RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q775_LEIMA

TriTrypDb:

LmjF.30.2180 , LMJLV39_300028900 , LMJSD75_300028700

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q775

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q775

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.588
CLV_NRD_NRD_1	186	188	PF00675	0.755
CLV_NRD_NRD_1	402	404	PF00675	0.659
CLV_PCSK_FUR_1	181	185	PF00082	0.754
CLV_PCSK_KEX2_1	150	152	PF00082	0.380
CLV_PCSK_KEX2_1	180	182	PF00082	0.749
CLV_PCSK_KEX2_1	183	185	PF00082	0.706
CLV_PCSK_KEX2_1	186	188	PF00082	0.656
CLV_PCSK_KEX2_1	402	404	PF00082	0.659
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.380
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.749
CLV_PCSK_PC7_1	181	187	PF00082	0.756
CLV_PCSK_SKI1_1	14	18	PF00082	0.435
CLV_PCSK_SKI1_1	150	154	PF00082	0.435
CLV_PCSK_SKI1_1	34	38	PF00082	0.199
DEG_SCF_FBW7_1	351	358	PF00400	0.828
DEG_SCF_FBW7_1	420	426	PF00400	0.834
DEG_SCF_FBW7_1	433	439	PF00400	0.601
DEG_SIAH_1	416	424	PF03145	0.824
DEG_SPOP_SBC_1	423	427	PF00917	0.840
DOC_CKS1_1	221	226	PF01111	0.614
DOC_CKS1_1	360	365	PF01111	0.832
DOC_CKS1_1	397	402	PF01111	0.818
DOC_CKS1_1	420	425	PF01111	0.833
DOC_CKS1_1	433	438	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.738
DOC_MAPK_gen_1	150	156	PF00069	0.580
DOC_MAPK_gen_1	43	52	PF00069	0.636
DOC_MAPK_gen_1	64	72	PF00069	0.636
DOC_PP2B_LxvP_1	225	228	PF13499	0.826
DOC_PP2B_LxvP_1	264	267	PF13499	0.752
DOC_PP2B_LxvP_1	489	492	PF13499	0.746
DOC_PP2B_PxIxI_1	470	476	PF00149	0.723
DOC_PP4_FxxP_1	203	206	PF00568	0.735
DOC_USP7_MATH_1	152	156	PF00917	0.608
DOC_USP7_MATH_1	217	221	PF00917	0.657
DOC_USP7_MATH_1	237	241	PF00917	0.774
DOC_USP7_MATH_1	297	301	PF00917	0.775
DOC_USP7_MATH_1	355	359	PF00917	0.825
DOC_USP7_MATH_1	423	427	PF00917	0.773
DOC_USP7_MATH_1	436	440	PF00917	0.599
DOC_USP7_UBL2_3	85	89	PF12436	0.700
DOC_WW_Pin1_4	202	207	PF00397	0.734
DOC_WW_Pin1_4	220	225	PF00397	0.690
DOC_WW_Pin1_4	233	238	PF00397	0.688
DOC_WW_Pin1_4	317	322	PF00397	0.775
DOC_WW_Pin1_4	351	356	PF00397	0.695
DOC_WW_Pin1_4	359	364	PF00397	0.729
DOC_WW_Pin1_4	396	401	PF00397	0.652
DOC_WW_Pin1_4	419	424	PF00397	0.761
DOC_WW_Pin1_4	432	437	PF00397	0.601
DOC_WW_Pin1_4	459	464	PF00397	0.799
LIG_14-3-3_CanoR_1	14	21	PF00244	0.636
LIG_14-3-3_CanoR_1	151	157	PF00244	0.552
LIG_BRCT_BRCA1_1	272	276	PF00533	0.822
LIG_BRCT_BRCA1_1	324	328	PF00533	0.823
LIG_BRCT_BRCA1_1	43	47	PF00533	0.528
LIG_EVH1_1	225	229	PF00568	0.767
LIG_FHA_1	205	211	PF00498	0.750
LIG_FHA_1	308	314	PF00498	0.781
LIG_FHA_1	433	439	PF00498	0.777
