Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7C1_LEIMA

TriTrypDb:

LmjF.30.1730 , LMJLV39_300023700 , LMJSD75_300023400

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.528
CLV_NRD_NRD_1	199	201	PF00675	0.663
CLV_NRD_NRD_1	357	359	PF00675	0.558
CLV_NRD_NRD_1	54	56	PF00675	0.756
CLV_PCSK_KEX2_1	199	201	PF00082	0.779
CLV_PCSK_KEX2_1	54	56	PF00082	0.756
CLV_PCSK_SKI1_1	171	175	PF00082	0.665
CLV_PCSK_SKI1_1	300	304	PF00082	0.554
CLV_PCSK_SKI1_1	385	389	PF00082	0.618
CLV_Separin_Metazoa	95	99	PF03568	0.345
DEG_APCC_KENBOX_2	128	132	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.621
DOC_CKS1_1	202	207	PF01111	0.650
DOC_CYCLIN_RxL_1	217	228	PF00134	0.650
DOC_MAPK_MEF2A_6	373	382	PF00069	0.575
DOC_PP1_RVXF_1	121	128	PF00149	0.560
DOC_USP7_MATH_1	106	110	PF00917	0.445
DOC_USP7_MATH_1	113	117	PF00917	0.481
DOC_USP7_MATH_1	48	52	PF00917	0.696
DOC_WW_Pin1_4	183	188	PF00397	0.655
DOC_WW_Pin1_4	201	206	PF00397	0.515
DOC_WW_Pin1_4	211	216	PF00397	0.576
LIG_14-3-3_CanoR_1	110	118	PF00244	0.559
LIG_14-3-3_CanoR_1	123	128	PF00244	0.425
LIG_14-3-3_CanoR_1	171	177	PF00244	0.732
LIG_14-3-3_CanoR_1	226	234	PF00244	0.693
LIG_14-3-3_CanoR_1	239	243	PF00244	0.566
LIG_14-3-3_CanoR_1	293	297	PF00244	0.601
LIG_14-3-3_CanoR_1	300	309	PF00244	0.452
LIG_14-3-3_CanoR_1	351	356	PF00244	0.574
LIG_14-3-3_CanoR_1	37	43	PF00244	0.652
LIG_AP2alpha_2	9	11	PF02296	0.497
LIG_BIR_III_2	35	39	PF00653	0.628
LIG_BRCT_BRCA1_1	123	127	PF00533	0.587
LIG_BRCT_BRCA1_2	123	129	PF00533	0.545
LIG_CtBP_PxDLS_1	215	219	PF00389	0.596
LIG_FHA_1	176	182	PF00498	0.704
LIG_FHA_1	269	275	PF00498	0.759
LIG_FHA_1	339	345	PF00498	0.519
LIG_FHA_1	350	356	PF00498	0.590
LIG_FHA_1	48	54	PF00498	0.755
LIG_FHA_2	172	178	PF00498	0.604
LIG_FHA_2	212	218	PF00498	0.748
LIG_FHA_2	278	284	PF00498	0.700
LIG_FHA_2	352	358	PF00498	0.502
LIG_LIR_Apic_2	228	234	PF02991	0.516
LIG_LIR_Gen_1	17	24	PF02991	0.550
LIG_LIR_Nem_3	17	23	PF02991	0.554
LIG_PCNA_yPIPBox_3	196	210	PF02747	0.609
LIG_SH2_CRK	231	235	PF00017	0.503
LIG_SH2_NCK_1	7	11	PF00017	0.498
LIG_SH2_SRC	20	23	PF00017	0.643
LIG_SH2_SRC	231	234	PF00017	0.506
LIG_SH2_SRC	7	10	PF00017	0.597
LIG_SH2_STAP1	20	24	PF00017	0.601
LIG_SH2_STAP1	90	94	PF00017	0.417
LIG_SH3_1	199	205	PF00018	0.504
LIG_SH3_3	184	190	PF00018	0.659
LIG_SH3_3	199	205	PF00018	0.495
LIG_SUMO_SIM_par_1	212	219	PF11976	0.581
LIG_TRAF2_1	152	155	PF00917	0.615
LIG_TRAF2_1	310	313	PF00917	0.497
LIG_TYR_ITIM	18	23	PF00017	0.520
LIG_Vh1_VBS_1	146	164	PF01044	0.544
MOD_CK1_1	109	115	PF00069	0.357
MOD_CK1_1	121	127	PF00069	0.338
