Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7E2_LEIMA

TriTrypDb:

LmjF.30.1620 , LMJLV39_300022800 , LMJSD75_300022500

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.458
CLV_C14_Caspase3-7	302	306	PF00656	0.497
CLV_C14_Caspase3-7	645	649	PF00656	0.462
CLV_NRD_NRD_1	11	13	PF00675	0.492
CLV_NRD_NRD_1	110	112	PF00675	0.589
CLV_NRD_NRD_1	146	148	PF00675	0.448
CLV_NRD_NRD_1	19	21	PF00675	0.487
CLV_NRD_NRD_1	231	233	PF00675	0.490
CLV_NRD_NRD_1	386	388	PF00675	0.484
CLV_NRD_NRD_1	452	454	PF00675	0.596
CLV_NRD_NRD_1	512	514	PF00675	0.550
CLV_NRD_NRD_1	589	591	PF00675	0.336
CLV_NRD_NRD_1	626	628	PF00675	0.641
CLV_PCSK_KEX2_1	11	13	PF00082	0.498
CLV_PCSK_KEX2_1	110	112	PF00082	0.589
CLV_PCSK_KEX2_1	19	21	PF00082	0.489
CLV_PCSK_KEX2_1	33	35	PF00082	0.476
CLV_PCSK_KEX2_1	385	387	PF00082	0.483
CLV_PCSK_KEX2_1	452	454	PF00082	0.542
CLV_PCSK_KEX2_1	512	514	PF00082	0.507
CLV_PCSK_KEX2_1	589	591	PF00082	0.333
CLV_PCSK_KEX2_1	603	605	PF00082	0.392
CLV_PCSK_KEX2_1	626	628	PF00082	0.641
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.645
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.467
CLV_PCSK_SKI1_1	151	155	PF00082	0.409
CLV_PCSK_SKI1_1	197	201	PF00082	0.375
CLV_PCSK_SKI1_1	252	256	PF00082	0.403
CLV_PCSK_SKI1_1	30	34	PF00082	0.641
CLV_PCSK_SKI1_1	319	323	PF00082	0.589
CLV_PCSK_SKI1_1	557	561	PF00082	0.418
CLV_Separin_Metazoa	654	658	PF03568	0.394
DEG_APCC_DBOX_1	196	204	PF00400	0.370
DEG_APCC_DBOX_1	251	259	PF00400	0.363
DEG_APCC_DBOX_1	401	409	PF00400	0.394
DEG_APCC_DBOX_1	603	611	PF00400	0.482
DEG_MDM2_SWIB_1	463	471	PF02201	0.475
DEG_Nend_UBRbox_1	1	4	PF02207	0.642
DEG_SPOP_SBC_1	441	445	PF00917	0.511
DOC_CYCLIN_RxL_1	589	602	PF00134	0.455
DOC_MAPK_gen_1	194	202	PF00069	0.345
DOC_MAPK_gen_1	339	347	PF00069	0.462
DOC_MAPK_gen_1	603	610	PF00069	0.584
DOC_MAPK_gen_1	8	17	PF00069	0.503
DOC_MAPK_MEF2A_6	464	473	PF00069	0.364
DOC_PP1_RVXF_1	172	179	PF00149	0.443
DOC_PP1_RVXF_1	404	410	PF00149	0.555
DOC_PP1_RVXF_1	462	468	PF00149	0.322
DOC_PP1_RVXF_1	517	524	PF00149	0.496
DOC_PP2B_LxvP_1	408	411	PF13499	0.418
DOC_PP4_FxxP_1	277	280	PF00568	0.548
DOC_PP4_FxxP_1	514	517	PF00568	0.535
DOC_SPAK_OSR1_1	571	575	PF12202	0.416
DOC_USP7_MATH_1	119	123	PF00917	0.481
DOC_USP7_MATH_1	209	213	PF00917	0.427
DOC_USP7_MATH_1	244	248	PF00917	0.453
DOC_USP7_MATH_1	321	325	PF00917	0.398
DOC_USP7_MATH_1	354	358	PF00917	0.612
DOC_USP7_MATH_1	418	422	PF00917	0.667
DOC_USP7_MATH_1	442	446	PF00917	0.515
DOC_USP7_MATH_1	472	476	PF00917	0.405
DOC_USP7_MATH_1	644	648	PF00917	0.535
DOC_USP7_MATH_1	650	654	PF00917	0.371
DOC_USP7_MATH_1	94	98	PF00917	0.704
DOC_USP7_MATH_2	297	303	PF00917	0.401
