RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase-like protein

Species:

Leishmania major

UniProt:

Q4Q7A0_LEIMA

TriTrypDb:

LmjF.30.1960 , LMJLV39_300025900 , LMJSD75_300025700

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q7A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q7A0

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	2
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	8
GO:0031118	rRNA pseudouridine synthesis	7	2
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.677
CLV_C14_Caspase3-7	49	53	PF00656	0.571
CLV_NRD_NRD_1	11	13	PF00675	0.505
CLV_NRD_NRD_1	117	119	PF00675	0.461
CLV_NRD_NRD_1	182	184	PF00675	0.779
CLV_NRD_NRD_1	438	440	PF00675	0.597
CLV_NRD_NRD_1	466	468	PF00675	0.486
CLV_PCSK_FUR_1	436	440	PF00082	0.501
CLV_PCSK_FUR_1	9	13	PF00082	0.440
CLV_PCSK_KEX2_1	11	13	PF00082	0.505
CLV_PCSK_KEX2_1	116	118	PF00082	0.434
CLV_PCSK_KEX2_1	181	183	PF00082	0.724
CLV_PCSK_KEX2_1	438	440	PF00082	0.597
CLV_PCSK_KEX2_1	466	468	PF00082	0.341
CLV_PCSK_SKI1_1	331	335	PF00082	0.243
CLV_PCSK_SKI1_1	341	345	PF00082	0.258
CLV_PCSK_SKI1_1	467	471	PF00082	0.307
CLV_PCSK_SKI1_1	474	478	PF00082	0.328
CLV_PCSK_SKI1_1	486	490	PF00082	0.479
CLV_Separin_Metazoa	113	117	PF03568	0.384
CLV_Separin_Metazoa	279	283	PF03568	0.461
DEG_SCF_FBW7_2	417	422	PF00400	0.413
DOC_CYCLIN_RxL_1	462	473	PF00134	0.471
DOC_MAPK_gen_1	223	233	PF00069	0.442
DOC_MAPK_gen_1	264	272	PF00069	0.662
DOC_MAPK_MEF2A_6	438	447	PF00069	0.644
DOC_PP1_RVXF_1	472	478	PF00149	0.387
DOC_PP2B_LxvP_1	71	74	PF13499	0.409
DOC_PP4_FxxP_1	477	480	PF00568	0.345
DOC_PP4_FxxP_1	65	68	PF00568	0.413
DOC_USP7_MATH_1	14	18	PF00917	0.446
DOC_USP7_MATH_1	159	163	PF00917	0.656
DOC_USP7_MATH_1	193	197	PF00917	0.751
DOC_USP7_MATH_1	198	202	PF00917	0.707
DOC_USP7_MATH_1	205	209	PF00917	0.630
DOC_USP7_MATH_1	235	239	PF00917	0.496
DOC_USP7_MATH_1	258	262	PF00917	0.547
DOC_USP7_MATH_1	271	275	PF00917	0.401
DOC_USP7_MATH_1	319	323	PF00917	0.496
DOC_USP7_MATH_1	454	458	PF00917	0.706
DOC_USP7_MATH_1	74	78	PF00917	0.448
DOC_WW_Pin1_4	142	147	PF00397	0.802
DOC_WW_Pin1_4	174	179	PF00397	0.759
DOC_WW_Pin1_4	201	206	PF00397	0.774
DOC_WW_Pin1_4	352	357	PF00397	0.557
DOC_WW_Pin1_4	415	420	PF00397	0.407
DOC_WW_Pin1_4	480	485	PF00397	0.474
DOC_WW_Pin1_4	490	495	PF00397	0.501
LIG_14-3-3_CanoR_1	129	133	PF00244	0.606
LIG_14-3-3_CanoR_1	213	217	PF00244	0.479
LIG_14-3-3_CanoR_1	486	491	PF00244	0.431
LIG_BIR_III_4	166	170	PF00653	0.642
LIG_BRCT_BRCA1_1	22	26	PF00533	0.489
LIG_BRCT_BRCA1_1	273	277	PF00533	0.536
LIG_eIF4E_1	106	112	PF01652	0.374
LIG_eIF4E_1	84	90	PF01652	0.420
LIG_FHA_1	137	143	PF00498	0.704
LIG_FHA_1	226	232	PF00498	0.458
LIG_FHA_1	291	297	PF00498	0.555
LIG_FHA_1	303	309	PF00498	0.350
LIG_FHA_1	471	477	PF00498	0.361
LIG_FHA_1	497	503	PF00498	0.406
LIG_FHA_1	86	92	PF00498	0.512
LIG_FHA_2	108	114	PF00498	0.377
LIG_FHA_2	132	138	PF00498	0.742
LIG_FHA_2	161	167	PF00498	0.743
LIG_FHA_2	47	53	PF00498	0.429
LIG_KLC1_Yacidic_2	430	435	PF13176	0.469
LIG_LIR_Gen_1	23	32	PF02991	0.452
LIG_LIR_Gen_1	274	285	PF02991	0.441
LIG_LIR_Gen_1	291	300	PF02991	0.458
LIG_LIR_Gen_1	303	312	PF02991	0.350
LIG_LIR_Gen_1	411	419	PF02991	0.425
LIG_LIR_LC3C_4	87	92	PF02991	0.275
LIG_LIR_Nem_3	23	29	PF02991	0.412
LIG_LIR_Nem_3	274	280	PF02991	0.457
LIG_LIR_Nem_3	291	295	PF02991	0.458
LIG_LIR_Nem_3	303	309	PF02991	0.474
LIG_LIR_Nem_3	361	366	PF02991	0.513
LIG_LIR_Nem_3	441	447	PF02991	0.550
LIG_LYPXL_yS_3	406	409	PF13949	0.350
LIG_SH2_CRK	292	296	PF00017	0.498
LIG_SH2_CRK	7	11	PF00017	0.403
LIG_SH2_SRC	444	447	PF00017	0.353
LIG_SH2_SRC	84	87	PF00017	0.413
LIG_SH2_STAP1	292	296	PF00017	0.536
LIG_SH2_STAT5	106	109	PF00017	0.502
LIG_SH2_STAT5	124	127	PF00017	0.288
LIG_SH2_STAT5	21	24	PF00017	0.310
LIG_SH2_STAT5	28	31	PF00017	0.355
LIG_SH2_STAT5	292	295	PF00017	0.461
LIG_SH2_STAT5	414	417	PF00017	0.417
LIG_SH2_STAT5	433	436	PF00017	0.331
LIG_SH2_STAT5	444	447	PF00017	0.440
LIG_SH2_STAT5	55	58	PF00017	0.422
LIG_SH2_STAT5	7	10	PF00017	0.467
LIG_SH3_3	172	178	PF00018	0.557
LIG_SH3_3	199	205	PF00018	0.570
LIG_SH3_3	350	356	PF00018	0.496
LIG_SH3_3	401	407	PF00018	0.482
LIG_SH3_3	440	446	PF00018	0.526
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.370
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.457
LIG_SUMO_SIM_anti_2	76	88	PF11976	0.484
LIG_SUMO_SIM_par_1	85	93	PF11976	0.489
LIG_TYR_ITIM	404	409	PF00017	0.350
LIG_UBA3_1	18	25	PF00899	0.483
LIG_UBA3_1	280	284	PF00899	0.281
LIG_WRC_WIRS_1	487	492	PF05994	0.383
LIG_WW_3	66	70	PF00397	0.466
MOD_CDC14_SPxK_1	483	486	PF00782	0.447
MOD_CDK_SPK_2	201	206	PF00069	0.513
MOD_CDK_SPK_2	352	357	PF00069	0.210
MOD_CDK_SPxK_1	415	421	PF00069	0.471
MOD_CDK_SPxK_1	480	486	PF00069	0.425
MOD_CDK_SPxxK_3	174	181	PF00069	0.721
MOD_CK1_1	127	133	PF00069	0.555
MOD_CK1_1	177	183	PF00069	0.655
MOD_CK1_1	201	207	PF00069	0.568
MOD_CK1_1	240	246	PF00069	0.333
MOD_CK1_1	457	463	PF00069	0.564
MOD_CK2_1	107	113	PF00069	0.438
