LeishMANIAdb
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AAA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AAA domain-containing protein
Gene product:
AAA domain (Cdc48 subfamily), putative
Species:
Leishmania major
UniProt:
Q4Q7C4_LEIMA
TriTrypDb:
LmjF.30.1700 * , LMJLV39_300023400 * , LMJSD75_300023100 *
Length:
857

Annotations

LeishMANIAdb annotations

These proteins are apparently divergent members of the greater ClpB family found in both Eukaryota and Prokaryota. The TM segments are unusual additions.. Anchored into the membrane using the very last 3 helical segment (similar to tail-anchored proteins)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q7C4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7C4

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 2
GO:0009266 response to temperature stimulus 3 2
GO:0009408 response to heat 3 2
GO:0009628 response to abiotic stimulus 2 2
GO:0009987 cellular process 1 2
GO:0033554 cellular response to stress 3 2
GO:0034605 cellular response to heat 4 2
GO:0050896 response to stimulus 1 2
GO:0051716 cellular response to stimulus 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 517 519 PF00675 0.328
CLV_NRD_NRD_1 586 588 PF00675 0.433
CLV_NRD_NRD_1 691 693 PF00675 0.593
CLV_NRD_NRD_1 71 73 PF00675 0.698
CLV_PCSK_FUR_1 86 90 PF00082 0.698
CLV_PCSK_KEX2_1 274 276 PF00082 0.395
CLV_PCSK_KEX2_1 344 346 PF00082 0.262
CLV_PCSK_KEX2_1 517 519 PF00082 0.318
CLV_PCSK_KEX2_1 586 588 PF00082 0.433
CLV_PCSK_KEX2_1 691 693 PF00082 0.598
CLV_PCSK_KEX2_1 71 73 PF00082 0.700
CLV_PCSK_KEX2_1 88 90 PF00082 0.760
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.427
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.341
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.693
CLV_PCSK_SKI1_1 163 167 PF00082 0.494
CLV_PCSK_SKI1_1 274 278 PF00082 0.324
CLV_PCSK_SKI1_1 286 290 PF00082 0.441
CLV_PCSK_SKI1_1 434 438 PF00082 0.269
CLV_PCSK_SKI1_1 480 484 PF00082 0.328
CLV_PCSK_SKI1_1 527 531 PF00082 0.329
CLV_PCSK_SKI1_1 638 642 PF00082 0.542
CLV_PCSK_SKI1_1 750 754 PF00082 0.386
CLV_PCSK_SKI1_1 766 770 PF00082 0.279
CLV_PCSK_SKI1_1 77 81 PF00082 0.749
CLV_PCSK_SKI1_1 824 828 PF00082 0.313
DEG_APCC_DBOX_1 162 170 PF00400 0.341
DEG_APCC_DBOX_1 264 272 PF00400 0.605
DEG_SCF_FBW7_1 681 688 PF00400 0.629
DEG_SPOP_SBC_1 136 140 PF00917 0.418
DEG_SPOP_SBC_1 222 226 PF00917 0.702
DEG_SPOP_SBC_1 608 612 PF00917 0.709
DEG_SPOP_SBC_1 615 619 PF00917 0.779
DEG_SPOP_SBC_1 701 705 PF00917 0.690
