Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q777_LEIMA

TriTrypDb:

LmjF.30.2160 , LMJLV39_300028500 , LMJSD75_300028300

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q777

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q777

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.669
CLV_C14_Caspase3-7	537	541	PF00656	0.760
CLV_NRD_NRD_1	181	183	PF00675	0.596
CLV_NRD_NRD_1	326	328	PF00675	0.667
CLV_NRD_NRD_1	333	335	PF00675	0.636
CLV_NRD_NRD_1	397	399	PF00675	0.754
CLV_NRD_NRD_1	410	412	PF00675	0.520
CLV_NRD_NRD_1	458	460	PF00675	0.696
CLV_NRD_NRD_1	470	472	PF00675	0.621
CLV_NRD_NRD_1	524	526	PF00675	0.649
CLV_PCSK_KEX2_1	181	183	PF00082	0.526
CLV_PCSK_KEX2_1	326	328	PF00082	0.667
CLV_PCSK_KEX2_1	333	335	PF00082	0.636
CLV_PCSK_KEX2_1	414	416	PF00082	0.738
CLV_PCSK_KEX2_1	458	460	PF00082	0.696
CLV_PCSK_KEX2_1	470	472	PF00082	0.621
CLV_PCSK_KEX2_1	524	526	PF00082	0.649
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.738
CLV_PCSK_PC7_1	177	183	PF00082	0.521
CLV_PCSK_SKI1_1	252	256	PF00082	0.671
CLV_PCSK_SKI1_1	304	308	PF00082	0.628
CLV_PCSK_SKI1_1	411	415	PF00082	0.648
CLV_PCSK_SKI1_1	470	474	PF00082	0.625
DEG_APCC_DBOX_1	295	303	PF00400	0.645
DEG_Nend_UBRbox_2	1	3	PF02207	0.763
DEG_SPOP_SBC_1	230	234	PF00917	0.682
DOC_ANK_TNKS_1	170	177	PF00023	0.624
DOC_CKS1_1	555	560	PF01111	0.800
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.639
DOC_MAPK_MEF2A_6	115	123	PF00069	0.620
DOC_MAPK_MEF2A_6	55	63	PF00069	0.643
DOC_PP1_RVXF_1	362	368	PF00149	0.594
DOC_PP2B_LxvP_1	240	243	PF13499	0.731
DOC_PP2B_LxvP_1	351	354	PF13499	0.548
DOC_PP2B_LxvP_1	472	475	PF13499	0.657
DOC_PP4_FxxP_1	250	253	PF00568	0.686
DOC_USP7_MATH_1	229	233	PF00917	0.802
DOC_USP7_MATH_1	253	257	PF00917	0.667
DOC_USP7_MATH_1	28	32	PF00917	0.596
DOC_USP7_MATH_1	345	349	PF00917	0.684
DOC_USP7_MATH_1	447	451	PF00917	0.802
DOC_USP7_MATH_1	475	479	PF00917	0.774
DOC_USP7_MATH_1	538	542	PF00917	0.742
DOC_WW_Pin1_4	23	28	PF00397	0.691
DOC_WW_Pin1_4	243	248	PF00397	0.743
DOC_WW_Pin1_4	29	34	PF00397	0.693
DOC_WW_Pin1_4	525	530	PF00397	0.718
DOC_WW_Pin1_4	554	559	PF00397	0.746
LIG_14-3-3_CanoR_1	185	190	PF00244	0.628
LIG_14-3-3_CanoR_1	277	285	PF00244	0.521
LIG_14-3-3_CanoR_1	481	488	PF00244	0.653
LIG_14-3-3_CanoR_1	513	517	PF00244	0.733
LIG_14-3-3_CanoR_1	596	604	PF00244	0.642
LIG_Actin_WH2_2	183	201	PF00022	0.732
LIG_Clathr_ClatBox_1	219	223	PF01394	0.764
LIG_deltaCOP1_diTrp_1	44	53	PF00928	0.646
LIG_eIF4E_1	305	311	PF01652	0.620
LIG_FHA_1	112	118	PF00498	0.728
LIG_FHA_1	152	158	PF00498	0.688
LIG_FHA_1	185	191	PF00498	0.714
LIG_FHA_1	236	242	PF00498	0.716
LIG_FHA_1	246	252	PF00498	0.700
LIG_FHA_1	259	265	PF00498	0.511
