Putative alcohol dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alcohol dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4Q784_LEIMA

TriTrypDb:

LmjF.30.2090 , LMJLV39_300027700

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q784

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q784

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004022	alcohol dehydrogenase (NAD+) activity	6	6
GO:0005488	binding	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	7
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	7
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	5	6
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	396	398	PF00675	0.382
CLV_NRD_NRD_1	96	98	PF00675	0.214
CLV_PCSK_KEX2_1	396	398	PF00082	0.382
CLV_PCSK_SKI1_1	134	138	PF00082	0.336
CLV_PCSK_SKI1_1	198	202	PF00082	0.329
CLV_PCSK_SKI1_1	227	231	PF00082	0.284
CLV_PCSK_SKI1_1	45	49	PF00082	0.284
CLV_PCSK_SKI1_1	78	82	PF00082	0.353
DEG_APCC_DBOX_1	126	134	PF00400	0.262
DOC_CDC14_PxL_1	140	148	PF14671	0.353
DOC_CDC14_PxL_1	31	39	PF14671	0.353
DOC_CKS1_1	126	131	PF01111	0.262
DOC_CKS1_1	180	185	PF01111	0.284
DOC_CYCLIN_RxL_1	39	51	PF00134	0.298
DOC_MAPK_gen_1	170	176	PF00069	0.305
DOC_MAPK_gen_1	39	49	PF00069	0.353
DOC_MAPK_gen_1	68	76	PF00069	0.305
DOC_MAPK_gen_1	97	107	PF00069	0.284
DOC_MAPK_RevD_3	84	98	PF00069	0.232
DOC_PP1_RVXF_1	136	142	PF00149	0.284
DOC_PP1_RVXF_1	328	335	PF00149	0.232
DOC_PP2B_LxvP_1	194	197	PF13499	0.208
DOC_PP4_FxxP_1	180	183	PF00568	0.353
DOC_USP7_MATH_1	163	167	PF00917	0.404
DOC_USP7_MATH_1	2	6	PF00917	0.381
DOC_USP7_MATH_1	309	313	PF00917	0.387
DOC_USP7_MATH_1	353	357	PF00917	0.262
DOC_WW_Pin1_4	125	130	PF00397	0.290
DOC_WW_Pin1_4	179	184	PF00397	0.284
LIG_AP2alpha_2	178	180	PF02296	0.353
LIG_APCC_ABBA_1	74	79	PF00400	0.284
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BRCT_BRCA1_1	4	8	PF00533	0.369
LIG_Clathr_ClatBox_1	174	178	PF01394	0.305
LIG_EH_1	376	380	PF12763	0.305
LIG_EVH1_1	141	145	PF00568	0.353
LIG_FHA_1	11	17	PF00498	0.409
LIG_FHA_1	191	197	PF00498	0.262
LIG_FHA_1	208	214	PF00498	0.284
LIG_FHA_2	153	159	PF00498	0.353
LIG_LIR_Apic_2	178	183	PF02991	0.353
LIG_LIR_Gen_1	214	222	PF02991	0.329
LIG_LIR_LC3C_4	172	176	PF02991	0.305
LIG_LIR_Nem_3	214	219	PF02991	0.329
LIG_LIR_Nem_3	392	398	PF02991	0.379
LIG_MYND_1	179	183	PF01753	0.284
LIG_PCNA_PIPBox_1	233	242	PF02747	0.353
LIG_PTB_Apo_2	374	381	PF02174	0.284
LIG_PTB_Phospho_1	374	380	PF10480	0.284
LIG_SH2_CRK	216	220	PF00017	0.305
LIG_SH2_CRK	286	290	PF00017	0.284
LIG_SH2_CRK	380	384	PF00017	0.353
LIG_SH2_GRB2like	216	219	PF00017	0.284
LIG_SH2_GRB2like	292	295	PF00017	0.353
LIG_SH2_NCK_1	216	220	PF00017	0.305
LIG_SH2_SRC	292	295	PF00017	0.353
LIG_SH2_STAP1	216	220	PF00017	0.305
LIG_SH2_STAT5	103	106	PF00017	0.294
LIG_SH2_STAT5	15	18	PF00017	0.411
LIG_SH2_STAT5	216	219	PF00017	0.284
LIG_SH2_STAT5	239	242	PF00017	0.284
LIG_SH2_STAT5	261	264	PF00017	0.284
LIG_SH2_STAT5	292	295	PF00017	0.208
LIG_SH3_3	123	129	PF00018	0.271
LIG_SH3_3	136	142	PF00018	0.316
LIG_SH3_3	162	168	PF00018	0.353
LIG_SH3_3	173	179	PF00018	0.229
LIG_SH3_3	184	190	PF00018	0.284
LIG_SH3_3	29	35	PF00018	0.208
LIG_SH3_3	293	299	PF00018	0.399
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.305
LIG_SUMO_SIM_par_1	145	152	PF11976	0.284
LIG_TRAF2_1	359	362	PF00917	0.236
MOD_CK1_1	157	163	PF00069	0.304
MOD_CK2_1	152	158	PF00069	0.284
MOD_CK2_1	245	251	PF00069	0.416
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.262
MOD_GlcNHglycan	27	30	PF01048	0.467
