Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7E4_LEIMA

TriTrypDb:

LmjF.30.1600 , LMJLV39_300022600 , LMJSD75_300022300

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.478
CLV_NRD_NRD_1	307	309	PF00675	0.474
CLV_NRD_NRD_1	375	377	PF00675	0.552
CLV_NRD_NRD_1	426	428	PF00675	0.635
CLV_PCSK_FUR_1	373	377	PF00082	0.572
CLV_PCSK_KEX2_1	123	125	PF00082	0.478
CLV_PCSK_KEX2_1	307	309	PF00082	0.484
CLV_PCSK_KEX2_1	361	363	PF00082	0.500
CLV_PCSK_KEX2_1	375	377	PF00082	0.552
CLV_PCSK_KEX2_1	379	381	PF00082	0.586
CLV_PCSK_KEX2_1	426	428	PF00082	0.740
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.500
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.611
CLV_PCSK_PC7_1	375	381	PF00082	0.573
CLV_PCSK_SKI1_1	245	249	PF00082	0.384
CLV_PCSK_SKI1_1	380	384	PF00082	0.588
CLV_PCSK_SKI1_1	93	97	PF00082	0.438
CLV_Separin_Metazoa	38	42	PF03568	0.472
DEG_APCC_DBOX_1	92	100	PF00400	0.477
DOC_CDC14_PxL_1	84	92	PF14671	0.435
DOC_CKS1_1	275	280	PF01111	0.511
DOC_CKS1_1	325	330	PF01111	0.606
DOC_CKS1_1	481	486	PF01111	0.604
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.473
DOC_MAPK_MEF2A_6	93	101	PF00069	0.363
DOC_PP1_RVXF_1	111	117	PF00149	0.382
DOC_PP2B_LxvP_1	347	350	PF13499	0.483
DOC_PP2B_LxvP_1	97	100	PF13499	0.434
DOC_USP7_MATH_1	100	104	PF00917	0.465
DOC_USP7_MATH_1	197	201	PF00917	0.537
DOC_USP7_MATH_1	53	57	PF00917	0.705
DOC_USP7_MATH_1	59	63	PF00917	0.749
DOC_USP7_UBL2_3	280	284	PF12436	0.708
DOC_WW_Pin1_4	238	243	PF00397	0.466
DOC_WW_Pin1_4	274	279	PF00397	0.498
DOC_WW_Pin1_4	324	329	PF00397	0.658
DOC_WW_Pin1_4	389	394	PF00397	0.611
DOC_WW_Pin1_4	480	485	PF00397	0.510
LIG_14-3-3_CanoR_1	165	174	PF00244	0.457
LIG_14-3-3_CanoR_1	378	383	PF00244	0.681
LIG_14-3-3_CanoR_1	434	442	PF00244	0.690
LIG_14-3-3_CanoR_1	502	508	PF00244	0.645
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	329	333	PF00533	0.604
LIG_CSL_BTD_1	490	493	PF09270	0.535
LIG_deltaCOP1_diTrp_1	109	116	PF00928	0.450
LIG_eIF4E_1	84	90	PF01652	0.429
LIG_FHA_1	127	133	PF00498	0.395
LIG_FHA_1	26	32	PF00498	0.525
LIG_FHA_1	34	40	PF00498	0.478
LIG_FHA_2	216	222	PF00498	0.702
LIG_FHA_2	49	55	PF00498	0.663
LIG_FHA_2	512	518	PF00498	0.511
LIG_FHA_2	65	71	PF00498	0.456
LIG_LIR_Gen_1	109	116	PF02991	0.521
LIG_LIR_Gen_1	365	374	PF02991	0.600
LIG_LIR_Gen_1	81	90	PF02991	0.521
LIG_LIR_Nem_3	109	114	PF02991	0.523
LIG_LIR_Nem_3	188	193	PF02991	0.559
LIG_LIR_Nem_3	28	32	PF02991	0.525
LIG_LIR_Nem_3	365	371	PF02991	0.591
LIG_LIR_Nem_3	81	87	PF02991	0.525
LIG_LYPXL_yS_3	29	32	PF13949	0.505
LIG_MYND_1	30	34	PF01753	0.367
LIG_NRBOX	312	318	PF00104	0.486
LIG_Rb_pABgroove_1	350	358	PF01858	0.429
LIG_SH2_CRK	84	88	PF00017	0.438
LIG_SH2_GRB2like	166	169	PF00017	0.468
LIG_SH2_SRC	351	354	PF00017	0.465
LIG_SH2_STAT3	11	14	PF00017	0.524
LIG_SH2_STAT5	18	21	PF00017	0.367
LIG_SH2_STAT5	351	354	PF00017	0.470
LIG_SH2_STAT5	358	361	PF00017	0.499
LIG_SH3_3	24	30	PF00018	0.536
LIG_SH3_3	322	328	PF00018	0.576
LIG_SH3_3	483	489	PF00018	0.596
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.531
LIG_SUMO_SIM_par_1	124	131	PF11976	0.356
LIG_SUMO_SIM_par_1	235	241	PF11976	0.466
LIG_TRAF2_1	443	446	PF00917	0.694
LIG_TRAF2_1	514	517	PF00917	0.562
LIG_TYR_ITIM	82	87	PF00017	0.430
LIG_UBA3_1	176	181	PF00899	0.407
LIG_UBA3_1	355	361	PF00899	0.415
MOD_CDK_SPxK_1	274	280	PF00069	0.503
MOD_CDK_SPxxK_3	238	245	PF00069	0.443
MOD_CK1_1	103	109	PF00069	0.475
MOD_CK1_1	149	155	PF00069	0.404
MOD_CK1_1	200	206	PF00069	0.633
