Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative papain-like cysteine peptidase (DUF1796), putative

Species:

Leishmania major

UniProt:

Q4Q7E7_LEIMA

TriTrypDb:

LmjF.30.1570 , LMJLV39_300022300 , LMJSD75_300022000

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q7E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.559
CLV_NRD_NRD_1	146	148	PF00675	0.338
CLV_NRD_NRD_1	242	244	PF00675	0.439
CLV_NRD_NRD_1	308	310	PF00675	0.624
CLV_NRD_NRD_1	396	398	PF00675	0.604
CLV_PCSK_FUR_1	397	401	PF00082	0.400
CLV_PCSK_KEX2_1	145	147	PF00082	0.386
CLV_PCSK_KEX2_1	242	244	PF00082	0.587
CLV_PCSK_KEX2_1	396	398	PF00082	0.531
CLV_PCSK_KEX2_1	399	401	PF00082	0.494
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.453
CLV_PCSK_SKI1_1	169	173	PF00082	0.456
CLV_PCSK_SKI1_1	207	211	PF00082	0.450
CLV_PCSK_SKI1_1	288	292	PF00082	0.381
CLV_PCSK_SKI1_1	410	414	PF00082	0.445
DEG_Nend_Nbox_1	1	3	PF02207	0.322
DEG_SCF_FBW7_2	312	318	PF00400	0.427
DEG_SPOP_SBC_1	247	251	PF00917	0.532
DOC_CKS1_1	312	317	PF01111	0.425
DOC_CYCLIN_RxL_1	407	415	PF00134	0.565
DOC_MAPK_gen_1	197	206	PF00069	0.396
DOC_MAPK_MEF2A_6	54	61	PF00069	0.198
DOC_PIKK_1	369	376	PF02985	0.370
DOC_PP1_RVXF_1	167	174	PF00149	0.413
DOC_PP1_RVXF_1	286	293	PF00149	0.298
DOC_USP7_MATH_1	107	111	PF00917	0.158
DOC_USP7_MATH_1	226	230	PF00917	0.524
DOC_USP7_MATH_1	247	251	PF00917	0.673
DOC_USP7_MATH_1	64	68	PF00917	0.276
DOC_USP7_MATH_1	89	93	PF00917	0.315
DOC_USP7_MATH_1	95	99	PF00917	0.257
DOC_WW_Pin1_4	231	236	PF00397	0.502
DOC_WW_Pin1_4	311	316	PF00397	0.561
DOC_WW_Pin1_4	53	58	PF00397	0.491
DOC_WW_Pin1_4	77	82	PF00397	0.476
DOC_WW_Pin1_4	96	101	PF00397	0.244
LIG_14-3-3_CanoR_1	169	174	PF00244	0.349
LIG_14-3-3_CanoR_1	245	254	PF00244	0.630
LIG_14-3-3_CanoR_1	3	8	PF00244	0.328
LIG_14-3-3_CanoR_1	35	39	PF00244	0.337
LIG_14-3-3_CterR_2	410	415	PF00244	0.556
LIG_APCC_ABBA_1	313	318	PF00400	0.433
LIG_BIR_III_4	257	261	PF00653	0.499
LIG_BRCT_BRCA1_1	27	31	PF00533	0.315
LIG_FHA_1	206	212	PF00498	0.347
LIG_FHA_1	217	223	PF00498	0.462
LIG_FHA_1	54	60	PF00498	0.276
LIG_FHA_1	69	75	PF00498	0.181
LIG_FHA_2	129	135	PF00498	0.371
LIG_FHA_2	193	199	PF00498	0.198
LIG_LIR_Gen_1	277	286	PF02991	0.432
LIG_LIR_Gen_1	28	38	PF02991	0.474
LIG_LIR_Gen_1	314	322	PF02991	0.548
LIG_LIR_Gen_1	404	413	PF02991	0.543
LIG_LIR_LC3C_4	208	212	PF02991	0.450
LIG_LIR_Nem_3	277	282	PF02991	0.440
LIG_LIR_Nem_3	28	34	PF02991	0.427
LIG_LIR_Nem_3	314	319	PF02991	0.541
LIG_LIR_Nem_3	37	41	PF02991	0.341
LIG_LIR_Nem_3	404	409	PF02991	0.515
LIG_NRBOX	408	414	PF00104	0.550
LIG_Pex14_2	335	339	PF04695	0.449
LIG_SH2_CRK	279	283	PF00017	0.469
LIG_SH2_SRC	305	308	PF00017	0.547
LIG_SH2_STAP1	302	306	PF00017	0.529
LIG_SH2_STAT5	305	308	PF00017	0.602
LIG_SH2_STAT5	316	319	PF00017	0.553
LIG_SH2_STAT5	87	90	PF00017	0.315
LIG_SH3_1	309	315	PF00018	0.443
LIG_SH3_1	54	60	PF00018	0.217
LIG_SH3_3	110	116	PF00018	0.223
LIG_SH3_3	309	315	PF00018	0.556
LIG_SH3_3	54	60	PF00018	0.315
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.347
LIG_SUMO_SIM_par_1	208	214	PF11976	0.402
LIG_SUMO_SIM_par_1	39	45	PF11976	0.315
LIG_SxIP_EBH_1	90	100	PF03271	0.198
LIG_TRAF2_1	163	166	PF00917	0.475
LIG_TRAF2_1	182	185	PF00917	0.337
