PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q7C0_LEIMA

TriTrypDb:

LmjF.30.1740 , LMJLV39_300023800 , LMJSD75_300023500

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.474
CLV_NRD_NRD_1	120	122	PF00675	0.553
CLV_NRD_NRD_1	9	11	PF00675	0.713
CLV_PCSK_KEX2_1	120	122	PF00082	0.665
CLV_PCSK_KEX2_1	264	266	PF00082	0.472
CLV_PCSK_KEX2_1	33	35	PF00082	0.655
CLV_PCSK_KEX2_1	82	84	PF00082	0.546
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.435
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.655
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.611
CLV_PCSK_SKI1_1	242	246	PF00082	0.548
CLV_PCSK_SKI1_1	264	268	PF00082	0.456
CLV_PCSK_SKI1_1	79	83	PF00082	0.554
DOC_CKS1_1	111	116	PF01111	0.670
DOC_USP7_MATH_1	94	98	PF00917	0.530
DOC_USP7_UBL2_3	29	33	PF12436	0.695
DOC_WW_Pin1_4	110	115	PF00397	0.675
DOC_WW_Pin1_4	184	189	PF00397	0.519
DOC_WW_Pin1_4	5	10	PF00397	0.733
LIG_14-3-3_CanoR_1	265	270	PF00244	0.523
LIG_14-3-3_CanoR_1	34	42	PF00244	0.546
LIG_APCC_ABBA_1	178	183	PF00400	0.471
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	229	233	PF00533	0.535
LIG_BRCT_BRCA1_1	96	100	PF00533	0.577
LIG_deltaCOP1_diTrp_1	290	299	PF00928	0.290
LIG_FHA_1	22	28	PF00498	0.685
LIG_FHA_1	245	251	PF00498	0.563
LIG_FHA_1	291	297	PF00498	0.341
LIG_FHA_1	46	52	PF00498	0.647
LIG_FHA_2	256	262	PF00498	0.554
LIG_FHA_2	283	289	PF00498	0.463
LIG_FHA_2	72	78	PF00498	0.562
LIG_LIR_Gen_1	168	174	PF02991	0.475
LIG_LIR_Gen_1	275	283	PF02991	0.417
LIG_LIR_Gen_1	290	300	PF02991	0.379
LIG_LIR_Nem_3	148	153	PF02991	0.449
LIG_LIR_Nem_3	168	172	PF02991	0.284
LIG_LIR_Nem_3	220	225	PF02991	0.424
LIG_LIR_Nem_3	275	281	PF02991	0.431
LIG_LIR_Nem_3	290	295	PF02991	0.377
LIG_LIR_Nem_3	297	302	PF02991	0.419
LIG_LIR_Nem_3	304	309	PF02991	0.473
LIG_LIR_Nem_3	62	67	PF02991	0.696
LIG_LIR_Nem_3	97	103	PF02991	0.473
LIG_PCNA_TLS_4	216	223	PF02747	0.492
LIG_Pex14_2	277	281	PF04695	0.404
LIG_PTB_Apo_2	300	307	PF02174	0.464
LIG_PTB_Phospho_1	300	306	PF10480	0.460
LIG_SH2_PTP2	222	225	PF00017	0.413
LIG_SH2_STAP1	67	71	PF00017	0.569
LIG_SH2_STAT5	179	182	PF00017	0.461
LIG_SH2_STAT5	222	225	PF00017	0.413
LIG_SH2_STAT5	278	281	PF00017	0.397
LIG_SH2_STAT5	298	301	PF00017	0.230
LIG_SH2_STAT5	309	312	PF00017	0.457
LIG_SH3_3	148	154	PF00018	0.449
LIG_SH3_3	182	188	PF00018	0.536
LIG_SH3_3	48	54	PF00018	0.782
LIG_SUMO_SIM_par_1	226	232	PF11976	0.401
LIG_TRAF2_1	258	261	PF00917	0.536
