AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q785_LEIMA

TriTrypDb:

LmjF.30.2080 , LMJLV39_300027500 , LMJSD75_300027400

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q785

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q785

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	211	217	PF00089	0.269
CLV_NRD_NRD_1	289	291	PF00675	0.269
CLV_NRD_NRD_1	374	376	PF00675	0.411
CLV_NRD_NRD_1	453	455	PF00675	0.586
CLV_NRD_NRD_1	524	526	PF00675	0.649
CLV_NRD_NRD_1	534	536	PF00675	0.567
CLV_PCSK_FUR_1	287	291	PF00082	0.269
CLV_PCSK_KEX2_1	11	13	PF00082	0.469
CLV_PCSK_KEX2_1	289	291	PF00082	0.269
CLV_PCSK_KEX2_1	374	376	PF00082	0.411
CLV_PCSK_KEX2_1	455	457	PF00082	0.504
CLV_PCSK_KEX2_1	507	509	PF00082	0.652
CLV_PCSK_KEX2_1	524	526	PF00082	0.667
CLV_PCSK_KEX2_1	534	536	PF00082	0.585
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.480
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.552
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.522
CLV_PCSK_SKI1_1	224	228	PF00082	0.391
CLV_PCSK_SKI1_1	382	386	PF00082	0.385
CLV_PCSK_SKI1_1	456	460	PF00082	0.490
DEG_APCC_DBOX_1	231	239	PF00400	0.337
DEG_MDM2_SWIB_1	74	81	PF02201	0.459
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DEG_SCF_FBW7_1	260	266	PF00400	0.314
DEG_SPOP_SBC_1	18	22	PF00917	0.650
DEG_SPOP_SBC_1	34	38	PF00917	0.655
DOC_ANK_TNKS_1	181	188	PF00023	0.453
DOC_CKS1_1	260	265	PF01111	0.314
DOC_CYCLIN_RxL_1	443	453	PF00134	0.445
DOC_MAPK_gen_1	100	109	PF00069	0.399
DOC_MAPK_gen_1	11	18	PF00069	0.552
DOC_MAPK_gen_1	202	211	PF00069	0.363
DOC_MAPK_HePTP_8	399	411	PF00069	0.383
DOC_MAPK_MEF2A_6	11	18	PF00069	0.474
DOC_MAPK_MEF2A_6	204	213	PF00069	0.352
DOC_MAPK_MEF2A_6	402	411	PF00069	0.379
DOC_PP2B_LxvP_1	165	168	PF13499	0.384
DOC_USP7_MATH_1	3	7	PF00917	0.692
DOC_USP7_MATH_1	34	38	PF00917	0.672
DOC_USP7_MATH_1	84	88	PF00917	0.498
DOC_USP7_UBL2_3	455	459	PF12436	0.390
DOC_WW_Pin1_4	259	264	PF00397	0.444
DOC_WW_Pin1_4	308	313	PF00397	0.324
DOC_WW_Pin1_4	388	393	PF00397	0.356
LIG_14-3-3_CanoR_1	128	137	PF00244	0.575
LIG_14-3-3_CanoR_1	197	201	PF00244	0.419
LIG_14-3-3_CanoR_1	264	268	PF00244	0.376
LIG_14-3-3_CanoR_1	387	392	PF00244	0.415
LIG_14-3-3_CanoR_1	535	544	PF00244	0.580
LIG_14-3-3_CanoR_1	66	74	PF00244	0.502
LIG_Actin_WH2_2	11	29	PF00022	0.578
LIG_Actin_WH2_2	113	130	PF00022	0.377
LIG_APCC_ABBA_1	448	453	PF00400	0.475
LIG_BRCT_BRCA1_1	389	393	PF00533	0.406
LIG_CaM_IQ_9	288	303	PF13499	0.395
LIG_FHA_1	11	17	PF00498	0.533
LIG_FHA_1	114	120	PF00498	0.420
LIG_FHA_1	168	174	PF00498	0.427
LIG_FHA_1	210	216	PF00498	0.279
LIG_FHA_1	244	250	PF00498	0.279
LIG_FHA_1	260	266	PF00498	0.269
LIG_FHA_2	138	144	PF00498	0.483