MOD_CK2_1	131	137	PF00069	0.612
MOD_CK2_1	243	249	PF00069	0.334
MOD_CK2_1	352	358	PF00069	0.210
MOD_GlcNHglycan	166	170	PF01048	0.705
MOD_GlcNHglycan	195	198	PF01048	0.766
MOD_GlcNHglycan	227	231	PF01048	0.305
MOD_GlcNHglycan	239	242	PF01048	0.383
MOD_GlcNHglycan	448	454	PF01048	0.567
MOD_GlcNHglycan	459	462	PF01048	0.437
MOD_GSK3_1	124	131	PF00069	0.525
MOD_GSK3_1	132	139	PF00069	0.713
MOD_GSK3_1	140	147	PF00069	0.720
MOD_GSK3_1	173	180	PF00069	0.747
MOD_GSK3_1	20	27	PF00069	0.490
MOD_GSK3_1	201	208	PF00069	0.678
MOD_GSK3_1	284	291	PF00069	0.384
MOD_GSK3_1	486	493	PF00069	0.441
MOD_NEK2_1	165	170	PF00069	0.745
MOD_NEK2_1	343	348	PF00069	0.422
MOD_NEK2_1	366	371	PF00069	0.393
MOD_NEK2_1	380	385	PF00069	0.287
MOD_NEK2_1	413	418	PF00069	0.420
MOD_NEK2_1	470	475	PF00069	0.410
MOD_NEK2_1	90	95	PF00069	0.448
MOD_PIKK_1	243	249	PF00454	0.220
MOD_PIKK_1	325	331	PF00454	0.432
MOD_PK_1	284	290	PF00069	0.306
MOD_PKA_1	117	123	PF00069	0.378
MOD_PKA_2	117	123	PF00069	0.541
MOD_PKA_2	128	134	PF00069	0.645
MOD_PKA_2	212	218	PF00069	0.302
MOD_Plk_1	107	113	PF00069	0.432
MOD_Plk_1	14	20	PF00069	0.440
MOD_Plk_1	302	308	PF00069	0.480
MOD_Plk_1	41	47	PF00069	0.515
MOD_Plk_1	84	90	PF00069	0.491
MOD_Plk_4	107	113	PF00069	0.404
MOD_Plk_4	14	20	PF00069	0.443
MOD_Plk_4	302	308	PF00069	0.382
MOD_Plk_4	486	492	PF00069	0.487
MOD_Plk_4	51	57	PF00069	0.490
MOD_Plk_4	85	91	PF00069	0.455
MOD_ProDKin_1	142	148	PF00069	0.802
MOD_ProDKin_1	174	180	PF00069	0.760
MOD_ProDKin_1	201	207	PF00069	0.774
MOD_ProDKin_1	352	358	PF00069	0.440
MOD_ProDKin_1	415	421	PF00069	0.413
MOD_ProDKin_1	480	486	PF00069	0.474
MOD_ProDKin_1	490	496	PF00069	0.508
TRG_DiLeu_BaEn_1	85	90	PF01217	0.421
TRG_DiLeu_BaEn_2	301	307	PF01217	0.322
TRG_ENDOCYTIC_2	292	295	PF00928	0.279
TRG_ENDOCYTIC_2	406	409	PF00928	0.350
TRG_ENDOCYTIC_2	414	417	PF00928	0.410
TRG_ENDOCYTIC_2	444	447	PF00928	0.353
TRG_ER_diArg_1	115	118	PF00400	0.400
TRG_ER_diArg_1	181	183	PF00400	0.775
TRG_ER_diArg_1	370	373	PF00400	0.294
TRG_ER_diArg_1	436	439	PF00400	0.504
TRG_ER_diArg_1	9	12	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME7	Leptomonas seymouri	50%	99%
A0A0S4JCR9	Bodo saltans	29%	85%
A0A3Q8IFN9	Leishmania donovani	90%	95%
A0A3R7MB50	Trypanosoma rangeli	37%	100%
A4HIC8	Leishmania braziliensis	76%	95%
A4I5M1	Leishmania infantum	90%	95%
C9ZQZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B0W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	95%
V5DQK8	Trypanosoma cruzi	38%	100%