Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-coa:3-ketoacid-coenzyme a transferase- like protein

Species:

Leishmania major

UniProt:

Q4Q7A3_LEIMA

TriTrypDb:

LmjF.30.1930 , LMJLV39_300025700 , LMJSD75_300025300

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q7A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7A3

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0016042	lipid catabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046950	cellular ketone body metabolic process	3	12
GO:0046952	ketone body catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901568	fatty acid derivative metabolic process	4	12
GO:1901569	fatty acid derivative catabolic process	5	12
GO:1901575	organic substance catabolic process	3	12
GO:1902224	ketone body metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	5	12
GO:0008410	CoA-transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016782	transferase activity, transferring sulphur-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.528
CLV_C14_Caspase3-7	283	287	PF00656	0.515
CLV_NRD_NRD_1	189	191	PF00675	0.322
CLV_NRD_NRD_1	248	250	PF00675	0.563
CLV_NRD_NRD_1	256	258	PF00675	0.539
CLV_NRD_NRD_1	278	280	PF00675	0.300
CLV_NRD_NRD_1	3	5	PF00675	0.579
CLV_PCSK_KEX2_1	189	191	PF00082	0.374
CLV_PCSK_KEX2_1	248	250	PF00082	0.542
CLV_PCSK_KEX2_1	278	280	PF00082	0.325
CLV_PCSK_KEX2_1	3	5	PF00082	0.579
CLV_PCSK_SKI1_1	208	212	PF00082	0.398
CLV_PCSK_SKI1_1	279	283	PF00082	0.323
CLV_PCSK_SKI1_1	390	394	PF00082	0.322
CLV_PCSK_SKI1_1	4	8	PF00082	0.623
CLV_PCSK_SKI1_1	448	452	PF00082	0.291
CLV_PCSK_SKI1_1	53	57	PF00082	0.295
CLV_PCSK_SKI1_1	76	80	PF00082	0.296
DEG_MDM2_SWIB_1	164	171	PF02201	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_SPOP_SBC_1	59	63	PF00917	0.522
DOC_CKS1_1	125	130	PF01111	0.609
DOC_MAPK_DCC_7	229	238	PF00069	0.609
DOC_MAPK_gen_1	186	195	PF00069	0.526
DOC_MAPK_gen_1	278	284	PF00069	0.506
DOC_MAPK_gen_1	3	9	PF00069	0.463
DOC_MAPK_HePTP_8	282	294	PF00069	0.609
DOC_MAPK_MEF2A_6	229	238	PF00069	0.609
DOC_MAPK_MEF2A_6	285	294	PF00069	0.609
DOC_MAPK_MEF2A_6	362	370	PF00069	0.525
DOC_MAPK_MEF2A_6	482	489	PF00069	0.357
DOC_MAPK_NFAT4_5	285	293	PF00069	0.609
DOC_PP4_FxxP_1	125	128	PF00568	0.609
DOC_USP7_MATH_1	269	273	PF00917	0.641
DOC_USP7_MATH_1	475	479	PF00917	0.417
DOC_WW_Pin1_4	124	129	PF00397	0.609
LIG_14-3-3_CanoR_1	167	172	PF00244	0.535
LIG_14-3-3_CanoR_1	196	204	PF00244	0.609
LIG_14-3-3_CanoR_1	3	7	PF00244	0.539
LIG_14-3-3_CanoR_1	474	483	PF00244	0.458
LIG_BRCT_BRCA1_1	477	481	PF00533	0.412
LIG_CSL_BTD_1	385	388	PF09270	0.609
LIG_FHA_1	228	234	PF00498	0.621
LIG_FHA_1	26	32	PF00498	0.524
LIG_FHA_1	287	293	PF00498	0.598
LIG_FHA_1	377	383	PF00498	0.577
LIG_FHA_1	406	412	PF00498	0.511
LIG_FHA_1	432	438	PF00498	0.467
LIG_FHA_1	50	56	PF00498	0.522
LIG_FHA_1	67	73	PF00498	0.428
LIG_FHA_1	81	87	PF00498	0.510
LIG_FHA_2	108	114	PF00498	0.525
LIG_FHA_2	13	19	PF00498	0.348
LIG_FHA_2	413	419	PF00498	0.561
LIG_FHA_2	467	473	PF00498	0.537
LIG_GBD_Chelix_1	436	444	PF00786	0.279
LIG_Integrin_isoDGR_2	165	167	PF01839	0.361
LIG_LIR_Apic_2	154	158	PF02991	0.566
LIG_LIR_Apic_2	302	306	PF02991	0.564
LIG_LIR_Apic_2	384	388	PF02991	0.609
LIG_LIR_Gen_1	178	187	PF02991	0.514
LIG_LIR_Gen_1	356	366	PF02991	0.526
LIG_LIR_Nem_3	178	182	PF02991	0.514
LIG_LIR_Nem_3	356	361	PF02991	0.526
LIG_LIR_Nem_3	446	450	PF02991	0.536
LIG_MAD2	422	430	PF02301	0.522
LIG_Pex14_2	101	105	PF04695	0.582
LIG_Pex14_2	164	168	PF04695	0.563
LIG_PTB_Apo_2	95	102	PF02174	0.482
LIG_SH2_CRK	155	159	PF00017	0.549
LIG_SH2_PTP2	303	306	PF00017	0.535
LIG_SH2_SRC	303	306	PF00017	0.561
LIG_SH2_STAT5	126	129	PF00017	0.500
LIG_SH2_STAT5	237	240	PF00017	0.500
LIG_SH2_STAT5	303	306	PF00017	0.538
LIG_SH2_STAT5	85	88	PF00017	0.525
LIG_SH3_1	143	149	PF00018	0.478
LIG_SH3_2	146	151	PF14604	0.478
LIG_SH3_3	143	149	PF00018	0.478
LIG_SH3_3	228	234	PF00018	0.528
LIG_SH3_3	239	245	PF00018	0.464
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.511
LIG_SUMO_SIM_par_1	407	413	PF11976	0.515
LIG_TRAF2_1	469	472	PF00917	0.522
LIG_UBA3_1	43	50	PF00899	0.508
LIG_WRC_WIRS_1	444	449	PF05994	0.489
MOD_CK1_1	262	268	PF00069	0.699
MOD_CK1_1	347	353	PF00069	0.530
MOD_CK1_1	354	360	PF00069	0.484
MOD_CK1_1	462	468	PF00069	0.491
MOD_CK1_1	90	96	PF00069	0.511
MOD_CK2_1	12	18	PF00069	0.437
MOD_CK2_1	412	418	PF00069	0.598
MOD_CK2_1	466	472	PF00069	0.507
MOD_CK2_1	60	66	PF00069	0.522
MOD_GlcNHglycan	205	208	PF01048	0.349
MOD_GlcNHglycan	346	349	PF01048	0.344
MOD_GlcNHglycan	353	356	PF01048	0.301
MOD_GlcNHglycan	375	379	PF01048	0.356
MOD_GlcNHglycan	403	406	PF01048	0.278
MOD_GlcNHglycan	477	480	PF01048	0.490
MOD_GlcNHglycan	62	65	PF01048	0.359
MOD_GSK3_1	126	133	PF00069	0.519
MOD_GSK3_1	338	345	PF00069	0.568
MOD_GSK3_1	347	354	PF00069	0.555
MOD_GSK3_1	401	408	PF00069	0.424
MOD_GSK3_1	439	446	PF00069	0.583
MOD_GSK3_1	462	469	PF00069	0.624
MOD_GSK3_1	49	56	PF00069	0.522
MOD_N-GLC_1	66	71	PF02516	0.282
MOD_NEK2_1	195	200	PF00069	0.500
MOD_NEK2_1	2	7	PF00069	0.572
MOD_NEK2_1	299	304	PF00069	0.598
MOD_NEK2_1	344	349	PF00069	0.556
MOD_NEK2_1	366	371	PF00069	0.536
MOD_NEK2_1	374	379	PF00069	0.525
MOD_NEK2_1	401	406	PF00069	0.457
MOD_NEK2_1	431	436	PF00069	0.619
MOD_PIKK_1	153	159	PF00454	0.554
MOD_PIKK_1	196	202	PF00454	0.609
MOD_PKA_2	158	164	PF00069	0.563
MOD_PKA_2	195	201	PF00069	0.525
MOD_PKA_2	2	8	PF00069	0.569
MOD_Plk_1	366	372	PF00069	0.525
MOD_Plk_1	87	93	PF00069	0.522
MOD_Plk_2-3	466	472	PF00069	0.497
MOD_Plk_4	107	113	PF00069	0.609
MOD_Plk_4	299	305	PF00069	0.572
MOD_Plk_4	347	353	PF00069	0.582
MOD_Plk_4	366	372	PF00069	0.380
MOD_Plk_4	381	387	PF00069	0.525
MOD_Plk_4	53	59	PF00069	0.500
MOD_Plk_4	81	87	PF00069	0.525
MOD_Plk_4	9	15	PF00069	0.363
MOD_ProDKin_1	124	130	PF00069	0.609
MOD_SUMO_rev_2	222	231	PF00179	0.609
MOD_SUMO_rev_2	252	259	PF00179	0.616
MOD_SUMO_rev_2	413	421	PF00179	0.598
TRG_ER_diArg_1	2	4	PF00400	0.563
TRG_ER_diArg_1	247	249	PF00400	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P584	Leptomonas seymouri	51%	100%
A0A0N1I0F3	Leptomonas seymouri	45%	100%
A0A0S4JH09	Bodo saltans	52%	100%
A0A1X0NIU4	Trypanosomatidae	49%	100%
A0A1X0P425	Trypanosomatidae	47%	100%
A0A3Q8IC07	Leishmania donovani	96%	100%
A0A3Q8IMK1	Leishmania donovani	45%	100%
A0A3R7LBN6	Trypanosoma rangeli	49%	100%
A0A3S7X3G0	Leishmania donovani	81%	100%
A4HLU7	Leishmania braziliensis	45%	100%
A4I5L8	Leishmania infantum	96%	100%
A4I5L9	Leishmania infantum	81%	100%
B2GV06	Rattus norvegicus	48%	96%
D0A680	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AHQ2	Leishmania infantum	45%	100%
E9B0W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B0W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B473	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
F1CYZ5	Acetobacterium woodii	27%	95%
P37766	Escherichia coli (strain K12)	25%	94%
P55809	Homo sapiens	49%	96%
Q09450	Caenorhabditis elegans	46%	96%
Q29551	Sus scrofa	49%	96%
Q4Q3V3	Leishmania major	45%	97%
Q4Q7A2	Leishmania major	82%	100%
Q54JD9	Dictyostelium discoideum	48%	98%
Q5XIJ9	Rattus norvegicus	49%	96%
Q8X5X6	Escherichia coli O157:H7	25%	94%
Q9BYC2	Homo sapiens	48%	96%
Q9D0K2	Mus musculus	48%	96%
Q9ESL0	Mus musculus	48%	96%
Q9JJN4	Mus musculus	48%	96%
Q9W058	Drosophila melanogaster	47%	97%
V5DQB8	Trypanosoma cruzi	48%	100%