Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related protein kinase 11, putative

Species:

Leishmania major

UniProt:

Q4Q7B6_LEIMA

TriTrypDb:

LmjF.30.1780 , LMJLV39_300024200 , LMJSD75_300023900

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0016592	mediator complex	3	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q7B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7B6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	2
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	2
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0097472	cyclin-dependent protein kinase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.537
CLV_C14_Caspase3-7	259	263	PF00656	0.498
CLV_C14_Caspase3-7	298	302	PF00656	0.573
CLV_C14_Caspase3-7	596	600	PF00656	0.586
CLV_NRD_NRD_1	140	142	PF00675	0.636
CLV_NRD_NRD_1	143	145	PF00675	0.510
CLV_NRD_NRD_1	268	270	PF00675	0.663
CLV_NRD_NRD_1	329	331	PF00675	0.404
CLV_NRD_NRD_1	590	592	PF00675	0.561
CLV_NRD_NRD_1	89	91	PF00675	0.592
CLV_PCSK_FUR_1	141	145	PF00082	0.414
CLV_PCSK_KEX2_1	140	142	PF00082	0.509
CLV_PCSK_KEX2_1	143	145	PF00082	0.396
CLV_PCSK_KEX2_1	148	150	PF00082	0.337
CLV_PCSK_KEX2_1	268	270	PF00082	0.612
CLV_PCSK_KEX2_1	329	331	PF00082	0.404
CLV_PCSK_KEX2_1	590	592	PF00082	0.654
CLV_PCSK_KEX2_1	89	91	PF00082	0.592
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.362
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.483
CLV_PCSK_PC7_1	144	150	PF00082	0.471
CLV_PCSK_PC7_1	325	331	PF00082	0.404
CLV_PCSK_SKI1_1	114	118	PF00082	0.636
CLV_PCSK_SKI1_1	148	152	PF00082	0.378
CLV_PCSK_SKI1_1	168	172	PF00082	0.357
CLV_PCSK_SKI1_1	329	333	PF00082	0.287
CLV_PCSK_SKI1_1	347	351	PF00082	0.242
CLV_PCSK_SKI1_1	377	381	PF00082	0.391
CLV_PCSK_SKI1_1	449	453	PF00082	0.351
CLV_PCSK_SKI1_1	537	541	PF00082	0.376
CLV_PCSK_SKI1_1	569	573	PF00082	0.419
CLV_PCSK_SKI1_1	591	595	PF00082	0.692
DEG_APCC_DBOX_1	328	336	PF00400	0.278
DEG_APCC_DBOX_1	590	598	PF00400	0.656
DEG_COP1_1	385	393	PF00400	0.204
DOC_CKS1_1	405	410	PF01111	0.335
DOC_CYCLIN_RxL_1	111	120	PF00134	0.500
DOC_CYCLIN_RxL_1	446	456	PF00134	0.314
DOC_CYCLIN_yClb1_LxF_4	62	67	PF00134	0.496
DOC_MAPK_gen_1	137	147	PF00069	0.514
DOC_MAPK_gen_1	268	276	PF00069	0.623
DOC_MAPK_gen_1	329	337	PF00069	0.382
DOC_MAPK_gen_1	347	356	PF00069	0.222
DOC_MAPK_gen_1	590	597	PF00069	0.568
DOC_MAPK_MEF2A_6	590	597	PF00069	0.578
DOC_PP1_RVXF_1	331	338	PF00149	0.338
DOC_PP1_RVXF_1	561	567	PF00149	0.495
DOC_PP2B_LxvP_1	468	471	PF13499	0.398
DOC_PP2B_LxvP_1	480	483	PF13499	0.414
DOC_PP4_FxxP_1	372	375	PF00568	0.404