LIG_FHA_1	443	449	PF00498	0.662
LIG_FHA_2	15	21	PF00498	0.636
LIG_FHA_2	177	183	PF00498	0.667
LIG_FHA_2	206	212	PF00498	0.625
LIG_FHA_2	58	64	PF00498	0.536
LIG_IBAR_NPY_1	416	418	PF08397	0.818
LIG_LIR_Gen_1	123	132	PF02991	0.636
LIG_LIR_Gen_1	142	149	PF02991	0.411
LIG_LIR_Gen_1	268	277	PF02991	0.836
LIG_LIR_Gen_1	325	335	PF02991	0.827
LIG_LIR_Gen_1	346	355	PF02991	0.573
LIG_LIR_Gen_1	60	70	PF02991	0.636
LIG_LIR_Nem_3	135	140	PF02991	0.636
LIG_LIR_Nem_3	142	146	PF02991	0.553
LIG_LIR_Nem_3	268	272	PF02991	0.829
LIG_LIR_Nem_3	325	331	PF02991	0.839
LIG_LIR_Nem_3	344	348	PF02991	0.670
LIG_LIR_Nem_3	44	50	PF02991	0.636
LIG_LIR_Nem_3	494	498	PF02991	0.580
LIG_LIR_Nem_3	60	65	PF02991	0.446
LIG_PCNA_PIPBox_1	1	10	PF02747	0.611
LIG_PCNA_PIPBox_1	109	118	PF02747	0.636
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.636
LIG_Pex14_2	115	119	PF04695	0.636
LIG_Pex14_2	341	345	PF04695	0.811
LIG_PROFILIN_1	226	232	PF00235	0.742
LIG_PTAP_UEV_1	443	448	PF05743	0.772
LIG_PTB_Apo_2	327	334	PF02174	0.833
LIG_PTB_Apo_2	474	481	PF02174	0.804
LIG_SH2_CRK	418	422	PF00017	0.828
LIG_SH2_GRB2like	162	165	PF00017	0.636
LIG_SH2_NCK_1	418	422	PF00017	0.828
LIG_SH2_SRC	173	176	PF00017	0.649
LIG_SH2_SRC	418	421	PF00017	0.675
LIG_SH2_STAT5	124	127	PF00017	0.636
LIG_SH2_STAT5	162	165	PF00017	0.636
LIG_SH2_STAT5	488	491	PF00017	0.635
LIG_SH2_STAT5	99	102	PF00017	0.636
LIG_SH3_1	357	363	PF00018	0.831
LIG_SH3_1	414	420	PF00018	0.822
LIG_SH3_2	229	234	PF14604	0.737
LIG_SH3_2	397	402	PF14604	0.740
LIG_SH3_3	221	227	PF00018	0.831
LIG_SH3_3	290	296	PF00018	0.667
LIG_SH3_3	306	312	PF00018	0.679
LIG_SH3_3	357	363	PF00018	0.831
LIG_SH3_3	394	400	PF00018	0.742
LIG_SH3_3	414	420	PF00018	0.822
LIG_SH3_3	430	436	PF00018	0.553
LIG_SH3_3	441	447	PF00018	0.596
LIG_SH3_3	465	471	PF00018	0.775
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.634
LIG_TRAF2_1	91	94	PF00917	0.702
MOD_CDK_SPxK_1	351	357	PF00069	0.827
MOD_CDK_SPxK_1	396	402	PF00069	0.635
MOD_CDK_SPxxK_3	396	403	PF00069	0.661
MOD_CK1_1	145	151	PF00069	0.537
MOD_CK1_1	176	182	PF00069	0.666
MOD_CK1_1	205	211	PF00069	0.722
MOD_CK1_1	220	226	PF00069	0.614
MOD_CK1_1	241	247	PF00069	0.637
MOD_CK1_1	248	254	PF00069	0.627
MOD_CK1_1	356	362	PF00069	0.756
MOD_CK1_1	405	411	PF00069	0.834
MOD_CK2_1	105	111	PF00069	0.521
MOD_CK2_1	176	182	PF00069	0.659
MOD_CK2_1	57	63	PF00069	0.536
MOD_GlcNHglycan	147	150	PF01048	0.389
MOD_GlcNHglycan	31	34	PF01048	0.316
MOD_GlcNHglycan	313	316	PF01048	0.827
MOD_GlcNHglycan	324	327	PF01048	0.702
MOD_GlcNHglycan	336	339	PF01048	0.603
MOD_GlcNHglycan	373	377	PF01048	0.716
