PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7E6_LEIMA

TriTrypDb:

LmjF.30.1580 , LMJLV39_300022400 , LMJSD75_300022100

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	662	666	PF00656	0.604
CLV_C14_Caspase3-7	682	686	PF00656	0.773
CLV_C14_Caspase3-7	690	694	PF00656	0.694
CLV_NRD_NRD_1	152	154	PF00675	0.781
CLV_NRD_NRD_1	179	181	PF00675	0.786
CLV_NRD_NRD_1	304	306	PF00675	0.582
CLV_NRD_NRD_1	531	533	PF00675	0.603
CLV_NRD_NRD_1	643	645	PF00675	0.663
CLV_NRD_NRD_1	772	774	PF00675	0.750
CLV_NRD_NRD_1	789	791	PF00675	0.517
CLV_PCSK_KEX2_1	304	306	PF00082	0.582
CLV_PCSK_KEX2_1	530	532	PF00082	0.685
CLV_PCSK_KEX2_1	643	645	PF00082	0.663
CLV_PCSK_KEX2_1	771	773	PF00082	0.757
CLV_PCSK_KEX2_1	789	791	PF00082	0.557
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.685
CLV_PCSK_SKI1_1	180	184	PF00082	0.608
CLV_PCSK_SKI1_1	304	308	PF00082	0.584
CLV_PCSK_SKI1_1	330	334	PF00082	0.651
CLV_PCSK_SKI1_1	381	385	PF00082	0.572
CLV_PCSK_SKI1_1	457	461	PF00082	0.469
CLV_PCSK_SKI1_1	588	592	PF00082	0.571
CLV_PCSK_SKI1_1	717	721	PF00082	0.588
CLV_PCSK_SKI1_1	8	12	PF00082	0.532
CLV_PCSK_SKI1_1	842	846	PF00082	0.602
CLV_PCSK_SKI1_1	86	90	PF00082	0.493
DEG_SCF_FBW7_1	708	713	PF00400	0.544
DEG_SIAH_1	418	426	PF03145	0.636
DEG_SPOP_SBC_1	710	714	PF00917	0.593
DOC_CKS1_1	763	768	PF01111	0.499
DOC_CYCLIN_RxL_1	322	333	PF00134	0.704
DOC_CYCLIN_RxL_1	839	846	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	589	595	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	837	843	PF00134	0.618
DOC_MAPK_gen_1	230	238	PF00069	0.532
DOC_MAPK_gen_1	48	56	PF00069	0.550
DOC_MAPK_gen_1	586	595	PF00069	0.520
DOC_MAPK_gen_1	789	799	PF00069	0.578
DOC_MAPK_MEF2A_6	355	364	PF00069	0.575
DOC_MAPK_MEF2A_6	792	800	PF00069	0.549
DOC_PP1_RVXF_1	455	462	PF00149	0.464
DOC_PP1_RVXF_1	589	596	PF00149	0.518
DOC_SPAK_OSR1_1	285	289	PF12202	0.466
DOC_USP7_MATH_1	106	110	PF00917	0.720
DOC_USP7_MATH_1	112	116	PF00917	0.736
DOC_USP7_MATH_1	176	180	PF00917	0.798
DOC_USP7_MATH_1	309	313	PF00917	0.623
DOC_USP7_MATH_1	323	327	PF00917	0.531
DOC_USP7_MATH_1	694	698	PF00917	0.724
DOC_USP7_MATH_1	710	714	PF00917	0.577
DOC_USP7_MATH_1	827	831	PF00917	0.502
DOC_WW_Pin1_4	1	6	PF00397	0.725
DOC_WW_Pin1_4	132	137	PF00397	0.816
DOC_WW_Pin1_4	166	171	PF00397	0.827
DOC_WW_Pin1_4	183	188	PF00397	0.799
DOC_WW_Pin1_4	264	269	PF00397	0.574
DOC_WW_Pin1_4	446	451	PF00397	0.738
DOC_WW_Pin1_4	479	484	PF00397	0.506
DOC_WW_Pin1_4	706	711	PF00397	0.742
DOC_WW_Pin1_4	762	767	PF00397	0.483
LIG_14-3-3_CanoR_1	22	26	PF00244	0.576
LIG_14-3-3_CanoR_1	298	303	PF00244	0.469
LIG_14-3-3_CanoR_1	330	337	PF00244	0.607
LIG_14-3-3_CanoR_1	36	40	PF00244	0.482
