ER membrane protein complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

Protein of unknown function (DUF1077), putative

Species:

Leishmania major

UniProt:

Q4Q7D8_LEIMA

TriTrypDb:

LmjF.30.1640 , LMJLV39_300023000 , LMJSD75_300022700

Length:

150


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0072546	EMC complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	9

Q4Q7D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7D8


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.255
CLV_PCSK_SKI1_1	13	17	PF00082	0.671
CLV_PCSK_SKI1_1	18	22	PF00082	0.515
DOC_MAPK_MEF2A_6	38	46	PF00069	0.271
DOC_PP1_RVXF_1	116	122	PF00149	0.265
DOC_USP7_MATH_1	126	130	PF00917	0.308
DOC_USP7_MATH_1	69	73	PF00917	0.437
DOC_WW_Pin1_4	133	138	PF00397	0.255
LIG_14-3-3_CanoR_1	28	36	PF00244	0.282
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BIR_III_3	1	5	PF00653	0.466
LIG_BRCT_BRCA1_1	144	148	PF00533	0.401
LIG_BRCT_BRCA1_1	57	61	PF00533	0.284
LIG_eIF4E_1	104	110	PF01652	0.298
LIG_FHA_1	32	38	PF00498	0.336
LIG_FHA_2	137	143	PF00498	0.399
LIG_FHA_2	14	20	PF00498	0.431
LIG_LIR_Gen_1	139	148	PF02991	0.425
LIG_LIR_Gen_1	55	65	PF02991	0.284
LIG_LIR_Nem_3	139	143	PF02991	0.428
LIG_Pex14_2	57	61	PF04695	0.265
LIG_SH2_STAT5	104	107	PF00017	0.272
LIG_SH3_3	63	69	PF00018	0.290
LIG_TRAF2_1	139	142	PF00917	0.414
LIG_WW_1	137	140	PF00397	0.352
MOD_CK1_1	55	61	PF00069	0.300
MOD_CK1_1	72	78	PF00069	0.475
MOD_CK2_1	13	19	PF00069	0.404
MOD_CK2_1	136	142	PF00069	0.400
MOD_GlcNHglycan	10	13	PF01048	0.603
MOD_GlcNHglycan	144	147	PF01048	0.661
MOD_GlcNHglycan	2	5	PF01048	0.645
MOD_GlcNHglycan	74	77	PF01048	0.279
MOD_GlcNHglycan	94	97	PF01048	0.249
MOD_GSK3_1	27	34	PF00069	0.274
MOD_N-GLC_1	8	13	PF02516	0.656
MOD_PIKK_1	31	37	PF00454	0.297
MOD_PKA_2	27	33	PF00069	0.314
MOD_Plk_1	52	58	PF00069	0.284
MOD_Plk_4	40	46	PF00069	0.247
MOD_Plk_4	52	58	PF00069	0.325
MOD_Plk_4	69	75	PF00069	0.423
MOD_ProDKin_1	133	139	PF00069	0.255
MOD_SUMO_rev_2	82	89	PF00179	0.519
TRG_ENDOCYTIC_2	140	143	PF00928	0.431
TRG_ER_diArg_1	22	25	PF00400	0.294
TRG_NES_CRM1_1	39	53	PF08389	0.275


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL3	Leptomonas seymouri	79%	100%
A0A0S4J2Y6	Bodo saltans	52%	100%
A0A1X0P234	Trypanosomatidae	67%	100%
A0A3Q8IJD4	Leishmania donovani	95%	100%
A0A3R7RTR5	Trypanosoma rangeli	57%	100%
A4HIA9	Leishmania braziliensis	87%	100%
A4I5J3	Leishmania infantum	96%	100%
B5XB24	Salmo salar	32%	80%
C9ZQS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B0T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O94520	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	78%
P53073	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	79%
Q3T0K8	Bos taurus	33%	82%
Q5J8M3	Homo sapiens	33%	82%
Q5RC35	Pongo abelii	33%	82%
Q6GR43	Xenopus laevis	34%	83%
Q6P011	Danio rerio	34%	79%
Q6PBF7	Xenopus tropicalis	35%	83%
Q9CZX9	Mus musculus	33%	82%