DOC_CKS1_1 540 545 PF01111 0.511
DOC_CKS1_1 706 711 PF01111 0.702
DOC_CYCLIN_RxL_1 735 745 PF00134 0.578
DOC_CYCLIN_RxL_1 766 780 PF00134 0.443
DOC_CYCLIN_yCln2_LP_2 812 818 PF00134 0.417
DOC_MAPK_gen_1 161 168 PF00069 0.282
DOC_MAPK_gen_1 514 523 PF00069 0.513
DOC_MAPK_HePTP_8 769 781 PF00069 0.541
DOC_MAPK_JIP1_4 325 331 PF00069 0.541
DOC_MAPK_MEF2A_6 161 170 PF00069 0.306
DOC_MAPK_MEF2A_6 325 332 PF00069 0.448
DOC_MAPK_MEF2A_6 517 525 PF00069 0.498
DOC_MAPK_MEF2A_6 772 781 PF00069 0.489
DOC_MAPK_MEF2A_6 834 842 PF00069 0.417
DOC_PP2B_LxvP_1 678 681 PF13499 0.689
DOC_PP2B_LxvP_1 812 815 PF13499 0.417
DOC_PP4_FxxP_1 331 334 PF00568 0.505
DOC_USP7_MATH_1 136 140 PF00917 0.526
DOC_USP7_MATH_1 188 192 PF00917 0.590
DOC_USP7_MATH_1 222 226 PF00917 0.782
DOC_USP7_MATH_1 254 258 PF00917 0.695
DOC_USP7_MATH_1 288 292 PF00917 0.601
DOC_USP7_MATH_1 296 300 PF00917 0.567
DOC_USP7_MATH_1 310 314 PF00917 0.554
DOC_USP7_MATH_1 439 443 PF00917 0.448
DOC_USP7_MATH_1 599 603 PF00917 0.665
DOC_USP7_MATH_1 608 612 PF00917 0.735
DOC_USP7_MATH_1 644 648 PF00917 0.686
DOC_USP7_MATH_1 685 689 PF00917 0.644
DOC_USP7_MATH_1 699 703 PF00917 0.756
DOC_USP7_MATH_1 717 721 PF00917 0.715
DOC_USP7_MATH_1 847 851 PF00917 0.430
DOC_WW_Pin1_4 286 291 PF00397 0.645
DOC_WW_Pin1_4 469 474 PF00397 0.513
DOC_WW_Pin1_4 539 544 PF00397 0.512
DOC_WW_Pin1_4 64 69 PF00397 0.513
DOC_WW_Pin1_4 676 681 PF00397 0.809
DOC_WW_Pin1_4 683 688 PF00397 0.711
DOC_WW_Pin1_4 697 702 PF00397 0.751
DOC_WW_Pin1_4 705 710 PF00397 0.764
DOC_WW_Pin1_4 89 94 PF00397 0.538
LIG_14-3-3_CanoR_1 255 264 PF00244 0.658
LIG_14-3-3_CanoR_1 265 269 PF00244 0.633
LIG_14-3-3_CanoR_1 345 350 PF00244 0.554
LIG_14-3-3_CanoR_1 441 447 PF00244 0.450
LIG_14-3-3_CanoR_1 552 557 PF00244 0.597
LIG_14-3-3_CanoR_1 626 635 PF00244 0.607
LIG_14-3-3_CanoR_1 9 17 PF00244 0.497
LIG_Actin_WH2_2 781 797 PF00022 0.417
LIG_AP2alpha_2 497 499 PF02296 0.433
LIG_APCC_ABBA_1 147 152 PF00400 0.434
LIG_BRCT_BRCA1_1 782 786 PF00533 0.244
LIG_DLG_GKlike_1 692 700 PF00625 0.606
LIG_EH1_1 785 793 PF00400 0.324
LIG_eIF4E_1 833 839 PF01652 0.378
LIG_FHA_1 116 122 PF00498 0.406
LIG_FHA_1 130 136 PF00498 0.460
LIG_FHA_1 144 150 PF00498 0.436
LIG_FHA_1 155 161 PF00498 0.494
LIG_FHA_1 214 220 PF00498 0.790
LIG_FHA_1 235 241 PF00498 0.612
LIG_FHA_1 325 331 PF00498 0.471
LIG_FHA_1 446 452 PF00498 0.453
LIG_FHA_1 565 571 PF00498 0.597
LIG_FHA_1 590 596 PF00498 0.600
LIG_FHA_1 701 707 PF00498 0.748
LIG_FHA_1 732 738 PF00498 0.628
LIG_FHA_1 747 753 PF00498 0.554
LIG_FHA_1 833 839 PF00498 0.317