LIG_14-3-3_CanoR_1	428	434	PF00244	0.520
LIG_14-3-3_CanoR_1	531	540	PF00244	0.546
LIG_14-3-3_CanoR_1	717	726	PF00244	0.704
LIG_Actin_WH2_2	70	88	PF00022	0.483
LIG_Actin_WH2_2	701	719	PF00022	0.552
LIG_AP2alpha_2	57	59	PF02296	0.645
LIG_APCC_ABBA_1	383	388	PF00400	0.665
LIG_Clathr_ClatBox_1	757	761	PF01394	0.548
LIG_deltaCOP1_diTrp_1	20	23	PF00928	0.510
LIG_deltaCOP1_diTrp_1	224	231	PF00928	0.590
LIG_deltaCOP1_diTrp_1	273	278	PF00928	0.527
LIG_deltaCOP1_diTrp_1	475	480	PF00928	0.472
LIG_deltaCOP1_diTrp_1	640	649	PF00928	0.598
LIG_FHA_1	100	106	PF00498	0.445
LIG_FHA_1	108	114	PF00498	0.678
LIG_FHA_1	206	212	PF00498	0.709
LIG_FHA_1	391	397	PF00498	0.668
LIG_FHA_1	540	546	PF00498	0.530
LIG_FHA_1	614	620	PF00498	0.514
LIG_FHA_1	72	78	PF00498	0.474
LIG_FHA_1	786	792	PF00498	0.541
LIG_FHA_1	87	93	PF00498	0.456
LIG_FHA_2	169	175	PF00498	0.777
LIG_FHA_2	331	337	PF00498	0.655
LIG_FHA_2	576	582	PF00498	0.646
LIG_FHA_2	676	682	PF00498	0.780
LIG_GBD_Chelix_1	11	19	PF00786	0.547
LIG_Integrin_isoDGR_2	769	771	PF01839	0.693
LIG_Integrin_RGD_1	161	163	PF01839	0.769
LIG_LIR_Apic_2	478	483	PF02991	0.502
LIG_LIR_Gen_1	312	319	PF02991	0.539
LIG_LIR_Gen_1	535	545	PF02991	0.519
LIG_LIR_Gen_1	554	563	PF02991	0.381
LIG_LIR_Gen_1	817	826	PF02991	0.513
LIG_LIR_Nem_3	26	32	PF02991	0.488
LIG_LIR_Nem_3	273	278	PF02991	0.465
LIG_LIR_Nem_3	284	290	PF02991	0.369
LIG_LIR_Nem_3	312	318	PF02991	0.559
LIG_LIR_Nem_3	334	340	PF02991	0.571
LIG_LIR_Nem_3	47	53	PF02991	0.593
LIG_LIR_Nem_3	535	541	PF02991	0.509
LIG_LIR_Nem_3	554	559	PF02991	0.307
LIG_LIR_Nem_3	646	652	PF02991	0.649
LIG_LIR_Nem_3	817	821	PF02991	0.510
LIG_NRBOX	96	102	PF00104	0.545
LIG_PAM2_1	374	386	PF00658	0.631
LIG_Pex14_1	21	25	PF04695	0.500
LIG_Pex14_1	231	235	PF04695	0.452
LIG_Pex14_2	10	14	PF04695	0.511
LIG_SH2_CRK	469	473	PF00017	0.569
LIG_SH2_CRK	502	506	PF00017	0.398
LIG_SH2_SRC	415	418	PF00017	0.632
LIG_SH2_SRC	469	472	PF00017	0.581
LIG_SH2_STAP1	25	29	PF00017	0.500
LIG_SH2_STAP1	556	560	PF00017	0.490
LIG_SH2_STAP1	93	97	PF00017	0.573
LIG_SH2_STAT5	259	262	PF00017	0.577
LIG_SH2_STAT5	29	32	PF00017	0.467
LIG_SH2_STAT5	300	303	PF00017	0.532
LIG_SH2_STAT5	363	366	PF00017	0.462
LIG_SH2_STAT5	71	74	PF00017	0.494
LIG_SH2_STAT5	756	759	PF00017	0.534
LIG_SH2_STAT5	818	821	PF00017	0.464
LIG_SH3_3	100	106	PF00018	0.585
LIG_SH3_3	133	139	PF00018	0.762
LIG_SH3_3	435	441	PF00018	0.526
LIG_SH3_3	510	516	PF00018	0.496
LIG_SH3_3	743	749	PF00018	0.593
LIG_SH3_3	760	766	PF00018	0.631
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.445
LIG_SUMO_SIM_anti_2	616	621	PF11976	0.486
LIG_SUMO_SIM_par_1	101	111	PF11976	0.643
LIG_SUMO_SIM_par_1	206	212	PF11976	0.711