LIG_FHA_2	167	173	PF00498	0.495
LIG_FHA_2	264	270	PF00498	0.314
LIG_FHA_2	320	326	PF00498	0.283
LIG_FHA_2	381	387	PF00498	0.393
LIG_FHA_2	486	492	PF00498	0.764
LIG_FHA_2	537	543	PF00498	0.577
LIG_FHA_2	89	95	PF00498	0.515
LIG_LIR_Apic_2	386	392	PF02991	0.495
LIG_LIR_Apic_2	513	518	PF02991	0.586
LIG_LIR_Gen_1	136	147	PF02991	0.432
LIG_LIR_Gen_1	311	321	PF02991	0.291
LIG_LIR_Gen_1	390	401	PF02991	0.411
LIG_LIR_Gen_1	491	498	PF02991	0.766
LIG_LIR_Gen_1	76	86	PF02991	0.421
LIG_LIR_Nem_3	103	107	PF02991	0.380
LIG_LIR_Nem_3	136	142	PF02991	0.426
LIG_LIR_Nem_3	143	149	PF02991	0.246
LIG_LIR_Nem_3	311	317	PF02991	0.285
LIG_LIR_Nem_3	390	396	PF02991	0.338
LIG_LIR_Nem_3	491	497	PF02991	0.765
LIG_LIR_Nem_3	541	547	PF02991	0.613
LIG_LIR_Nem_3	76	81	PF02991	0.347
LIG_NRBOX	347	353	PF00104	0.269
LIG_Pex14_2	74	78	PF04695	0.452
LIG_SH2_CRK	389	393	PF00017	0.403
LIG_SH2_CRK	494	498	PF00017	0.651
LIG_SH2_CRK	515	519	PF00017	0.542
LIG_SH2_NCK_1	139	143	PF00017	0.406
LIG_SH2_NCK_1	389	393	PF00017	0.403
LIG_SH2_NCK_1	515	519	PF00017	0.609
LIG_SH2_PTP2	408	411	PF00017	0.368
LIG_SH2_SRC	218	221	PF00017	0.413
LIG_SH2_SRC	314	317	PF00017	0.303
LIG_SH2_SRC	408	411	PF00017	0.402
LIG_SH2_STAP1	113	117	PF00017	0.442
LIG_SH2_STAP1	494	498	PF00017	0.572
LIG_SH2_STAP1	85	89	PF00017	0.500
LIG_SH2_STAT5	139	142	PF00017	0.503
LIG_SH2_STAT5	175	178	PF00017	0.523
LIG_SH2_STAT5	218	221	PF00017	0.317
LIG_SH2_STAT5	284	287	PF00017	0.413
LIG_SH2_STAT5	314	317	PF00017	0.284
LIG_SH2_STAT5	408	411	PF00017	0.334
LIG_SH2_STAT5	460	463	PF00017	0.498
LIG_SH2_STAT5	494	497	PF00017	0.728
LIG_SH2_STAT5	50	53	PF00017	0.376
LIG_SH3_3	257	263	PF00018	0.328
LIG_Sin3_3	223	230	PF02671	0.284
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.284
LIG_SUMO_SIM_par_1	234	239	PF11976	0.269
LIG_TRAF2_1	321	324	PF00917	0.337
LIG_TRAF2_1	370	373	PF00917	0.403
LIG_UBA3_1	235	240	PF00899	0.339
LIG_UBA3_1	447	455	PF00899	0.456
LIG_WRC_WIRS_1	85	90	PF05994	0.436
MOD_CDK_SPK_2	259	264	PF00069	0.314
MOD_CK1_1	391	397	PF00069	0.438
MOD_CK1_1	49	55	PF00069	0.559
MOD_CK1_1	506	512	PF00069	0.757
MOD_CK1_1	6	12	PF00069	0.621
MOD_CK1_1	70	76	PF00069	0.376
MOD_CK2_1	109	115	PF00069	0.270
MOD_CK2_1	137	143	PF00069	0.409
MOD_CK2_1	18	24	PF00069	0.600
MOD_CK2_1	267	273	PF00069	0.306
MOD_CK2_1	319	325	PF00069	0.284
MOD_CK2_1	367	373	PF00069	0.421
MOD_CK2_1	380	386	PF00069	0.458
MOD_CK2_1	439	445	PF00069	0.526
MOD_CK2_1	485	491	PF00069	0.767
MOD_CK2_1	536	542	PF00069	0.563
MOD_CK2_1	84	90	PF00069	0.433
MOD_Cter_Amidation	522	525	PF01082	0.679
MOD_GlcNHglycan	157	160	PF01048	0.606
MOD_GlcNHglycan	37	40	PF01048	0.670
MOD_GlcNHglycan	43	46	PF01048	0.563
MOD_GlcNHglycan	435	439	PF01048	0.469