LIG_FHA_2 108 114 PF00498 0.442
LIG_FHA_2 287 293 PF00498 0.630
LIG_FHA_2 492 498 PF00498 0.461
LIG_FHA_2 511 517 PF00498 0.441
LIG_FHA_2 558 564 PF00498 0.647
LIG_FHA_2 598 604 PF00498 0.680
LIG_FHA_2 654 660 PF00498 0.733
LIG_FHA_2 669 675 PF00498 0.760
LIG_FHA_2 746 752 PF00498 0.610
LIG_FHA_2 760 766 PF00498 0.497
LIG_FHA_2 97 103 PF00498 0.581
LIG_GBD_Chelix_1 774 782 PF00786 0.290
LIG_GBD_Chelix_1 788 796 PF00786 0.280
LIG_GBD_Chelix_1 804 812 PF00786 0.348
LIG_LIR_Apic_2 538 543 PF02991 0.585
LIG_LIR_Gen_1 109 117 PF02991 0.478
LIG_LIR_Gen_1 376 387 PF02991 0.470
LIG_LIR_Gen_1 542 553 PF02991 0.586
LIG_LIR_Gen_1 643 652 PF02991 0.645
LIG_LIR_Gen_1 727 737 PF02991 0.627
LIG_LIR_Nem_3 146 150 PF02991 0.461
LIG_LIR_Nem_3 376 382 PF02991 0.470
LIG_LIR_Nem_3 504 509 PF02991 0.488
LIG_LIR_Nem_3 542 548 PF02991 0.580
LIG_LIR_Nem_3 643 648 PF02991 0.662
LIG_LIR_Nem_3 727 733 PF02991 0.636
LIG_MYND_1 681 685 PF01753 0.616
LIG_MYND_3 355 359 PF01753 0.519
LIG_NRBOX 524 530 PF00104 0.578
LIG_NRBOX 777 783 PF00104 0.367
LIG_NRBOX 825 831 PF00104 0.324
LIG_NRBOX 837 843 PF00104 0.219
LIG_PCNA_PIPBox_1 476 485 PF02747 0.541
LIG_PCNA_yPIPBox_3 161 169 PF02747 0.350
LIG_PCNA_yPIPBox_3 476 488 PF02747 0.558
LIG_Pex14_1 423 427 PF04695 0.448
LIG_SH2_CRK 540 544 PF00017 0.615
LIG_SH2_NCK_1 379 383 PF00017 0.448
LIG_SH2_NCK_1 512 516 PF00017 0.557
LIG_SH2_NCK_1 540 544 PF00017 0.565
LIG_SH2_STAP1 150 154 PF00017 0.453
LIG_SH2_STAP1 177 181 PF00017 0.501
LIG_SH2_STAT3 301 304 PF00017 0.513
LIG_SH2_STAT5 301 304 PF00017 0.492
LIG_SH2_STAT5 366 369 PF00017 0.499
LIG_SH2_STAT5 468 471 PF00017 0.448
LIG_SH2_STAT5 512 515 PF00017 0.544
LIG_SH3_3 179 185 PF00018 0.579
LIG_SH3_3 214 220 PF00018 0.779
LIG_SH3_3 28 34 PF00018 0.518
LIG_SH3_3 379 385 PF00018 0.450
LIG_SH3_3 505 511 PF00018 0.491
LIG_SH3_3 592 598 PF00018 0.539
LIG_SH3_3 646 652 PF00018 0.695
LIG_SH3_3 716 722 PF00018 0.677
LIG_SUMO_SIM_anti_2 241 246 PF11976 0.620
LIG_SUMO_SIM_anti_2 403 410 PF11976 0.450
LIG_SUMO_SIM_anti_2 592 597 PF11976 0.591
LIG_SUMO_SIM_anti_2 765 771 PF11976 0.602
LIG_SUMO_SIM_par_1 403 410 PF11976 0.470
LIG_SUMO_SIM_par_1 628 637 PF11976 0.758
LIG_SUMO_SIM_par_1 738 743 PF11976 0.655
LIG_SUMO_SIM_par_1 775 780 PF11976 0.355
LIG_SUMO_SIM_par_1 837 843 PF11976 0.348
LIG_TRAF2_1 474 477 PF00917 0.498
LIG_TRAF2_1 560 563 PF00917 0.600
LIG_UBA3_1 394 400 PF00899 0.446
LIG_UBA3_1 739 744 PF00899 0.622
LIG_UBA3_1 767 772 PF00899 0.624
LIG_UBA3_1 787 795 PF00899 0.253