LIG_TRFH_1	233	237	PF08558	0.539
LIG_TYR_ITIM	296	301	PF00017	0.366
LIG_WRC_WIRS_1	278	283	PF05994	0.388
MOD_CDK_SPK_2	5	10	PF00069	0.686
MOD_CDK_SPxK_1	5	11	PF00069	0.703
MOD_CDK_SPxxK_3	9	16	PF00069	0.597
MOD_CK1_1	112	118	PF00069	0.613
MOD_CK1_1	12	18	PF00069	0.743
MOD_CK1_1	125	131	PF00069	0.508
MOD_CK1_1	84	90	PF00069	0.561
MOD_CK2_1	255	261	PF00069	0.567
MOD_CK2_1	269	275	PF00069	0.356
MOD_CK2_1	71	77	PF00069	0.558
MOD_Cter_Amidation	118	121	PF01082	0.607
MOD_GlcNHglycan	117	120	PF01048	0.593
MOD_GlcNHglycan	271	274	PF01048	0.519
MOD_GSK3_1	122	129	PF00069	0.699
MOD_GSK3_1	145	152	PF00069	0.461
MOD_GSK3_1	21	28	PF00069	0.543
MOD_GSK3_1	223	230	PF00069	0.402
MOD_GSK3_1	244	251	PF00069	0.471
MOD_GSK3_1	255	262	PF00069	0.579
MOD_GSK3_1	265	272	PF00069	0.309
MOD_GSK3_1	301	308	PF00069	0.370
MOD_GSK3_1	45	52	PF00069	0.718
MOD_GSK3_1	5	12	PF00069	0.787
MOD_N-GLC_1	211	216	PF02516	0.496
MOD_N-GLC_1	255	260	PF02516	0.522
MOD_N-GLC_2	303	305	PF02516	0.370
MOD_NEK2_1	122	127	PF00069	0.649
MOD_NEK2_1	190	195	PF00069	0.472
MOD_NEK2_1	227	232	PF00069	0.400
MOD_NEK2_1	244	249	PF00069	0.471
MOD_NEK2_1	269	274	PF00069	0.504
MOD_NEK2_1	277	282	PF00069	0.348
MOD_NEK2_1	301	306	PF00069	0.464
MOD_NEK2_1	40	45	PF00069	0.673
MOD_NEK2_1	81	86	PF00069	0.663
MOD_PIKK_1	282	288	PF00454	0.465
MOD_PIKK_1	45	51	PF00454	0.670
MOD_PKA_1	33	39	PF00069	0.594
MOD_PKA_2	33	39	PF00069	0.594
MOD_Plk_1	204	210	PF00069	0.441
MOD_Plk_1	214	220	PF00069	0.486
MOD_Plk_1	45	51	PF00069	0.685
MOD_Plk_4	122	128	PF00069	0.707
MOD_Plk_4	145	151	PF00069	0.435
MOD_Plk_4	206	212	PF00069	0.467
MOD_Plk_4	223	229	PF00069	0.336
MOD_Plk_4	277	283	PF00069	0.394
MOD_ProDKin_1	110	116	PF00069	0.672
MOD_ProDKin_1	184	190	PF00069	0.512
MOD_ProDKin_1	5	11	PF00069	0.736
MOD_SUMO_rev_2	106	112	PF00179	0.649
MOD_SUMO_rev_2	12	17	PF00179	0.592
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.606
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.498
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.474
TRG_ENDOCYTIC_2	222	225	PF00928	0.413
TRG_ENDOCYTIC_2	278	281	PF00928	0.397
TRG_ENDOCYTIC_2	298	301	PF00928	0.230
TRG_ER_diArg_1	120	122	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT80	Leptomonas seymouri	58%	100%
A0A3Q8IFU1	Leishmania donovani	89%	100%
A4HIB7	Leishmania braziliensis	67%	100%
A4I5K1	Leishmania infantum	88%	100%
E9B0U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%