LIG_SUMO_SIM_par_1	213	219	PF11976	0.521
LIG_SUMO_SIM_par_1	397	402	PF11976	0.642
LIG_SUMO_SIM_par_1	756	761	PF11976	0.562
LIG_TRAF2_1	292	295	PF00917	0.490
LIG_TRAF2_1	414	417	PF00917	0.582
LIG_TYR_ITIM	288	293	PF00017	0.552
LIG_UBA3_1	216	223	PF00899	0.519
LIG_WRC_WIRS_1	350	355	PF05994	0.554
LIG_WRC_WIRS_1	53	58	PF05994	0.567
MOD_CDK_SPxxK_3	1	8	PF00069	0.712
MOD_CK1_1	107	113	PF00069	0.780
MOD_CK1_1	123	129	PF00069	0.635
MOD_CK1_1	166	172	PF00069	0.738
MOD_CK1_1	175	181	PF00069	0.786
MOD_CK1_1	248	254	PF00069	0.582
MOD_CK1_1	389	395	PF00069	0.630
MOD_CK1_1	444	450	PF00069	0.630
MOD_CK1_1	574	580	PF00069	0.640
MOD_CK2_1	10	16	PF00069	0.556
MOD_CK2_1	168	174	PF00069	0.777
MOD_CK2_1	216	222	PF00069	0.522
MOD_CK2_1	249	255	PF00069	0.569
MOD_CK2_1	289	295	PF00069	0.488
MOD_CK2_1	574	580	PF00069	0.746
MOD_CK2_1	675	681	PF00069	0.770
MOD_CK2_1	827	833	PF00069	0.649
MOD_CMANNOS	477	480	PF00535	0.514
MOD_Cter_Amidation	769	772	PF01082	0.742
MOD_DYRK1A_RPxSP_1	446	450	PF00069	0.532
MOD_GlcNHglycan	110	113	PF01048	0.699
MOD_GlcNHglycan	116	119	PF01048	0.734
MOD_GlcNHglycan	140	143	PF01048	0.766
MOD_GlcNHglycan	166	169	PF01048	0.810
MOD_GlcNHglycan	174	177	PF01048	0.714
MOD_GlcNHglycan	248	251	PF01048	0.564
MOD_GlcNHglycan	281	284	PF01048	0.621
MOD_GlcNHglycan	333	336	PF01048	0.614
MOD_GlcNHglycan	345	348	PF01048	0.371
MOD_GlcNHglycan	388	391	PF01048	0.604
MOD_GlcNHglycan	443	446	PF01048	0.760
MOD_GlcNHglycan	464	467	PF01048	0.611
MOD_GlcNHglycan	524	527	PF01048	0.694
MOD_GlcNHglycan	678	681	PF01048	0.801
MOD_GSK3_1	104	111	PF00069	0.649
MOD_GSK3_1	119	126	PF00069	0.759
MOD_GSK3_1	145	152	PF00069	0.729
MOD_GSK3_1	164	171	PF00069	0.772
MOD_GSK3_1	172	179	PF00069	0.790
MOD_GSK3_1	190	197	PF00069	0.729
MOD_GSK3_1	203	210	PF00069	0.672
MOD_GSK3_1	245	252	PF00069	0.500
MOD_GSK3_1	345	352	PF00069	0.432
MOD_GSK3_1	354	361	PF00069	0.516
MOD_GSK3_1	386	393	PF00069	0.653
MOD_GSK3_1	395	402	PF00069	0.579
MOD_GSK3_1	440	447	PF00069	0.621
MOD_GSK3_1	471	478	PF00069	0.602
MOD_GSK3_1	571	578	PF00069	0.690
MOD_GSK3_1	689	696	PF00069	0.742
MOD_GSK3_1	700	707	PF00069	0.738
MOD_LATS_1	674	680	PF00433	0.609
MOD_N-GLC_1	203	208	PF02516	0.670
MOD_N-GLC_2	673	675	PF02516	0.776
MOD_N-GLC_2	836	838	PF02516	0.681
MOD_NEK2_1	10	15	PF00069	0.503
MOD_NEK2_1	149	154	PF00069	0.797
MOD_NEK2_1	194	199	PF00069	0.686
MOD_NEK2_1	203	208	PF00069	0.737
MOD_NEK2_1	216	221	PF00069	0.476
MOD_NEK2_1	276	281	PF00069	0.441
MOD_NEK2_1	32	37	PF00069	0.505
MOD_NEK2_1	365	370	PF00069	0.434
MOD_NEK2_1	399	404	PF00069	0.670
MOD_NEK2_1	539	544	PF00069	0.505
MOD_NEK2_1	704	709	PF00069	0.718
MOD_NEK2_2	323	328	PF00069	0.719
MOD_NEK2_2	59	64	PF00069	0.572
