p1/s1 nuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

p1/s1 nuclease

Gene product:

p1/s1 nuclease

Species:

Leishmania major

UniProt:

Q4Q7F4_LEIMA

TriTrypDb:

LmjF.30.1500 , LMJLV39_300021500 , LMJSD75_300021200

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 23, no: 6
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0009986	cell surface	2	1

Expansion

Sequence features

Q4Q7F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7F4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	30
GO:0006259	DNA metabolic process	4	30
GO:0006308	DNA catabolic process	5	30
GO:0006725	cellular aromatic compound metabolic process	3	30
GO:0006807	nitrogen compound metabolic process	2	30
GO:0008152	metabolic process	1	30
GO:0009056	catabolic process	2	30
GO:0009057	macromolecule catabolic process	4	30
GO:0009987	cellular process	1	30
GO:0019439	aromatic compound catabolic process	4	30
GO:0034641	cellular nitrogen compound metabolic process	3	30
GO:0034655	nucleobase-containing compound catabolic process	4	30
GO:0043170	macromolecule metabolic process	3	30
GO:0044237	cellular metabolic process	2	30
GO:0044238	primary metabolic process	2	30
GO:0044248	cellular catabolic process	3	30
GO:0044260	obsolete cellular macromolecule metabolic process	3	30
GO:0044265	obsolete cellular macromolecule catabolic process	4	30
GO:0044270	cellular nitrogen compound catabolic process	4	30
GO:0046483	heterocycle metabolic process	3	30
GO:0046700	heterocycle catabolic process	4	30
GO:0071704	organic substance metabolic process	2	30
GO:0090304	nucleic acid metabolic process	4	30
GO:1901360	organic cyclic compound metabolic process	3	30
GO:1901361	organic cyclic compound catabolic process	4	30
GO:1901575	organic substance catabolic process	3	30
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006196	AMP catabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1
GO:0009126	purine nucleoside monophosphate metabolic process	6	1
GO:0009128	purine nucleoside monophosphate catabolic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009158	ribonucleoside monophosphate catabolic process	7	1
GO:0009161	ribonucleoside monophosphate metabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	1
GO:0009169	purine ribonucleoside monophosphate catabolic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046033	AMP metabolic process	7	1
GO:0046434	organophosphate catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	30
GO:0003824	catalytic activity	1	30
GO:0004518	nuclease activity	4	30
GO:0004519	endonuclease activity	5	30
GO:0005488	binding	1	30
GO:0016787	hydrolase activity	2	30
GO:0016788	hydrolase activity, acting on ester bonds	3	30
GO:0043167	ion binding	2	30
GO:0043169	cation binding	3	30
GO:0046872	metal ion binding	4	30
GO:0097159	organic cyclic compound binding	2	30
GO:1901363	heterocyclic compound binding	2	30
GO:0008252	nucleotidase activity	6	1
GO:0008254	3'-nucleotidase activity	7	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.220
CLV_C14_Caspase3-7	53	57	PF00656	0.235
CLV_NRD_NRD_1	130	132	PF00675	0.452
CLV_NRD_NRD_1	183	185	PF00675	0.445
CLV_PCSK_FUR_1	202	206	PF00082	0.518
CLV_PCSK_FUR_1	270	274	PF00082	0.435
CLV_PCSK_FUR_1	311	315	PF00082	0.418
CLV_PCSK_KEX2_1	130	132	PF00082	0.442
CLV_PCSK_KEX2_1	183	185	PF00082	0.428
CLV_PCSK_KEX2_1	204	206	PF00082	0.471
CLV_PCSK_KEX2_1	272	274	PF00082	0.520
CLV_PCSK_KEX2_1	313	315	PF00082	0.676
CLV_PCSK_KEX2_1	85	87	PF00082	0.504
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.413
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.518
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.535
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.445
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.504
DEG_APCC_DBOX_1	7	15	PF00400	0.467
DEG_SCF_FBW7_1	255	262	PF00400	0.249
DOC_CKS1_1	98	103	PF01111	0.294
DOC_CYCLIN_yClb5_NLxxxL_5	141	150	PF00134	0.213
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.683
DOC_MAPK_gen_1	130	138	PF00069	0.296
DOC_MAPK_MEF2A_6	172	181	PF00069	0.279
DOC_PP2B_LxvP_1	7	10	PF13499	0.468
DOC_PP4_FxxP_1	98	101	PF00568	0.235
DOC_USP7_MATH_1	67	71	PF00917	0.351
DOC_WW_Pin1_4	196	201	PF00397	0.253
DOC_WW_Pin1_4	255	260	PF00397	0.249
DOC_WW_Pin1_4	68	73	PF00397	0.347
