BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7B1_LEIMA

TriTrypDb:

LmjF.30.1840 , LMJLV39_300024700 , LMJSD75_300024500

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.667
CLV_C14_Caspase3-7	55	59	PF00656	0.780
CLV_C14_Caspase3-7	665	669	PF00656	0.749
CLV_C14_Caspase3-7	767	771	PF00656	0.681
CLV_NRD_NRD_1	444	446	PF00675	0.801
CLV_NRD_NRD_1	448	450	PF00675	0.668
CLV_NRD_NRD_1	460	462	PF00675	0.645
CLV_NRD_NRD_1	574	576	PF00675	0.745
CLV_NRD_NRD_1	655	657	PF00675	0.605
CLV_NRD_NRD_1	665	667	PF00675	0.823
CLV_NRD_NRD_1	716	718	PF00675	0.745
CLV_NRD_NRD_1	719	721	PF00675	0.687
CLV_PCSK_FUR_1	445	449	PF00082	0.811
CLV_PCSK_FUR_1	653	657	PF00082	0.654
CLV_PCSK_FUR_1	717	721	PF00082	0.740
CLV_PCSK_KEX2_1	384	386	PF00082	0.616
CLV_PCSK_KEX2_1	446	448	PF00082	0.845
CLV_PCSK_KEX2_1	460	462	PF00082	0.526
CLV_PCSK_KEX2_1	574	576	PF00082	0.745
CLV_PCSK_KEX2_1	652	654	PF00082	0.815
CLV_PCSK_KEX2_1	655	657	PF00082	0.770
CLV_PCSK_KEX2_1	716	718	PF00082	0.745
CLV_PCSK_KEX2_1	719	721	PF00082	0.687
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.616
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.845
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.815
CLV_PCSK_SKI1_1	344	348	PF00082	0.718
CLV_PCSK_SKI1_1	449	453	PF00082	0.748
CLV_PCSK_SKI1_1	491	495	PF00082	0.606
CLV_PCSK_SKI1_1	690	694	PF00082	0.681
DEG_SCF_FBW7_1	224	231	PF00400	0.617
DEG_SPOP_SBC_1	17	21	PF00917	0.602
DEG_SPOP_SBC_1	228	232	PF00917	0.750
DEG_SPOP_SBC_1	308	312	PF00917	0.591
DOC_CDC14_PxL_1	501	509	PF14671	0.680
DOC_CKS1_1	298	303	PF01111	0.590
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.775
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.596
DOC_MAPK_DCC_7	399	407	PF00069	0.683
DOC_MAPK_gen_1	260	268	PF00069	0.722
DOC_MAPK_gen_1	445	454	PF00069	0.674
DOC_MAPK_HePTP_8	779	791	PF00069	0.622
DOC_MAPK_MEF2A_6	399	407	PF00069	0.683
DOC_MAPK_MEF2A_6	782	791	PF00069	0.628
DOC_PP2B_LxvP_1	156	159	PF13499	0.715
DOC_PP2B_LxvP_1	164	167	PF13499	0.629
DOC_PP2B_LxvP_1	400	403	PF13499	0.738
DOC_PP2B_LxvP_1	452	455	PF13499	0.602
DOC_PP2B_LxvP_1	482	485	PF13499	0.627
DOC_PP2B_LxvP_1	537	540	PF13499	0.737
DOC_PP2B_LxvP_1	76	79	PF13499	0.637
DOC_PP2B_PxIxI_1	110	116	PF00149	0.558
DOC_PP4_FxxP_1	380	383	PF00568	0.749
DOC_USP7_MATH_1	103	107	PF00917	0.730
DOC_USP7_MATH_1	109	113	PF00917	0.675
DOC_USP7_MATH_1	171	175	PF00917	0.745
DOC_USP7_MATH_1	179	183	PF00917	0.632
DOC_USP7_MATH_1	18	22	PF00917	0.607
DOC_USP7_MATH_1	293	297	PF00917	0.797
DOC_USP7_MATH_1	309	313	PF00917	0.570
DOC_USP7_MATH_1	31	35	PF00917	0.651
