ER membrane protein complex subunit 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7E5_LEIMA

TriTrypDb:

LmjF.30.1590 , LMJLV39_300022500 , LMJSD75_300022200

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q7E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.810
CLV_NRD_NRD_1	312	314	PF00675	0.671
CLV_NRD_NRD_1	347	349	PF00675	0.462
CLV_NRD_NRD_1	361	363	PF00675	0.486
CLV_NRD_NRD_1	97	99	PF00675	0.585
CLV_PCSK_KEX2_1	346	348	PF00082	0.434
CLV_PCSK_KEX2_1	361	363	PF00082	0.409
CLV_PCSK_KEX2_1	97	99	PF00082	0.563
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.441
CLV_PCSK_SKI1_1	269	273	PF00082	0.630
CLV_PCSK_SKI1_1	308	312	PF00082	0.691
DEG_APCC_DBOX_1	153	161	PF00400	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.725
DOC_CKS1_1	303	308	PF01111	0.385
DOC_MAPK_gen_1	151	160	PF00069	0.423
DOC_MAPK_gen_1	313	320	PF00069	0.488
DOC_MAPK_JIP1_4	154	160	PF00069	0.443
DOC_MAPK_MEF2A_6	151	159	PF00069	0.422
DOC_MAPK_MEF2A_6	323	331	PF00069	0.302
DOC_PP2B_LxvP_1	24	27	PF13499	0.564
DOC_PP2B_LxvP_1	367	370	PF13499	0.682
DOC_PP4_FxxP_1	127	130	PF00568	0.415
DOC_USP7_MATH_1	227	231	PF00917	0.476
DOC_USP7_MATH_1	242	246	PF00917	0.564
DOC_USP7_MATH_1	304	308	PF00917	0.480
DOC_WW_Pin1_4	302	307	PF00397	0.369
DOC_WW_Pin1_4	72	77	PF00397	0.375
LIG_14-3-3_CanoR_1	107	112	PF00244	0.444
LIG_14-3-3_CanoR_1	269	276	PF00244	0.366
LIG_14-3-3_CanoR_1	97	102	PF00244	0.442
LIG_BRCT_BRCA1_1	142	146	PF00533	0.554
LIG_BRCT_BRCA1_1	62	66	PF00533	0.425
LIG_BRCT_BRCA1_1	74	78	PF00533	0.299
LIG_Clathr_ClatBox_1	157	161	PF01394	0.364
LIG_eIF4E_1	178	184	PF01652	0.424
LIG_FHA_1	171	177	PF00498	0.464
LIG_FHA_1	279	285	PF00498	0.478
LIG_FHA_2	270	276	PF00498	0.419
LIG_FHA_2	291	297	PF00498	0.449
LIG_LIR_Apic_2	125	130	PF02991	0.407
LIG_LIR_Apic_2	175	180	PF02991	0.373
LIG_Pex14_1	299	303	PF04695	0.356
LIG_Pex14_2	46	50	PF04695	0.429
LIG_SH2_CRK	303	307	PF00017	0.375
LIG_SH2_CRK	324	328	PF00017	0.441
LIG_SH2_NCK_1	303	307	PF00017	0.403
LIG_SH2_SRC	178	181	PF00017	0.417
LIG_SH2_STAT5	178	181	PF00017	0.417
LIG_SH3_1	73	79	PF00018	0.382
LIG_SH3_2	76	81	PF14604	0.445
LIG_SH3_3	277	283	PF00018	0.411
LIG_SH3_3	73	79	PF00018	0.382
LIG_SUMO_SIM_par_1	156	161	PF11976	0.392
LIG_UBA3_1	86	93	PF00899	0.456
MOD_CDK_SPxK_1	302	308	PF00069	0.393
MOD_CK1_1	117	123	PF00069	0.457
MOD_CK1_1	22	28	PF00069	0.501
MOD_CK1_1	243	249	PF00069	0.590
MOD_CK1_1	340	346	PF00069	0.566
MOD_CK1_1	57	63	PF00069	0.345
MOD_CK2_1	269	275	PF00069	0.356
MOD_CK2_1	290	296	PF00069	0.469
MOD_Cter_Amidation	344	347	PF01082	0.503
MOD_GlcNHglycan	116	119	PF01048	0.629
MOD_GlcNHglycan	139	143	PF01048	0.781
MOD_GlcNHglycan	195	199	PF01048	0.664
MOD_GlcNHglycan	200	203	PF01048	0.647
MOD_GlcNHglycan	21	24	PF01048	0.623
MOD_GlcNHglycan	229	232	PF01048	0.598
MOD_GlcNHglycan	254	259	PF01048	0.755
MOD_GlcNHglycan	275	279	PF01048	0.593
MOD_GlcNHglycan	339	342	PF01048	0.432
MOD_GlcNHglycan	37	40	PF01048	0.719
MOD_GlcNHglycan	62	65	PF01048	0.560
MOD_GSK3_1	194	201	PF00069	0.406
MOD_GSK3_1	209	216	PF00069	0.412
MOD_GSK3_1	240	247	PF00069	0.510
MOD_GSK3_1	254	261	PF00069	0.499
MOD_GSK3_1	274	281	PF00069	0.215
MOD_GSK3_1	285	292	PF00069	0.419
MOD_GSK3_1	35	42	PF00069	0.537
MOD_GSK3_1	50	57	PF00069	0.238
MOD_GSK3_1	93	100	PF00069	0.462
MOD_N-GLC_1	376	381	PF02516	0.395
MOD_N-GLC_1	66	71	PF02516	0.554
MOD_NEK2_1	170	175	PF00069	0.415
MOD_NEK2_1	19	24	PF00069	0.410
MOD_NEK2_1	2	7	PF00069	0.628
MOD_NEK2_1	355	360	PF00069	0.552
MOD_NEK2_1	50	55	PF00069	0.349
MOD_NEK2_1	59	64	PF00069	0.319
MOD_NEK2_1	66	71	PF00069	0.272
MOD_NEK2_2	172	177	PF00069	0.449
MOD_PIKK_1	57	63	PF00454	0.400
MOD_PK_1	244	250	PF00069	0.537
MOD_PKA_1	97	103	PF00069	0.379
MOD_PKA_2	153	159	PF00069	0.417
MOD_PKA_2	164	170	PF00069	0.451
MOD_PKA_2	3	9	PF00069	0.601
MOD_PKA_2	97	103	PF00069	0.442
MOD_Plk_1	66	72	PF00069	0.355
MOD_Plk_2-3	207	213	PF00069	0.479
MOD_Plk_4	117	123	PF00069	0.271
MOD_Plk_4	153	159	PF00069	0.327
MOD_Plk_4	172	178	PF00069	0.452
MOD_Plk_4	244	250	PF00069	0.568
MOD_Plk_4	54	60	PF00069	0.338
MOD_Plk_4	97	103	PF00069	0.487
MOD_ProDKin_1	302	308	PF00069	0.378
MOD_ProDKin_1	72	78	PF00069	0.377
MOD_SUMO_for_1	365	368	PF00179	0.701
MOD_SUMO_rev_2	110	117	PF00179	0.426
MOD_SUMO_rev_2	85	94	PF00179	0.456
TRG_DiLeu_BaEn_1	153	158	PF01217	0.412
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.684
TRG_ENDOCYTIC_2	324	327	PF00928	0.442
TRG_ER_diArg_1	236	239	PF00400	0.501
TRG_ER_diArg_1	347	350	PF00400	0.651
TRG_ER_diArg_1	70	73	PF00400	0.398
TRG_NLS_MonoCore_2	131	136	PF00514	0.530
TRG_NLS_MonoExtC_3	345	350	PF00514	0.686
TRG_NLS_MonoExtN_4	129	136	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH7	Leptomonas seymouri	53%	99%
A0A1X0P321	Trypanosomatidae	33%	100%
A0A3S7X3C2	Leishmania donovani	89%	100%
A0A422P4W9	Trypanosoma rangeli	30%	100%
A4HIA4	Leishmania braziliensis	67%	100%
A4I5I8	Leishmania infantum	89%	100%
C9ZQS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B0T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BPM9	Trypanosoma cruzi	31%	100%