DOC_USP7_MATH_1	192	196	PF00917	0.666
DOC_USP7_MATH_1	294	298	PF00917	0.557
DOC_USP7_MATH_1	309	313	PF00917	0.573
DOC_USP7_MATH_1	375	379	PF00917	0.477
DOC_USP7_MATH_1	481	485	PF00917	0.270
DOC_USP7_MATH_1	501	505	PF00917	0.354
DOC_USP7_MATH_1	71	75	PF00917	0.687
DOC_USP7_MATH_2	489	495	PF00917	0.204
DOC_WW_Pin1_4	115	120	PF00397	0.531
DOC_WW_Pin1_4	22	27	PF00397	0.696
DOC_WW_Pin1_4	292	297	PF00397	0.566
DOC_WW_Pin1_4	310	315	PF00397	0.663
DOC_WW_Pin1_4	384	389	PF00397	0.335
DOC_WW_Pin1_4	404	409	PF00397	0.271
DOC_WW_Pin1_4	58	63	PF00397	0.521
LIG_14-3-3_CanoR_1	412	416	PF00244	0.289
LIG_14-3-3_CanoR_1	533	540	PF00244	0.271
LIG_14-3-3_CanoR_1	569	574	PF00244	0.426
LIG_Actin_WH2_1	320	335	PF00022	0.426
LIG_Actin_WH2_2	348	365	PF00022	0.335
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BRCT_BRCA1_1	368	372	PF00533	0.349
LIG_deltaCOP1_diTrp_1	434	442	PF00928	0.271
LIG_EH1_1	325	333	PF00400	0.267
LIG_eIF4E_1	326	332	PF01652	0.404
LIG_FHA_1	302	308	PF00498	0.674
LIG_FHA_1	339	345	PF00498	0.329
LIG_FHA_1	509	515	PF00498	0.322
LIG_FHA_1	577	583	PF00498	0.541
LIG_FHA_2	242	248	PF00498	0.462
LIG_FHA_2	296	302	PF00498	0.600
LIG_FHA_2	380	386	PF00498	0.342
LIG_FHA_2	429	435	PF00498	0.411
LIG_FHA_2	533	539	PF00498	0.267
LIG_FHA_2	553	559	PF00498	0.313
LIG_Integrin_RGD_1	260	262	PF01839	0.569
LIG_LIR_Apic_2	369	375	PF02991	0.404
LIG_LIR_Apic_2	414	420	PF02991	0.271
LIG_LIR_Apic_2	472	476	PF02991	0.400
LIG_LIR_Nem_3	25	31	PF02991	0.566
LIG_SH2_CRK	473	477	PF00017	0.292
LIG_SH2_NCK_1	473	477	PF00017	0.292
LIG_SH2_STAT5	326	329	PF00017	0.271
LIG_SH2_STAT5	34	37	PF00017	0.550
LIG_SH3_3	225	231	PF00018	0.365
LIG_SH3_3	246	252	PF00018	0.344
LIG_SH3_3	311	317	PF00018	0.561
LIG_SH3_3	385	391	PF00018	0.285
LIG_SH3_3	41	47	PF00018	0.684
LIG_SH3_3	480	486	PF00018	0.404
LIG_SH3_3	495	501	PF00018	0.417
LIG_SH3_3	60	66	PF00018	0.554
LIG_SUMO_SIM_anti_2	454	462	PF11976	0.409
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.291
LIG_SUMO_SIM_par_1	593	599	PF11976	0.584
LIG_UBA3_1	441	449	PF00899	0.433
LIG_UBA3_1	460	466	PF00899	0.314
LIG_WW_3	487	491	PF00397	0.292
LIG_WW_3	61	65	PF00397	0.461
MOD_CDK_SPxK_1	58	64	PF00069	0.516
MOD_CK1_1	197	203	PF00069	0.556
MOD_CK1_1	279	285	PF00069	0.621
MOD_CK1_1	292	298	PF00069	0.705
MOD_CK1_1	312	318	PF00069	0.594
MOD_CK1_1	410	416	PF00069	0.314
MOD_CK1_1	73	79	PF00069	0.425
MOD_CK2_1	16	22	PF00069	0.609
MOD_CK2_1	241	247	PF00069	0.486
MOD_CK2_1	379	385	PF00069	0.358
MOD_CK2_1	386	392	PF00069	0.379
MOD_CK2_1	451	457	PF00069	0.291
