CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q7C6_LEIMA

TriTrypDb:

LmjF.30.1680 , LMJLV39_300023200 , LMJSD75_300022900

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7C6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005319	lipid transporter activity	2	2
GO:0005548	phospholipid transporter activity	3	2
GO:0008526	phosphatidylinositol transfer activity	5	2
GO:0120013	lipid transfer activity	3	2
GO:0120014	phospholipid transfer activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.340
CLV_NRD_NRD_1	153	155	PF00675	0.296
CLV_NRD_NRD_1	63	65	PF00675	0.328
CLV_PCSK_SKI1_1	171	175	PF00082	0.447
CLV_PCSK_SKI1_1	182	186	PF00082	0.362
DOC_CDC14_PxL_1	235	243	PF14671	0.546
DOC_CKS1_1	175	180	PF01111	0.357
DOC_CYCLIN_RxL_1	168	177	PF00134	0.450
DOC_MAPK_gen_1	114	121	PF00069	0.338
DOC_MAPK_gen_1	151	160	PF00069	0.323

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSE8	Leptomonas seymouri	59%	98%
A0A0S4IM09	Bodo saltans	27%	95%
A0A0S4IP40	Bodo saltans	25%	84%
A0A0S4J1X8	Bodo saltans	24%	67%
A0A0S4JUF9	Bodo saltans	39%	96%
A0A3R7MB63	Trypanosoma rangeli	53%	100%
A0A3S7X3C3	Leishmania donovani	94%	82%
A4I5J5	Leishmania infantum	94%	82%
E9B0U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	82%
P53844	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	70%

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