MOD_GlcNHglycan	306	309	PF01048	0.274
MOD_GSK3_1	148	155	PF00069	0.284
MOD_GSK3_1	2	9	PF00069	0.376
MOD_N-GLC_2	99	101	PF02516	0.284
MOD_NEK2_1	192	197	PF00069	0.353
MOD_NEK2_1	257	262	PF00069	0.348
MOD_NEK2_1	265	270	PF00069	0.277
MOD_NEK2_1	304	309	PF00069	0.313
MOD_PIKK_1	22	28	PF00454	0.305
MOD_Plk_1	157	163	PF00069	0.284
MOD_Plk_1	90	96	PF00069	0.305
MOD_Plk_4	108	114	PF00069	0.284
MOD_Plk_4	11	17	PF00069	0.483
MOD_Plk_4	257	263	PF00069	0.353
MOD_Plk_4	90	96	PF00069	0.250
MOD_ProDKin_1	125	131	PF00069	0.290
MOD_ProDKin_1	179	185	PF00069	0.284
TRG_DiLeu_BaEn_3	362	368	PF01217	0.305
TRG_DiLeu_BaEn_4	90	96	PF01217	0.353
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.353
TRG_ENDOCYTIC_2	216	219	PF00928	0.284
TRG_ENDOCYTIC_2	222	225	PF00928	0.284
TRG_ENDOCYTIC_2	77	80	PF00928	0.353
TRG_ER_diArg_1	395	397	PF00400	0.377
TRG_NLS_MonoExtC_3	96	102	PF00514	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM0	Leptomonas seymouri	67%	98%
A0A0N1P9Y7	Leptomonas seymouri	35%	100%
A0A0S1X9S7	Thermococcus barophilus	29%	100%
A0A1X0P6U8	Trypanosomatidae	37%	100%
A0A3R7LCK2	Trypanosoma rangeli	34%	100%
A0A3S7X3G7	Leishmania donovani	95%	100%
A4HIE1	Leishmania braziliensis	80%	100%
A4I5N8	Leishmania infantum	95%	100%
A4IP64	Geobacillus thermodenitrificans (strain NG80-2)	34%	100%
A4ISB9	Geobacillus thermodenitrificans (strain NG80-2)	27%	100%
A6QP15	Bos taurus	28%	86%
A6ZTT5	Saccharomyces cerevisiae (strain YJM789)	34%	100%
A8WTJ7	Caenorhabditis briggsae	28%	86%
B1VB76	Citrobacter freundii	32%	100%
C5MRT8	Mycobacterium sp. (strain DSM 3803 / JC1)	35%	94%
E5Y946	Bilophila wadsworthia (strain 3_1_6)	26%	100%
E9B0Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F8DVL8	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	37%	100%
O05239	Bacillus subtilis (strain 168)	28%	100%
O05240	Bacillus subtilis (strain 168)	29%	100%
O30847	Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13)	24%	100%
O87612	Pseudomonas aeruginosa	24%	100%
P0A9S1	Escherichia coli (strain K12)	33%	100%
P0A9S2	Escherichia coli O157:H7	33%	100%
P0DJA2	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	37%	100%
P10127	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P13604	Clostridium saccharobutylicum	30%	100%
P27137	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	23%	100%
P31005	Bacillus methanolicus	36%	100%
P37686	Escherichia coli (strain K12)	38%	100%
P41795	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	37%	100%
P45513	Citrobacter freundii	38%	100%
P71017	Bacillus subtilis (strain 168)	36%	99%
P76553	Escherichia coli (strain K12)	34%	100%
Q04944	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	26%	100%
Q08B39	Xenopus laevis	29%	86%
Q09669	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	95%
Q17EN4	Aedes aegypti	28%	86%
Q24857	Entamoeba histolytica	23%	100%
Q28XT3	Drosophila pseudoobscura pseudoobscura	28%	86%
Q45072	Burkholderia cepacia	27%	100%
Q46856	Escherichia coli (strain K12)	28%	100%
Q4QQW3	Rattus norvegicus	28%	85%
Q53062	Rhodococcus erythropolis	35%	94%
Q54GJ7	Dictyostelium discoideum	27%	73%
Q59104	Cupriavidus necator	35%	100%
Q59477	Klebsiella pneumoniae	39%	100%
Q5RF11	Pongo abelii	29%	85%
Q6P371	Xenopus tropicalis	29%	86%
Q7Q547	Anopheles gambiae	29%	86%
Q8IWW8	Homo sapiens	31%	85%
Q8R0N6	Mus musculus	31%	86%
Q9RCG0	Amycolatopsis methanolica	34%	93%
Q9U2M4	Caenorhabditis elegans	28%	86%
Q9W265	Drosophila melanogaster	29%	86%
Q9XDN0	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	100%
V5BRQ8	Trypanosoma cruzi	37%	100%