MOD_CK2_1	532	538	PF00069	0.311
MOD_Cter_Amidation	141	144	PF01082	0.456
MOD_GlcNHglycan	104	107	PF01048	0.668
MOD_GlcNHglycan	161	165	PF01048	0.543
MOD_GlcNHglycan	216	220	PF01048	0.512
MOD_GlcNHglycan	279	282	PF01048	0.614
MOD_GlcNHglycan	292	295	PF01048	0.705
MOD_GlcNHglycan	368	371	PF01048	0.289
MOD_GlcNHglycan	377	380	PF01048	0.280
MOD_GlcNHglycan	473	476	PF01048	0.378
MOD_GlcNHglycan	493	496	PF01048	0.472
MOD_GlcNHglycan	550	553	PF01048	0.558
MOD_GlcNHglycan	68	71	PF01048	0.502
MOD_GlcNHglycan	97	100	PF01048	0.522
MOD_GSK3_1	190	197	PF00069	0.541
MOD_GSK3_1	22	29	PF00069	0.660
MOD_GSK3_1	272	279	PF00069	0.578
MOD_GSK3_1	290	297	PF00069	0.714
MOD_GSK3_1	312	319	PF00069	0.632
MOD_GSK3_1	375	382	PF00069	0.314
MOD_GSK3_1	407	414	PF00069	0.336
MOD_GSK3_1	471	478	PF00069	0.284
MOD_GSK3_1	548	555	PF00069	0.640
MOD_GSK3_1	66	73	PF00069	0.435
MOD_NEK2_1	241	246	PF00069	0.349
MOD_NEK2_1	276	281	PF00069	0.545
MOD_NEK2_1	289	294	PF00069	0.636
MOD_NEK2_1	338	343	PF00069	0.357
MOD_NEK2_1	349	354	PF00069	0.487
MOD_NEK2_1	4	9	PF00069	0.552
MOD_NEK2_1	593	598	PF00069	0.780
MOD_NEK2_2	26	31	PF00069	0.555
MOD_NEK2_2	272	277	PF00069	0.602
MOD_OFUCOSY	336	342	PF10250	0.335
MOD_PIKK_1	36	42	PF00454	0.700
MOD_PKA_2	411	417	PF00069	0.271
MOD_PKA_2	491	497	PF00069	0.270
MOD_PKA_2	532	538	PF00069	0.271
MOD_Plk_1	168	174	PF00069	0.354
MOD_Plk_1	197	203	PF00069	0.516
MOD_Plk_4	162	168	PF00069	0.512
MOD_Plk_4	272	278	PF00069	0.616
MOD_Plk_4	475	481	PF00069	0.413
MOD_Plk_4	569	575	PF00069	0.521
MOD_ProDKin_1	115	121	PF00069	0.530
MOD_ProDKin_1	22	28	PF00069	0.693
MOD_ProDKin_1	292	298	PF00069	0.568
MOD_ProDKin_1	310	316	PF00069	0.645
MOD_ProDKin_1	384	390	PF00069	0.335
MOD_ProDKin_1	404	410	PF00069	0.271
MOD_ProDKin_1	58	64	PF00069	0.516
MOD_SUMO_for_1	82	85	PF00179	0.488
MOD_SUMO_rev_2	105	113	PF00179	0.581
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.464
TRG_ENDOCYTIC_2	225	228	PF00928	0.485
TRG_ENDOCYTIC_2	97	100	PF00928	0.425
TRG_ER_diArg_1	140	143	PF00400	0.478
TRG_ER_diArg_1	328	330	PF00400	0.404
TRG_ER_diArg_1	561	564	PF00400	0.440
TRG_ER_diArg_1	590	592	PF00400	0.561
TRG_ER_diArg_1	88	90	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJY2	Leptomonas seymouri	48%	96%
A0A1X0P246	Trypanosomatidae	30%	100%
A0A3S5H7N0	Leishmania donovani	93%	100%
A0A422P3I6	Trypanosoma rangeli	30%	100%
A4H934	Leishmania braziliensis	76%	100%
A4I5K5	Leishmania infantum	93%	100%
C9ZQY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B0V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DQL7	Trypanosoma cruzi	30%	100%