MOD_CK1_1	381	387	PF00069	0.682
MOD_CK1_1	391	397	PF00069	0.665
MOD_CK1_1	429	435	PF00069	0.674
MOD_CK1_1	453	459	PF00069	0.653
MOD_CK1_1	460	466	PF00069	0.610
MOD_CK1_1	469	475	PF00069	0.731
MOD_CK1_1	480	486	PF00069	0.625
MOD_CK1_1	498	504	PF00069	0.419
MOD_CK1_1	60	66	PF00069	0.692
MOD_CK2_1	103	109	PF00069	0.471
MOD_CK2_1	215	221	PF00069	0.789
MOD_CK2_1	400	406	PF00069	0.640
MOD_CK2_1	440	446	PF00069	0.759
MOD_CK2_1	468	474	PF00069	0.616
MOD_CK2_1	511	517	PF00069	0.488
MOD_GlcNHglycan	102	105	PF01048	0.334
MOD_GlcNHglycan	133	136	PF01048	0.426
MOD_GlcNHglycan	230	233	PF01048	0.617
MOD_GlcNHglycan	329	332	PF01048	0.670
MOD_GlcNHglycan	406	409	PF01048	0.748
MOD_GlcNHglycan	437	440	PF01048	0.749
MOD_GlcNHglycan	463	466	PF01048	0.726
MOD_GlcNHglycan	54	58	PF01048	0.707
MOD_GlcNHglycan	59	62	PF01048	0.714
MOD_GlcNHglycan	67	70	PF01048	0.618
MOD_GSK3_1	160	167	PF00069	0.499
MOD_GSK3_1	193	200	PF00069	0.540
MOD_GSK3_1	323	330	PF00069	0.644
MOD_GSK3_1	378	385	PF00069	0.591
MOD_GSK3_1	400	407	PF00069	0.707
MOD_GSK3_1	422	429	PF00069	0.707
MOD_GSK3_1	430	437	PF00069	0.690
MOD_GSK3_1	450	457	PF00069	0.662
MOD_GSK3_1	459	466	PF00069	0.605
MOD_GSK3_1	469	476	PF00069	0.666
MOD_GSK3_1	53	60	PF00069	0.635
MOD_GSK3_1	99	106	PF00069	0.468
MOD_N-GLC_1	200	205	PF02516	0.573
MOD_N-GLC_1	521	526	PF02516	0.519
MOD_NEK2_1	128	133	PF00069	0.396
MOD_NEK2_1	180	185	PF00069	0.345
MOD_NEK2_1	228	233	PF00069	0.629
MOD_NEK2_1	382	387	PF00069	0.657
MOD_NEK2_1	455	460	PF00069	0.623
MOD_NEK2_1	495	500	PF00069	0.448
MOD_PIKK_1	384	390	PF00454	0.557
MOD_PIKK_1	477	483	PF00454	0.432
MOD_PKA_1	378	384	PF00069	0.602
MOD_PKA_1	426	432	PF00069	0.563
MOD_PKA_2	164	170	PF00069	0.540
MOD_PKA_2	398	404	PF00069	0.824
MOD_PKA_2	426	432	PF00069	0.645
MOD_PKA_2	433	439	PF00069	0.658
MOD_PKA_2	501	507	PF00069	0.556
MOD_PKA_2	518	524	PF00069	0.363
MOD_PKB_1	288	296	PF00069	0.675
MOD_PKB_1	376	384	PF00069	0.611
MOD_Plk_1	109	115	PF00069	0.540
MOD_Plk_1	200	206	PF00069	0.598
MOD_Plk_1	450	456	PF00069	0.719
MOD_Plk_1	473	479	PF00069	0.695
MOD_Plk_4	14	20	PF00069	0.366
MOD_Plk_4	200	206	PF00069	0.538
MOD_Plk_4	290	296	PF00069	0.591
MOD_Plk_4	463	469	PF00069	0.594
MOD_Plk_4	473	479	PF00069	0.625
MOD_Plk_4	495	501	PF00069	0.472
MOD_Plk_4	521	527	PF00069	0.553
MOD_ProDKin_1	238	244	PF00069	0.460
MOD_ProDKin_1	274	280	PF00069	0.503
MOD_ProDKin_1	324	330	PF00069	0.660
MOD_ProDKin_1	389	395	PF00069	0.614
MOD_ProDKin_1	480	486	PF00069	0.519
TRG_DiLeu_BaEn_1	38	43	PF01217	0.496
TRG_DiLeu_BaEn_4	109	115	PF01217	0.475
TRG_DiLeu_BaEn_4	450	456	PF01217	0.563
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.533
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.456
TRG_DiLeu_LyEn_5	38	43	PF01217	0.496
TRG_ENDOCYTIC_2	257	260	PF00928	0.377
TRG_ENDOCYTIC_2	29	32	PF00928	0.519
TRG_ENDOCYTIC_2	353	356	PF00928	0.438
TRG_ENDOCYTIC_2	84	87	PF00928	0.435
TRG_ER_diArg_1	123	125	PF00400	0.478
TRG_ER_diArg_1	306	308	PF00400	0.519
TRG_ER_diArg_1	375	378	PF00400	0.577
TRG_NES_CRM1_1	175	189	PF08389	0.462
TRG_NLS_Bipartite_1	361	382	PF00514	0.553
TRG_NLS_MonoExtN_4	375	382	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P973	Leptomonas seymouri	45%	100%
A0A3Q8IFL5	Leishmania donovani	90%	100%
A0A3R7NW81	Trypanosoma rangeli	25%	100%
A4HIA5	Leishmania braziliensis	72%	100%
A4I5I9	Leishmania infantum	90%	100%
E9B0T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BZ01	Trypanosoma cruzi	24%	100%