DOC_WW_Pin1_4	640	645	PF00397	0.694
LIG_14-3-3_CanoR_1	135	144	PF00244	0.552
LIG_14-3-3_CanoR_1	160	170	PF00244	0.488
LIG_14-3-3_CanoR_1	2	6	PF00244	0.572
LIG_14-3-3_CanoR_1	252	260	PF00244	0.337
LIG_14-3-3_CanoR_1	271	280	PF00244	0.565
LIG_14-3-3_CanoR_1	348	356	PF00244	0.446
LIG_14-3-3_CanoR_1	390	398	PF00244	0.491
LIG_14-3-3_CanoR_1	429	435	PF00244	0.662
LIG_14-3-3_CanoR_1	464	468	PF00244	0.463
LIG_14-3-3_CanoR_1	678	683	PF00244	0.460
LIG_Actin_WH2_2	374	392	PF00022	0.333
LIG_BRCT_BRCA1_1	273	277	PF00533	0.414
LIG_BRCT_BRCA1_1	375	379	PF00533	0.336
LIG_CSL_BTD_1	408	411	PF09270	0.500
LIG_deltaCOP1_diTrp_1	568	572	PF00928	0.426
LIG_eIF4E_1	457	463	PF01652	0.473
LIG_FHA_1	2	8	PF00498	0.509
LIG_FHA_1	213	219	PF00498	0.359
LIG_FHA_1	320	326	PF00498	0.483
LIG_FHA_1	390	396	PF00498	0.353
LIG_FHA_1	464	470	PF00498	0.328
LIG_FHA_2	102	108	PF00498	0.574
LIG_LIR_Apic_2	274	280	PF02991	0.524
LIG_LIR_Apic_2	664	669	PF02991	0.409
LIG_LIR_Gen_1	167	178	PF02991	0.282
LIG_LIR_Gen_1	482	492	PF02991	0.337
LIG_LIR_Nem_3	152	157	PF02991	0.335
LIG_LIR_Nem_3	167	173	PF02991	0.369
LIG_LIR_Nem_3	350	356	PF02991	0.488
LIG_LIR_Nem_3	376	382	PF02991	0.329
LIG_LIR_Nem_3	482	487	PF02991	0.348
LIG_LIR_Nem_3	567	573	PF02991	0.332
LIG_MYND_1	582	586	PF01753	0.455
LIG_Pex14_2	154	158	PF04695	0.312
LIG_Pex14_2	463	467	PF04695	0.453
LIG_SH2_CRK	398	402	PF00017	0.334
LIG_SH2_CRK	484	488	PF00017	0.440
LIG_SH2_STAP1	138	142	PF00017	0.388
LIG_SH2_STAP1	670	674	PF00017	0.392
LIG_SH2_STAT3	412	415	PF00017	0.529
LIG_SH2_STAT5	221	224	PF00017	0.349
LIG_SH2_STAT5	64	67	PF00017	0.598
LIG_SH3_1	414	420	PF00018	0.638
LIG_SH3_3	113	119	PF00018	0.532
LIG_SH3_3	414	420	PF00018	0.601
LIG_SH3_3	576	582	PF00018	0.434
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.359
LIG_WRC_WIRS_1	154	159	PF05994	0.385
LIG_WW_3	682	686	PF00397	0.510
MOD_CK1_1	122	128	PF00069	0.357
MOD_CK1_1	156	162	PF00069	0.454
MOD_CK1_1	164	170	PF00069	0.524
MOD_CK1_1	212	218	PF00069	0.497
MOD_CK1_1	357	363	PF00069	0.543
MOD_CK2_1	101	107	PF00069	0.727
MOD_CK2_1	321	327	PF00069	0.572
MOD_CK2_1	648	654	PF00069	0.446
MOD_GlcNHglycan	112	115	PF01048	0.517
MOD_GlcNHglycan	116	119	PF01048	0.397
MOD_GlcNHglycan	140	143	PF01048	0.539
MOD_GlcNHglycan	163	166	PF01048	0.434
MOD_GlcNHglycan	244	247	PF01048	0.327
MOD_GlcNHglycan	290	293	PF01048	0.603
MOD_GlcNHglycan	301	304	PF01048	0.364
MOD_GlcNHglycan	350	353	PF01048	0.645
MOD_GlcNHglycan	357	360	PF01048	0.552
MOD_GlcNHglycan	363	366	PF01048	0.412
MOD_GlcNHglycan	444	447	PF01048	0.558
MOD_GlcNHglycan	481	484	PF01048	0.329
MOD_GlcNHglycan	617	620	PF01048	0.582
MOD_GlcNHglycan	623	626	PF01048	0.623
