Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q7A4_LEIMA

TriTrypDb:

LmjF.30.1920 , LMJLV39_300025400 , LMJSD75_300025200

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7A4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.553
CLV_NRD_NRD_1	128	130	PF00675	0.853
CLV_NRD_NRD_1	143	145	PF00675	0.530
CLV_NRD_NRD_1	150	152	PF00675	0.509
CLV_NRD_NRD_1	164	166	PF00675	0.548
CLV_NRD_NRD_1	181	183	PF00675	0.710
CLV_NRD_NRD_1	408	410	PF00675	0.676
CLV_NRD_NRD_1	449	451	PF00675	0.684
CLV_PCSK_KEX2_1	127	129	PF00082	0.867
CLV_PCSK_KEX2_1	143	145	PF00082	0.516
CLV_PCSK_KEX2_1	150	152	PF00082	0.500
CLV_PCSK_KEX2_1	164	166	PF00082	0.548
CLV_PCSK_KEX2_1	181	183	PF00082	0.710
CLV_PCSK_KEX2_1	230	232	PF00082	0.689
CLV_PCSK_KEX2_1	33	35	PF00082	0.688
CLV_PCSK_KEX2_1	393	395	PF00082	0.710
CLV_PCSK_KEX2_1	408	410	PF00082	0.676
CLV_PCSK_KEX2_1	448	450	PF00082	0.674
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.652
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.688
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.710
CLV_PCSK_PC7_1	123	129	PF00082	0.861
CLV_PCSK_PC7_1	226	232	PF00082	0.686
CLV_PCSK_SKI1_1	165	169	PF00082	0.620
CLV_Separin_Metazoa	62	66	PF03568	0.614
DEG_APCC_DBOX_1	163	171	PF00400	0.589
DEG_APCC_DBOX_1	77	85	PF00400	0.708
DOC_ANK_TNKS_1	35	42	PF00023	0.681
DOC_MAPK_gen_1	230	238	PF00069	0.686
DOC_MAPK_gen_1	408	418	PF00069	0.473
DOC_MAPK_gen_1	448	456	PF00069	0.627
DOC_MAPK_gen_1	76	83	PF00069	0.707
DOC_MAPK_HePTP_8	359	371	PF00069	0.588
DOC_MAPK_MEF2A_6	230	238	PF00069	0.686
DOC_MAPK_MEF2A_6	362	371	PF00069	0.597
DOC_PP1_RVXF_1	417	424	PF00149	0.649
DOC_PP2B_LxvP_1	552	555	PF13499	0.525
DOC_USP7_MATH_1	198	202	PF00917	0.735
DOC_USP7_MATH_1	251	255	PF00917	0.681
DOC_USP7_MATH_1	345	349	PF00917	0.501
DOC_USP7_MATH_1	48	52	PF00917	0.708
DOC_USP7_MATH_1	501	505	PF00917	0.686
DOC_USP7_MATH_1	519	523	PF00917	0.520
DOC_WW_Pin1_4	132	137	PF00397	0.776
DOC_WW_Pin1_4	171	176	PF00397	0.693
DOC_WW_Pin1_4	194	199	PF00397	0.737
DOC_WW_Pin1_4	517	522	PF00397	0.607
LIG_14-3-3_CanoR_1	127	132	PF00244	0.731
LIG_14-3-3_CanoR_1	164	173	PF00244	0.636
LIG_14-3-3_CanoR_1	194	198	PF00244	0.693
LIG_14-3-3_CanoR_1	25	31	PF00244	0.692
LIG_14-3-3_CanoR_1	253	261	PF00244	0.555
LIG_14-3-3_CanoR_1	496	501	PF00244	0.607
LIG_14-3-3_CanoR_1	71	79	PF00244	0.704
LIG_14-3-3_CanoR_1	80	84	PF00244	0.596
LIG_BIR_III_4	336	340	PF00653	0.723
LIG_BRCT_BRCA1_1	202	206	PF00533	0.731
LIG_FHA_1	247	253	PF00498	0.590
LIG_FHA_1	3	9	PF00498	0.744
LIG_FHA_1	321	327	PF00498	0.601
LIG_FHA_1	458	464	PF00498	0.610
LIG_FHA_1	475	481	PF00498	0.418
LIG_FHA_1	59	65	PF00498	0.658
LIG_FHA_1	591	597	PF00498	0.722
LIG_FHA_2	276	282	PF00498	0.706
LIG_FHA_2	432	438	PF00498	0.663
LIG_FHA_2	506	512	PF00498	0.755
LIG_FHA_2	96	102	PF00498	0.691
LIG_LIR_Apic_2	207	213	PF02991	0.729
LIG_LIR_Gen_1	312	320	PF02991	0.692
LIG_LIR_Gen_1	50	59	PF02991	0.713
LIG_LIR_LC3C_4	414	418	PF02991	0.639
LIG_LIR_Nem_3	312	318	PF02991	0.691
LIG_LIR_Nem_3	50	56	PF02991	0.709
LIG_NRBOX	234	240	PF00104	0.688
LIG_PTAP_UEV_1	244	249	PF05743	0.689
LIG_SH2_CRK	296	300	PF00017	0.698
LIG_SH2_CRK	469	473	PF00017	0.623
LIG_SH2_GRB2like	332	335	PF00017	0.693
LIG_SH2_PTP2	210	213	PF00017	0.671
LIG_SH2_SRC	315	318	PF00017	0.633
LIG_SH2_SRC	332	335	PF00017	0.521
LIG_SH2_STAT3	142	145	PF00017	0.670
LIG_SH2_STAT3	398	401	PF00017	0.740
LIG_SH2_STAT3	537	540	PF00017	0.666
LIG_SH2_STAT5	148	151	PF00017	0.624
LIG_SH2_STAT5	166	169	PF00017	0.486
LIG_SH2_STAT5	187	190	PF00017	0.568
LIG_SH2_STAT5	210	213	PF00017	0.680
LIG_SH2_STAT5	315	318	PF00017	0.633
LIG_SH2_STAT5	332	335	PF00017	0.521
LIG_SH2_STAT5	455	458	PF00017	0.720
LIG_SH2_STAT5	469	472	PF00017	0.518
LIG_SH3_3	242	248	PF00018	0.708
LIG_SH3_3	276	282	PF00018	0.669
LIG_SH3_3	42	48	PF00018	0.628
LIG_SH3_3	477	483	PF00018	0.651
LIG_SH3_3	597	603	PF00018	0.760
LIG_SH3_CIN85_PxpxPR_1	599	604	PF14604	0.767
LIG_TRAF2_1	113	116	PF00917	0.538
LIG_TRAF2_1	220	223	PF00917	0.710
LIG_TRAF2_1	98	101	PF00917	0.693
LIG_ULM_U2AF65_1	150	155	PF00076	0.468
LIG_WW_3	599	603	PF00397	0.764
MOD_CK1_1	130	136	PF00069	0.762
MOD_CK1_1	197	203	PF00069	0.731
MOD_CK1_1	214	220	PF00069	0.490
MOD_CK1_1	243	249	PF00069	0.665
MOD_CK1_1	407	413	PF00069	0.709
MOD_CK1_1	457	463	PF00069	0.683
MOD_CK1_1	514	520	PF00069	0.685
MOD_CK1_1	522	528	PF00069	0.590
MOD_CK1_1	542	548	PF00069	0.706
MOD_CK1_1	95	101	PF00069	0.615
MOD_CK2_1	379	385	PF00069	0.624
MOD_CK2_1	95	101	PF00069	0.725
MOD_CMANNOS	154	157	PF00535	0.701
MOD_Cter_Amidation	162	165	PF01082	0.588
MOD_Cter_Amidation	31	34	PF01082	0.701
MOD_GlcNHglycan	10	13	PF01048	0.642
MOD_GlcNHglycan	132	135	PF01048	0.733
MOD_GlcNHglycan	139	142	PF01048	0.633
MOD_GlcNHglycan	2	5	PF01048	0.761
MOD_GlcNHglycan	213	216	PF01048	0.661
MOD_GlcNHglycan	242	245	PF01048	0.741
MOD_GlcNHglycan	249	252	PF01048	0.655
MOD_GlcNHglycan	50	53	PF01048	0.675
MOD_GlcNHglycan	513	516	PF01048	0.713
MOD_GlcNHglycan	534	537	PF01048	0.705
MOD_GlcNHglycan	544	547	PF01048	0.556
MOD_GlcNHglycan	94	97	PF01048	0.664
MOD_GSK3_1	193	200	PF00069	0.732
MOD_GSK3_1	243	250	PF00069	0.653
MOD_GSK3_1	4	11	PF00069	0.711
MOD_GSK3_1	431	438	PF00069	0.742
MOD_GSK3_1	501	508	PF00069	0.750
MOD_GSK3_1	510	517	PF00069	0.665
MOD_N-GLC_1	404	409	PF02516	0.531
MOD_N-GLC_1	501	506	PF02516	0.532
MOD_NEK2_1	274	279	PF00069	0.661
MOD_NEK2_1	327	332	PF00069	0.703
MOD_NEK2_1	344	349	PF00069	0.615
MOD_NEK2_1	439	444	PF00069	0.643
MOD_NEK2_1	474	479	PF00069	0.685
MOD_NEK2_1	524	529	PF00069	0.701
MOD_NEK2_1	590	595	PF00069	0.721
MOD_NEK2_1	8	13	PF00069	0.728
MOD_NEK2_2	4	9	PF00069	0.702
MOD_NEK2_2	505	510	PF00069	0.684
MOD_PIKK_1	297	303	PF00454	0.715
MOD_PIKK_1	309	315	PF00454	0.596
MOD_PIKK_1	519	525	PF00454	0.551
MOD_PK_1	496	502	PF00069	0.684
MOD_PKA_1	127	133	PF00069	0.782
MOD_PKA_2	106	112	PF00069	0.789
MOD_PKA_2	127	133	PF00069	0.782
MOD_PKA_2	193	199	PF00069	0.691
MOD_PKA_2	407	413	PF00069	0.753
MOD_PKA_2	70	76	PF00069	0.709
MOD_PKA_2	79	85	PF00069	0.597
MOD_Plk_1	345	351	PF00069	0.587
MOD_Plk_1	501	507	PF00069	0.643
MOD_Plk_4	166	172	PF00069	0.565
MOD_Plk_4	26	32	PF00069	0.660
MOD_Plk_4	275	281	PF00069	0.708
MOD_Plk_4	327	333	PF00069	0.722
MOD_Plk_4	501	507	PF00069	0.660
MOD_Plk_4	79	85	PF00069	0.713
MOD_ProDKin_1	132	138	PF00069	0.768
MOD_ProDKin_1	171	177	PF00069	0.691
MOD_ProDKin_1	194	200	PF00069	0.739
MOD_ProDKin_1	517	523	PF00069	0.608
MOD_SUMO_rev_2	95	105	PF00179	0.583
TRG_DiLeu_BaEn_1	322	327	PF01217	0.588
TRG_DiLeu_BaEn_1	40	45	PF01217	0.687
TRG_DiLeu_BaEn_4	223	229	PF01217	0.658
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.638
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.685
TRG_ENDOCYTIC_2	296	299	PF00928	0.701
TRG_ENDOCYTIC_2	315	318	PF00928	0.625
TRG_ENDOCYTIC_2	468	471	PF00928	0.613
TRG_ER_diArg_1	127	129	PF00400	0.861
TRG_ER_diArg_1	142	144	PF00400	0.533
TRG_ER_diArg_1	150	153	PF00400	0.494
TRG_ER_diArg_1	164	166	PF00400	0.548
TRG_ER_diArg_1	252	255	PF00400	0.608
TRG_ER_diArg_1	408	411	PF00400	0.519
TRG_ER_diArg_1	448	450	PF00400	0.622
TRG_ER_diArg_1	601	604	PF00400	0.776
TRG_ER_diArg_1	86	89	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.687
TRG_PTS1	602	605	PF00515	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRZ9	Leishmania donovani	93%	100%
A4HIC5	Leishmania braziliensis	70%	94%
A4I5L7	Leishmania infantum	92%	100%
E9B0W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	97%