PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase, putative

Species:

Leishmania major

UniProt:

Q4Q779_LEIMA

TriTrypDb:

LmjF.30.2140 , LMJLV39_300028300 , LMJSD75_300028100

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q779

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q779

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	6
GO:0016042	lipid catabolic process	4	6
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901575	organic substance catabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004806	triglyceride lipase activity	5	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0052689	carboxylic ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.501
CLV_C14_Caspase3-7	329	333	PF00656	0.693
CLV_MEL_PAP_1	718	724	PF00089	0.419
CLV_NRD_NRD_1	243	245	PF00675	0.478
CLV_NRD_NRD_1	38	40	PF00675	0.243
CLV_NRD_NRD_1	425	427	PF00675	0.423
CLV_NRD_NRD_1	654	656	PF00675	0.265
CLV_PCSK_KEX2_1	116	118	PF00082	0.265
CLV_PCSK_KEX2_1	38	40	PF00082	0.243
CLV_PCSK_KEX2_1	425	427	PF00082	0.423
CLV_PCSK_KEX2_1	536	538	PF00082	0.490
CLV_PCSK_KEX2_1	654	656	PF00082	0.265
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.265
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.533
CLV_PCSK_PC7_1	34	40	PF00082	0.243
CLV_PCSK_SKI1_1	2	6	PF00082	0.386
CLV_PCSK_SKI1_1	304	308	PF00082	0.472
CLV_PCSK_SKI1_1	453	457	PF00082	0.269
CLV_PCSK_SKI1_1	536	540	PF00082	0.465
CLV_PCSK_SKI1_1	590	594	PF00082	0.465
CLV_PCSK_SKI1_1	654	658	PF00082	0.345
CLV_PCSK_SKI1_1	786	790	PF00082	0.315
DEG_APCC_DBOX_1	653	661	PF00400	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.564
DOC_MAPK_gen_1	185	194	PF00069	0.642
DOC_MAPK_gen_1	536	547	PF00069	0.265
DOC_MAPK_gen_1	654	660	PF00069	0.643
DOC_MAPK_gen_1	721	729	PF00069	0.608
DOC_MAPK_gen_1	797	807	PF00069	0.524
DOC_MAPK_MEF2A_6	2	11	PF00069	0.570
DOC_MAPK_MEF2A_6	385	392	PF00069	0.618
DOC_MAPK_MEF2A_6	82	90	PF00069	0.451
DOC_MAPK_NFAT4_5	2	10	PF00069	0.573
DOC_MAPK_RevD_3	23	39	PF00069	0.520
DOC_PP1_RVXF_1	302	309	PF00149	0.636
DOC_PP1_RVXF_1	32	38	PF00149	0.519
DOC_PP1_RVXF_1	695	701	PF00149	0.561
DOC_PP2B_LxvP_1	679	682	PF13499	0.566
DOC_PP4_FxxP_1	324	327	PF00568	0.678
DOC_PP4_FxxP_1	678	681	PF00568	0.562
DOC_USP7_MATH_1	212	216	PF00917	0.662
DOC_USP7_MATH_1	217	221	PF00917	0.686
DOC_USP7_MATH_1	360	364	PF00917	0.752
DOC_USP7_MATH_1	411	415	PF00917	0.644
DOC_USP7_MATH_1	60	64	PF00917	0.465
DOC_USP7_MATH_1	744	748	PF00917	0.590
DOC_USP7_UBL2_3	442	446	PF12436	0.531
DOC_USP7_UBL2_3	536	540	PF12436	0.273
DOC_WW_Pin1_4	176	181	PF00397	0.634
DOC_WW_Pin1_4	208	213	PF00397	0.699
DOC_WW_Pin1_4	264	269	PF00397	0.675
DOC_WW_Pin1_4	318	323	PF00397	0.635
DOC_WW_Pin1_4	344	349	PF00397	0.675
DOC_WW_Pin1_4	371	376	PF00397	0.666
DOC_WW_Pin1_4	384	389	PF00397	0.654