MOD_GlcNHglycan	650	653	PF01048	0.405
MOD_GlcNHglycan	96	99	PF01048	0.620
MOD_GSK3_1	106	113	PF00069	0.550
MOD_GSK3_1	122	129	PF00069	0.287
MOD_GSK3_1	156	163	PF00069	0.331
MOD_GSK3_1	205	212	PF00069	0.412
MOD_GSK3_1	228	235	PF00069	0.472
MOD_GSK3_1	271	278	PF00069	0.593
MOD_GSK3_1	357	364	PF00069	0.581
MOD_GSK3_1	436	443	PF00069	0.577
MOD_GSK3_1	54	61	PF00069	0.515
MOD_GSK3_1	553	560	PF00069	0.545
MOD_GSK3_1	636	643	PF00069	0.621
MOD_GSK3_1	644	651	PF00069	0.496
MOD_GSK3_1	94	101	PF00069	0.652
MOD_LATS_1	317	323	PF00433	0.449
MOD_LATS_1	346	352	PF00433	0.439
MOD_N-GLC_1	205	210	PF02516	0.486
MOD_NEK2_1	1	6	PF00069	0.578
MOD_NEK2_1	184	189	PF00069	0.407
MOD_NEK2_1	213	218	PF00069	0.386
MOD_NEK2_1	347	352	PF00069	0.694
MOD_NEK2_1	463	468	PF00069	0.442
MOD_NEK2_2	169	174	PF00069	0.354
MOD_PIKK_1	122	128	PF00454	0.481
MOD_PIKK_1	275	281	PF00454	0.457
MOD_PIKK_1	40	46	PF00454	0.471
MOD_PIKK_1	499	505	PF00454	0.399
MOD_PK_1	262	268	PF00069	0.352
MOD_PK_1	629	635	PF00069	0.690
MOD_PKA_1	110	116	PF00069	0.575
MOD_PKA_1	232	238	PF00069	0.693
MOD_PKA_2	1	7	PF00069	0.546
MOD_PKA_2	110	116	PF00069	0.725
MOD_PKA_2	136	142	PF00069	0.457
MOD_PKA_2	347	353	PF00069	0.439
MOD_PKA_2	389	395	PF00069	0.497
MOD_PKA_2	463	469	PF00069	0.387
MOD_PKB_1	135	143	PF00069	0.588
MOD_PKB_1	627	635	PF00069	0.527
MOD_Plk_1	213	219	PF00069	0.468
MOD_Plk_2-3	234	240	PF00069	0.461
MOD_Plk_4	244	250	PF00069	0.402
MOD_Plk_4	262	268	PF00069	0.281
MOD_Plk_4	311	317	PF00069	0.341
MOD_Plk_4	321	327	PF00069	0.423
MOD_Plk_4	458	464	PF00069	0.453
MOD_ProDKin_1	640	646	PF00069	0.693
MOD_SUMO_for_1	507	510	PF00179	0.500
TRG_DiLeu_BaEn_1	369	374	PF01217	0.454
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.377
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.356
TRG_ENDOCYTIC_2	170	173	PF00928	0.465
TRG_ENDOCYTIC_2	398	401	PF00928	0.485
TRG_ENDOCYTIC_2	484	487	PF00928	0.434
TRG_ER_diArg_1	10	12	PF00400	0.486
TRG_ER_diArg_1	110	112	PF00400	0.589
TRG_ER_diArg_1	135	138	PF00400	0.374
TRG_ER_diArg_1	385	387	PF00400	0.379
TRG_ER_diArg_1	452	454	PF00400	0.595
TRG_ER_diArg_1	511	513	PF00400	0.510
TRG_ER_diArg_1	589	591	PF00400	0.333
TRG_ER_diArg_1	626	629	PF00400	0.537
TRG_ER_diArg_1	677	680	PF00400	0.487
TRG_NES_CRM1_1	27	40	PF08389	0.471
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA41	Leptomonas seymouri	46%	94%
A0A1X0P203	Trypanosomatidae	26%	100%
A0A422P4Y6	Trypanosoma rangeli	24%	100%
A4HIA7	Leishmania braziliensis	74%	99%
A4I5J1	Leishmania infantum	92%	99%
C9ZQS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	99%
E9B0T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BU74	Trypanosoma cruzi	25%	100%