LeishMANIAdb
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Class i nuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Class i nuclease-like protein
Gene product:
class i nuclease-like protein
Species:
Leishmania major
UniProt:
Q4Q7F5_LEIMA
TriTrypDb:
LmjF.30.1490 , LMJLV39_300021500 , LMJSD75_300021200
Length:
163

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4
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Expansion

Sequence features

Q4Q7F5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7F5

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 5
GO:0006259 DNA metabolic process 4 5
GO:0006308 DNA catabolic process 5 5
GO:0006725 cellular aromatic compound metabolic process 3 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009056 catabolic process 2 5
GO:0009057 macromolecule catabolic process 4 5
GO:0009987 cellular process 1 5
GO:0019439 aromatic compound catabolic process 4 5
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Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004518 nuclease activity 4 5
GO:0004519 endonuclease activity 5 5
GO:0005488 binding 1 5
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 5
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 109 113 PF00656 0.675
CLV_PCSK_FUR_1 117 121 PF00082 0.483
CLV_PCSK_FUR_1 158 162 PF00082 0.622
CLV_PCSK_KEX2_1 119 121 PF00082 0.376
CLV_PCSK_KEX2_1 160 162 PF00082 0.558
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.376
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.558
CLV_PCSK_SKI1_1 57 61 PF00082 0.596
DEG_Nend_UBRbox_4 1 3 PF02207 0.661
DEG_SCF_FBW7_1 102 109 PF00400 0.675
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Homologs

ProteinTaxonomySequence identityCoverage
Q4Q7F6 Leishmania major 100% 93%
Q4Q7F7 Leishmania major 100% 91%
Q4Q7F8 Leishmania major 100% 91%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS