PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q7A5_LEIMA

TriTrypDb:

LmjF.30.1900 , LMJLV39_300025300 , LMJSD75_300025100

Length:

1024

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1007	1011	PF00656	0.558
CLV_C14_Caspase3-7	422	426	PF00656	0.428
CLV_C14_Caspase3-7	566	570	PF00656	0.564
CLV_C14_Caspase3-7	991	995	PF00656	0.464
CLV_NRD_NRD_1	150	152	PF00675	0.502
CLV_NRD_NRD_1	293	295	PF00675	0.485
CLV_NRD_NRD_1	607	609	PF00675	0.466
CLV_NRD_NRD_1	921	923	PF00675	0.447
CLV_NRD_NRD_1	958	960	PF00675	0.504
CLV_PCSK_KEX2_1	150	152	PF00082	0.502
CLV_PCSK_KEX2_1	293	295	PF00082	0.485
CLV_PCSK_KEX2_1	41	43	PF00082	0.646
CLV_PCSK_KEX2_1	607	609	PF00082	0.466
CLV_PCSK_KEX2_1	957	959	PF00082	0.494
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.646
CLV_PCSK_PC7_1	954	960	PF00082	0.512
CLV_PCSK_SKI1_1	1015	1019	PF00082	0.603
CLV_PCSK_SKI1_1	308	312	PF00082	0.541
CLV_PCSK_SKI1_1	436	440	PF00082	0.434
CLV_PCSK_SKI1_1	510	514	PF00082	0.476
CLV_PCSK_SKI1_1	607	611	PF00082	0.559
CLV_PCSK_SKI1_1	618	622	PF00082	0.480
CLV_PCSK_SKI1_1	697	701	PF00082	0.488
CLV_PCSK_SKI1_1	717	721	PF00082	0.502
CLV_PCSK_SKI1_1	856	860	PF00082	0.382
DEG_APCC_DBOX_1	435	443	PF00400	0.437
DEG_APCC_DBOX_1	606	614	PF00400	0.660
DOC_CKS1_1	61	66	PF01111	0.512
DOC_CYCLIN_RxL_1	305	315	PF00134	0.465
DOC_CYCLIN_yClb3_PxF_3	190	196	PF00134	0.650
DOC_CYCLIN_yClb5_NLxxxL_5	580	589	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	585	591	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	863	869	PF00134	0.446
DOC_MAPK_gen_1	293	300	PF00069	0.448
DOC_MAPK_gen_1	714	724	PF00069	0.678
DOC_MAPK_HePTP_8	290	302	PF00069	0.438
DOC_MAPK_HePTP_8	806	818	PF00069	0.408
DOC_MAPK_MEF2A_6	293	302	PF00069	0.438
DOC_MAPK_MEF2A_6	462	469	PF00069	0.536
DOC_MAPK_MEF2A_6	809	818	PF00069	0.410
DOC_MAPK_RevD_3	281	294	PF00069	0.528
DOC_PP1_RVXF_1	1013	1019	PF00149	0.600
DOC_PP1_RVXF_1	116	122	PF00149	0.504
DOC_PP1_RVXF_1	854	860	PF00149	0.395
DOC_PP2B_LxvP_1	585	588	PF13499	0.488
DOC_PP2B_LxvP_1	863	866	PF13499	0.421
DOC_PP2B_LxvP_1	938	941	PF13499	0.487
DOC_PP2B_LxvP_1	943	946	PF13499	0.502
DOC_PP4_FxxP_1	159	162	PF00568	0.463
DOC_PP4_FxxP_1	540	543	PF00568	0.547
DOC_PP4_FxxP_1	91	94	PF00568	0.583
DOC_USP7_MATH_1	1004	1008	PF00917	0.571
DOC_USP7_MATH_1	206	210	PF00917	0.621
DOC_USP7_MATH_1	257	261	PF00917	0.434
DOC_USP7_MATH_1	323	327	PF00917	0.515
DOC_USP7_MATH_1	355	359	PF00917	0.551
DOC_USP7_MATH_1	378	382	PF00917	0.621
DOC_USP7_MATH_1	400	404	PF00917	0.594
DOC_USP7_MATH_1	482	486	PF00917	0.506
DOC_USP7_MATH_1	500	504	PF00917	0.541
DOC_USP7_MATH_1	505	509	PF00917	0.526
DOC_USP7_MATH_1	543	547	PF00917	0.621
DOC_USP7_MATH_1	560	564	PF00917	0.615
DOC_USP7_MATH_1	620	624	PF00917	0.506
DOC_USP7_UBL2_3	114	118	PF12436	0.515
DOC_USP7_UBL2_3	330	334	PF12436	0.545
DOC_WW_Pin1_4	1008	1013	PF00397	0.651
DOC_WW_Pin1_4	136	141	PF00397	0.523
DOC_WW_Pin1_4	198	203	PF00397	0.654
DOC_WW_Pin1_4	539	544	PF00397	0.567
DOC_WW_Pin1_4	60	65	PF00397	0.490
DOC_WW_Pin1_4	728	733	PF00397	0.609
DOC_WW_Pin1_4	771	776	PF00397	0.654
DOC_WW_Pin1_4	867	872	PF00397	0.564
LIG_14-3-3_CanoR_1	293	299	PF00244	0.647
LIG_14-3-3_CanoR_1	312	320	PF00244	0.342
LIG_14-3-3_CanoR_1	582	588	PF00244	0.528
LIG_14-3-3_CanoR_1	607	613	PF00244	0.631
LIG_14-3-3_CanoR_1	81	86	PF00244	0.510
LIG_14-3-3_CanoR_1	977	986	PF00244	0.567
LIG_Actin_WH2_2	139	155	PF00022	0.451
LIG_Actin_WH2_2	605	620	PF00022	0.564
LIG_Actin_WH2_2	803	819	PF00022	0.504
LIG_BIR_III_2	178	182	PF00653	0.557
LIG_BIR_III_2	994	998	PF00653	0.404
LIG_BIR_III_4	304	308	PF00653	0.492
LIG_BRCT_BRCA1_1	1013	1017	PF00533	0.700
LIG_BRCT_BRCA1_1	194	198	PF00533	0.584
LIG_BRCT_BRCA1_1	277	281	PF00533	0.536
LIG_BRCT_BRCA1_1	773	777	PF00533	0.557
LIG_EVH1_1	204	208	PF00568	0.608
LIG_EVH1_2	192	196	PF00568	0.666
LIG_FHA_1	199	205	PF00498	0.644
LIG_FHA_1	249	255	PF00498	0.711
LIG_FHA_1	295	301	PF00498	0.515
LIG_FHA_1	358	364	PF00498	0.449
LIG_FHA_1	384	390	PF00498	0.507
LIG_FHA_1	485	491	PF00498	0.517
LIG_FHA_1	515	521	PF00498	0.668
LIG_FHA_1	612	618	PF00498	0.517
LIG_FHA_1	708	714	PF00498	0.495
LIG_FHA_1	716	722	PF00498	0.508
LIG_FHA_1	891	897	PF00498	0.412
LIG_FHA_1	980	986	PF00498	0.444
LIG_FHA_1	988	994	PF00498	0.432
LIG_FHA_2	247	253	PF00498	0.636
LIG_FHA_2	702	708	PF00498	0.430
LIG_FHA_2	748	754	PF00498	0.643
LIG_FHA_2	967	973	PF00498	0.629
LIG_GBD_Chelix_1	572	580	PF00786	0.471
LIG_GBD_Chelix_1	985	993	PF00786	0.403
LIG_LIR_Apic_2	89	94	PF02991	0.597
LIG_LIR_Gen_1	841	851	PF02991	0.409
LIG_LIR_Nem_3	1014	1020	PF02991	0.605
LIG_LIR_Nem_3	155	161	PF02991	0.484
LIG_LIR_Nem_3	841	846	PF02991	0.439
LIG_LIR_Nem_3	852	857	PF02991	0.422
LIG_MYND_1	202	206	PF01753	0.681
LIG_MYND_1	239	243	PF01753	0.651
LIG_MYND_1	318	322	PF01753	0.494
LIG_MYND_3	230	234	PF01753	0.552
LIG_MYND_3	317	321	PF01753	0.555
LIG_PCNA_yPIPBox_3	842	854	PF02747	0.355
LIG_PROFILIN_1	180	186	PF00235	0.622
LIG_PROFILIN_1	187	193	PF00235	0.574
LIG_REV1ctd_RIR_1	1015	1023	PF16727	0.598
LIG_SH2_CRK	100	104	PF00017	0.603
LIG_SH2_CRK	116	120	PF00017	0.417
LIG_SH2_CRK	854	858	PF00017	0.352
LIG_SH2_NCK_1	100	104	PF00017	0.554
LIG_SH2_NCK_1	745	749	PF00017	0.610
LIG_SH2_STAT3	660	663	PF00017	0.540
LIG_SH2_STAT5	116	119	PF00017	0.521
LIG_SH2_STAT5	144	147	PF00017	0.446
LIG_SH2_STAT5	655	658	PF00017	0.463
LIG_SH2_STAT5	660	663	PF00017	0.493
LIG_SH2_STAT5	745	748	PF00017	0.616
LIG_SH3_1	404	410	PF00018	0.633
LIG_SH3_3	177	183	PF00018	0.696
LIG_SH3_3	184	190	PF00018	0.614
LIG_SH3_3	199	205	PF00018	0.704
LIG_SH3_3	237	243	PF00018	0.543
LIG_SH3_3	370	376	PF00018	0.473
LIG_SH3_3	404	410	PF00018	0.657
LIG_SH3_3	476	482	PF00018	0.433
LIG_SH3_3	58	64	PF00018	0.496
LIG_SH3_3	732	738	PF00018	0.697
LIG_SUMO_SIM_anti_2	124	131	PF11976	0.531
LIG_SUMO_SIM_anti_2	718	723	PF11976	0.497
LIG_SUMO_SIM_anti_2	981	991	PF11976	0.444
LIG_SUMO_SIM_par_1	608	615	PF11976	0.553
LIG_SUMO_SIM_par_1	981	991	PF11976	0.492
LIG_SxIP_EBH_1	441	453	PF03271	0.423
LIG_TRAF2_1	643	646	PF00917	0.598
LIG_TYR_ITIM	792	797	PF00017	0.544
LIG_WRC_WIRS_1	258	263	PF05994	0.430
LIG_WRC_WIRS_1	908	913	PF05994	0.435
LIG_WW_2	202	205	PF00397	0.626
MOD_CDK_SPK_2	60	65	PF00069	0.513
MOD_CDK_SPxxK_3	1008	1015	PF00069	0.683
MOD_CK1_1	1011	1017	PF00069	0.598
MOD_CK1_1	345	351	PF00069	0.569
MOD_CK1_1	383	389	PF00069	0.541
MOD_CK1_1	508	514	PF00069	0.499
MOD_CK1_1	523	529	PF00069	0.530
MOD_CK1_1	596	602	PF00069	0.598
MOD_CK1_1	611	617	PF00069	0.415
MOD_CK2_1	246	252	PF00069	0.611
MOD_CK2_1	427	433	PF00069	0.530
MOD_CK2_1	560	566	PF00069	0.637
MOD_CK2_1	747	753	PF00069	0.664
MOD_CK2_1	966	972	PF00069	0.531
MOD_CK2_1	981	987	PF00069	0.318
MOD_Cter_Amidation	148	151	PF01082	0.517
MOD_Cter_Amidation	605	608	PF01082	0.473
MOD_GlcNHglycan	1000	1003	PF01048	0.600
MOD_GlcNHglycan	1006	1009	PF01048	0.632
MOD_GlcNHglycan	108	111	PF01048	0.399
MOD_GlcNHglycan	208	211	PF01048	0.624
MOD_GlcNHglycan	339	342	PF01048	0.620
MOD_GlcNHglycan	356	360	PF01048	0.429
MOD_GlcNHglycan	36	39	PF01048	0.568
MOD_GlcNHglycan	398	401	PF01048	0.735
MOD_GlcNHglycan	507	510	PF01048	0.543
MOD_GlcNHglycan	51	54	PF01048	0.562
MOD_GlcNHglycan	522	525	PF01048	0.509
MOD_GlcNHglycan	535	538	PF01048	0.576
MOD_GlcNHglycan	545	548	PF01048	0.584
MOD_GlcNHglycan	562	565	PF01048	0.682
MOD_GlcNHglycan	585	588	PF01048	0.635
MOD_GlcNHglycan	602	605	PF01048	0.402
MOD_GlcNHglycan	618	621	PF01048	0.560
MOD_GlcNHglycan	622	625	PF01048	0.466
MOD_GlcNHglycan	786	789	PF01048	0.746
MOD_GlcNHglycan	88	91	PF01048	0.527
MOD_GlcNHglycan	912	916	PF01048	0.484
MOD_GSK3_1	1004	1011	PF00069	0.675
MOD_GSK3_1	117	124	PF00069	0.472
MOD_GSK3_1	192	199	PF00069	0.667
MOD_GSK3_1	213	220	PF00069	0.664
MOD_GSK3_1	257	264	PF00069	0.413
MOD_GSK3_1	266	273	PF00069	0.383
MOD_GSK3_1	312	319	PF00069	0.510
MOD_GSK3_1	396	403	PF00069	0.657
MOD_GSK3_1	465	472	PF00069	0.515
MOD_GSK3_1	508	515	PF00069	0.566
MOD_GSK3_1	516	523	PF00069	0.507
MOD_GSK3_1	539	546	PF00069	0.575
MOD_GSK3_1	567	574	PF00069	0.506
MOD_GSK3_1	596	603	PF00069	0.509
MOD_GSK3_1	608	615	PF00069	0.464
MOD_GSK3_1	616	623	PF00069	0.410
MOD_GSK3_1	743	750	PF00069	0.722
MOD_GSK3_1	907	914	PF00069	0.465
MOD_GSK3_1	962	969	PF00069	0.585
MOD_LATS_1	292	298	PF00433	0.541
MOD_N-GLC_1	121	126	PF02516	0.616
MOD_N-GLC_1	275	280	PF02516	0.488
MOD_N-GLC_1	583	588	PF02516	0.517
MOD_N-GLC_1	846	851	PF02516	0.372
MOD_NEK2_1	1018	1023	PF00069	0.622
MOD_NEK2_1	196	201	PF00069	0.636
MOD_NEK2_1	217	222	PF00069	0.808
MOD_NEK2_1	261	266	PF00069	0.409
MOD_NEK2_1	337	342	PF00069	0.445
MOD_NEK2_1	427	432	PF00069	0.550
MOD_NEK2_1	469	474	PF00069	0.511
MOD_NEK2_1	49	54	PF00069	0.504
MOD_NEK2_1	514	519	PF00069	0.473
MOD_NEK2_1	612	617	PF00069	0.466
MOD_NEK2_1	795	800	PF00069	0.447
MOD_NEK2_1	900	905	PF00069	0.544
MOD_NEK2_1	911	916	PF00069	0.479
MOD_NEK2_1	988	993	PF00069	0.393
MOD_NEK2_2	516	521	PF00069	0.531
MOD_NEK2_2	924	929	PF00069	0.556
MOD_NEK2_2	934	939	PF00069	0.483
MOD_PIKK_1	631	637	PF00454	0.605
MOD_PIKK_1	659	665	PF00454	0.478
MOD_PIKK_1	738	744	PF00454	0.536
MOD_PKA_2	1004	1010	PF00069	0.738
MOD_PKA_2	1018	1024	PF00069	0.526
MOD_PKA_2	152	158	PF00069	0.458
MOD_PKA_2	49	55	PF00069	0.507
MOD_PKA_2	520	526	PF00069	0.454
MOD_PKA_2	978	984	PF00069	0.573
MOD_PKB_1	977	985	PF00069	0.383
MOD_Plk_1	213	219	PF00069	0.666
MOD_Plk_1	715	721	PF00069	0.496
MOD_Plk_1	795	801	PF00069	0.442
MOD_Plk_1	846	852	PF00069	0.378
MOD_Plk_1	900	906	PF00069	0.461
MOD_Plk_1	934	940	PF00069	0.477
MOD_Plk_1	950	956	PF00069	0.531
MOD_Plk_4	257	263	PF00069	0.442
MOD_Plk_4	276	282	PF00069	0.452
MOD_Plk_4	448	454	PF00069	0.486
MOD_Plk_4	608	614	PF00069	0.659
MOD_Plk_4	717	723	PF00069	0.535
MOD_Plk_4	981	987	PF00069	0.457
MOD_Plk_4	988	994	PF00069	0.351
MOD_ProDKin_1	1008	1014	PF00069	0.653
MOD_ProDKin_1	136	142	PF00069	0.515
MOD_ProDKin_1	198	204	PF00069	0.653
MOD_ProDKin_1	539	545	PF00069	0.570
MOD_ProDKin_1	60	66	PF00069	0.490
MOD_ProDKin_1	728	734	PF00069	0.611
MOD_ProDKin_1	771	777	PF00069	0.657
MOD_ProDKin_1	867	873	PF00069	0.560
MOD_SUMO_for_1	713	716	PF00179	0.482
MOD_SUMO_rev_2	54	64	PF00179	0.529
MOD_SUMO_rev_2	693	699	PF00179	0.514
TRG_DiLeu_BaEn_1	434	439	PF01217	0.595
TRG_DiLeu_BaEn_1	887	892	PF01217	0.530
TRG_DiLeu_BaEn_3	950	956	PF01217	0.530
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.618
TRG_ENDOCYTIC_2	100	103	PF00928	0.604
TRG_ENDOCYTIC_2	116	119	PF00928	0.424
TRG_ENDOCYTIC_2	666	669	PF00928	0.520
TRG_ENDOCYTIC_2	794	797	PF00928	0.444
TRG_ENDOCYTIC_2	854	857	PF00928	0.356
TRG_ER_diArg_1	130	133	PF00400	0.497
TRG_ER_diArg_1	150	153	PF00400	0.339
TRG_ER_diArg_1	311	314	PF00400	0.540
TRG_ER_diArg_1	607	609	PF00400	0.473
TRG_ER_diArg_1	683	686	PF00400	0.521
TRG_ER_diArg_1	956	959	PF00400	0.485
TRG_ER_diArg_1	976	979	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM5	Leptomonas seymouri	55%	91%
A0A3Q8IEY3	Leishmania donovani	94%	100%
A4HIC4	Leishmania braziliensis	73%	100%
A4I5L6	Leishmania infantum	93%	100%
E9B0W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%