Hsp33 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7C7_LEIMA

TriTrypDb:

LmjF.30.1670 , LMJLV39_300023100 , LMJSD75_300022800

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q7C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7C7

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0042026	protein refolding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0044183	protein folding chaperone	1	2
GO:0051082	unfolded protein binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.407
CLV_NRD_NRD_1	176	178	PF00675	0.533
CLV_NRD_NRD_1	200	202	PF00675	0.421
CLV_NRD_NRD_1	255	257	PF00675	0.504
CLV_NRD_NRD_1	36	38	PF00675	0.382
CLV_NRD_NRD_1	364	366	PF00675	0.409
CLV_NRD_NRD_1	426	428	PF00675	0.265
CLV_PCSK_KEX2_1	176	178	PF00082	0.533
CLV_PCSK_KEX2_1	200	202	PF00082	0.462
CLV_PCSK_KEX2_1	255	257	PF00082	0.360
CLV_PCSK_KEX2_1	36	38	PF00082	0.363
CLV_PCSK_KEX2_1	364	366	PF00082	0.442
CLV_PCSK_KEX2_1	426	428	PF00082	0.331
CLV_PCSK_SKI1_1	184	188	PF00082	0.442
CLV_PCSK_SKI1_1	255	259	PF00082	0.418
CLV_PCSK_SKI1_1	28	32	PF00082	0.460
CLV_PCSK_SKI1_1	364	368	PF00082	0.476
CLV_PCSK_SKI1_1	7	11	PF00082	0.349
DEG_APCC_DBOX_1	255	263	PF00400	0.405
DOC_CKS1_1	269	274	PF01111	0.411
DOC_MAPK_DCC_7	201	211	PF00069	0.456
DOC_MAPK_gen_1	5	13	PF00069	0.376
DOC_MAPK_MEF2A_6	5	13	PF00069	0.356
DOC_PP1_RVXF_1	16	23	PF00149	0.423
DOC_PP2B_LxvP_1	11	14	PF13499	0.403
DOC_PP2B_LxvP_1	142	145	PF13499	0.501
DOC_PP2B_LxvP_1	169	172	PF13499	0.437
DOC_PP2B_LxvP_1	297	300	PF13499	0.347
DOC_PP4_FxxP_1	372	375	PF00568	0.417
DOC_USP7_MATH_1	129	133	PF00917	0.366
DOC_USP7_MATH_1	153	157	PF00917	0.617
DOC_USP7_MATH_1	182	186	PF00917	0.467
DOC_USP7_MATH_1	381	385	PF00917	0.261
DOC_USP7_MATH_1	408	412	PF00917	0.531
DOC_WW_Pin1_4	268	273	PF00397	0.453
DOC_WW_Pin1_4	443	448	PF00397	0.625
LIG_14-3-3_CanoR_1	200	207	PF00244	0.410
LIG_14-3-3_CanoR_1	21	25	PF00244	0.361
LIG_14-3-3_CanoR_1	442	447	PF00244	0.509
LIG_14-3-3_CanoR_1	77	85	PF00244	0.343
LIG_Actin_WH2_2	6	23	PF00022	0.403
LIG_deltaCOP1_diTrp_1	181	187	PF00928	0.463
LIG_FHA_1	112	118	PF00498	0.498
LIG_FHA_1	306	312	PF00498	0.429
LIG_FHA_1	4	10	PF00498	0.393
LIG_FHA_1	59	65	PF00498	0.290
LIG_FHA_1	85	91	PF00498	0.332
LIG_FHA_2	77	83	PF00498	0.420
LIG_LIR_Apic_2	371	375	PF02991	0.427
LIG_LIR_Gen_1	127	138	PF02991	0.426
LIG_LIR_Gen_1	222	233	PF02991	0.464
LIG_LIR_Gen_1	434	441	PF02991	0.426
LIG_LIR_Gen_1	49	58	PF02991	0.325
LIG_LIR_Gen_1	59	68	PF02991	0.308
LIG_LIR_Nem_3	127	133	PF02991	0.419
LIG_LIR_Nem_3	181	186	PF02991	0.425
LIG_LIR_Nem_3	222	228	PF02991	0.420
LIG_LIR_Nem_3	265	269	PF02991	0.326
LIG_LIR_Nem_3	434	438	PF02991	0.407
LIG_LIR_Nem_3	49	53	PF02991	0.337
LIG_LIR_Nem_3	59	63	PF02991	0.292
LIG_MAD2	121	129	PF02301	0.425
LIG_NRBOX	137	143	PF00104	0.492
LIG_PCNA_yPIPBox_3	391	402	PF02747	0.531
LIG_Pex14_1	183	187	PF04695	0.456
LIG_REV1ctd_RIR_1	386	395	PF16727	0.480
LIG_SH2_CRK	196	200	PF00017	0.446
LIG_SH2_STAT3	103	106	PF00017	0.482
LIG_SH2_STAT5	170	173	PF00017	0.473
