ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q788_LEIMA

TriTrypDb:

LmjF.30.2060 , LMJLV39_300027200 , LMJSD75_300027100

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q788

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q788

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.546
CLV_C14_Caspase3-7	302	306	PF00656	0.492
CLV_C14_Caspase3-7	317	321	PF00656	0.526
CLV_C14_Caspase3-7	364	368	PF00656	0.545
CLV_C14_Caspase3-7	369	373	PF00656	0.493
CLV_C14_Caspase3-7	394	398	PF00656	0.545
CLV_C14_Caspase3-7	834	838	PF00656	0.444
CLV_NRD_NRD_1	137	139	PF00675	0.727
CLV_NRD_NRD_1	160	162	PF00675	0.782
CLV_NRD_NRD_1	282	284	PF00675	0.747
CLV_NRD_NRD_1	338	340	PF00675	0.746
CLV_NRD_NRD_1	431	433	PF00675	0.686
CLV_NRD_NRD_1	628	630	PF00675	0.731
CLV_NRD_NRD_1	841	843	PF00675	0.719
CLV_NRD_NRD_1	864	866	PF00675	0.669
CLV_NRD_NRD_1	933	935	PF00675	0.511
CLV_PCSK_KEX2_1	137	139	PF00082	0.727
CLV_PCSK_KEX2_1	160	162	PF00082	0.782
CLV_PCSK_KEX2_1	282	284	PF00082	0.803
CLV_PCSK_KEX2_1	338	340	PF00082	0.746
CLV_PCSK_KEX2_1	431	433	PF00082	0.686
CLV_PCSK_KEX2_1	628	630	PF00082	0.682
CLV_PCSK_KEX2_1	863	865	PF00082	0.682
CLV_PCSK_KEX2_1	906	908	PF00082	0.735
CLV_PCSK_KEX2_1	933	935	PF00082	0.511
CLV_PCSK_PC1ET2_1	906	908	PF00082	0.725
CLV_PCSK_PC7_1	334	340	PF00082	0.746
CLV_PCSK_SKI1_1	145	149	PF00082	0.702
CLV_PCSK_SKI1_1	184	188	PF00082	0.678
CLV_PCSK_SKI1_1	393	397	PF00082	0.762
CLV_PCSK_SKI1_1	432	436	PF00082	0.682
CLV_PCSK_SKI1_1	843	847	PF00082	0.712
CLV_PCSK_SKI1_1	865	869	PF00082	0.648
DEG_APCC_DBOX_1	933	941	PF00400	0.716
DEG_Nend_UBRbox_2	1	3	PF02207	0.475
DEG_SPOP_SBC_1	314	318	PF00917	0.482
DEG_SPOP_SBC_1	516	520	PF00917	0.521
DEG_SPOP_SBC_1	542	546	PF00917	0.444
DEG_SPOP_SBC_1	855	859	PF00917	0.609
DOC_CKS1_1	30	35	PF01111	0.518
DOC_CKS1_1	881	886	PF01111	0.511
DOC_CYCLIN_yCln2_LP_2	667	673	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	914	920	PF00134	0.411
DOC_MAPK_DCC_7	66	74	PF00069	0.566
DOC_MAPK_gen_1	282	291	PF00069	0.533
DOC_MAPK_gen_1	338	348	PF00069	0.476
DOC_MAPK_gen_1	863	871	PF00069	0.488
DOC_MAPK_gen_1	906	913	PF00069	0.519
DOC_MAPK_gen_1	933	939	PF00069	0.683
DOC_MAPK_MEF2A_6	66	74	PF00069	0.512
DOC_MAPK_MEF2A_6	863	871	PF00069	0.558
DOC_MAPK_MEF2A_6	94	103	PF00069	0.489
DOC_PP1_RVXF_1	286	292	PF00149	0.477
DOC_PP2B_LxvP_1	103	106	PF13499	0.568
DOC_PP2B_LxvP_1	67	70	PF13499	0.480
DOC_PP4_FxxP_1	30	33	PF00568	0.480
