LeishMANIAdb
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Flavoprotein domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Flavoprotein domain-containing protein
Gene product:
phosphopantothenoylcysteine decarboxylase, putative
Species:
Leishmania major
UniProt:
Q4Q7F0_LEIMA
TriTrypDb:
LmjF.30.1540 , LMJLV39_300021800 * , LMJSD75_300021500
Length:
323

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0032991 protein-containing complex 1 2
GO:0071513 phosphopantothenoylcysteine decarboxylase complex 3 2
GO:1902494 catalytic complex 2 2
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Expansion

Sequence features

Q4Q7F0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7F0

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006163 purine nucleotide metabolic process 5 2
GO:0006164 purine nucleotide biosynthetic process 6 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006753 nucleoside phosphate metabolic process 4 2
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009058 biosynthetic process 2 2
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 2
GO:0003824 catalytic activity 1 9
GO:0004633 phosphopantothenoylcysteine decarboxylase activity 5 4
GO:0005488 binding 1 2
GO:0010181 FMN binding 4 2
GO:0016829 lyase activity 2 4
GO:0016830 carbon-carbon lyase activity 3 4
GO:0016831 carboxy-lyase activity 4 4
GO:0032553 ribonucleotide binding 3 2
GO:0036094 small molecule binding 2 2
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 295 297 PF00675 0.625
CLV_NRD_NRD_1 304 306 PF00675 0.716
CLV_NRD_NRD_1 62 64 PF00675 0.434
CLV_NRD_NRD_1 99 101 PF00675 0.370
CLV_PCSK_KEX2_1 261 263 PF00082 0.479
CLV_PCSK_KEX2_1 294 296 PF00082 0.592
CLV_PCSK_KEX2_1 304 306 PF00082 0.646
CLV_PCSK_KEX2_1 62 64 PF00082 0.472
CLV_PCSK_KEX2_1 99 101 PF00082 0.390
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.479
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PGH1 Leptomonas seymouri 63% 100%
A0A3Q8IBY6 Leishmania donovani 95% 100%
A0A3R7KRR4 Trypanosoma rangeli 51% 100%
A4HI99 Leishmania braziliensis 80% 86%
A4I5I3 Leishmania infantum 95% 100%
C9ZQW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9B0S8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS