Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q7A9_LEIMA

TriTrypDb:

LmjF.30.1860 , LMJLV39_300024900 , LMJSD75_300024700

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.651
CLV_C14_Caspase3-7	295	299	PF00656	0.681
CLV_NRD_NRD_1	19	21	PF00675	0.624
CLV_NRD_NRD_1	264	266	PF00675	0.675
CLV_NRD_NRD_1	309	311	PF00675	0.649
CLV_NRD_NRD_1	480	482	PF00675	0.610
CLV_PCSK_KEX2_1	108	110	PF00082	0.637
CLV_PCSK_KEX2_1	19	21	PF00082	0.624
CLV_PCSK_KEX2_1	264	266	PF00082	0.678
CLV_PCSK_KEX2_1	309	311	PF00082	0.649
CLV_PCSK_KEX2_1	462	464	PF00082	0.633
CLV_PCSK_KEX2_1	480	482	PF00082	0.483
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.637
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.629
CLV_PCSK_SKI1_1	13	17	PF00082	0.606
CLV_PCSK_SKI1_1	20	24	PF00082	0.626
DEG_COP1_1	282	293	PF00400	0.673
DEG_SPOP_SBC_1	51	55	PF00917	0.579
DOC_CKS1_1	365	370	PF01111	0.611
DOC_CYCLIN_RxL_1	446	456	PF00134	0.638
DOC_MAPK_DCC_7	264	272	PF00069	0.690
DOC_MAPK_gen_1	264	272	PF00069	0.690
DOC_MAPK_MEF2A_6	264	272	PF00069	0.690
DOC_MAPK_MEF2A_6	437	446	PF00069	0.604
DOC_PP1_RVXF_1	447	454	PF00149	0.639
DOC_USP7_MATH_1	110	114	PF00917	0.637
DOC_USP7_MATH_1	152	156	PF00917	0.626
DOC_USP7_MATH_1	177	181	PF00917	0.668
DOC_USP7_MATH_1	203	207	PF00917	0.589
DOC_USP7_MATH_1	293	297	PF00917	0.687
DOC_USP7_MATH_1	381	385	PF00917	0.671
DOC_USP7_MATH_1	461	465	PF00917	0.553
DOC_USP7_MATH_1	50	54	PF00917	0.664
DOC_USP7_UBL2_3	193	197	PF12436	0.571
DOC_WW_Pin1_4	179	184	PF00397	0.732
DOC_WW_Pin1_4	248	253	PF00397	0.634
DOC_WW_Pin1_4	274	279	PF00397	0.645
DOC_WW_Pin1_4	289	294	PF00397	0.635
DOC_WW_Pin1_4	333	338	PF00397	0.721
DOC_WW_Pin1_4	364	369	PF00397	0.699
DOC_WW_Pin1_4	403	408	PF00397	0.659
DOC_WW_Pin1_4	418	423	PF00397	0.558
DOC_WW_Pin1_4	429	434	PF00397	0.571
DOC_WW_Pin1_4	471	476	PF00397	0.722
LIG_14-3-3_CanoR_1	109	115	PF00244	0.614
LIG_14-3-3_CanoR_1	13	19	PF00244	0.653
LIG_14-3-3_CanoR_1	190	198	PF00244	0.618
LIG_14-3-3_CanoR_1	221	227	PF00244	0.557
LIG_14-3-3_CanoR_1	449	454	PF00244	0.691
LIG_14-3-3_CanoR_1	52	57	PF00244	0.704
LIG_EH1_1	71	79	PF00400	0.520
LIG_FHA_2	174	180	PF00498	0.622
LIG_FHA_2	19	25	PF00498	0.620
LIG_FHA_2	199	205	PF00498	0.789
LIG_FHA_2	223	229	PF00498	0.595
LIG_FHA_2	396	402	PF00498	0.654
LIG_FHA_2	419	425	PF00498	0.629
LIG_FHA_2	52	58	PF00498	0.767
LIG_LIR_Gen_1	126	137	PF02991	0.617
LIG_LIR_Gen_1	372	382	PF02991	0.538
LIG_LIR_Gen_1	40	51	PF02991	0.644
LIG_LIR_Gen_1	69	78	PF02991	0.526
LIG_LIR_Nem_3	126	132	PF02991	0.622
LIG_LIR_Nem_3	372	377	PF02991	0.562
LIG_LIR_Nem_3	40	46	PF02991	0.638
LIG_LIR_Nem_3	468	473	PF02991	0.599
LIG_LIR_Nem_3	69	75	PF02991	0.532
LIG_SH2_CRK	470	474	PF00017	0.601
LIG_SH2_PTP2	43	46	PF00017	0.577
LIG_SH2_SRC	351	354	PF00017	0.619
LIG_SH2_STAT5	248	251	PF00017	0.633
LIG_SH2_STAT5	376	379	PF00017	0.540
LIG_SH2_STAT5	43	46	PF00017	0.662
LIG_SH3_1	334	340	PF00018	0.719
LIG_SH3_2	151	156	PF14604	0.570
LIG_SH3_2	337	342	PF14604	0.710
LIG_SH3_3	148	154	PF00018	0.666
LIG_SH3_3	246	252	PF00018	0.638
LIG_SH3_3	287	293	PF00018	0.673
LIG_SH3_3	308	314	PF00018	0.671
LIG_SH3_3	334	340	PF00018	0.719
LIG_SH3_3	362	368	PF00018	0.622
LIG_SH3_3	380	386	PF00018	0.476
LIG_SH3_3	41	47	PF00018	0.579
LIG_SH3_3	430	436	PF00018	0.647
LIG_SUMO_SIM_par_1	222	228	PF11976	0.460
LIG_SUMO_SIM_par_1	73	81	PF11976	0.610
LIG_TRAF2_1	124	127	PF00917	0.625
LIG_TRAF2_1	176	179	PF00917	0.623
LIG_TRAF2_1	206	209	PF00917	0.672
LIG_TRAF2_1	387	390	PF00917	0.675
LIG_TRFH_1	43	47	PF08558	0.587
LIG_TYR_ITSM	466	473	PF00017	0.535
LIG_UBA3_1	15	23	PF00899	0.614
LIG_WW_3	310	314	PF00397	0.665
MOD_CDC14_SPxK_1	251	254	PF00782	0.628
MOD_CDK_SPK_2	289	294	PF00069	0.721
MOD_CDK_SPxK_1	248	254	PF00069	0.633
MOD_CK1_1	191	197	PF00069	0.685
MOD_CK1_1	222	228	PF00069	0.605
MOD_CK1_1	279	285	PF00069	0.718
MOD_CK1_1	292	298	PF00069	0.593
MOD_CK1_1	299	305	PF00069	0.555
MOD_CK1_1	354	360	PF00069	0.663
MOD_CK1_1	369	375	PF00069	0.578
MOD_CK1_1	418	424	PF00069	0.623
MOD_CK1_1	471	477	PF00069	0.661
MOD_CK2_1	121	127	PF00069	0.761
MOD_CK2_1	152	158	PF00069	0.725
MOD_CK2_1	173	179	PF00069	0.627
MOD_CK2_1	18	24	PF00069	0.621
MOD_CK2_1	202	208	PF00069	0.685
MOD_CK2_1	222	228	PF00069	0.605
MOD_CK2_1	283	289	PF00069	0.678
MOD_CK2_1	318	324	PF00069	0.711
MOD_CK2_1	395	401	PF00069	0.682
MOD_CK2_1	449	455	PF00069	0.622
MOD_CK2_1	51	57	PF00069	0.695
MOD_Cter_Amidation	262	265	PF01082	0.655
MOD_Cter_Amidation	307	310	PF01082	0.592
MOD_GlcNHglycan	104	107	PF01048	0.670
MOD_GlcNHglycan	123	126	PF01048	0.554
MOD_GlcNHglycan	295	298	PF01048	0.628
MOD_GlcNHglycan	34	37	PF01048	0.590
MOD_GlcNHglycan	368	371	PF01048	0.629
MOD_GlcNHglycan	417	420	PF01048	0.686
MOD_GlcNHglycan	469	473	PF01048	0.687
MOD_GSK3_1	117	124	PF00069	0.636
MOD_GSK3_1	14	21	PF00069	0.598
MOD_GSK3_1	167	174	PF00069	0.708
MOD_GSK3_1	198	205	PF00069	0.658
MOD_GSK3_1	272	279	PF00069	0.722
MOD_GSK3_1	285	292	PF00069	0.591
MOD_GSK3_1	296	303	PF00069	0.617
MOD_GSK3_1	347	354	PF00069	0.681
MOD_GSK3_1	377	384	PF00069	0.687
MOD_GSK3_1	392	399	PF00069	0.652
MOD_GSK3_1	461	468	PF00069	0.629
MOD_LATS_1	343	349	PF00433	0.631
MOD_N-GLC_1	198	203	PF02516	0.554
MOD_NEK2_1	18	23	PF00069	0.623
MOD_NEK2_1	32	37	PF00069	0.573
MOD_NEK2_1	377	382	PF00069	0.762
MOD_NEK2_1	90	95	PF00069	0.660
MOD_NEK2_2	14	19	PF00069	0.534
MOD_PIKK_1	272	278	PF00454	0.704
MOD_PIKK_1	280	286	PF00454	0.658
MOD_PKA_1	108	114	PF00069	0.691
MOD_PKA_2	108	114	PF00069	0.659
MOD_PKA_2	18	24	PF00069	0.721
MOD_PKA_2	293	299	PF00069	0.721
MOD_PKA_2	51	57	PF00069	0.629
MOD_Plk_1	125	131	PF00069	0.620
MOD_Plk_1	203	209	PF00069	0.544
MOD_Plk_1	354	360	PF00069	0.625
MOD_Plk_2-3	76	82	PF00069	0.524
MOD_ProDKin_1	179	185	PF00069	0.735
MOD_ProDKin_1	248	254	PF00069	0.633
MOD_ProDKin_1	274	280	PF00069	0.645
MOD_ProDKin_1	289	295	PF00069	0.635
MOD_ProDKin_1	333	339	PF00069	0.722
MOD_ProDKin_1	364	370	PF00069	0.699
MOD_ProDKin_1	403	409	PF00069	0.659
MOD_ProDKin_1	418	424	PF00069	0.559
MOD_ProDKin_1	429	435	PF00069	0.567
MOD_ProDKin_1	471	477	PF00069	0.725
TRG_ENDOCYTIC_2	376	379	PF00928	0.540
TRG_ENDOCYTIC_2	43	46	PF00928	0.650
TRG_ENDOCYTIC_2	470	473	PF00928	0.605
TRG_ER_diArg_1	18	20	PF00400	0.618
TRG_ER_diArg_1	264	266	PF00400	0.677
TRG_ER_diArg_1	309	311	PF00400	0.649
TRG_ER_diArg_1	479	481	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	449	454	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3E1	Leishmania donovani	88%	100%
A4H927	Leishmania braziliensis	58%	87%
A4I5L2	Leishmania infantum	88%	100%
E9B0V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	87%