MOD_PIKK_1	168	174	PF00454	0.816
MOD_PIKK_1	694	700	PF00454	0.745
MOD_PIKK_1	744	750	PF00454	0.607
MOD_PK_1	289	295	PF00069	0.532
MOD_PKA_1	180	186	PF00069	0.604
MOD_PKA_1	531	537	PF00069	0.451
MOD_PKA_1	643	649	PF00069	0.662
MOD_PKA_1	772	778	PF00069	0.730
MOD_PKA_2	21	27	PF00069	0.565
MOD_PKA_2	246	252	PF00069	0.499
MOD_PKA_2	35	41	PF00069	0.496
MOD_PKA_2	531	537	PF00069	0.641
MOD_PKA_2	572	578	PF00069	0.696
MOD_PKA_2	59	65	PF00069	0.623
MOD_PKA_2	643	649	PF00069	0.629
MOD_PKA_2	675	681	PF00069	0.781
MOD_PKA_2	772	778	PF00069	0.730
MOD_PKB_1	328	336	PF00069	0.651
MOD_Plk_1	124	130	PF00069	0.815
MOD_Plk_1	700	706	PF00069	0.661
MOD_Plk_2-3	576	582	PF00069	0.550
MOD_Plk_2-3	79	85	PF00069	0.591
MOD_Plk_4	10	16	PF00069	0.466
MOD_Plk_4	345	351	PF00069	0.469
MOD_Plk_4	358	364	PF00069	0.428
MOD_Plk_4	49	55	PF00069	0.559
MOD_Plk_4	613	619	PF00069	0.461
MOD_Plk_4	92	98	PF00069	0.574
MOD_Plk_4	99	105	PF00069	0.498
MOD_ProDKin_1	1	7	PF00069	0.721
MOD_ProDKin_1	132	138	PF00069	0.816
MOD_ProDKin_1	166	172	PF00069	0.827
MOD_ProDKin_1	183	189	PF00069	0.796
MOD_ProDKin_1	264	270	PF00069	0.584
MOD_ProDKin_1	446	452	PF00069	0.727
MOD_ProDKin_1	479	485	PF00069	0.508
MOD_ProDKin_1	706	712	PF00069	0.742
MOD_ProDKin_1	762	768	PF00069	0.492
MOD_SUMO_for_1	669	672	PF00179	0.603
MOD_SUMO_rev_2	13	19	PF00179	0.469
MOD_SUMO_rev_2	42	50	PF00179	0.517
MOD_SUMO_rev_2	662	671	PF00179	0.604
MOD_SUMO_rev_2	747	755	PF00179	0.617
TRG_DiLeu_BaEn_1	240	245	PF01217	0.517
TRG_DiLeu_BaEn_2	25	31	PF01217	0.490
TRG_DiLeu_BaEn_2	794	800	PF01217	0.600
TRG_DiLeu_BaEn_4	584	590	PF01217	0.627
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.545
TRG_ENDOCYTIC_2	235	238	PF00928	0.403
TRG_ENDOCYTIC_2	29	32	PF00928	0.464
TRG_ENDOCYTIC_2	290	293	PF00928	0.561
TRG_ENDOCYTIC_2	337	340	PF00928	0.565
TRG_ENDOCYTIC_2	556	559	PF00928	0.440
TRG_ENDOCYTIC_2	818	821	PF00928	0.464
TRG_ER_diArg_1	227	230	PF00400	0.643
TRG_ER_diArg_1	304	306	PF00400	0.546
TRG_ER_diArg_1	327	330	PF00400	0.660
TRG_ER_diArg_1	549	552	PF00400	0.598
TRG_ER_diArg_1	586	589	PF00400	0.629
TRG_ER_diArg_1	642	644	PF00400	0.647
TRG_ER_diArg_1	771	773	PF00400	0.757
TRG_ER_diArg_1	789	792	PF00400	0.560
TRG_NLS_MonoExtC_3	529	535	PF00514	0.491
TRG_NLS_MonoExtN_4	528	534	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	842	846	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V2	Leptomonas seymouri	58%	96%
A0A1X0P232	Trypanosomatidae	25%	100%
A0A3S7X3F2	Leishmania donovani	92%	100%
A0A422P3I5	Trypanosoma rangeli	25%	100%
A4HIA3	Leishmania braziliensis	78%	100%
A4I5I7	Leishmania infantum	92%	100%
E9B0T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%