DOC_WW_Pin1_4	409	414	PF00397	0.591
DOC_WW_Pin1_4	499	504	PF00397	0.301
DOC_WW_Pin1_4	520	525	PF00397	0.282
LIG_14-3-3_CanoR_1	129	135	PF00244	0.501
LIG_14-3-3_CanoR_1	2	8	PF00244	0.580
LIG_14-3-3_CanoR_1	263	268	PF00244	0.727
LIG_14-3-3_CanoR_1	38	47	PF00244	0.443
LIG_14-3-3_CanoR_1	394	403	PF00244	0.611
LIG_14-3-3_CanoR_1	425	434	PF00244	0.665
LIG_14-3-3_CanoR_1	786	795	PF00244	0.508
LIG_Actin_WH2_2	228	246	PF00022	0.633
LIG_APCC_ABBA_1	522	527	PF00400	0.265
LIG_BIR_III_2	76	80	PF00653	0.501
LIG_BRCT_BRCA1_1	304	308	PF00533	0.629
LIG_BRCT_BRCA1_1	320	324	PF00533	0.647
LIG_BRCT_BRCA1_1	362	366	PF00533	0.637
LIG_eIF4E_1	451	457	PF01652	0.630
LIG_FHA_1	140	146	PF00498	0.465
LIG_FHA_1	216	222	PF00498	0.727
LIG_FHA_1	230	236	PF00498	0.624
LIG_FHA_1	256	262	PF00498	0.643
LIG_FHA_1	359	365	PF00498	0.674
LIG_FHA_1	452	458	PF00498	0.489
LIG_FHA_1	539	545	PF00498	0.300
LIG_FHA_1	776	782	PF00498	0.497
LIG_FHA_1	99	105	PF00498	0.486
LIG_FHA_2	327	333	PF00498	0.649
LIG_FHA_2	54	60	PF00498	0.465
LIG_FHA_2	560	566	PF00498	0.361
LIG_FHA_2	596	602	PF00498	0.347
LIG_FHA_2	787	793	PF00498	0.487
LIG_GBD_Chelix_1	787	795	PF00786	0.320
LIG_IBAR_NPY_1	672	674	PF08397	0.518
LIG_LIR_Apic_2	321	327	PF02991	0.675
LIG_LIR_Gen_1	338	346	PF02991	0.672
LIG_LIR_Gen_1	41	48	PF02991	0.451
LIG_LIR_Gen_1	726	736	PF02991	0.599
LIG_LIR_Gen_1	754	762	PF02991	0.566
LIG_LIR_Nem_3	126	131	PF02991	0.465
LIG_LIR_Nem_3	338	342	PF02991	0.671
LIG_LIR_Nem_3	41	47	PF02991	0.451
LIG_LIR_Nem_3	51	57	PF02991	0.476
LIG_LIR_Nem_3	633	637	PF02991	0.465
LIG_LIR_Nem_3	65	70	PF02991	0.480
LIG_LIR_Nem_3	726	732	PF02991	0.613
LIG_LIR_Nem_3	754	758	PF02991	0.567
LIG_LIR_Nem_3	763	769	PF02991	0.550
LIG_LIR_Nem_3	776	782	PF02991	0.497
LIG_MYND_1	677	681	PF01753	0.556
LIG_NRBOX	110	116	PF00104	0.465
LIG_NRBOX	20	26	PF00104	0.489
LIG_NRBOX	6	12	PF00104	0.554
LIG_PCNA_PIPBox_1	15	24	PF02747	0.540
LIG_PCNA_yPIPBox_3	15	26	PF02747	0.541
LIG_Pex14_1	27	31	PF04695	0.531
LIG_Pex14_2	539	543	PF04695	0.265
LIG_Pex14_2	725	729	PF04695	0.558
LIG_REV1ctd_RIR_1	536	544	PF16727	0.265
LIG_SH2_CRK	67	71	PF00017	0.451
LIG_SH2_GRB2like	130	133	PF00017	0.501
LIG_SH2_GRB2like	755	758	PF00017	0.548
LIG_SH2_NCK_1	131	135	PF00017	0.473
LIG_SH2_PTP2	674	677	PF00017	0.524
LIG_SH2_SRC	637	640	PF00017	0.502
LIG_SH2_SRC	665	668	PF00017	0.523
LIG_SH2_SRC	674	677	PF00017	0.488
LIG_SH2_STAP1	141	145	PF00017	0.465
LIG_SH2_STAT5	141	144	PF00017	0.488
LIG_SH2_STAT5	596	599	PF00017	0.302
LIG_SH2_STAT5	637	640	PF00017	0.465
LIG_SH2_STAT5	665	668	PF00017	0.495
LIG_SH2_STAT5	67	70	PF00017	0.458
LIG_SH2_STAT5	674	677	PF00017	0.589
LIG_SH2_STAT5	755	758	PF00017	0.579
LIG_SH2_STAT5	766	769	PF00017	0.579
LIG_SH3_3	174	180	PF00018	0.648
LIG_SH3_3	199	205	PF00018	0.669
LIG_SH3_3	313	319	PF00018	0.619