MOD_GlcNHglycan	482	485	PF01048	0.714
MOD_GlcNHglycan	521	524	PF01048	0.748
MOD_GlcNHglycan	69	72	PF01048	0.502
MOD_GlcNHglycan	75	78	PF01048	0.470
MOD_GSK3_1	109	116	PF00069	0.369
MOD_GSK3_1	129	136	PF00069	0.372
MOD_GSK3_1	2	9	PF00069	0.561
MOD_GSK3_1	259	266	PF00069	0.355
MOD_GSK3_1	387	394	PF00069	0.367
MOD_GSK3_1	475	482	PF00069	0.629
MOD_GSK3_1	506	513	PF00069	0.776
MOD_GSK3_1	69	76	PF00069	0.412
MOD_GSK3_1	84	91	PF00069	0.424
MOD_N-GLC_1	308	313	PF02516	0.284
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	109	114	PF00069	0.265
MOD_NEK2_1	209	214	PF00069	0.340
MOD_NEK2_1	236	241	PF00069	0.274
MOD_NEK2_1	243	248	PF00069	0.276
MOD_NEK2_1	339	344	PF00069	0.274
MOD_NEK2_1	380	385	PF00069	0.444
MOD_NEK2_1	46	51	PF00069	0.430
MOD_NEK2_2	113	118	PF00069	0.446
MOD_PIKK_1	129	135	PF00454	0.511
MOD_PIKK_1	330	336	PF00454	0.284
MOD_PKA_2	155	161	PF00069	0.430
MOD_PKA_2	196	202	PF00069	0.367
MOD_PKA_2	231	237	PF00069	0.413
MOD_PKA_2	263	269	PF00069	0.413
MOD_PKA_2	485	491	PF00069	0.761
MOD_PKA_2	536	542	PF00069	0.684
MOD_Plk_1	434	440	PF00069	0.365
MOD_Plk_1	46	52	PF00069	0.540
MOD_Plk_2-3	319	325	PF00069	0.413
MOD_Plk_4	118	124	PF00069	0.337
MOD_Plk_4	196	202	PF00069	0.414
MOD_Plk_4	231	237	PF00069	0.275
MOD_Plk_4	244	250	PF00069	0.248
MOD_Plk_4	263	269	PF00069	0.269
MOD_Plk_4	3	9	PF00069	0.602
MOD_Plk_4	380	386	PF00069	0.439
MOD_Plk_4	46	52	PF00069	0.540
MOD_Plk_4	492	498	PF00069	0.788
MOD_Plk_4	84	90	PF00069	0.561
MOD_ProDKin_1	259	265	PF00069	0.444
MOD_ProDKin_1	308	314	PF00069	0.324
MOD_ProDKin_1	388	394	PF00069	0.358
MOD_SUMO_rev_2	499	509	PF00179	0.579
MOD_SUMO_rev_2	540	550	PF00179	0.586
TRG_DiLeu_BaEn_1	115	120	PF01217	0.303
TRG_DiLeu_BaEn_1	435	440	PF01217	0.517
TRG_ENDOCYTIC_2	139	142	PF00928	0.503
TRG_ENDOCYTIC_2	314	317	PF00928	0.284
TRG_ENDOCYTIC_2	408	411	PF00928	0.309
TRG_ENDOCYTIC_2	494	497	PF00928	0.652
TRG_ENDOCYTIC_2	544	547	PF00928	0.636
TRG_ENDOCYTIC_2	85	88	PF00928	0.502
TRG_ER_diArg_1	201	204	PF00400	0.387
TRG_ER_diArg_1	287	290	PF00400	0.269
TRG_ER_diArg_1	374	377	PF00400	0.412
TRG_ER_diArg_1	524	526	PF00400	0.704
TRG_ER_diArg_1	534	537	PF00400	0.657
TRG_NLS_MonoExtC_3	454	459	PF00514	0.387
TRG_NLS_MonoExtN_4	454	460	PF00514	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P0	Leptomonas seymouri	65%	98%
A0A0S4JQC6	Bodo saltans	53%	100%
A0A1X0P383	Trypanosomatidae	58%	100%
A0A3Q8IFP8	Leishmania donovani	93%	100%
A0A422P3G0	Trypanosoma rangeli	62%	100%
A4HIE0	Leishmania braziliensis	81%	100%
A4I5N7	Leishmania infantum	93%	100%
C9ZR06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B0Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DQJ7	Trypanosoma cruzi	63%	94%