C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2H2 type zinc-finger (2 copies), putative

Species:

Leishmania major

UniProt:

Q4Q797_LEIMA

TriTrypDb:

LmjF.30.1980 , LMJLV39_300026300 , LMJSD75_300026100

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q797

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q797

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.660
CLV_C14_Caspase3-7	279	283	PF00656	0.417
CLV_C14_Caspase3-7	90	94	PF00656	0.420
CLV_MEL_PAP_1	274	280	PF00089	0.497
CLV_NRD_NRD_1	218	220	PF00675	0.302
CLV_NRD_NRD_1	236	238	PF00675	0.142
CLV_NRD_NRD_1	276	278	PF00675	0.440
CLV_PCSK_KEX2_1	218	220	PF00082	0.311
CLV_PCSK_KEX2_1	236	238	PF00082	0.311
CLV_PCSK_KEX2_1	276	278	PF00082	0.440
CLV_PCSK_SKI1_1	10	14	PF00082	0.452
CLV_PCSK_SKI1_1	259	263	PF00082	0.311
DEG_COP1_1	309	321	PF00400	0.526
DOC_USP7_MATH_1	238	242	PF00917	0.553
DOC_USP7_MATH_1	326	330	PF00917	0.523
DOC_USP7_MATH_1	91	95	PF00917	0.485
DOC_USP7_UBL2_3	6	10	PF12436	0.498
DOC_WW_Pin1_4	147	152	PF00397	0.579
DOC_WW_Pin1_4	74	79	PF00397	0.491
LIG_14-3-3_CanoR_1	213	217	PF00244	0.471
LIG_14-3-3_CanoR_1	237	246	PF00244	0.506
LIG_14-3-3_CanoR_1	276	286	PF00244	0.515
LIG_14-3-3_CanoR_1	330	338	PF00244	0.538
LIG_APCC_ABBA_1	189	194	PF00400	0.386
LIG_APCC_ABBA_1	266	271	PF00400	0.368
LIG_APCC_ABBAyCdc20_2	219	225	PF00400	0.471
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_FHA_2	164	170	PF00498	0.677
LIG_FHA_2	298	304	PF00498	0.504
LIG_FHA_2	306	312	PF00498	0.507
LIG_FHA_2	318	324	PF00498	0.486
LIG_FHA_2	88	94	PF00498	0.471
LIG_Integrin_RGD_1	158	160	PF01839	0.603
LIG_LIR_Gen_1	224	234	PF02991	0.447
LIG_LIR_Gen_1	292	299	PF02991	0.456
LIG_LIR_Nem_3	167	173	PF02991	0.607
LIG_LIR_Nem_3	22	27	PF02991	0.376
LIG_LIR_Nem_3	224	229	PF02991	0.458
LIG_LIR_Nem_3	312	318	PF02991	0.466
LIG_MAD2	135	143	PF02301	0.476
LIG_NRBOX	66	72	PF00104	0.448
LIG_PCNA_PIPBox_1	36	45	PF02747	0.448
LIG_SH2_CRK	226	230	PF00017	0.417
LIG_SH2_STAT5	192	195	PF00017	0.487
LIG_SH3_3	126	132	PF00018	0.551
LIG_SH3_3	145	151	PF00018	0.422
LIG_SH3_3	284	290	PF00018	0.440
LIG_SH3_3	310	316	PF00018	0.515
LIG_SH3_3	55	61	PF00018	0.471
LIG_SH3_3	72	78	PF00018	0.347
LIG_TRAF2_1	161	164	PF00917	0.715
LIG_TRAF2_1	308	311	PF00917	0.613
LIG_TRAF2_1	320	323	PF00917	0.510
MOD_CK1_1	127	133	PF00069	0.658
MOD_CK1_1	73	79	PF00069	0.523
MOD_CK1_1	94	100	PF00069	0.519
MOD_CK2_1	163	169	PF00069	0.667
MOD_CK2_1	297	303	PF00069	0.557
MOD_CK2_1	305	311	PF00069	0.560
MOD_CK2_1	317	323	PF00069	0.473
MOD_GlcNHglycan	126	129	PF01048	0.581
MOD_GlcNHglycan	194	198	PF01048	0.314
MOD_GlcNHglycan	300	303	PF01048	0.532
MOD_GlcNHglycan	93	96	PF01048	0.331
MOD_GSK3_1	142	149	PF00069	0.623
MOD_GSK3_1	293	300	PF00069	0.467
MOD_GSK3_1	334	341	PF00069	0.573
MOD_GSK3_1	66	73	PF00069	0.475
MOD_GSK3_1	87	94	PF00069	0.451
MOD_NEK2_1	137	142	PF00069	0.663
MOD_NEK2_1	212	217	PF00069	0.471
MOD_NEK2_1	297	302	PF00069	0.426
MOD_NEK2_1	5	10	PF00069	0.446
MOD_NEK2_1	70	75	PF00069	0.447
MOD_PIKK_1	27	33	PF00454	0.437
MOD_PKA_1	276	282	PF00069	0.448
MOD_PKA_2	212	218	PF00069	0.471
MOD_PKA_2	276	282	PF00069	0.520
MOD_Plk_2-3	163	169	PF00069	0.771
MOD_Plk_4	212	218	PF00069	0.519
MOD_Plk_4	66	72	PF00069	0.441
MOD_Plk_4	94	100	PF00069	0.463
MOD_ProDKin_1	147	153	PF00069	0.577
MOD_ProDKin_1	74	80	PF00069	0.491
MOD_SUMO_rev_2	163	173	PF00179	0.488
TRG_DiLeu_BaEn_3	22	28	PF01217	0.305
TRG_ENDOCYTIC_2	226	229	PF00928	0.417
TRG_ER_diArg_1	217	219	PF00400	0.514
TRG_ER_diArg_1	235	237	PF00400	0.549
TRG_ER_diArg_1	275	277	PF00400	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N5	Leptomonas seymouri	55%	100%
A0A0S4JM68	Bodo saltans	31%	100%
A0A3Q8IJF7	Leishmania donovani	95%	100%
A0A422P3H1	Trypanosoma rangeli	37%	100%
A4HID1	Leishmania braziliensis	78%	100%
A4I5M4	Leishmania infantum	95%	100%
C9ZQZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B0W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9W1V7	Drosophila melanogaster	25%	75%
V5BYU5	Trypanosoma cruzi	38%	100%