DOC_WW_Pin1_4	97	102	PF00397	0.296
LIG_14-3-3_CanoR_1	162	168	PF00244	0.420
LIG_14-3-3_CanoR_1	205	210	PF00244	0.304
LIG_14-3-3_CanoR_1	278	282	PF00244	0.314
LIG_14-3-3_CanoR_1	8	14	PF00244	0.606
LIG_14-3-3_CterR_2	311	316	PF00244	0.420
LIG_APCC_ABBA_1	239	244	PF00400	0.235
LIG_BRCT_BRCA1_1	244	248	PF00533	0.366
LIG_BRCT_BRCA1_1	64	68	PF00533	0.242
LIG_DLG_GKlike_1	205	212	PF00625	0.249
LIG_eIF4E_1	284	290	PF01652	0.365
LIG_FHA_1	108	114	PF00498	0.353
LIG_FHA_1	24	30	PF00498	0.567
LIG_FHA_2	225	231	PF00498	0.389
LIG_FHA_2	232	238	PF00498	0.398
LIG_FHA_2	260	266	PF00498	0.380
LIG_LIR_Apic_2	224	229	PF02991	0.306
LIG_LIR_Gen_1	208	217	PF02991	0.333
LIG_LIR_Gen_1	94	102	PF02991	0.332
LIG_LIR_Nem_3	208	212	PF02991	0.333
LIG_LIR_Nem_3	252	257	PF02991	0.278
LIG_LIR_Nem_3	94	98	PF02991	0.340
LIG_LYPXL_yS_3	254	257	PF13949	0.329
LIG_NRBOX	285	291	PF00104	0.333
LIG_RPA_C_Fungi	118	130	PF08784	0.227
LIG_SH2_CRK	203	207	PF00017	0.386
LIG_SH2_NCK_1	90	94	PF00017	0.254
LIG_SH2_STAP1	163	167	PF00017	0.442
LIG_SH2_STAP1	209	213	PF00017	0.277
LIG_SH2_STAT5	137	140	PF00017	0.269
LIG_SH2_STAT5	209	212	PF00017	0.386
LIG_SH2_STAT5	226	229	PF00017	0.418
LIG_SH2_STAT5	267	270	PF00017	0.275
LIG_SH2_STAT5	288	291	PF00017	0.439
LIG_SH3_3	292	298	PF00018	0.445
LIG_SH3_3	98	104	PF00018	0.345
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.402
LIG_SUMO_SIM_par_1	15	21	PF11976	0.586
LIG_SUMO_SIM_par_1	237	245	PF11976	0.236
LIG_TYR_ITIM	207	212	PF00017	0.388
LIG_TYR_ITSM	250	257	PF00017	0.258
LIG_WW_1	200	203	PF00397	0.277
LIG_WW_3	199	203	PF00397	0.393
MOD_CDK_SPxK_1	196	202	PF00069	0.262
MOD_CK1_1	161	167	PF00069	0.335
MOD_CK2_1	224	230	PF00069	0.419
MOD_Cter_Amidation	181	184	PF01082	0.277
MOD_GlcNHglycan	196	199	PF01048	0.492
MOD_GlcNHglycan	20	23	PF01048	0.667
MOD_GlcNHglycan	64	67	PF01048	0.312
MOD_GSK3_1	125	132	PF00069	0.389
MOD_GSK3_1	158	165	PF00069	0.284
MOD_GSK3_1	255	262	PF00069	0.402
MOD_N-GLC_1	107	112	PF02516	0.348
MOD_N-GLC_1	250	255	PF02516	0.391
MOD_N-GLC_2	194	196	PF02516	0.297
MOD_NEK2_1	125	130	PF00069	0.431
MOD_NEK2_1	17	22	PF00069	0.553
MOD_NEK2_1	222	227	PF00069	0.366
MOD_NEK2_1	62	67	PF00069	0.283
MOD_PKA_2	129	135	PF00069	0.337
MOD_PKA_2	161	167	PF00069	0.297
MOD_PKA_2	277	283	PF00069	0.399
MOD_Plk_1	242	248	PF00069	0.365
MOD_Plk_1	250	256	PF00069	0.379
MOD_Plk_1	300	306	PF00069	0.473
MOD_Plk_2-3	224	230	PF00069	0.272
MOD_Plk_2-3	300	306	PF00069	0.351
MOD_Plk_4	9	15	PF00069	0.482
MOD_ProDKin_1	196	202	PF00069	0.283
MOD_ProDKin_1	255	261	PF00069	0.277
MOD_ProDKin_1	68	74	PF00069	0.415
MOD_ProDKin_1	97	103	PF00069	0.343
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.297
TRG_ENDOCYTIC_2	209	212	PF00928	0.372
TRG_ENDOCYTIC_2	254	257	PF00928	0.321
TRG_ER_diArg_1	129	131	PF00400	0.283
TRG_NES_CRM1_1	230	244	PF08389	0.258
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Q7	Leptomonas seymouri	57%	88%
A0A0S4JAL3	Bodo saltans	38%	93%
A0A0S4JML7	Bodo saltans	31%	87%
A0A1X0P2K7	Trypanosomatidae	41%	96%
A0A3Q8IBF6	Leishmania donovani	37%	83%
A0A3Q8IEW3	Leishmania donovani	86%	100%
A0A3Q8IFH4	Leishmania donovani	39%	84%
A0A3Q8IK90	Leishmania donovani	37%	91%
A0A3S7X3A6	Leishmania donovani	85%	100%
A0A422N7B0	Trypanosoma rangeli	44%	96%
A4H6V5	Leishmania braziliensis	38%	84%
A4HI96	Leishmania braziliensis	63%	96%
A4HJL3	Leishmania braziliensis	39%	83%
A4I5I0	Leishmania infantum	84%	100%
A4I736	Leishmania infantum	39%	84%
C9ZQH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZQH6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZQW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	97%
E9AGC7	Leishmania infantum	37%	83%
E9ANW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	83%
E9B0S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B0S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B231	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	84%
F4JJL0	Arabidopsis thaliana	27%	100%
F4JJL3	Arabidopsis thaliana	27%	100%
P24021	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q4Q630	Leishmania major	36%	100%
Q4Q7F3	Leishmania major	99%	100%
Q4QGQ3	Leishmania major	38%	100%
Q66VY6	Leishmania major	37%	100%
Q8LDW6	Arabidopsis thaliana	26%	100%
Q9C9G4	Arabidopsis thaliana	28%	100%
Q9SXA6	Arabidopsis thaliana	26%	100%
V5B8Z9	Trypanosoma cruzi	43%	81%