MOD_CK1_1	175	181	PF00069	0.729
MOD_CK1_1	225	231	PF00069	0.699
MOD_CK1_1	238	244	PF00069	0.533
MOD_CK1_1	268	274	PF00069	0.640
MOD_CK1_1	292	298	PF00069	0.595
MOD_CK2_1	113	119	PF00069	0.426
MOD_CK2_1	148	154	PF00069	0.583
MOD_CK2_1	171	177	PF00069	0.715
MOD_CK2_1	211	217	PF00069	0.637
MOD_CK2_1	277	283	PF00069	0.704
MOD_GlcNHglycan	150	153	PF01048	0.606
MOD_GlcNHglycan	165	168	PF01048	0.453
MOD_GlcNHglycan	183	186	PF01048	0.651
MOD_GlcNHglycan	2	5	PF01048	0.591
MOD_GlcNHglycan	385	388	PF01048	0.434
MOD_GlcNHglycan	50	53	PF01048	0.737
MOD_GlcNHglycan	61	64	PF01048	0.551
MOD_GlcNHglycan	79	82	PF01048	0.602
MOD_GSK3_1	109	116	PF00069	0.484
MOD_GSK3_1	117	124	PF00069	0.501
MOD_GSK3_1	159	166	PF00069	0.497
MOD_GSK3_1	171	178	PF00069	0.582
MOD_GSK3_1	218	225	PF00069	0.697
MOD_GSK3_1	265	272	PF00069	0.674
MOD_GSK3_1	274	281	PF00069	0.610
MOD_GSK3_1	38	45	PF00069	0.714
MOD_GSK3_1	71	78	PF00069	0.655
MOD_LATS_1	169	175	PF00433	0.623
MOD_NEK2_1	118	123	PF00069	0.515
MOD_NEK2_1	159	164	PF00069	0.413
MOD_NEK2_1	176	181	PF00069	0.665
MOD_NEK2_1	216	221	PF00069	0.567
MOD_NEK2_1	222	227	PF00069	0.523
MOD_NEK2_1	269	274	PF00069	0.555
MOD_NEK2_1	331	336	PF00069	0.543
MOD_PIKK_1	295	301	PF00454	0.669
MOD_PIKK_1	331	337	PF00454	0.545
MOD_PKA_1	54	60	PF00069	0.570
MOD_PKA_2	109	115	PF00069	0.521
MOD_PKA_2	225	231	PF00069	0.764
MOD_PKA_2	238	244	PF00069	0.523
MOD_PKA_2	292	298	PF00069	0.636
MOD_PKA_2	38	44	PF00069	0.638
MOD_PKA_2	53	59	PF00069	0.648
MOD_PKB_1	349	357	PF00069	0.519
MOD_Plk_1	106	112	PF00069	0.419
MOD_Plk_1	118	124	PF00069	0.523
MOD_Plk_1	176	182	PF00069	0.716
MOD_Plk_2-3	22	28	PF00069	0.530
MOD_Plk_4	265	271	PF00069	0.603
MOD_Plk_4	71	77	PF00069	0.573
MOD_ProDKin_1	183	189	PF00069	0.655
MOD_ProDKin_1	201	207	PF00069	0.513
MOD_ProDKin_1	211	217	PF00069	0.576
MOD_SUMO_rev_2	151	160	PF00179	0.451
MOD_SUMO_rev_2	365	375	PF00179	0.525
MOD_SUMO_rev_2	95	104	PF00179	0.446
TRG_DiLeu_BaEn_1	155	160	PF01217	0.577
TRG_DiLeu_BaEn_3	155	161	PF01217	0.505
TRG_ENDOCYTIC_2	20	23	PF00928	0.526
TRG_ER_diArg_1	142	145	PF00400	0.582
TRG_ER_diArg_1	350	353	PF00400	0.564
TRG_ER_diArg_1	382	385	PF00400	0.384
TRG_ER_diArg_1	53	55	PF00400	0.589
TRG_NLS_MonoExtN_4	358	363	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I207	Leptomonas seymouri	41%	100%
A0A1X0P1T9	Trypanosomatidae	26%	100%
A0A3Q8IBZ6	Leishmania donovani	90%	100%
A0A422P3J4	Trypanosoma rangeli	28%	100%
A4HIB6	Leishmania braziliensis	70%	100%
A4I5K0	Leishmania infantum	90%	100%
E9B0U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
V5B8Y5	Trypanosoma cruzi	27%	100%