CPSF_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q778_LEIMA

TriTrypDb:

LmjF.30.2150 , LMJLV39_300028400 , LMJSD75_300028200

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q778

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q778

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.423
CLV_C14_Caspase3-7	514	518	PF00656	0.470
CLV_C14_Caspase3-7	557	561	PF00656	0.473
CLV_NRD_NRD_1	255	257	PF00675	0.685
CLV_NRD_NRD_1	366	368	PF00675	0.535
CLV_NRD_NRD_1	421	423	PF00675	0.727
CLV_NRD_NRD_1	440	442	PF00675	0.484
CLV_NRD_NRD_1	452	454	PF00675	0.527
CLV_NRD_NRD_1	56	58	PF00675	0.482
CLV_NRD_NRD_1	635	637	PF00675	0.495
CLV_PCSK_KEX2_1	254	256	PF00082	0.655
CLV_PCSK_KEX2_1	366	368	PF00082	0.535
CLV_PCSK_KEX2_1	420	422	PF00082	0.715
CLV_PCSK_KEX2_1	442	444	PF00082	0.630
CLV_PCSK_KEX2_1	56	58	PF00082	0.476
CLV_PCSK_KEX2_1	635	637	PF00082	0.469
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.607
CLV_PCSK_SKI1_1	131	135	PF00082	0.448
CLV_PCSK_SKI1_1	412	416	PF00082	0.783
CLV_PCSK_SKI1_1	622	626	PF00082	0.386
CLV_PCSK_SKI1_1	723	727	PF00082	0.481
CLV_PCSK_SKI1_1	760	764	PF00082	0.505
CLV_PCSK_SKI1_1	832	836	PF00082	0.477
DEG_APCC_DBOX_1	485	493	PF00400	0.550
DEG_SCF_FBW7_1	23	30	PF00400	0.391
DEG_SPOP_SBC_1	12	16	PF00917	0.529
DEG_SPOP_SBC_1	649	653	PF00917	0.696
DOC_CKS1_1	321	326	PF01111	0.532
DOC_PP1_RVXF_1	527	534	PF00149	0.447
DOC_PP1_RVXF_1	64	71	PF00149	0.442
DOC_PP2B_LxvP_1	268	271	PF13499	0.731
DOC_PP2B_PxIxI_1	784	790	PF00149	0.485
DOC_SPAK_OSR1_1	667	671	PF12202	0.504
DOC_USP7_MATH_1	11	15	PF00917	0.511
DOC_USP7_MATH_1	249	253	PF00917	0.624
DOC_USP7_MATH_1	273	277	PF00917	0.617
DOC_USP7_MATH_1	334	338	PF00917	0.669
DOC_USP7_MATH_1	465	469	PF00917	0.643
DOC_USP7_MATH_1	494	498	PF00917	0.596
DOC_USP7_MATH_1	648	652	PF00917	0.698
DOC_USP7_MATH_1	791	795	PF00917	0.361
DOC_WW_Pin1_4	168	173	PF00397	0.661
DOC_WW_Pin1_4	23	28	PF00397	0.582
DOC_WW_Pin1_4	320	325	PF00397	0.528
DOC_WW_Pin1_4	391	396	PF00397	0.411
DOC_WW_Pin1_4	580	585	PF00397	0.494
DOC_WW_Pin1_4	586	591	PF00397	0.446
LIG_14-3-3_CanoR_1	191	196	PF00244	0.452
LIG_14-3-3_CanoR_1	243	250	PF00244	0.433
LIG_14-3-3_CanoR_1	256	264	PF00244	0.427
LIG_14-3-3_CanoR_1	308	312	PF00244	0.484
LIG_14-3-3_CanoR_1	486	490	PF00244	0.586
LIG_14-3-3_CanoR_1	57	63	PF00244	0.435
LIG_14-3-3_CanoR_1	667	671	PF00244	0.486
LIG_Actin_WH2_2	132	148	PF00022	0.278
LIG_BIR_III_4	38	42	PF00653	0.670
LIG_BRCT_BRCA1_1	13	17	PF00533	0.531
LIG_BRCT_BRCA1_1	27	31	PF00533	0.433
LIG_BRCT_BRCA1_1	88	92	PF00533	0.559
LIG_Clathr_ClatBox_1	133	137	PF01394	0.463
LIG_Clathr_ClatBox_1	20	24	PF01394	0.431
LIG_CSL_BTD_1	581	584	PF09270	0.493
LIG_CSL_BTD_1	827	830	PF09270	0.470
LIG_eIF4E_1	619	625	PF01652	0.399
LIG_FHA_1	187	193	PF00498	0.539
LIG_FHA_1	214	220	PF00498	0.390
LIG_FHA_1	228	234	PF00498	0.397
LIG_FHA_1	308	314	PF00498	0.449
LIG_FHA_1	316	322	PF00498	0.459
LIG_FHA_1	334	340	PF00498	0.542
LIG_FHA_1	372	378	PF00498	0.551
LIG_FHA_1	467	473	PF00498	0.549
LIG_FHA_1	502	508	PF00498	0.446
LIG_FHA_1	539	545	PF00498	0.498
LIG_FHA_1	716	722	PF00498	0.448
LIG_FHA_1	751	757	PF00498	0.368
LIG_FHA_2	282	288	PF00498	0.507
LIG_FHA_2	397	403	PF00498	0.635
LIG_FHA_2	488	494	PF00498	0.576
LIG_FHA_2	49	55	PF00498	0.552
LIG_FHA_2	512	518	PF00498	0.463
LIG_FHA_2	555	561	PF00498	0.460
LIG_FHA_2	59	65	PF00498	0.521
LIG_Integrin_isoDGR_2	349	351	PF01839	0.509
LIG_LIR_Gen_1	14	23	PF02991	0.502
LIG_LIR_Gen_1	28	39	PF02991	0.588
LIG_LIR_Gen_1	314	325	PF02991	0.588
LIG_LIR_Gen_1	477	484	PF02991	0.566
LIG_LIR_LC3C_4	205	209	PF02991	0.405
LIG_LIR_Nem_3	14	20	PF02991	0.481
LIG_LIR_Nem_3	314	320	PF02991	0.565
LIG_LIR_Nem_3	477	481	PF02991	0.545
LIG_LIR_Nem_3	825	831	PF02991	0.377
LIG_NRBOX	619	625	PF00104	0.463
LIG_Pex14_2	474	478	PF04695	0.565
LIG_SH2_CRK	317	321	PF00017	0.570
LIG_SH2_GRB2like	354	357	PF00017	0.447
LIG_SH2_NCK_1	430	434	PF00017	0.654
LIG_SH2_NCK_1	732	736	PF00017	0.474
LIG_SH2_PTP2	354	357	PF00017	0.383
LIG_SH2_SRC	354	357	PF00017	0.460
LIG_SH2_STAP1	317	321	PF00017	0.534
LIG_SH2_STAT5	317	320	PF00017	0.576
LIG_SH2_STAT5	354	357	PF00017	0.518
LIG_SH2_STAT5	363	366	PF00017	0.451
LIG_SH2_STAT5	430	433	PF00017	0.680
LIG_SH2_STAT5	619	622	PF00017	0.377
LIG_SH2_STAT5	822	825	PF00017	0.449
LIG_SH3_1	605	611	PF00018	0.428
LIG_SH3_3	161	167	PF00018	0.547
LIG_SH3_3	605	611	PF00018	0.521
LIG_SH3_3	827	833	PF00018	0.496
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.495
LIG_SUMO_SIM_anti_2	8	16	PF11976	0.405
LIG_SUMO_SIM_anti_2	81	89	PF11976	0.476
LIG_SUMO_SIM_par_1	132	138	PF11976	0.458
LIG_SUMO_SIM_par_1	19	24	PF11976	0.418
LIG_SUMO_SIM_par_1	281	287	PF11976	0.491
LIG_SUMO_SIM_par_1	293	300	PF11976	0.445
LIG_SUMO_SIM_par_1	567	572	PF11976	0.452
LIG_SUMO_SIM_par_1	788	794	PF11976	0.348
LIG_SUMO_SIM_par_1	8	16	PF11976	0.405
LIG_SUMO_SIM_par_1	81	89	PF11976	0.413
LIG_TRAF2_1	51	54	PF00917	0.523
LIG_UBA3_1	689	697	PF00899	0.364
LIG_WRC_WIRS_1	107	112	PF05994	0.470
MOD_CDK_SPxxK_3	580	587	PF00069	0.526
MOD_CK1_1	154	160	PF00069	0.594
MOD_CK1_1	213	219	PF00069	0.391
MOD_CK1_1	257	263	PF00069	0.648
MOD_CK1_1	307	313	PF00069	0.544
MOD_CK1_1	315	321	PF00069	0.553
MOD_CK1_1	428	434	PF00069	0.627
MOD_CK1_1	5	11	PF00069	0.501
MOD_CK1_1	644	650	PF00069	0.698
MOD_CK1_1	651	657	PF00069	0.669
MOD_CK1_1	669	675	PF00069	0.389
MOD_CK1_1	72	78	PF00069	0.521
MOD_CK1_1	749	755	PF00069	0.485
MOD_CK1_1	821	827	PF00069	0.447
MOD_CK2_1	241	247	PF00069	0.517
MOD_CK2_1	41	47	PF00069	0.724
MOD_CK2_1	465	471	PF00069	0.633
MOD_CK2_1	48	54	PF00069	0.490
MOD_CK2_1	487	493	PF00069	0.566
MOD_CK2_1	649	655	PF00069	0.630
MOD_CK2_1	692	698	PF00069	0.491
MOD_GlcNHglycan	199	202	PF01048	0.585
MOD_GlcNHglycan	256	259	PF01048	0.699
MOD_GlcNHglycan	314	317	PF01048	0.505
MOD_GlcNHglycan	336	339	PF01048	0.555
MOD_GlcNHglycan	378	381	PF01048	0.567
MOD_GlcNHglycan	405	408	PF01048	0.694
MOD_GlcNHglycan	427	430	PF01048	0.581
MOD_GlcNHglycan	461	464	PF01048	0.670
MOD_GlcNHglycan	496	499	PF01048	0.547
MOD_GlcNHglycan	571	574	PF01048	0.398
MOD_GlcNHglycan	598	601	PF01048	0.596
MOD_GlcNHglycan	677	680	PF01048	0.384
MOD_GlcNHglycan	738	741	PF01048	0.583
MOD_GlcNHglycan	746	749	PF01048	0.430
MOD_GlcNHglycan	82	85	PF01048	0.528
MOD_GlcNHglycan	840	843	PF01048	0.506
MOD_GSK3_1	1	8	PF00069	0.496
MOD_GSK3_1	106	113	PF00069	0.568
MOD_GSK3_1	116	123	PF00069	0.515
MOD_GSK3_1	150	157	PF00069	0.665
MOD_GSK3_1	186	193	PF00069	0.499
MOD_GSK3_1	23	30	PF00069	0.551
MOD_GSK3_1	293	300	PF00069	0.466
MOD_GSK3_1	315	322	PF00069	0.457
MOD_GSK3_1	461	468	PF00069	0.709
MOD_GSK3_1	507	514	PF00069	0.373
MOD_GSK3_1	592	599	PF00069	0.571
MOD_GSK3_1	640	647	PF00069	0.634
MOD_GSK3_1	723	730	PF00069	0.467
MOD_GSK3_1	746	753	PF00069	0.517
MOD_GSK3_1	771	778	PF00069	0.488
MOD_GSK3_1	818	825	PF00069	0.442
MOD_N-GLC_1	168	173	PF02516	0.676
MOD_N-GLC_1	213	218	PF02516	0.519
MOD_N-GLC_1	561	566	PF02516	0.454
MOD_NEK2_1	110	115	PF00069	0.517
MOD_NEK2_1	195	200	PF00069	0.523
MOD_NEK2_1	210	215	PF00069	0.483
MOD_NEK2_1	362	367	PF00069	0.477