MOD_GlcNHglycan	390	393	PF01048	0.815
MOD_GlcNHglycan	409	412	PF01048	0.834
MOD_GSK3_1	158	165	PF00069	0.560
MOD_GSK3_1	205	212	PF00069	0.741
MOD_GSK3_1	233	240	PF00069	0.722
MOD_GSK3_1	241	248	PF00069	0.767
MOD_GSK3_1	297	304	PF00069	0.725
MOD_GSK3_1	307	314	PF00069	0.655
MOD_GSK3_1	351	358	PF00069	0.828
MOD_GSK3_1	37	44	PF00069	0.543
MOD_GSK3_1	401	408	PF00069	0.836
MOD_GSK3_1	419	426	PF00069	0.817
MOD_GSK3_1	427	434	PF00069	0.686
MOD_N-GLC_1	14	19	PF02516	0.435
MOD_N-GLC_1	158	163	PF02516	0.339
MOD_N-GLC_1	364	369	PF02516	0.844
MOD_N-GLC_1	405	410	PF02516	0.835
MOD_N-GLC_1	428	433	PF02516	0.749
MOD_N-GLC_1	65	70	PF02516	0.435
MOD_N-GLC_2	78	80	PF02516	0.517
MOD_NEK2_1	105	110	PF00069	0.501
MOD_NEK2_1	132	137	PF00069	0.580
MOD_NEK2_1	163	168	PF00069	0.600
MOD_NEK2_1	246	251	PF00069	0.762
MOD_NEK2_1	301	306	PF00069	0.638
MOD_NEK2_1	341	346	PF00069	0.646
MOD_NEK2_1	364	369	PF00069	0.844
MOD_NEK2_1	37	42	PF00069	0.636
MOD_NEK2_1	372	377	PF00069	0.684
MOD_NEK2_1	390	395	PF00069	0.671
MOD_NEK2_1	407	412	PF00069	0.757
MOD_NEK2_1	437	442	PF00069	0.659
MOD_NEK2_1	453	458	PF00069	0.602
MOD_NEK2_1	65	70	PF00069	0.636
MOD_NEK2_1	92	97	PF00069	0.519
MOD_NEK2_2	152	157	PF00069	0.608
MOD_PIKK_1	105	111	PF00454	0.636
MOD_PIKK_1	217	223	PF00454	0.654
MOD_PIKK_1	307	313	PF00454	0.765
MOD_PKA_1	402	408	PF00069	0.760
MOD_PKA_2	401	407	PF00069	0.834
MOD_Plk_1	158	164	PF00069	0.544
MOD_Plk_1	364	370	PF00069	0.834
MOD_Plk_1	65	71	PF00069	0.563
MOD_Plk_2-3	142	148	PF00069	0.636
MOD_Plk_4	132	138	PF00069	0.636
MOD_Plk_4	297	303	PF00069	0.790
MOD_Plk_4	324	330	PF00069	0.742
MOD_Plk_4	346	352	PF00069	0.695
MOD_ProDKin_1	202	208	PF00069	0.734
MOD_ProDKin_1	220	226	PF00069	0.685
MOD_ProDKin_1	233	239	PF00069	0.688
MOD_ProDKin_1	317	323	PF00069	0.770
MOD_ProDKin_1	351	357	PF00069	0.698
MOD_ProDKin_1	359	365	PF00069	0.730
MOD_ProDKin_1	396	402	PF00069	0.658
MOD_ProDKin_1	419	425	PF00069	0.764
MOD_ProDKin_1	432	438	PF00069	0.601
MOD_ProDKin_1	459	465	PF00069	0.799
MOD_SUMO_rev_2	84	91	PF00179	0.686
TRG_DiLeu_BaEn_2	110	116	PF01217	0.636
TRG_DiLeu_BaEn_4	93	99	PF01217	0.625
TRG_ENDOCYTIC_2	124	127	PF00928	0.636
TRG_ENDOCYTIC_2	140	143	PF00928	0.446
TRG_ENDOCYTIC_2	348	351	PF00928	0.698
TRG_ENDOCYTIC_2	418	421	PF00928	0.827
TRG_ENDOCYTIC_2	62	65	PF00928	0.636
TRG_ER_diArg_1	183	186	PF00400	0.756
TRG_ER_diArg_1	401	403	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3L2	Leishmania donovani	93%	99%
A4HIF0	Leishmania braziliensis	73%	100%
A4I5P7	Leishmania infantum	93%	99%
E9B0Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%