DOC_PP4_FxxP_1	34	37	PF00568	0.457
DOC_PP4_FxxP_1	852	855	PF00568	0.532
DOC_USP7_MATH_1	315	319	PF00917	0.646
DOC_USP7_MATH_1	377	381	PF00917	0.552
DOC_USP7_MATH_1	471	475	PF00917	0.495
DOC_USP7_MATH_1	517	521	PF00917	0.473
DOC_USP7_MATH_1	560	564	PF00917	0.527
DOC_USP7_MATH_1	585	589	PF00917	0.600
DOC_USP7_MATH_1	614	618	PF00917	0.459
DOC_USP7_MATH_1	741	745	PF00917	0.550
DOC_USP7_MATH_1	758	762	PF00917	0.588
DOC_USP7_MATH_1	763	767	PF00917	0.580
DOC_WW_Pin1_4	17	22	PF00397	0.595
DOC_WW_Pin1_4	214	219	PF00397	0.517
DOC_WW_Pin1_4	29	34	PF00397	0.538
DOC_WW_Pin1_4	322	327	PF00397	0.631
DOC_WW_Pin1_4	352	357	PF00397	0.607
DOC_WW_Pin1_4	370	375	PF00397	0.446
DOC_WW_Pin1_4	583	588	PF00397	0.543
DOC_WW_Pin1_4	733	738	PF00397	0.603
DOC_WW_Pin1_4	780	785	PF00397	0.595
DOC_WW_Pin1_4	829	834	PF00397	0.614
DOC_WW_Pin1_4	880	885	PF00397	0.491
DOC_WW_Pin1_4	913	918	PF00397	0.387
LIG_14-3-3_CanoR_1	114	120	PF00244	0.566
LIG_14-3-3_CanoR_1	137	143	PF00244	0.545
LIG_14-3-3_CanoR_1	254	260	PF00244	0.477
LIG_14-3-3_CanoR_1	262	267	PF00244	0.488
LIG_14-3-3_CanoR_1	288	294	PF00244	0.527
LIG_14-3-3_CanoR_1	393	402	PF00244	0.548
LIG_14-3-3_CanoR_1	431	435	PF00244	0.551
LIG_14-3-3_CanoR_1	457	461	PF00244	0.525
LIG_14-3-3_CanoR_1	762	771	PF00244	0.563
LIG_Actin_WH2_2	540	557	PF00022	0.443
LIG_Actin_WH2_2	749	767	PF00022	0.477
LIG_APCC_ABBA_1	187	192	PF00400	0.475
LIG_BIR_III_4	467	471	PF00653	0.497
LIG_BIR_III_4	837	841	PF00653	0.435
LIG_BRCT_BRCA1_1	336	340	PF00533	0.461
LIG_BRCT_BRCA1_1	498	502	PF00533	0.546
LIG_BRCT_BRCA1_1	881	885	PF00533	0.442
LIG_BRCT_BRCA1_1	915	919	PF00533	0.411
LIG_Clathr_ClatBox_1	478	482	PF01394	0.390
LIG_Clathr_ClatBox_1	592	596	PF01394	0.505
LIG_FHA_1	123	129	PF00498	0.561
LIG_FHA_1	390	396	PF00498	0.505
LIG_FHA_1	443	449	PF00498	0.472
LIG_FHA_1	457	463	PF00498	0.525
LIG_FHA_1	481	487	PF00498	0.468
LIG_FHA_1	549	555	PF00498	0.505
LIG_FHA_1	766	772	PF00498	0.579
LIG_FHA_1	856	862	PF00498	0.557
LIG_FHA_1	889	895	PF00498	0.482
LIG_FHA_1	924	930	PF00498	0.411
LIG_FHA_1	94	100	PF00498	0.504
LIG_FHA_2	315	321	PF00498	0.598
LIG_FHA_2	362	368	PF00498	0.599
LIG_FHA_2	392	398	PF00498	0.565
LIG_FHA_2	529	535	PF00498	0.552
LIG_FHA_2	578	584	PF00498	0.591
LIG_LIR_Apic_2	32	37	PF02991	0.437
LIG_LIR_Gen_1	261	271	PF02991	0.489
LIG_LIR_Gen_1	499	508	PF02991	0.466
LIG_LIR_LC3C_4	203	206	PF02991	0.551
LIG_LIR_Nem_3	24	30	PF02991	0.515
LIG_LIR_Nem_3	499	505	PF02991	0.472
