Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q783_LEIMA

TriTrypDb:

LmjF.30.2100 , LMJLV39_300027900 , LMJSD75_300027700

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q783

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q783

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.523
CLV_C14_Caspase3-7	229	233	PF00656	0.493
CLV_MEL_PAP_1	172	178	PF00089	0.525
CLV_NRD_NRD_1	117	119	PF00675	0.572
CLV_NRD_NRD_1	126	128	PF00675	0.532
CLV_NRD_NRD_1	210	212	PF00675	0.472
CLV_NRD_NRD_1	345	347	PF00675	0.657
CLV_NRD_NRD_1	386	388	PF00675	0.629
CLV_NRD_NRD_1	75	77	PF00675	0.765
CLV_PCSK_KEX2_1	126	128	PF00082	0.559
CLV_PCSK_KEX2_1	345	347	PF00082	0.657
CLV_PCSK_KEX2_1	386	388	PF00082	0.629
CLV_PCSK_KEX2_1	427	429	PF00082	0.410
CLV_PCSK_KEX2_1	75	77	PF00082	0.771
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.410
CLV_PCSK_SKI1_1	244	248	PF00082	0.656
CLV_PCSK_SKI1_1	277	281	PF00082	0.557
CLV_PCSK_SKI1_1	427	431	PF00082	0.385
CLV_PCSK_SKI1_1	474	478	PF00082	0.506
DEG_APCC_DBOX_1	505	513	PF00400	0.460
DEG_MDM2_SWIB_1	260	267	PF02201	0.510
DOC_CYCLIN_RxL_1	424	432	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.494
DOC_MAPK_RevD_3	331	346	PF00069	0.546
DOC_MIT_MIM_1	502	512	PF04212	0.500
DOC_PP1_RVXF_1	328	335	PF00149	0.537
DOC_PP1_RVXF_1	415	422	PF00149	0.425
DOC_PP2B_LxvP_1	249	252	PF13499	0.534
DOC_PP4_FxxP_1	122	125	PF00568	0.670
DOC_PP4_FxxP_1	311	314	PF00568	0.539
DOC_PP4_FxxP_1	421	424	PF00568	0.386
DOC_SPAK_OSR1_1	330	334	PF12202	0.466
DOC_USP7_MATH_1	108	112	PF00917	0.756
DOC_USP7_MATH_1	216	220	PF00917	0.578
DOC_USP7_MATH_1	370	374	PF00917	0.677
DOC_USP7_MATH_1	385	389	PF00917	0.605
DOC_USP7_MATH_1	399	403	PF00917	0.706
DOC_USP7_MATH_1	412	416	PF00917	0.623
DOC_USP7_MATH_1	612	616	PF00917	0.591
DOC_USP7_MATH_1	64	68	PF00917	0.595
DOC_USP7_MATH_1	87	91	PF00917	0.645
DOC_WW_Pin1_4	103	108	PF00397	0.690
DOC_WW_Pin1_4	125	130	PF00397	0.621
DOC_WW_Pin1_4	162	167	PF00397	0.632
DOC_WW_Pin1_4	189	194	PF00397	0.675
DOC_WW_Pin1_4	203	208	PF00397	0.416
DOC_WW_Pin1_4	366	371	PF00397	0.797
DOC_WW_Pin1_4	38	43	PF00397	0.523
DOC_WW_Pin1_4	420	425	PF00397	0.500
DOC_WW_Pin1_4	58	63	PF00397	0.585
DOC_WW_Pin1_4	83	88	PF00397	0.678
LIG_14-3-3_CanoR_1	118	123	PF00244	0.543
LIG_14-3-3_CanoR_1	293	297	PF00244	0.570
LIG_14-3-3_CanoR_1	428	437	PF00244	0.399
LIG_14-3-3_CanoR_1	537	543	PF00244	0.528
LIG_14-3-3_CanoR_1	54	62	PF00244	0.616
LIG_14-3-3_CanoR_1	82	87	PF00244	0.695
LIG_14-3-3_CanoR_1	95	99	PF00244	0.657
LIG_BIR_II_1	1	5	PF00653	0.411
LIG_BIR_III_2	349	353	PF00653	0.595
LIG_BIR_III_4	230	234	PF00653	0.506
LIG_CaM_NSCaTE_8	52	59	PF13499	0.508
LIG_Clathr_ClatBox_1	266	270	PF01394	0.405
LIG_CSL_BTD_1	421	424	PF09270	0.485
LIG_deltaCOP1_diTrp_1	262	269	PF00928	0.497
LIG_deltaCOP1_diTrp_1	460	469	PF00928	0.417
LIG_eIF4E_1	17	23	PF01652	0.480
LIG_FHA_1	154	160	PF00498	0.613
LIG_FHA_1	342	348	PF00498	0.733
LIG_FHA_1	537	543	PF00498	0.490
LIG_FHA_1	61	67	PF00498	0.548
LIG_FHA_1	7	13	PF00498	0.447
LIG_FHA_2	16	22	PF00498	0.458
LIG_FHA_2	278	284	PF00498	0.556
LIG_Integrin_isoDGR_2	356	358	PF01839	0.700
LIG_LIR_Apic_2	121	125	PF02991	0.656
LIG_LIR_Apic_2	309	314	PF02991	0.534
LIG_LIR_Apic_2	418	424	PF02991	0.396
LIG_LIR_Gen_1	2	12	PF02991	0.486
LIG_LIR_Gen_1	27	37	PF02991	0.483
LIG_LIR_Gen_1	305	314	PF02991	0.539
LIG_LIR_Gen_1	475	483	PF02991	0.460
LIG_LIR_Gen_1	501	509	PF02991	0.501
LIG_LIR_Gen_1	589	597	PF02991	0.585
LIG_LIR_Nem_3	167	172	PF02991	0.611
LIG_LIR_Nem_3	2	8	PF02991	0.411
LIG_LIR_Nem_3	262	267	PF02991	0.502
LIG_LIR_Nem_3	27	33	PF02991	0.428
LIG_LIR_Nem_3	305	311	PF02991	0.537
LIG_LIR_Nem_3	475	480	PF02991	0.486
LIG_LIR_Nem_3	501	505	PF02991	0.427
LIG_LIR_Nem_3	589	594	PF02991	0.484
LIG_NBox_RRM_1	269	279	PF00076	0.527
LIG_Pex14_2	260	264	PF04695	0.532
LIG_SH2_SRC	591	594	PF00017	0.517
LIG_SH2_STAT5	138	141	PF00017	0.704
LIG_SH2_STAT5	17	20	PF00017	0.508
LIG_SH2_STAT5	24	27	PF00017	0.510
LIG_SH2_STAT5	633	636	PF00017	0.436
LIG_SH3_3	360	366	PF00018	0.733
LIG_SH3_3	392	398	PF00018	0.546
LIG_SH3_3	620	626	PF00018	0.437
LIG_SUMO_SIM_anti_2	26	35	PF11976	0.500
LIG_SUMO_SIM_anti_2	568	575	PF11976	0.440
LIG_SUMO_SIM_par_1	156	163	PF11976	0.622
LIG_SUMO_SIM_par_1	339	344	PF11976	0.570
LIG_SUMO_SIM_par_1	584	589	PF11976	0.506
LIG_TRAF2_1	252	255	PF00917	0.593
LIG_TRAF2_1	280	283	PF00917	0.613
LIG_TRAF2_1	452	455	PF00917	0.489
LIG_TRAF2_1	605	608	PF00917	0.524
LIG_WW_3	123	127	PF00397	0.607
MOD_CDC14_SPxK_1	128	131	PF00782	0.612
MOD_CDC14_SPxK_1	86	89	PF00782	0.533
MOD_CDK_SPxK_1	125	131	PF00069	0.628
MOD_CDK_SPxK_1	83	89	PF00069	0.534
MOD_CDK_SPxxK_3	420	427	PF00069	0.504
MOD_CK1_1	111	117	PF00069	0.749
MOD_CK1_1	15	21	PF00069	0.622
MOD_CK1_1	206	212	PF00069	0.493
MOD_CK1_1	26	32	PF00069	0.427
MOD_CK1_1	400	406	PF00069	0.604
MOD_CK1_1	415	421	PF00069	0.451
MOD_CK1_1	536	542	PF00069	0.446
MOD_CK1_1	615	621	PF00069	0.530
MOD_CK2_1	144	150	PF00069	0.615
MOD_CK2_1	151	157	PF00069	0.539
MOD_CK2_1	277	283	PF00069	0.643
MOD_CK2_1	333	339	PF00069	0.614
MOD_CK2_1	420	426	PF00069	0.424
MOD_CK2_1	586	592	PF00069	0.511
MOD_GlcNHglycan	1	4	PF01048	0.529
MOD_GlcNHglycan	14	17	PF01048	0.391
MOD_GlcNHglycan	146	149	PF01048	0.548
MOD_GlcNHglycan	186	189	PF01048	0.723
MOD_GlcNHglycan	218	221	PF01048	0.720
MOD_GlcNHglycan	236	239	PF01048	0.411
MOD_GlcNHglycan	372	375	PF01048	0.671
MOD_GlcNHglycan	56	59	PF01048	0.676