LIG_SH3_3	369	375	PF00018	0.670
LIG_SH3_3	594	600	PF00018	0.257
LIG_SH3_3	633	639	PF00018	0.465
LIG_SH3_3	756	762	PF00018	0.545
LIG_SH3_5	762	766	PF00018	0.574
LIG_SUMO_SIM_anti_2	340	347	PF11976	0.620
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.540
LIG_SUMO_SIM_par_1	3	8	PF11976	0.561
LIG_TRAF2_1	581	584	PF00917	0.265
LIG_TYR_ITIM	663	668	PF00017	0.487
LIG_UBA3_1	493	501	PF00899	0.265
LIG_WRC_WIRS_1	107	112	PF05994	0.501
LIG_WRC_WIRS_1	54	59	PF05994	0.458
MOD_CDK_SPxxK_3	344	351	PF00069	0.701
MOD_CK1_1	161	167	PF00069	0.683
MOD_CK1_1	213	219	PF00069	0.685
MOD_CK1_1	220	226	PF00069	0.673
MOD_CK1_1	277	283	PF00069	0.690
MOD_CK1_1	289	295	PF00069	0.721
MOD_CK1_1	340	346	PF00069	0.648
MOD_CK1_1	371	377	PF00069	0.701
MOD_CK1_1	399	405	PF00069	0.648
MOD_CK1_1	459	465	PF00069	0.309
MOD_CK1_1	489	495	PF00069	0.265
MOD_CK1_1	53	59	PF00069	0.465
MOD_CK1_1	606	612	PF00069	0.311
MOD_CK2_1	499	505	PF00069	0.276
MOD_CK2_1	53	59	PF00069	0.501
MOD_CK2_1	559	565	PF00069	0.358
MOD_CK2_1	578	584	PF00069	0.300
MOD_CK2_1	786	792	PF00069	0.487
MOD_CMANNOS	699	702	PF00535	0.386
MOD_GlcNHglycan	132	135	PF01048	0.273
MOD_GlcNHglycan	160	163	PF01048	0.479
MOD_GlcNHglycan	167	170	PF01048	0.429
MOD_GlcNHglycan	195	199	PF01048	0.403
MOD_GlcNHglycan	215	218	PF01048	0.493
MOD_GlcNHglycan	222	225	PF01048	0.468
MOD_GlcNHglycan	269	272	PF01048	0.520
MOD_GlcNHglycan	276	279	PF01048	0.465
MOD_GlcNHglycan	376	379	PF01048	0.565
MOD_GlcNHglycan	413	416	PF01048	0.460
MOD_GlcNHglycan	427	430	PF01048	0.422
MOD_GlcNHglycan	458	461	PF01048	0.333
MOD_GlcNHglycan	488	491	PF01048	0.501
MOD_GlcNHglycan	569	572	PF01048	0.479
MOD_GlcNHglycan	605	608	PF01048	0.393
MOD_GlcNHglycan	690	693	PF01048	0.477
MOD_GlcNHglycan	736	739	PF01048	0.357
MOD_GlcNHglycan	762	765	PF01048	0.342
MOD_GSK3_1	106	113	PF00069	0.501
MOD_GSK3_1	161	168	PF00069	0.660
MOD_GSK3_1	208	215	PF00069	0.692
MOD_GSK3_1	255	262	PF00069	0.681
MOD_GSK3_1	263	270	PF00069	0.690
MOD_GSK3_1	273	280	PF00069	0.668
MOD_GSK3_1	283	290	PF00069	0.740
MOD_GSK3_1	292	299	PF00069	0.667
MOD_GSK3_1	340	347	PF00069	0.692
MOD_GSK3_1	349	356	PF00069	0.701
MOD_GSK3_1	358	365	PF00069	0.707
MOD_GSK3_1	395	402	PF00069	0.627
MOD_GSK3_1	409	416	PF00069	0.673
MOD_GSK3_1	43	50	PF00069	0.449
MOD_GSK3_1	447	454	PF00069	0.507
MOD_GSK3_1	456	463	PF00069	0.297
MOD_GSK3_1	485	492	PF00069	0.278
MOD_GSK3_1	509	516	PF00069	0.300
MOD_GSK3_1	574	581	PF00069	0.265
MOD_GSK3_1	681	688	PF00069	0.580
MOD_GSK3_1	708	715	PF00069	0.552
MOD_GSK3_1	734	741	PF00069	0.602
MOD_GSK3_1	765	772	PF00069	0.527
MOD_LATS_1	423	429	PF00433	0.621
MOD_N-GLC_1	358	363	PF02516	0.506
MOD_N-GLC_1	48	53	PF02516	0.265
MOD_N-GLC_1	574	579	PF02516	0.465
MOD_NEK2_1	110	115	PF00069	0.426
MOD_NEK2_1	123	128	PF00069	0.486