LIG_LIR_Nem_3	565	571	PF02991	0.545
LIG_LIR_Nem_3	875	881	PF02991	0.472
LIG_LIR_Nem_3	916	922	PF02991	0.420
LIG_MYND_3	188	192	PF01753	0.479
LIG_PCNA_yPIPBox_3	527	539	PF02747	0.478
LIG_Pex14_2	30	34	PF04695	0.483
LIG_Pex14_2	671	675	PF04695	0.593
LIG_Pex14_2	83	87	PF04695	0.605
LIG_Pex14_2	848	852	PF04695	0.517
LIG_Pex14_2	919	923	PF04695	0.358
LIG_SH2_CRK	878	882	PF00017	0.459
LIG_SH2_SRC	496	499	PF00017	0.549
LIG_SH2_SRC	886	889	PF00017	0.437
LIG_SH2_STAP1	168	172	PF00017	0.461
LIG_SH2_STAP1	568	572	PF00017	0.492
LIG_SH2_STAP1	909	913	PF00017	0.363
LIG_SH2_STAT3	207	210	PF00017	0.497
LIG_SH2_STAT3	909	912	PF00017	0.336
LIG_SH2_STAT5	158	161	PF00017	0.488
LIG_SH2_STAT5	264	267	PF00017	0.533
LIG_SH2_STAT5	29	32	PF00017	0.555
LIG_SH2_STAT5	460	463	PF00017	0.455
LIG_SH2_STAT5	571	574	PF00017	0.518
LIG_SH2_STAT5	612	615	PF00017	0.504
LIG_SH2_STAT5	886	889	PF00017	0.511
LIG_SH3_3	350	356	PF00018	0.613
LIG_SH3_3	371	377	PF00018	0.582
LIG_SH3_3	731	737	PF00018	0.547
LIG_SH3_3	864	870	PF00018	0.567
LIG_SH3_3	878	884	PF00018	0.379
LIG_SH3_CIN85_PxpxPR_1	354	359	PF14604	0.557
LIG_SUMO_SIM_anti_2	396	404	PF11976	0.430
LIG_SUMO_SIM_anti_2	473	480	PF11976	0.484
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.469
LIG_SUMO_SIM_anti_2	518	526	PF11976	0.548
LIG_SUMO_SIM_anti_2	824	830	PF11976	0.534
LIG_SUMO_SIM_par_1	146	152	PF11976	0.489
LIG_SUMO_SIM_par_1	459	465	PF11976	0.485
LIG_SUMO_SIM_par_1	588	596	PF11976	0.583
LIG_SUMO_SIM_par_1	772	777	PF11976	0.587
LIG_TRAF2_1	21	24	PF00917	0.612
LIG_TRAF2_1	436	439	PF00917	0.545
LIG_TRAF2_1	531	534	PF00917	0.547
LIG_TRAF2_1	796	799	PF00917	0.481
LIG_UBA3_1	259	268	PF00899	0.489
MOD_CDK_SPK_2	322	327	PF00069	0.607
MOD_CDK_SPK_2	370	375	PF00069	0.578
MOD_CDK_SPxxK_3	214	221	PF00069	0.517
MOD_CDK_SPxxK_3	322	329	PF00069	0.638
MOD_CDK_SPxxK_3	352	359	PF00069	0.554
MOD_CK1_1	117	123	PF00069	0.391
MOD_CK1_1	214	220	PF00069	0.591
MOD_CK1_1	284	290	PF00069	0.530
MOD_CK1_1	3	9	PF00069	0.512
MOD_CK1_1	325	331	PF00069	0.598
MOD_CK1_1	368	374	PF00069	0.523
MOD_CK1_1	398	404	PF00069	0.426
MOD_CK1_1	451	457	PF00069	0.500
MOD_CK1_1	520	526	PF00069	0.525
MOD_CK1_1	537	543	PF00069	0.351
MOD_CK1_1	588	594	PF00069	0.586
MOD_CK1_1	617	623	PF00069	0.518
MOD_CK1_1	649	655	PF00069	0.598
MOD_CK1_1	766	772	PF00069	0.575
MOD_CK1_1	818	824	PF00069	0.588
MOD_CK1_1	92	98	PF00069	0.554
MOD_CK1_1	925	931	PF00069	0.397
MOD_CK2_1	370	376	PF00069	0.578
MOD_CK2_1	486	492	PF00069	0.500
MOD_CK2_1	528	534	PF00069	0.556
MOD_CK2_1	560	566	PF00069	0.537
MOD_CK2_1	577	583	PF00069	0.409
MOD_CK2_1	655	661	PF00069	0.543
MOD_CK2_1	702	708	PF00069	0.603
MOD_CK2_1	718	724	PF00069	0.572
MOD_Cter_Amidation	861	864	PF01082	0.802
MOD_Cter_Amidation	904	907	PF01082	0.712
MOD_GlcNHglycan	151	154	PF01048	0.675
MOD_GlcNHglycan	2	5	PF01048	0.798
MOD_GlcNHglycan	283	286	PF01048	0.642
MOD_GlcNHglycan	317	320	PF01048	0.850
MOD_GlcNHglycan	488	491	PF01048	0.691
MOD_GlcNHglycan	519	522	PF01048	0.711
MOD_GlcNHglycan	604	607	PF01048	0.713
MOD_GlcNHglycan	657	660	PF01048	0.837
MOD_GlcNHglycan	704	707	PF01048	0.804
MOD_GlcNHglycan	752	755	PF01048	0.768
MOD_GlcNHglycan	800	806	PF01048	0.791
MOD_GlcNHglycan	817	820	PF01048	0.799
MOD_GlcNHglycan	833	836	PF01048	0.658
MOD_GlcNHglycan	901	904	PF01048	0.762
MOD_GSK3_1	137	144	PF00069	0.471
MOD_GSK3_1	258	265	PF00069	0.514
MOD_GSK3_1	315	322	PF00069	0.648
MOD_GSK3_1	361	368	PF00069	0.581
MOD_GSK3_1	389	396	PF00069	0.566
MOD_GSK3_1	412	419	PF00069	0.448
MOD_GSK3_1	516	523	PF00069	0.494
MOD_GSK3_1	534	541	PF00069	0.444
MOD_GSK3_1	651	658	PF00069	0.523
MOD_GSK3_1	673	680	PF00069	0.459
MOD_GSK3_1	741	748	PF00069	0.522
MOD_GSK3_1	763	770	PF00069	0.564
MOD_GSK3_1	780	787	PF00069	0.452
MOD_GSK3_1	89	96	PF00069	0.514
MOD_N-GLC_1	115	120	PF02516	0.762
MOD_N-GLC_1	655	660	PF02516	0.744
MOD_N-GLC_1	780	785	PF02516	0.795
MOD_N-GLC_1	923	928	PF02516	0.513
MOD_N-GLC_2	418	420	PF02516	0.658
MOD_NEK2_1	122	127	PF00069	0.490
MOD_NEK2_1	128	133	PF00069	0.482
MOD_NEK2_1	148	153	PF00069	0.320
MOD_NEK2_1	191	196	PF00069	0.467
MOD_NEK2_1	209	214	PF00069	0.501
MOD_NEK2_1	289	294	PF00069	0.500
MOD_NEK2_1	391	396	PF00069	0.502
MOD_NEK2_1	416	421	PF00069	0.432
MOD_NEK2_1	448	453	PF00069	0.514
MOD_NEK2_1	486	491	PF00069	0.490
MOD_NEK2_1	515	520	PF00069	0.479
MOD_NEK2_1	538	543	PF00069	0.460
MOD_NEK2_1	643	648	PF00069	0.568
MOD_NEK2_1	651	656	PF00069	0.507
MOD_NEK2_1	677	682	PF00069	0.571
MOD_NEK2_1	764	769	PF00069	0.552
MOD_NEK2_1	922	927	PF00069	0.415
MOD_NEK2_2	377	382	PF00069	0.618
MOD_NEK2_2	673	678	PF00069	0.523
MOD_PIKK_1	320	326	PF00454	0.484
MOD_PIKK_1	506	512	PF00454	0.416
MOD_PIKK_1	528	534	PF00454	0.556
MOD_PIKK_1	643	649	PF00454	0.624
MOD_PKA_1	137	143	PF00069	0.545
MOD_PKA_2	137	143	PF00069	0.545
MOD_PKA_2	281	287	PF00069	0.548
MOD_PKA_2	365	371	PF00069	0.475
MOD_PKA_2	430	436	PF00069	0.553
MOD_PKA_2	456	462	PF00069	0.528
MOD_PKA_2	602	608	PF00069	0.516
MOD_PKA_2	677	683	PF00069	0.499
MOD_PKA_2	764	770	PF00069	0.628
MOD_Plk_1	101	107	PF00069	0.551
MOD_Plk_1	115	121	PF00069	0.400
MOD_Plk_1	191	197	PF00069	0.476
MOD_Plk_1	366	372	PF00069	0.585
MOD_Plk_1	377	383	PF00069	0.530
MOD_Plk_1	412	418	PF00069	0.429
MOD_Plk_1	57	63	PF00069	0.500
MOD_Plk_1	588	594	PF00069	0.513
MOD_Plk_1	673	679	PF00069	0.520
MOD_Plk_1	741	747	PF00069	0.514
MOD_Plk_1	821	827	PF00069	0.611
MOD_Plk_1	923	929	PF00069	0.513
MOD_Plk_2-3	480	486	PF00069	0.484
MOD_Plk_2-3	713	719	PF00069	0.649
MOD_Plk_4	117	123	PF00069	0.468
MOD_Plk_4	128	134	PF00069	0.411
MOD_Plk_4	138	144	PF00069	0.432
MOD_Plk_4	255	261	PF00069	0.477
MOD_Plk_4	262	268	PF00069	0.492
MOD_Plk_4	395	401	PF00069	0.468
MOD_Plk_4	448	454	PF00069	0.500
MOD_Plk_4	456	462	PF00069	0.456
MOD_Plk_4	520	526	PF00069	0.536
MOD_Plk_4	534	540	PF00069	0.434
MOD_Plk_4	549	555	PF00069	0.433
MOD_Plk_4	588	594	PF00069	0.513
MOD_Plk_4	821	827	PF00069	0.586
MOD_Plk_4	890	896	PF00069	0.483
MOD_Plk_4	925	931	PF00069	0.495
MOD_ProDKin_1	17	23	PF00069	0.595
MOD_ProDKin_1	214	220	PF00069	0.518
MOD_ProDKin_1	29	35	PF00069	0.537
MOD_ProDKin_1	322	328	PF00069	0.631
MOD_ProDKin_1	352	358	PF00069	0.606
MOD_ProDKin_1	370	376	PF00069	0.446
MOD_ProDKin_1	583	589	PF00069	0.542
MOD_ProDKin_1	733	739	PF00069	0.606
MOD_ProDKin_1	780	786	PF00069	0.595
MOD_ProDKin_1	829	835	PF00069	0.612
MOD_ProDKin_1	880	886	PF00069	0.488
MOD_ProDKin_1	913	919	PF00069	0.387
MOD_SUMO_for_1	232	235	PF00179	0.467
TRG_DiLeu_BaEn_1	192	197	PF01217	0.480
TRG_DiLeu_BaEn_1	439	444	PF01217	0.464
TRG_DiLeu_BaEn_1	482	487	PF01217	0.463
TRG_DiLeu_LyEn_5	192	197	PF01217	0.480
TRG_ENDOCYTIC_2	264	267	PF00928	0.533
TRG_ENDOCYTIC_2	612	615	PF00928	0.504
TRG_ENDOCYTIC_2	878	881	PF00928	0.495
TRG_ER_diArg_1	136	138	PF00400	0.548
TRG_ER_diArg_1	159	161	PF00400	0.581
TRG_ER_diArg_1	193	196	PF00400	0.443
TRG_ER_diArg_1	286	289	PF00400	0.532
TRG_ER_diArg_1	296	299	PF00400	0.488
TRG_ER_diArg_1	326	329	PF00400	0.616
TRG_ER_diArg_1	338	340	PF00400	0.412
TRG_ER_diArg_1	572	575	PF00400	0.500
TRG_ER_diArg_1	863	865	PF00400	0.482
TRG_ER_diArg_1	933	935	PF00400	0.685
TRG_NES_CRM1_1	590	602	PF08389	0.576
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N8	Leptomonas seymouri	48%	81%
A0A3S7X3H1	Leishmania donovani	88%	100%
A4HID7	Leishmania braziliensis	75%	78%
A4I5N4	Leishmania infantum	88%	78%
E9B0X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%