LIG_FHA_1	273	279	PF00498	0.724
LIG_FHA_1	306	312	PF00498	0.585
LIG_FHA_1	364	370	PF00498	0.597
LIG_FHA_1	371	377	PF00498	0.631
LIG_FHA_1	483	489	PF00498	0.626
LIG_FHA_1	561	567	PF00498	0.677
LIG_FHA_1	615	621	PF00498	0.656
LIG_FHA_2	146	152	PF00498	0.626
LIG_FHA_2	35	41	PF00498	0.789
LIG_FHA_2	353	359	PF00498	0.642
LIG_FHA_2	430	436	PF00498	0.705
LIG_FHA_2	52	58	PF00498	0.502
LIG_FHA_2	542	548	PF00498	0.762
LIG_FHA_2	557	563	PF00498	0.626
LIG_FHA_2	569	575	PF00498	0.558
LIG_FHA_2	619	625	PF00498	0.761
LIG_FHA_2	627	633	PF00498	0.665
LIG_FHA_2	71	77	PF00498	0.416
LIG_LIR_Apic_2	248	253	PF02991	0.704
LIG_LIR_Apic_2	515	519	PF02991	0.794
LIG_LIR_Gen_1	118	128	PF02991	0.733
LIG_LIR_Gen_1	284	289	PF02991	0.619
LIG_LIR_Gen_1	292	302	PF02991	0.648
LIG_LIR_Nem_3	118	123	PF02991	0.733
LIG_LIR_Nem_3	279	285	PF02991	0.629
LIG_LIR_Nem_3	292	297	PF02991	0.625
LIG_NRBOX	58	64	PF00104	0.663
LIG_Pex14_2	77	81	PF04695	0.573
LIG_SH2_CRK	285	289	PF00017	0.582
LIG_SH2_CRK	516	520	PF00017	0.583
LIG_SH2_PTP2	294	297	PF00017	0.723
LIG_SH2_STAP1	285	289	PF00017	0.619
LIG_SH2_STAT5	169	172	PF00017	0.731
LIG_SH2_STAT5	294	297	PF00017	0.635
LIG_SH2_STAT5	305	308	PF00017	0.522
LIG_SH3_3	186	192	PF00018	0.584
LIG_SH3_3	2	8	PF00018	0.571
LIG_SH3_3	212	218	PF00018	0.571
LIG_SH3_3	292	298	PF00018	0.597
LIG_SH3_3	383	389	PF00018	0.684
LIG_SH3_3	552	558	PF00018	0.833
LIG_SUMO_SIM_anti_2	56	66	PF11976	0.689
LIG_SUMO_SIM_anti_2	571	577	PF11976	0.754
LIG_SUMO_SIM_par_1	121	126	PF11976	0.724
LIG_SUMO_SIM_par_1	56	66	PF11976	0.640
LIG_SxIP_EBH_1	584	593	PF03271	0.583
LIG_TRAF2_1	148	151	PF00917	0.642
LIG_TRAF2_1	354	357	PF00917	0.660
LIG_TRAF2_1	54	57	PF00917	0.748
LIG_TRAF2_1	559	562	PF00917	0.718
LIG_TYR_ITIM	210	215	PF00017	0.598
MOD_CDK_SPxK_1	554	560	PF00069	0.583
MOD_CK1_1	145	151	PF00069	0.629
MOD_CK1_1	256	262	PF00069	0.615
MOD_CK1_1	276	282	PF00069	0.521
MOD_CK1_1	329	335	PF00069	0.767
MOD_CK1_1	441	447	PF00069	0.814
MOD_CK1_1	450	456	PF00069	0.631
MOD_CK1_1	536	542	PF00069	0.746
MOD_CK1_1	595	601	PF00069	0.721
MOD_CK1_1	618	624	PF00069	0.691
MOD_CK2_1	123	129	PF00069	0.655
MOD_CK2_1	145	151	PF00069	0.629
MOD_CK2_1	34	40	PF00069	0.758
MOD_CK2_1	352	358	PF00069	0.709
MOD_CK2_1	429	435	PF00069	0.814
MOD_CK2_1	480	486	PF00069	0.756
MOD_CK2_1	51	57	PF00069	0.652
MOD_CK2_1	556	562	PF00069	0.738
MOD_CK2_1	568	574	PF00069	0.578
MOD_CK2_1	626	632	PF00069	0.668
MOD_CK2_1	640	646	PF00069	0.670
MOD_DYRK1A_RPxSP_1	525	529	PF00069	0.717
MOD_GlcNHglycan	100	103	PF01048	0.706
MOD_GlcNHglycan	255	258	PF01048	0.677
MOD_GlcNHglycan	289	292	PF01048	0.745
MOD_GlcNHglycan	317	320	PF01048	0.662
MOD_GlcNHglycan	443	446	PF01048	0.810
MOD_GlcNHglycan	449	452	PF01048	0.649
MOD_GlcNHglycan	536	539	PF01048	0.705
MOD_GSK3_1	107	114	PF00069	0.589
MOD_GSK3_1	138	145	PF00069	0.684
MOD_GSK3_1	231	238	PF00069	0.785
MOD_GSK3_1	253	260	PF00069	0.600
MOD_GSK3_1	272	279	PF00069	0.534
MOD_GSK3_1	311	318	PF00069	0.622
MOD_GSK3_1	363	370	PF00069	0.525
MOD_GSK3_1	40	47	PF00069	0.737
MOD_GSK3_1	476	483	PF00069	0.760
MOD_GSK3_1	532	539	PF00069	0.762
MOD_GSK3_1	542	549	PF00069	0.824
MOD_GSK3_1	556	563	PF00069	0.648
MOD_GSK3_1	614	621	PF00069	0.760
MOD_GSK3_1	94	101	PF00069	0.671
MOD_N-GLC_1	533	538	PF02516	0.766
MOD_N-GLC_2	130	132	PF02516	0.773
MOD_NEK2_1	123	128	PF00069	0.697
MOD_NEK2_1	162	167	PF00069	0.605
MOD_NEK2_1	34	39	PF00069	0.593
MOD_NEK2_1	532	537	PF00069	0.842
MOD_NEK2_1	614	619	PF00069	0.823
MOD_PIKK_1	143	149	PF00454	0.691
MOD_PIKK_1	305	311	PF00454	0.707
MOD_PIKK_1	70	76	PF00454	0.608
MOD_PKA_1	326	332	PF00069	0.641
MOD_PKA_2	142	148	PF00069	0.734
MOD_PKA_2	184	190	PF00069	0.629
MOD_PKA_2	235	241	PF00069	0.800
MOD_PKA_2	276	282	PF00069	0.521
MOD_PKA_2	326	332	PF00069	0.641
MOD_PKA_2	370	376	PF00069	0.623
MOD_PKA_2	429	435	PF00069	0.635
MOD_PKA_2	480	486	PF00069	0.756
MOD_PKA_2	512	518	PF00069	0.691
MOD_PKA_2	595	601	PF00069	0.634
MOD_Plk_1	123	129	PF00069	0.734
MOD_Plk_1	273	279	PF00069	0.614
MOD_Plk_1	393	399	PF00069	0.767
MOD_Plk_1	614	620	PF00069	0.699
MOD_Plk_2-3	40	46	PF00069	0.697
MOD_Plk_2-3	419	425	PF00069	0.770
MOD_Plk_2-3	542	548	PF00069	0.768
MOD_Plk_4	185	191	PF00069	0.550
MOD_Plk_4	201	207	PF00069	0.674
MOD_Plk_4	562	568	PF00069	0.691
MOD_Plk_4	615	621	PF00069	0.673
MOD_ProDKin_1	23	29	PF00069	0.694
MOD_ProDKin_1	243	249	PF00069	0.741
MOD_ProDKin_1	525	531	PF00069	0.719
MOD_ProDKin_1	554	560	PF00069	0.744
MOD_SUMO_for_1	413	416	PF00179	0.737
TRG_AP2beta_CARGO_1	118	127	PF09066	0.731
TRG_DiLeu_BaEn_1	265	270	PF01217	0.590
TRG_DiLeu_BaEn_1	284	289	PF01217	0.599
TRG_DiLeu_BaEn_1	56	61	PF01217	0.640
TRG_DiLeu_BaEn_1	562	567	PF01217	0.771
TRG_DiLeu_BaEn_4	356	362	PF01217	0.696
TRG_ENDOCYTIC_2	212	215	PF00928	0.711
TRG_ENDOCYTIC_2	285	288	PF00928	0.581
TRG_ENDOCYTIC_2	294	297	PF00928	0.646
TRG_ER_diArg_1	181	183	PF00400	0.526
TRG_ER_diArg_1	266	269	PF00400	0.529
TRG_ER_diArg_1	325	327	PF00400	0.635
TRG_ER_diArg_1	457	459	PF00400	0.796
TRG_ER_diArg_1	470	472	PF00400	0.527
TRG_NES_CRM1_1	564	578	PF08389	0.761
TRG_NLS_Bipartite_1	398	415	PF00514	0.626
TRG_NLS_MonoExtC_3	410	415	PF00514	0.620
TRG_NLS_MonoExtN_4	409	415	PF00514	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E3	Leptomonas seymouri	35%	97%
A0A3Q8IJH1	Leishmania donovani	89%	100%
A4HIE8	Leishmania braziliensis	68%	99%
A4I5P5	Leishmania infantum	89%	100%
E9B0Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%