LIG_UBA3_1 826 834 PF00899 0.386
LIG_WRC_WIRS_1 108 113 PF05994 0.486
LIG_WRC_WIRS_1 144 149 PF05994 0.404
LIG_WRC_WIRS_1 369 374 PF05994 0.448
LIG_WRC_WIRS_1 553 558 PF05994 0.539
MOD_CDC14_SPxK_1 679 682 PF00782 0.671
MOD_CDK_SPxK_1 676 682 PF00069 0.676
MOD_CDK_SPxxK_3 286 293 PF00069 0.638
MOD_CDK_SPxxK_3 64 71 PF00069 0.505
MOD_CK1_1 107 113 PF00069 0.352
MOD_CK1_1 224 230 PF00069 0.699
MOD_CK1_1 371 377 PF00069 0.448
MOD_CK1_1 442 448 PF00069 0.448
MOD_CK1_1 64 70 PF00069 0.418
MOD_CK1_1 695 701 PF00069 0.713
MOD_CK1_1 702 708 PF00069 0.683
MOD_CK1_1 780 786 PF00069 0.387
MOD_CK1_1 91 97 PF00069 0.494
MOD_CK2_1 254 260 PF00069 0.630
MOD_CK2_1 286 292 PF00069 0.564
MOD_CK2_1 411 417 PF00069 0.541
MOD_CK2_1 432 438 PF00069 0.480
MOD_CK2_1 510 516 PF00069 0.480
MOD_CK2_1 528 534 PF00069 0.500
MOD_CK2_1 557 563 PF00069 0.515
MOD_CK2_1 597 603 PF00069 0.674
MOD_CK2_1 653 659 PF00069 0.677
MOD_CK2_1 668 674 PF00069 0.753
MOD_GlcNHglycan 12 15 PF01048 0.701
MOD_GlcNHglycan 211 214 PF01048 0.515
MOD_GlcNHglycan 281 285 PF01048 0.451
MOD_GlcNHglycan 316 319 PF01048 0.403
MOD_GlcNHglycan 334 337 PF01048 0.199
MOD_GlcNHglycan 359 363 PF01048 0.262
MOD_GlcNHglycan 390 393 PF01048 0.275
MOD_GlcNHglycan 395 398 PF01048 0.248
MOD_GlcNHglycan 424 427 PF01048 0.255
MOD_GlcNHglycan 45 48 PF01048 0.732
MOD_GlcNHglycan 469 472 PF01048 0.258
MOD_GlcNHglycan 578 581 PF01048 0.361
MOD_GlcNHglycan 622 625 PF01048 0.594
MOD_GlcNHglycan 697 700 PF01048 0.576
MOD_GlcNHglycan 719 722 PF01048 0.498
MOD_GlcNHglycan 842 845 PF01048 0.366
MOD_GlcNHglycan 851 854 PF01048 0.674
MOD_GlcNHglycan 93 96 PF01048 0.732
MOD_GSK3_1 126 133 PF00069 0.470
MOD_GSK3_1 209 216 PF00069 0.760
MOD_GSK3_1 220 227 PF00069 0.759
MOD_GSK3_1 310 317 PF00069 0.512
MOD_GSK3_1 32 39 PF00069 0.498
MOD_GSK3_1 441 448 PF00069 0.450
MOD_GSK3_1 535 542 PF00069 0.622
MOD_GSK3_1 576 583 PF00069 0.605
MOD_GSK3_1 610 617 PF00069 0.729
MOD_GSK3_1 681 688 PF00069 0.716
MOD_GSK3_1 691 698 PF00069 0.707
MOD_GSK3_1 701 708 PF00069 0.702
MOD_GSK3_1 84 91 PF00069 0.493
MOD_N-GLC_1 154 159 PF02516 0.532
MOD_N-GLC_1 209 214 PF02516 0.513
MOD_N-GLC_1 439 444 PF02516 0.348
MOD_N-GLC_2 489 491 PF02516 0.255
MOD_NEK2_1 264 269 PF00069 0.607
MOD_NEK2_1 358 363 PF00069 0.505
MOD_NEK2_1 411 416 PF00069 0.494
MOD_NEK2_1 422 427 PF00069 0.407
MOD_NEK2_1 450 455 PF00069 0.448
MOD_NEK2_1 467 472 PF00069 0.448
MOD_NEK2_1 528 533 PF00069 0.558
MOD_NEK2_1 794 799 PF00069 0.309
MOD_NEK2_1 840 845 PF00069 0.273
MOD_PIKK_1 115 121 PF00454 0.491
