Class i nuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

class i nuclease-like protein

Species:

Leishmania major

UniProt:

Q4Q7F5_LEIMA

TriTrypDb:

LmjF.30.1490 , LMJLV39_300021500 , LMJSD75_300021200

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q7F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7F5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006259	DNA metabolic process	4	5
GO:0006308	DNA catabolic process	5	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0009057	macromolecule catabolic process	4	5
GO:0009987	cellular process	1	5
GO:0019439	aromatic compound catabolic process	4	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034655	nucleobase-containing compound catabolic process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044248	cellular catabolic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044265	obsolete cellular macromolecule catabolic process	4	5
GO:0044270	cellular nitrogen compound catabolic process	4	5
GO:0046483	heterocycle metabolic process	3	5
GO:0046700	heterocycle catabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901361	organic cyclic compound catabolic process	4	5
GO:1901575	organic substance catabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004519	endonuclease activity	5	5
GO:0005488	binding	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.675
CLV_PCSK_FUR_1	117	121	PF00082	0.483
CLV_PCSK_FUR_1	158	162	PF00082	0.622
CLV_PCSK_KEX2_1	119	121	PF00082	0.376
CLV_PCSK_KEX2_1	160	162	PF00082	0.558
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.376
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.558
CLV_PCSK_SKI1_1	57	61	PF00082	0.596
DEG_Nend_UBRbox_4	1	3	PF02207	0.661
DEG_SCF_FBW7_1	102	109	PF00400	0.675
DOC_AGCK_PIF_2	42	47	PF00069	0.583
DOC_PP2B_PxIxI_1	20	26	PF00149	0.320
DOC_PP4_FxxP_1	13	16	PF00568	0.320
DOC_WW_Pin1_4	102	107	PF00397	0.683
DOC_WW_Pin1_4	12	17	PF00397	0.336
LIG_14-3-3_CanoR_1	125	129	PF00244	0.558
LIG_14-3-3_CterR_2	158	163	PF00244	0.828
LIG_APCC_ABBA_1	86	91	PF00400	0.683
LIG_BRCT_BRCA1_1	91	95	PF00533	0.683
LIG_eIF4E_1	131	137	PF01652	0.683
LIG_FHA_2	107	113	PF00498	0.675
LIG_FHA_2	72	78	PF00498	0.683
LIG_FHA_2	79	85	PF00498	0.595
LIG_LIR_Apic_2	15	21	PF02991	0.320
LIG_LIR_Apic_2	71	76	PF02991	0.683
LIG_LIR_Gen_1	43	50	PF02991	0.583
LIG_LIR_Nem_3	17	23	PF02991	0.386
LIG_LIR_Nem_3	34	40	PF02991	0.339
LIG_LIR_Nem_3	43	48	PF02991	0.466
LIG_LIR_Nem_3	99	104	PF02991	0.683
LIG_LYPXL_S_1	19	23	PF13949	0.320
LIG_LYPXL_yS_3	101	104	PF13949	0.683
LIG_LYPXL_yS_3	20	23	PF13949	0.320
LIG_NRBOX	132	138	PF00104	0.683
LIG_Pex14_2	38	42	PF04695	0.583
LIG_Pex14_2	56	60	PF04695	0.808
LIG_SH2_CRK	26	30	PF00017	0.341
LIG_SH2_CRK	45	49	PF00017	0.583
LIG_SH2_PTP2	28	31	PF00017	0.510
LIG_SH2_SRC	18	21	PF00017	0.493
LIG_SH2_SRC	28	31	PF00017	0.447
LIG_SH2_STAT5	114	117	PF00017	0.558
LIG_SH2_STAT5	135	138	PF00017	0.671
LIG_SH2_STAT5	18	21	PF00017	0.397
LIG_SH2_STAT5	24	27	PF00017	0.579
LIG_SH2_STAT5	28	31	PF00017	0.381
LIG_SH2_STAT5	32	35	PF00017	0.370
LIG_SH2_STAT5	37	40	PF00017	0.374
LIG_SH2_STAT5	73	76	PF00017	0.625
LIG_SH3_3	139	145	PF00018	0.769
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.683
LIG_SUMO_SIM_par_1	84	92	PF11976	0.683
LIG_TYR_ITSM	97	104	PF00017	0.683
MOD_CK2_1	71	77	PF00069	0.564
MOD_GlcNHglycan	42	45	PF01048	0.583
MOD_GSK3_1	102	109	PF00069	0.675
MOD_N-GLC_1	97	102	PF02516	0.389
MOD_NEK2_1	69	74	PF00069	0.556
MOD_PKA_2	124	130	PF00069	0.558
MOD_Plk_1	147	153	PF00069	0.773
MOD_Plk_1	89	95	PF00069	0.683
MOD_Plk_1	97	103	PF00069	0.583
MOD_Plk_2-3	147	153	PF00069	0.773
MOD_Plk_2-3	71	77	PF00069	0.683
MOD_Plk_4	14	20	PF00069	0.459
MOD_ProDKin_1	102	108	PF00069	0.683
MOD_ProDKin_1	12	18	PF00069	0.336
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.683
TRG_ENDOCYTIC_2	101	104	PF00928	0.558
TRG_ENDOCYTIC_2	20	23	PF00928	0.545
TRG_ENDOCYTIC_2	24	27	PF00928	0.661
TRG_ENDOCYTIC_2	28	31	PF00928	0.404
TRG_ENDOCYTIC_2	37	40	PF00928	0.281
TRG_ENDOCYTIC_2	45	48	PF00928	0.583
TRG_NES_CRM1_1	77	91	PF08389	0.683
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4Q7F6	Leishmania major	100%	93%
Q4Q7F7	Leishmania major	100%	91%
Q4Q7F8	Leishmania major	100%	91%