MOD_NEK2_1	492	497	PF00069	0.524
MOD_NEK2_1	569	574	PF00069	0.370
MOD_NEK2_1	623	628	PF00069	0.454
MOD_NEK2_1	744	749	PF00069	0.439
MOD_NEK2_1	750	755	PF00069	0.337
MOD_NEK2_1	86	91	PF00069	0.495
MOD_NEK2_2	122	127	PF00069	0.453
MOD_NEK2_2	249	254	PF00069	0.422
MOD_NEK2_2	281	286	PF00069	0.368
MOD_PIKK_1	116	122	PF00454	0.404
MOD_PIKK_1	257	263	PF00454	0.637
MOD_PIKK_1	315	321	PF00454	0.578
MOD_PIKK_1	368	374	PF00454	0.560
MOD_PIKK_1	658	664	PF00454	0.528
MOD_PIKK_1	766	772	PF00454	0.499
MOD_PIKK_1	791	797	PF00454	0.439
MOD_PKA_1	254	260	PF00069	0.589
MOD_PKA_2	190	196	PF00069	0.466
MOD_PKA_2	242	248	PF00069	0.549
MOD_PKA_2	254	260	PF00069	0.657
MOD_PKA_2	307	313	PF00069	0.484
MOD_PKA_2	485	491	PF00069	0.546
MOD_PKA_2	538	544	PF00069	0.432
MOD_PKA_2	666	672	PF00069	0.549
MOD_PKA_2	727	733	PF00069	0.572
MOD_PKB_1	420	428	PF00069	0.521
MOD_Plk_1	110	116	PF00069	0.490
MOD_Plk_1	5	11	PF00069	0.568
MOD_Plk_1	592	598	PF00069	0.542
MOD_Plk_1	72	78	PF00069	0.535
MOD_Plk_4	13	19	PF00069	0.480
MOD_Plk_4	203	209	PF00069	0.508
MOD_Plk_4	27	33	PF00069	0.625
MOD_Plk_4	281	287	PF00069	0.525
MOD_Plk_4	396	402	PF00069	0.515
MOD_Plk_4	477	483	PF00069	0.588
MOD_Plk_4	5	11	PF00069	0.445
MOD_Plk_4	705	711	PF00069	0.529
MOD_Plk_4	818	824	PF00069	0.418
MOD_ProDKin_1	168	174	PF00069	0.649
MOD_ProDKin_1	23	29	PF00069	0.590
MOD_ProDKin_1	320	326	PF00069	0.529
MOD_ProDKin_1	391	397	PF00069	0.407
MOD_ProDKin_1	580	586	PF00069	0.505
MOD_SUMO_rev_2	379	385	PF00179	0.589
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.453
TRG_ENDOCYTIC_2	306	309	PF00928	0.526
TRG_ENDOCYTIC_2	317	320	PF00928	0.564
TRG_ENDOCYTIC_2	354	357	PF00928	0.528
TRG_ER_diArg_1	253	256	PF00400	0.645
TRG_ER_diArg_1	420	422	PF00400	0.660
TRG_ER_diArg_1	55	57	PF00400	0.587
TRG_ER_diArg_1	634	636	PF00400	0.458
TRG_NLS_MonoExtC_3	441	446	PF00514	0.512
TRG_NLS_MonoExtN_4	441	447	PF00514	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P916	Leptomonas seymouri	45%	91%
A0A0S4ILJ2	Bodo saltans	26%	100%
A0A1X0P1Y6	Trypanosomatidae	25%	100%
A0A3S5IQN0	Trypanosoma rangeli	27%	100%
A0A3S7X3K9	Leishmania donovani	91%	100%
A4HIE7	Leishmania braziliensis	76%	100%
A4I5P4	Leishmania infantum	91%	100%
C9ZR12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B0Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BC72	Trypanosoma cruzi	26%	96%