LIG_SH2_STAT5	198	201	PF00017	0.410
LIG_SH2_STAT5	98	101	PF00017	0.371
LIG_SH3_2	113	118	PF14604	0.390
LIG_SH3_3	110	116	PF00018	0.500
LIG_SH3_3	266	272	PF00018	0.306
LIG_SH3_3	356	362	PF00018	0.451
LIG_SH3_3	399	405	PF00018	0.468
LIG_SUMO_SIM_par_1	327	333	PF11976	0.401
LIG_TRAF2_1	79	82	PF00917	0.441
LIG_WW_3	404	408	PF00397	0.465
MOD_CK1_1	185	191	PF00069	0.479
MOD_CK1_1	202	208	PF00069	0.265
MOD_CK1_1	23	29	PF00069	0.453
MOD_CK1_1	298	304	PF00069	0.420
MOD_CK1_1	330	336	PF00069	0.370
MOD_CK1_1	400	406	PF00069	0.487
MOD_CK1_1	415	421	PF00069	0.456
MOD_CK1_1	443	449	PF00069	0.587
MOD_CK2_1	63	69	PF00069	0.451
MOD_CK2_1	76	82	PF00069	0.354
MOD_Cter_Amidation	424	427	PF01082	0.331
MOD_GlcNHglycan	156	159	PF01048	0.674
MOD_GlcNHglycan	161	165	PF01048	0.364
MOD_GlcNHglycan	297	300	PF01048	0.537
MOD_GlcNHglycan	308	311	PF01048	0.558
MOD_GlcNHglycan	332	335	PF01048	0.377
MOD_GlcNHglycan	383	386	PF01048	0.363
MOD_GlcNHglycan	402	405	PF01048	0.335
MOD_GlcNHglycan	442	445	PF01048	0.594
MOD_GlcNHglycan	65	68	PF01048	0.447
MOD_GSK3_1	185	192	PF00069	0.417
MOD_GSK3_1	20	27	PF00069	0.212
MOD_GSK3_1	3	10	PF00069	0.417
MOD_GSK3_1	408	415	PF00069	0.464
MOD_GSK3_1	59	66	PF00069	0.307
MOD_N-GLC_1	189	194	PF02516	0.290
MOD_NEK2_1	20	25	PF00069	0.387
MOD_NEK2_1	31	36	PF00069	0.301
MOD_NEK2_1	40	45	PF00069	0.226
MOD_NEK2_1	440	445	PF00069	0.539
MOD_NEK2_1	53	58	PF00069	0.259
MOD_NEK2_1	63	68	PF00069	0.347
MOD_NEK2_2	182	187	PF00069	0.432
MOD_NEK2_2	189	194	PF00069	0.345
MOD_NEK2_2	408	413	PF00069	0.531
MOD_PIKK_1	53	59	PF00454	0.425
MOD_PKA_2	199	205	PF00069	0.359
MOD_PKA_2	20	26	PF00069	0.340
MOD_PKA_2	390	396	PF00069	0.447
MOD_PKA_2	41	47	PF00069	0.415
MOD_PKA_2	76	82	PF00069	0.360
MOD_PKB_1	5	13	PF00069	0.365
MOD_Plk_1	189	195	PF00069	0.290
MOD_Plk_1	415	421	PF00069	0.414
MOD_Plk_1	7	13	PF00069	0.378
MOD_Plk_1	81	87	PF00069	0.353
MOD_Plk_2-3	241	247	PF00069	0.586
MOD_Plk_4	129	135	PF00069	0.494
MOD_Plk_4	182	188	PF00069	0.483
MOD_Plk_4	327	333	PF00069	0.395
MOD_Plk_4	397	403	PF00069	0.531
MOD_Plk_4	59	65	PF00069	0.343
MOD_Plk_4	81	87	PF00069	0.369
MOD_ProDKin_1	268	274	PF00069	0.464
MOD_ProDKin_1	443	449	PF00069	0.640
MOD_SUMO_rev_2	244	251	PF00179	0.557
TRG_DiLeu_BaEn_1	292	297	PF01217	0.442
TRG_DiLeu_BaEn_4	81	87	PF01217	0.395
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.479
TRG_ENDOCYTIC_2	196	199	PF00928	0.333
TRG_ER_diArg_1	176	178	PF00400	0.529
TRG_ER_diArg_1	199	201	PF00400	0.454
TRG_ER_diArg_1	254	256	PF00400	0.396
TRG_ER_diArg_1	35	37	PF00400	0.370
TRG_ER_diArg_1	363	365	PF00400	0.420
TRG_ER_diArg_1	4	7	PF00400	0.426
TRG_ER_diArg_1	426	428	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI4	Leptomonas seymouri	62%	88%
A0A0S4J763	Bodo saltans	24%	100%
A0A1X0P2N8	Trypanosomatidae	38%	98%
A0A3Q8IES4	Leishmania donovani	94%	98%
A0A422P4Y1	Trypanosoma rangeli	37%	100%
A4HIB0	Leishmania braziliensis	77%	75%
A4I5J4	Leishmania infantum	94%	98%
C9ZQT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DQR0	Trypanosoma cruzi	35%	100%