MOD_Plk_2-3	83	89	PF00069	0.683
MOD_ProDKin_1	114	120	PF00069	0.683
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.683
TRG_ENDOCYTIC_2	113	116	PF00928	0.683
TRG_ENDOCYTIC_2	21	24	PF00928	0.455
TRG_ENDOCYTIC_2	30	33	PF00928	0.568
TRG_ENDOCYTIC_2	34	37	PF00928	0.440
TRG_ENDOCYTIC_2	40	43	PF00928	0.418
TRG_ENDOCYTIC_2	49	52	PF00928	0.290
TRG_ENDOCYTIC_2	57	60	PF00928	0.269
TRG_ER_diArg_1	26	29	PF00400	0.298
TRG_NES_CRM1_1	89	103	PF08389	0.683
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4Q7F5	Leishmania major	100%	100%
Q4Q7F7	Leishmania major	100%	97%
Q4Q7F8	Leishmania major	100%	97%