CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7C6_LEIMA

TriTrypDb:

LmjF.30.1680 , LMJLV39_300023200 , LMJSD75_300022900

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7C6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005319	lipid transporter activity	2	2
GO:0005548	phospholipid transporter activity	3	2
GO:0008526	phosphatidylinositol transfer activity	5	2
GO:0120013	lipid transfer activity	3	2
GO:0120014	phospholipid transfer activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.340
CLV_NRD_NRD_1	153	155	PF00675	0.296
CLV_NRD_NRD_1	63	65	PF00675	0.328
CLV_PCSK_SKI1_1	171	175	PF00082	0.447
CLV_PCSK_SKI1_1	182	186	PF00082	0.362
DOC_CDC14_PxL_1	235	243	PF14671	0.546
DOC_CKS1_1	175	180	PF01111	0.357
DOC_CYCLIN_RxL_1	168	177	PF00134	0.450
DOC_MAPK_gen_1	114	121	PF00069	0.338
DOC_MAPK_gen_1	151	160	PF00069	0.323
DOC_PP1_RVXF_1	130	136	PF00149	0.369
DOC_USP7_MATH_1	141	145	PF00917	0.361
DOC_USP7_UBL2_3	151	155	PF12436	0.356
DOC_USP7_UBL2_3	5	9	PF12436	0.527
DOC_WW_Pin1_4	174	179	PF00397	0.324
LIG_14-3-3_CanoR_1	132	136	PF00244	0.375
LIG_FHA_1	1	7	PF00498	0.635
LIG_FHA_1	113	119	PF00498	0.396
LIG_FHA_1	132	138	PF00498	0.160
LIG_FHA_1	155	161	PF00498	0.338
LIG_FHA_2	108	114	PF00498	0.413
LIG_FHA_2	5	11	PF00498	0.430
LIG_FHA_2	71	77	PF00498	0.518
LIG_LIR_Gen_1	177	188	PF02991	0.369
LIG_LIR_Gen_1	36	45	PF02991	0.379
LIG_LIR_Nem_3	36	42	PF02991	0.377
LIG_PCNA_PIPBox_1	158	167	PF02747	0.313
LIG_Pex14_1	135	139	PF04695	0.313
LIG_SH2_NCK_1	130	134	PF00017	0.435
LIG_SH2_STAP1	70	74	PF00017	0.511
LIG_SH2_STAT5	120	123	PF00017	0.353
LIG_SH2_STAT5	180	183	PF00017	0.313
LIG_SH2_STAT5	39	42	PF00017	0.363
LIG_SH2_STAT5	87	90	PF00017	0.451
LIG_TRAF2_1	110	113	PF00917	0.413
LIG_TRAF2_1	73	76	PF00917	0.571
MOD_CK1_1	230	236	PF00069	0.492
MOD_CK1_1	35	41	PF00069	0.444
MOD_CK2_1	107	113	PF00069	0.413
MOD_CK2_1	230	236	PF00069	0.462
MOD_CK2_1	4	10	PF00069	0.440
MOD_CK2_1	70	76	PF00069	0.562
MOD_GlcNHglycan	229	232	PF01048	0.542
MOD_GSK3_1	223	230	PF00069	0.473
MOD_N-GLC_2	107	109	PF02516	0.369
MOD_NEK2_1	122	127	PF00069	0.369
MOD_NEK2_1	227	232	PF00069	0.470
MOD_NEK2_1	34	39	PF00069	0.450
MOD_NEK2_1	57	62	PF00069	0.482
MOD_NEK2_1	81	86	PF00069	0.493
MOD_NEK2_2	223	228	PF00069	0.551
MOD_PKA_1	154	160	PF00069	0.338
MOD_PKA_1	51	57	PF00069	0.443
MOD_PKA_1	64	70	PF00069	0.497
MOD_PKA_2	131	137	PF00069	0.403
MOD_PKB_1	62	70	PF00069	0.344
MOD_Plk_1	107	113	PF00069	0.401
MOD_Plk_1	35	41	PF00069	0.409
MOD_Plk_4	35	41	PF00069	0.441
MOD_Plk_4	82	88	PF00069	0.443
MOD_ProDKin_1	174	180	PF00069	0.324
MOD_SUMO_for_1	17	20	PF00179	0.500
TRG_DiLeu_BaEn_4	236	242	PF01217	0.581
TRG_ENDOCYTIC_2	130	133	PF00928	0.369
TRG_ENDOCYTIC_2	180	183	PF00928	0.441
TRG_ENDOCYTIC_2	39	42	PF00928	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSE8	Leptomonas seymouri	59%	98%
A0A0S4IM09	Bodo saltans	27%	95%
A0A0S4IP40	Bodo saltans	25%	84%
A0A0S4J1X8	Bodo saltans	24%	67%
A0A0S4JUF9	Bodo saltans	39%	96%
A0A3R7MB63	Trypanosoma rangeli	53%	100%
A0A3S7X3C3	Leishmania donovani	94%	82%
A4I5J5	Leishmania infantum	94%	82%
E9B0U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	82%
P53844	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	70%
P53860	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	70%
P53989	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	81%
Q55CU8	Dictyostelium discoideum	27%	67%
V5DQM7	Trypanosoma cruzi	51%	100%