RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q775_LEIMA

TriTrypDb:

LmjF.30.2180 , LMJLV39_300028900 , LMJSD75_300028700

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

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Expansion

Sequence features

Q4Q775

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q775

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.588
CLV_NRD_NRD_1	186	188	PF00675	0.755
CLV_NRD_NRD_1	402	404	PF00675	0.659
CLV_PCSK_FUR_1	181	185	PF00082	0.754
CLV_PCSK_KEX2_1	150	152	PF00082	0.380
CLV_PCSK_KEX2_1	180	182	PF00082	0.749
CLV_PCSK_KEX2_1	183	185	PF00082	0.706
CLV_PCSK_KEX2_1	186	188	PF00082	0.656
CLV_PCSK_KEX2_1	402	404	PF00082	0.659
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.380

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3L2	Leishmania donovani	93%	99%
A4HIF0	Leishmania braziliensis	73%	100%
A4I5P7	Leishmania infantum	93%	99%
E9B0Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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