DOC_USP7_MATH_1	403	407	PF00917	0.760
DOC_USP7_MATH_1	43	47	PF00917	0.602
DOC_USP7_MATH_1	514	518	PF00917	0.806
DOC_USP7_MATH_1	61	65	PF00917	0.529
DOC_USP7_MATH_1	662	666	PF00917	0.755
DOC_USP7_MATH_1	686	690	PF00917	0.767
DOC_USP7_MATH_1	754	758	PF00917	0.687
DOC_USP7_UBL2_3	803	807	PF12436	0.758
DOC_WW_Pin1_4	143	148	PF00397	0.748
DOC_WW_Pin1_4	159	164	PF00397	0.592
DOC_WW_Pin1_4	169	174	PF00397	0.674
DOC_WW_Pin1_4	195	200	PF00397	0.733
DOC_WW_Pin1_4	220	225	PF00397	0.768
DOC_WW_Pin1_4	232	237	PF00397	0.687
DOC_WW_Pin1_4	266	271	PF00397	0.769
DOC_WW_Pin1_4	275	280	PF00397	0.686
DOC_WW_Pin1_4	284	289	PF00397	0.570
DOC_WW_Pin1_4	297	302	PF00397	0.656
DOC_WW_Pin1_4	384	389	PF00397	0.764
DOC_WW_Pin1_4	558	563	PF00397	0.623
DOC_WW_Pin1_4	606	611	PF00397	0.810
DOC_WW_Pin1_4	625	630	PF00397	0.518
DOC_WW_Pin1_4	768	773	PF00397	0.694
LIG_14-3-3_CanoR_1	165	171	PF00244	0.726
LIG_14-3-3_CanoR_1	241	249	PF00244	0.813
LIG_14-3-3_CanoR_1	624	628	PF00244	0.771
LIG_14-3-3_CanoR_1	722	728	PF00244	0.646
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BIR_III_2	305	309	PF00653	0.605
LIG_FHA_1	190	196	PF00498	0.810
LIG_FHA_1	245	251	PF00498	0.806
LIG_FHA_1	292	298	PF00498	0.737
LIG_FHA_1	314	320	PF00498	0.644
LIG_FHA_1	384	390	PF00498	0.816
LIG_FHA_1	402	408	PF00498	0.528
LIG_FHA_1	42	48	PF00498	0.652
LIG_FHA_1	641	647	PF00498	0.829
LIG_FHA_1	75	81	PF00498	0.645
LIG_FHA_1	797	803	PF00498	0.728
LIG_FHA_1	85	91	PF00498	0.723
LIG_FHA_2	257	263	PF00498	0.698
LIG_FHA_2	309	315	PF00498	0.741
LIG_FHA_2	34	40	PF00498	0.774
LIG_FHA_2	55	61	PF00498	0.677
LIG_FHA_2	559	565	PF00498	0.696
LIG_FHA_2	584	590	PF00498	0.702
LIG_FHA_2	724	730	PF00498	0.651
LIG_IRF3_LxIS_1	553	559	PF10401	0.597
LIG_LIR_Apic_2	253	257	PF02991	0.665
LIG_LIR_Apic_2	379	383	PF02991	0.750
LIG_LIR_Apic_2	95	101	PF02991	0.752
LIG_LIR_Gen_1	421	432	PF02991	0.696
LIG_LIR_Gen_1	799	808	PF02991	0.649
LIG_LIR_Nem_3	421	427	PF02991	0.737
LIG_LIR_Nem_3	799	804	PF02991	0.680
LIG_MYND_1	105	109	PF01753	0.783
LIG_SH2_CRK	254	258	PF00017	0.573
LIG_SH2_NCK_1	254	258	PF00017	0.695
LIG_SH2_PTP2	801	804	PF00017	0.650
LIG_SH2_SRC	783	786	PF00017	0.625
LIG_SH2_STAP1	776	780	PF00017	0.607
LIG_SH2_STAT3	580	583	PF00017	0.811
LIG_SH2_STAT5	254	257	PF00017	0.593
LIG_SH2_STAT5	714	717	PF00017	0.748
LIG_SH2_STAT5	801	804	PF00017	0.657
LIG_SH3_1	748	754	PF00018	0.712
LIG_SH3_3	167	173	PF00018	0.749
LIG_SH3_3	196	202	PF00018	0.714
LIG_SH3_3	273	279	PF00018	0.787
LIG_SH3_3	295	301	PF00018	0.668
LIG_SH3_3	314	320	PF00018	0.670
LIG_SH3_3	426	432	PF00018	0.734
LIG_SH3_3	456	462	PF00018	0.719
LIG_SH3_3	533	539	PF00018	0.762
LIG_SH3_3	604	610	PF00018	0.748
LIG_SH3_3	748	754	PF00018	0.712
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.556
LIG_SUMO_SIM_par_1	403	410	PF11976	0.612
LIG_SUMO_SIM_par_1	425	430	PF11976	0.646
LIG_TRAF2_1	211	214	PF00917	0.604
LIG_TRAF2_1	259	262	PF00917	0.704
LIG_TRAF2_1	311	314	PF00917	0.741
LIG_TRAF2_1	561	564	PF00917	0.693
LIG_TYR_ITIM	774	779	PF00017	0.580
LIG_TYR_ITSM	797	804	PF00017	0.635
LIG_ULM_U2AF65_1	719	724	PF00076	0.513
LIG_WW_1	711	714	PF00397	0.756
MOD_CDC14_SPxK_1	162	165	PF00782	0.721
MOD_CDK_SPxK_1	159	165	PF00069	0.730
MOD_CK1_1	16	22	PF00069	0.563
MOD_CK1_1	169	175	PF00069	0.771
MOD_CK1_1	177	183	PF00069	0.668
MOD_CK1_1	189	195	PF00069	0.562
MOD_CK1_1	198	204	PF00069	0.654
MOD_CK1_1	2	8	PF00069	0.706
MOD_CK1_1	229	235	PF00069	0.833
MOD_CK1_1	33	39	PF00069	0.551
MOD_CK1_1	358	364	PF00069	0.720
MOD_CK1_1	406	412	PF00069	0.733
MOD_CK1_1	46	52	PF00069	0.577
MOD_CK1_1	590	596	PF00069	0.719
MOD_CK1_1	606	612	PF00069	0.782
MOD_CK1_1	633	639	PF00069	0.664
MOD_CK1_1	640	646	PF00069	0.657
MOD_CK1_1	796	802	PF00069	0.686
MOD_CK1_1	81	87	PF00069	0.749
MOD_CK1_1	9	15	PF00069	0.683
MOD_CK2_1	256	262	PF00069	0.779
MOD_CK2_1	307	313	PF00069	0.737
MOD_CK2_1	33	39	PF00069	0.767
MOD_CK2_1	520	526	PF00069	0.772
MOD_CK2_1	558	564	PF00069	0.696
MOD_CK2_1	723	729	PF00069	0.642
MOD_CK2_1	761	767	PF00069	0.654
MOD_Cter_Amidation	601	604	PF01082	0.596
MOD_Cter_Amidation	653	656	PF01082	0.604
MOD_GlcNHglycan	11	14	PF01048	0.685
MOD_GlcNHglycan	129	132	PF01048	0.587
MOD_GlcNHglycan	15	18	PF01048	0.690
MOD_GlcNHglycan	20	23	PF01048	0.625
MOD_GlcNHglycan	231	234	PF01048	0.775
MOD_GlcNHglycan	291	294	PF01048	0.810
MOD_GlcNHglycan	33	36	PF01048	0.569
MOD_GlcNHglycan	331	334	PF01048	0.675
MOD_GlcNHglycan	482	485	PF01048	0.770
MOD_GlcNHglycan	487	490	PF01048	0.711
MOD_GlcNHglycan	49	52	PF01048	0.551
MOD_GlcNHglycan	516	519	PF01048	0.761
MOD_GlcNHglycan	522	525	PF01048	0.810
MOD_GlcNHglycan	600	603	PF01048	0.755
MOD_GlcNHglycan	618	621	PF01048	0.666
MOD_GlcNHglycan	62	66	PF01048	0.541
MOD_GlcNHglycan	668	671	PF01048	0.666
MOD_GSK3_1	1	8	PF00069	0.715
MOD_GSK3_1	125	132	PF00069	0.692
MOD_GSK3_1	136	143	PF00069	0.628
MOD_GSK3_1	165	172	PF00069	0.780
MOD_GSK3_1	174	181	PF00069	0.671
MOD_GSK3_1	185	192	PF00069	0.521
MOD_GSK3_1	220	227	PF00069	0.799
MOD_GSK3_1	228	235	PF00069	0.780
MOD_GSK3_1	240	247	PF00069	0.588
MOD_GSK3_1	252	259	PF00069	0.569
MOD_GSK3_1	289	296	PF00069	0.783
MOD_GSK3_1	309	316	PF00069	0.517
MOD_GSK3_1	38	45	PF00069	0.717
MOD_GSK3_1	384	391	PF00069	0.701
MOD_GSK3_1	503	510	PF00069	0.780
MOD_GSK3_1	554	561	PF00069	0.735
MOD_GSK3_1	583	590	PF00069	0.704
MOD_GSK3_1	605	612	PF00069	0.741
MOD_GSK3_1	630	637	PF00069	0.745
MOD_GSK3_1	658	665	PF00069	0.769
MOD_GSK3_1	718	725	PF00069	0.731
MOD_GSK3_1	74	81	PF00069	0.728
MOD_GSK3_1	82	89	PF00069	0.714
MOD_GSK3_1	9	16	PF00069	0.650
MOD_NEK2_1	1	6	PF00069	0.724
MOD_NEK2_1	357	362	PF00069	0.693
MOD_NEK2_1	480	485	PF00069	0.671
MOD_NEK2_1	507	512	PF00069	0.679
MOD_NEK2_1	556	561	PF00069	0.737
MOD_PIKK_1	179	185	PF00454	0.727
MOD_PIKK_1	235	241	PF00454	0.821
MOD_PK_1	603	609	PF00069	0.693
MOD_PKA_1	603	609	PF00069	0.588
MOD_PKA_1	666	672	PF00069	0.815
MOD_PKA_2	240	246	PF00069	0.727
MOD_PKA_2	520	526	PF00069	0.709
MOD_PKA_2	623	629	PF00069	0.785
MOD_PKA_2	718	724	PF00069	0.725
MOD_PKB_1	720	728	PF00069	0.749
MOD_Plk_1	244	250	PF00069	0.752
MOD_Plk_1	313	319	PF00069	0.705
MOD_Plk_1	796	802	PF00069	0.521
MOD_Plk_4	136	142	PF00069	0.676
MOD_Plk_4	503	509	PF00069	0.716
MOD_Plk_4	680	686	PF00069	0.683
MOD_Plk_4	796	802	PF00069	0.521
MOD_ProDKin_1	143	149	PF00069	0.747
MOD_ProDKin_1	159	165	PF00069	0.593
MOD_ProDKin_1	169	175	PF00069	0.675
MOD_ProDKin_1	195	201	PF00069	0.735
MOD_ProDKin_1	220	226	PF00069	0.770
MOD_ProDKin_1	232	238	PF00069	0.687
MOD_ProDKin_1	266	272	PF00069	0.766
MOD_ProDKin_1	275	281	PF00069	0.689
MOD_ProDKin_1	284	290	PF00069	0.570
MOD_ProDKin_1	297	303	PF00069	0.655
MOD_ProDKin_1	384	390	PF00069	0.764
MOD_ProDKin_1	558	564	PF00069	0.625
MOD_ProDKin_1	606	612	PF00069	0.810
MOD_ProDKin_1	625	631	PF00069	0.518
MOD_ProDKin_1	768	774	PF00069	0.692
MOD_SUMO_for_1	802	805	PF00179	0.733
MOD_SUMO_for_1	806	809	PF00179	0.696
MOD_SUMO_for_1	814	817	PF00179	0.629
MOD_SUMO_rev_2	468	473	PF00179	0.751
TRG_DiLeu_BaEn_4	261	267	PF01217	0.721
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.784
TRG_ENDOCYTIC_2	776	779	PF00928	0.614
TRG_ENDOCYTIC_2	801	804	PF00928	0.650
TRG_ER_diArg_1	445	448	PF00400	0.809
TRG_ER_diArg_1	459	461	PF00400	0.525
TRG_ER_diArg_1	573	575	PF00400	0.807
TRG_ER_diArg_1	653	656	PF00400	0.604
TRG_ER_diArg_1	716	719	PF00400	0.741
TRG_ER_diArg_1	720	723	PF00400	0.661
TRG_NLS_MonoCore_2	444	449	PF00514	0.808
TRG_NLS_MonoExtC_3	444	449	PF00514	0.808
TRG_NLS_MonoExtC_3	651	656	PF00514	0.599
TRG_NLS_MonoExtN_4	442	449	PF00514	0.806
TRG_NLS_MonoExtN_4	650	656	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3D6	Leishmania donovani	87%	100%
A4H929	Leishmania braziliensis	53%	94%
A4I5L0	Leishmania infantum	87%	100%
E9B0V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%