Ferric reductase transmembrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein-like protein

Species:

Leishmania major

UniProt:

Q4Q789_LEIMA

TriTrypDb:

LmjF.30.2050 , LMJLV39_300027100 , LMJSD75_300027000

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q789

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q789

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	11
GO:0020037	heme binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140575	transmembrane monodehydroascorbate reductase activity	3	11
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.295
CLV_NRD_NRD_1	45	47	PF00675	0.462
CLV_NRD_NRD_1	85	87	PF00675	0.354
CLV_PCSK_KEX2_1	167	169	PF00082	0.370
CLV_PCSK_KEX2_1	29	31	PF00082	0.295
CLV_PCSK_KEX2_1	85	87	PF00082	0.364
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.370
CLV_PCSK_PC7_1	81	87	PF00082	0.321
CLV_PCSK_SKI1_1	158	162	PF00082	0.389
CLV_PCSK_SKI1_1	75	79	PF00082	0.259
DOC_MAPK_gen_1	29	36	PF00069	0.560
DOC_MAPK_MEF2A_6	176	184	PF00069	0.496
DOC_MAPK_MEF2A_6	29	38	PF00069	0.549
DOC_PP1_SILK_1	154	159	PF00149	0.390
DOC_USP7_MATH_1	18	22	PF00917	0.633
DOC_WW_Pin1_4	84	89	PF00397	0.553
LIG_Actin_WH2_2	144	160	PF00022	0.390
LIG_Actin_WH2_2	67	83	PF00022	0.477
LIG_EH1_1	57	65	PF00400	0.368
LIG_FHA_1	179	185	PF00498	0.406
LIG_FHA_1	209	215	PF00498	0.493
LIG_FHA_2	2	8	PF00498	0.746
LIG_FHA_2	48	54	PF00498	0.317
LIG_LIR_Gen_1	121	130	PF02991	0.313
LIG_LIR_Gen_1	48	59	PF02991	0.326
LIG_LIR_Nem_3	121	125	PF02991	0.335
LIG_LIR_Nem_3	48	54	PF02991	0.328
LIG_LYPXL_yS_3	129	132	PF13949	0.321
LIG_SH2_CRK	122	126	PF00017	0.385
LIG_SH2_CRK	57	61	PF00017	0.282
LIG_SH2_NCK_1	51	55	PF00017	0.343
LIG_SH2_STAP1	199	203	PF00017	0.404
LIG_SH2_STAP1	51	55	PF00017	0.343
LIG_SH2_STAT5	122	125	PF00017	0.381
LIG_SH2_STAT5	159	162	PF00017	0.563
LIG_SH2_STAT5	51	54	PF00017	0.433
LIG_SH3_2	163	168	PF14604	0.584
LIG_SH3_3	157	163	PF00018	0.574
LIG_SUMO_SIM_par_1	179	185	PF11976	0.355
LIG_TRFH_1	159	163	PF08558	0.447
LIG_TYR_ITIM	120	125	PF00017	0.477
LIG_WRC_WIRS_1	104	109	PF05994	0.477
MOD_CDC14_SPxK_1	87	90	PF00782	0.346
MOD_CDK_SPxK_1	84	90	PF00069	0.346
MOD_CK1_1	10	16	PF00069	0.573
MOD_CK1_1	217	223	PF00069	0.390
MOD_GlcNHglycan	47	50	PF01048	0.539
MOD_GSK3_1	178	185	PF00069	0.391
MOD_GSK3_1	204	211	PF00069	0.473
MOD_GSK3_1	213	220	PF00069	0.330
MOD_GSK3_1	45	52	PF00069	0.498
MOD_NEK2_1	1	6	PF00069	0.672
MOD_NEK2_1	208	213	PF00069	0.393
MOD_NEK2_1	45	50	PF00069	0.501
MOD_PK_1	176	182	PF00069	0.480
MOD_PKA_2	45	51	PF00069	0.509
MOD_Plk_1	7	13	PF00069	0.709
MOD_Plk_4	103	109	PF00069	0.390
MOD_Plk_4	143	149	PF00069	0.456
MOD_Plk_4	152	158	PF00069	0.150
MOD_Plk_4	18	24	PF00069	0.597
MOD_Plk_4	204	210	PF00069	0.409
MOD_ProDKin_1	84	90	PF00069	0.434
MOD_SUMO_rev_2	72	80	PF00179	0.390
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.356
TRG_ENDOCYTIC_2	122	125	PF00928	0.453
TRG_ENDOCYTIC_2	129	132	PF00928	0.477
TRG_ENDOCYTIC_2	51	54	PF00928	0.421
TRG_ENDOCYTIC_2	57	60	PF00928	0.317
TRG_ER_diArg_1	29	31	PF00400	0.354
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNM4	Bodo saltans	26%	95%
A0A1X0P2F3	Trypanosomatidae	27%	92%
A0A3Q8IC17	Leishmania donovani	89%	100%
A0A3R7RSY6	Trypanosoma rangeli	29%	94%
A4HID6	Leishmania braziliensis	68%	97%
A4I5N2	Leishmania infantum	84%	100%
C9ZR03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
E9B0X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BPF8	Trypanosoma cruzi	26%	95%