LIG_TRAF2_1	24	27	PF00917	0.371
LIG_TRAF2_1	81	84	PF00917	0.315
LIG_UBA3_1	282	291	PF00899	0.401
LIG_WW_3	245	249	PF00397	0.415
MOD_CDK_SPK_2	77	82	PF00069	0.198
MOD_CK1_1	156	162	PF00069	0.217
MOD_CK1_1	250	256	PF00069	0.758
MOD_CK1_1	337	343	PF00069	0.585
MOD_CK1_1	69	75	PF00069	0.456
MOD_CK1_1	96	102	PF00069	0.479
MOD_CK2_1	192	198	PF00069	0.420
MOD_GlcNHglycan	155	158	PF01048	0.360
MOD_GlcNHglycan	262	265	PF01048	0.544
MOD_GlcNHglycan	339	342	PF01048	0.610
MOD_GlcNHglycan	357	360	PF01048	0.564
MOD_GlcNHglycan	68	71	PF01048	0.492
MOD_GlcNHglycan	95	98	PF01048	0.293
MOD_GSK3_1	103	110	PF00069	0.191
MOD_GSK3_1	11	18	PF00069	0.455
MOD_GSK3_1	169	176	PF00069	0.350
MOD_GSK3_1	246	253	PF00069	0.603
MOD_GSK3_1	256	263	PF00069	0.671
MOD_GSK3_1	278	285	PF00069	0.487
MOD_GSK3_1	291	298	PF00069	0.472
MOD_GSK3_1	301	308	PF00069	0.474
MOD_GSK3_1	330	337	PF00069	0.446
MOD_GSK3_1	49	56	PF00069	0.483
MOD_GSK3_1	64	71	PF00069	0.328
MOD_GSK3_1	89	96	PF00069	0.315
MOD_N-GLC_1	135	140	PF02516	0.475
MOD_N-GLC_1	77	82	PF02516	0.462
MOD_NEK2_1	122	127	PF00069	0.372
MOD_NEK2_1	15	20	PF00069	0.346
MOD_NEK2_1	173	178	PF00069	0.328
MOD_NEK2_1	192	197	PF00069	0.328
MOD_NEK2_1	295	300	PF00069	0.579
MOD_NEK2_1	335	340	PF00069	0.518
MOD_NEK2_1	49	54	PF00069	0.486
MOD_NEK2_1	68	73	PF00069	0.231
MOD_NEK2_2	107	112	PF00069	0.198
MOD_OFUCOSY	105	111	PF10250	0.198
MOD_PIKK_1	122	128	PF00454	0.402
MOD_PIKK_1	216	222	PF00454	0.316
MOD_PKA_2	22	28	PF00069	0.357
MOD_PKA_2	247	253	PF00069	0.667
MOD_PKA_2	328	334	PF00069	0.461
MOD_PKA_2	34	40	PF00069	0.317
MOD_PKA_2	89	95	PF00069	0.422
MOD_PKB_1	167	175	PF00069	0.256
MOD_Plk_1	25	31	PF00069	0.476
MOD_Plk_1	295	301	PF00069	0.489
MOD_Plk_1	317	323	PF00069	0.527
MOD_Plk_2-3	267	273	PF00069	0.525
MOD_Plk_4	11	17	PF00069	0.493
MOD_Plk_4	169	175	PF00069	0.337
MOD_Plk_4	267	273	PF00069	0.540
MOD_Plk_4	278	284	PF00069	0.457
MOD_Plk_4	301	307	PF00069	0.539
MOD_ProDKin_1	231	237	PF00069	0.493
MOD_ProDKin_1	311	317	PF00069	0.430
MOD_ProDKin_1	53	59	PF00069	0.491
MOD_ProDKin_1	77	83	PF00069	0.476
MOD_ProDKin_1	96	102	PF00069	0.244
MOD_SUMO_for_1	81	84	PF00179	0.217
TRG_DiLeu_BaEn_1	267	272	PF01217	0.472
TRG_DiLeu_BaEn_4	184	190	PF01217	0.443
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.179
TRG_ENDOCYTIC_2	279	282	PF00928	0.409
TRG_ENDOCYTIC_2	316	319	PF00928	0.475
TRG_ER_diArg_1	144	147	PF00400	0.402
TRG_ER_diArg_1	167	170	PF00400	0.495
TRG_ER_diArg_1	201	204	PF00400	0.276
TRG_ER_diArg_1	241	243	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L5	Leptomonas seymouri	30%	100%
A0A0S4JE30	Bodo saltans	37%	100%
A0A0S4JK16	Bodo saltans	28%	95%
A0A1X0NVQ6	Trypanosomatidae	28%	100%
A0A1X0P1X9	Trypanosomatidae	42%	100%
A0A3Q8IFT0	Leishmania donovani	93%	100%
A0A3R7KWZ0	Trypanosoma rangeli	29%	100%
A0A3R7KYN0	Trypanosoma rangeli	43%	100%
A0A3S7WTN3	Leishmania donovani	27%	100%
A4H8A5	Leishmania braziliensis	28%	100%
A4HIA2	Leishmania braziliensis	83%	100%
A4HWM5	Leishmania infantum	28%	100%
A4I5I6	Leishmania infantum	93%	100%
C9ZXR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AQD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QF43	Leishmania major	28%	100%
V5BPI9	Trypanosoma cruzi	41%	100%
V5BUE5	Trypanosoma cruzi	28%	100%