MOD_NEK2_1	194	199	PF00069	0.623
MOD_NEK2_1	207	212	PF00069	0.665
MOD_NEK2_1	243	248	PF00069	0.681
MOD_NEK2_1	274	279	PF00069	0.703
MOD_NEK2_1	285	290	PF00069	0.687
MOD_NEK2_1	37	42	PF00069	0.455
MOD_NEK2_1	396	401	PF00069	0.650
MOD_NEK2_1	456	461	PF00069	0.416
MOD_NEK2_1	485	490	PF00069	0.295
MOD_NEK2_1	497	502	PF00069	0.320
MOD_NEK2_1	5	10	PF00069	0.550
MOD_NEK2_1	509	514	PF00069	0.286
MOD_NEK2_1	538	543	PF00069	0.275
MOD_NEK2_1	574	579	PF00069	0.265
MOD_NEK2_1	666	671	PF00069	0.489
MOD_NEK2_1	98	103	PF00069	0.520
MOD_PIKK_1	38	44	PF00454	0.455
MOD_PIKK_1	578	584	PF00454	0.265
MOD_PIKK_1	666	672	PF00454	0.528
MOD_PK_1	43	49	PF00069	0.443
MOD_PKA_1	38	44	PF00069	0.443
MOD_PKA_1	425	431	PF00069	0.613
MOD_PKA_2	243	249	PF00069	0.661
MOD_PKA_2	37	43	PF00069	0.443
MOD_PKA_2	396	402	PF00069	0.629
MOD_PKA_2	425	431	PF00069	0.691
MOD_PKB_1	784	792	PF00069	0.488
MOD_Plk_1	123	129	PF00069	0.518
MOD_Plk_1	171	177	PF00069	0.675
MOD_Plk_1	302	308	PF00069	0.682
MOD_Plk_1	337	343	PF00069	0.720
MOD_Plk_1	559	565	PF00069	0.300
MOD_Plk_1	574	580	PF00069	0.300
MOD_Plk_1	624	630	PF00069	0.423
MOD_Plk_1	738	744	PF00069	0.504
MOD_Plk_4	106	112	PF00069	0.481
MOD_Plk_4	123	129	PF00069	0.428
MOD_Plk_4	302	308	PF00069	0.683
MOD_Plk_4	340	346	PF00069	0.715
MOD_Plk_4	43	49	PF00069	0.455
MOD_Plk_4	489	495	PF00069	0.296
MOD_Plk_4	5	11	PF00069	0.541
MOD_Plk_4	53	59	PF00069	0.483
MOD_Plk_4	559	565	PF00069	0.265
MOD_Plk_4	690	696	PF00069	0.574
MOD_Plk_4	708	714	PF00069	0.647
MOD_Plk_4	744	750	PF00069	0.607
MOD_ProDKin_1	176	182	PF00069	0.633
MOD_ProDKin_1	208	214	PF00069	0.700
MOD_ProDKin_1	264	270	PF00069	0.676
MOD_ProDKin_1	318	324	PF00069	0.639
MOD_ProDKin_1	344	350	PF00069	0.676
MOD_ProDKin_1	371	377	PF00069	0.667
MOD_ProDKin_1	384	390	PF00069	0.648
MOD_ProDKin_1	409	415	PF00069	0.597
MOD_ProDKin_1	499	505	PF00069	0.301
MOD_ProDKin_1	520	526	PF00069	0.282
TRG_DiLeu_BaEn_2	504	510	PF01217	0.265
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.712
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.670
TRG_DiLeu_BaLyEn_6	652	657	PF01217	0.465
TRG_ENDOCYTIC_2	54	57	PF00928	0.461
TRG_ENDOCYTIC_2	665	668	PF00928	0.483
TRG_ENDOCYTIC_2	67	70	PF00928	0.485
TRG_ENDOCYTIC_2	755	758	PF00928	0.585
TRG_ER_diArg_1	37	39	PF00400	0.443
TRG_ER_diArg_1	653	655	PF00400	0.465
TRG_ER_diArg_1	784	787	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	654	659	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	793	798	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P1	Leptomonas seymouri	53%	98%
A0A3Q8INR2	Leishmania donovani	27%	100%
A4HB80	Leishmania braziliensis	27%	100%
A4HIE6	Leishmania braziliensis	77%	100%
A4I5P3	Leishmania infantum	92%	91%
A4IAC8	Leishmania infantum	28%	100%
E9B0Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%