MOD_GlcNHglycan	574	577	PF01048	0.557
MOD_GlcNHglycan	588	591	PF01048	0.501
MOD_GlcNHglycan	598	602	PF01048	0.481
MOD_GlcNHglycan	66	69	PF01048	0.594
MOD_GlcNHglycan	90	93	PF01048	0.694
MOD_GSK3_1	108	115	PF00069	0.583
MOD_GSK3_1	180	187	PF00069	0.633
MOD_GSK3_1	189	196	PF00069	0.719
MOD_GSK3_1	366	373	PF00069	0.778
MOD_GSK3_1	399	406	PF00069	0.598
MOD_GSK3_1	54	61	PF00069	0.685
MOD_GSK3_1	62	69	PF00069	0.612
MOD_GSK3_1	77	84	PF00069	0.604
MOD_GSK3_1	94	101	PF00069	0.665
MOD_N-GLC_1	108	113	PF02516	0.751
MOD_N-GLC_2	567	569	PF02516	0.321
MOD_NEK2_1	12	17	PF00069	0.500
MOD_NEK2_1	179	184	PF00069	0.647
MOD_NEK2_1	223	228	PF00069	0.612
MOD_NEK2_1	234	239	PF00069	0.491
MOD_NEK2_1	429	434	PF00069	0.377
MOD_NEK2_1	531	536	PF00069	0.442
MOD_NEK2_1	572	577	PF00069	0.436
MOD_PIKK_1	438	444	PF00454	0.529
MOD_PIKK_1	467	473	PF00454	0.478
MOD_PIKK_1	485	491	PF00454	0.352
MOD_PKA_1	118	124	PF00069	0.529
MOD_PKA_2	174	180	PF00069	0.588
MOD_PKA_2	184	190	PF00069	0.562
MOD_PKA_2	292	298	PF00069	0.572
MOD_PKA_2	357	363	PF00069	0.698
MOD_PKA_2	385	391	PF00069	0.707
MOD_PKA_2	400	406	PF00069	0.619
MOD_PKA_2	536	542	PF00069	0.522
MOD_PKA_2	6	12	PF00069	0.465
MOD_PKA_2	81	87	PF00069	0.662
MOD_PKA_2	88	94	PF00069	0.625
MOD_Plk_1	108	114	PF00069	0.733
MOD_Plk_1	244	250	PF00069	0.592
MOD_Plk_1	26	32	PF00069	0.500
MOD_Plk_1	78	84	PF00069	0.628
MOD_Plk_2-3	472	478	PF00069	0.457
MOD_Plk_4	118	124	PF00069	0.660
MOD_Plk_4	26	32	PF00069	0.500
MOD_Plk_4	472	478	PF00069	0.485
MOD_ProDKin_1	103	109	PF00069	0.689
MOD_ProDKin_1	125	131	PF00069	0.616
MOD_ProDKin_1	162	168	PF00069	0.625
MOD_ProDKin_1	189	195	PF00069	0.670
MOD_ProDKin_1	203	209	PF00069	0.411
MOD_ProDKin_1	366	372	PF00069	0.795
MOD_ProDKin_1	38	44	PF00069	0.522
MOD_ProDKin_1	420	426	PF00069	0.503
MOD_ProDKin_1	58	64	PF00069	0.586
MOD_ProDKin_1	83	89	PF00069	0.679
MOD_SUMO_for_1	132	135	PF00179	0.587
MOD_SUMO_rev_2	470	476	PF00179	0.482
TRG_DiLeu_BaEn_1	135	140	PF01217	0.585
TRG_DiLeu_BaEn_1	262	267	PF01217	0.502
TRG_DiLeu_BaEn_4	282	288	PF01217	0.488
TRG_DiLeu_BaEn_4	454	460	PF01217	0.482
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.552
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.486
TRG_ENDOCYTIC_2	591	594	PF00928	0.441
TRG_ER_diArg_1	125	127	PF00400	0.578
TRG_ER_diArg_1	345	347	PF00400	0.657
TRG_ER_diArg_1	505	508	PF00400	0.458
TRG_NES_CRM1_1	285	297	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P209	Trypanosomatidae	33%	100%
A0A3S5H7N2	Leishmania donovani	95%	100%
A4HIE2	Leishmania braziliensis	84%	78%
A4I5N9	Leishmania infantum	95%	100%
E9B0Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BL95	Trypanosoma cruzi	35%	100%