MOD_PIKK_1 138 144 PF00454 0.475
MOD_PIKK_1 296 302 PF00454 0.595
MOD_PIKK_1 528 534 PF00454 0.592
MOD_PIKK_1 564 570 PF00454 0.616
MOD_PIKK_1 653 659 PF00454 0.598
MOD_PK_1 345 351 PF00069 0.541
MOD_PKA_1 691 697 PF00069 0.767
MOD_PKA_1 88 94 PF00069 0.513
MOD_PKA_2 254 260 PF00069 0.664
MOD_PKA_2 264 270 PF00069 0.627
MOD_PKA_2 446 452 PF00069 0.501
MOD_PKA_2 625 631 PF00069 0.670
MOD_PKA_2 691 697 PF00069 0.680
MOD_PKA_2 847 853 PF00069 0.451
MOD_PKA_2 88 94 PF00069 0.513
MOD_Plk_1 104 110 PF00069 0.475
MOD_Plk_1 439 445 PF00069 0.494
MOD_Plk_1 636 642 PF00069 0.611
MOD_Plk_1 692 698 PF00069 0.680
MOD_Plk_2-3 104 110 PF00069 0.475
MOD_Plk_2-3 759 765 PF00069 0.524
MOD_Plk_4 324 330 PF00069 0.489
MOD_Plk_4 345 351 PF00069 0.541
MOD_Plk_4 374 380 PF00069 0.448
MOD_Plk_4 446 452 PF00069 0.455
MOD_Plk_4 692 698 PF00069 0.609
MOD_Plk_4 777 783 PF00069 0.328
MOD_Plk_4 794 800 PF00069 0.189
MOD_Plk_4 814 820 PF00069 0.150
MOD_ProDKin_1 286 292 PF00069 0.643
MOD_ProDKin_1 469 475 PF00069 0.513
MOD_ProDKin_1 539 545 PF00069 0.510
MOD_ProDKin_1 64 70 PF00069 0.507
MOD_ProDKin_1 676 682 PF00069 0.811
MOD_ProDKin_1 683 689 PF00069 0.711
MOD_ProDKin_1 697 703 PF00069 0.754
MOD_ProDKin_1 705 711 PF00069 0.762
MOD_ProDKin_1 89 95 PF00069 0.539
MOD_SUMO_rev_2 148 154 PF00179 0.468
TRG_DiLeu_BaEn_1 273 278 PF01217 0.668
TRG_DiLeu_BaEn_2 515 521 PF01217 0.548
TRG_DiLeu_BaEn_4 103 109 PF01217 0.483
TRG_DiLeu_BaLyEn_6 524 529 PF01217 0.576
TRG_ENDOCYTIC_2 366 369 PF00928 0.472
TRG_ENDOCYTIC_2 379 382 PF00928 0.418
TRG_ENDOCYTIC_2 730 733 PF00928 0.628
TRG_ER_diArg_1 586 588 PF00400 0.633
TRG_ER_diArg_1 71 74 PF00400 0.509
TRG_NES_CRM1_1 731 745 PF08389 0.543
TRG_Pf-PMV_PEXEL_1 275 279 PF00026 0.333
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.258
TRG_Pf-PMV_PEXEL_1 480 484 PF00026 0.313
TRG_Pf-PMV_PEXEL_1 527 532 PF00026 0.292
TRG_Pf-PMV_PEXEL_1 638 643 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 738 743 PF00026 0.420
TRG_Pf-PMV_PEXEL_1 750 755 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 756 761 PF00026 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHZ4 Leptomonas seymouri 56% 86%
A0A1X0P2X6 Trypanosomatidae 42% 97%
A0A3Q8IEX3 Leishmania donovani 92% 100%
A0A422P3I3 Trypanosoma rangeli 39% 100%
A4HIB3 Leishmania braziliensis 82% 100%
A4I5J7 Leishmania infantum 92% 100%
C9ZQX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9B0U2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BPI4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS