LeishMANIAdb
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Zf-C2H2_12 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Zf-C2H2_12 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q7A7_LEIMA
TriTrypDb:
LmjF.30.1880 , LMJLV39_300025100 , LMJSD75_300024900
Length:
118

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7A7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7A7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 36 38 PF00675 0.448
CLV_NRD_NRD_1 50 52 PF00675 0.463
CLV_NRD_NRD_1 96 98 PF00675 0.512
CLV_PCSK_KEX2_1 35 37 PF00082 0.482
CLV_PCSK_KEX2_1 95 97 PF00082 0.503
DEG_APCC_DBOX_1 50 58 PF00400 0.326
DEG_Nend_UBRbox_1 1 4 PF02207 0.576
DOC_CYCLIN_yCln2_LP_2 18 21 PF00134 0.529
DOC_MAPK_gen_1 51 62 PF00069 0.485
DOC_MAPK_gen_1 95 102 PF00069 0.523
DOC_MAPK_MEF2A_6 56 64 PF00069 0.418
DOC_PP2B_LxvP_1 109 112 PF13499 0.432
DOC_PP2B_LxvP_1 18 21 PF13499 0.529
DOC_USP7_UBL2_3 52 56 PF12436 0.526
LIG_14-3-3_CanoR_1 69 74 PF00244 0.532
LIG_Actin_WH2_2 42 60 PF00022 0.524
LIG_Integrin_RGD_1 114 116 PF01839 0.536
LIG_LIR_Gen_1 22 33 PF02991 0.448
LIG_LIR_Nem_3 22 28 PF02991 0.444
LIG_LIR_Nem_3 84 90 PF02991 0.506
LIG_PDZ_Class_3 113 118 PF00595 0.650
LIG_SH2_PTP2 59 62 PF00017 0.425
LIG_SH2_STAT5 4 7 PF00017 0.505
LIG_SH2_STAT5 59 62 PF00017 0.425
LIG_SH3_3 105 111 PF00018 0.575
LIG_TYR_ITIM 57 62 PF00017 0.425
MOD_CK2_1 60 66 PF00069 0.519
MOD_CK2_1 74 80 PF00069 0.459
MOD_Cter_Amidation 49 52 PF01082 0.520
MOD_GlcNHglycan 76 79 PF01048 0.566
MOD_N-GLC_1 74 79 PF02516 0.608
MOD_NEK2_1 24 29 PF00069 0.439
MOD_PIKK_1 9 15 PF00454 0.450
MOD_PKA_2 9 15 PF00069 0.440
MOD_PKB_1 67 75 PF00069 0.477
MOD_Plk_4 60 66 PF00069 0.477
TRG_ENDOCYTIC_2 59 62 PF00928 0.425
TRG_ER_diArg_1 35 37 PF00400 0.481
TRG_ER_diArg_1 95 97 PF00400 0.553
TRG_NLS_Bipartite_1 35 55 PF00514 0.502
TRG_NLS_MonoExtN_4 48 55 PF00514 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCW4 Leptomonas seymouri 74% 91%
A0A0S4JF46 Bodo saltans 40% 100%
A0A1X0P2V6 Trypanosomatidae 56% 100%
A0A3Q8IHY2 Leishmania donovani 97% 100%
A0A3R7NV36 Trypanosoma rangeli 54% 100%
A4HIC2 Leishmania braziliensis 85% 100%
A4I5L4 Leishmania infantum 97% 100%
C9ZQZ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 80%
E9B0V9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS