Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q774_LEIMA

TriTrypDb:

LmjF.30.2190 , LMJLV39_300029100 , LMJSD75_300028800

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0005829	cytosol	2	1

Expansion

Sequence features

Q4Q774

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q774

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	3
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003727	single-stranded RNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.528
CLV_NRD_NRD_1	251	253	PF00675	0.559
CLV_NRD_NRD_1	65	67	PF00675	0.250
CLV_PCSK_FUR_1	182	186	PF00082	0.538
CLV_PCSK_KEX2_1	182	184	PF00082	0.576
CLV_PCSK_KEX2_1	185	187	PF00082	0.580
CLV_PCSK_KEX2_1	251	253	PF00082	0.559
CLV_PCSK_SKI1_1	149	153	PF00082	0.303
CLV_PCSK_SKI1_1	33	37	PF00082	0.265
CLV_PCSK_SKI1_1	408	412	PF00082	0.569
CLV_PCSK_SKI1_1	56	60	PF00082	0.332
CLV_PCSK_SKI1_1	66	70	PF00082	0.250
CLV_PCSK_SKI1_1	88	92	PF00082	0.537
DOC_CKS1_1	264	269	PF01111	0.531
DOC_CKS1_1	283	288	PF01111	0.773
DOC_CKS1_1	298	303	PF01111	0.462
DOC_CKS1_1	378	383	PF01111	0.514
DOC_CYCLIN_RxL_1	405	415	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.497
DOC_MAPK_gen_1	42	51	PF00069	0.496
DOC_PP2B_LxvP_1	342	345	PF13499	0.559
DOC_PP4_FxxP_1	200	203	PF00568	0.586
DOC_PP4_FxxP_1	290	293	PF00568	0.609
DOC_PP4_FxxP_1	391	394	PF00568	0.699
DOC_USP7_MATH_1	250	254	PF00917	0.692
DOC_USP7_MATH_1	317	321	PF00917	0.533
DOC_USP7_MATH_1	333	337	PF00917	0.716
DOC_USP7_UBL2_3	241	245	PF12436	0.613
DOC_WW_Pin1_4	263	268	PF00397	0.607
DOC_WW_Pin1_4	282	287	PF00397	0.759
DOC_WW_Pin1_4	297	302	PF00397	0.445
DOC_WW_Pin1_4	377	382	PF00397	0.521
DOC_WW_Pin1_4	390	395	PF00397	0.661
LIG_14-3-3_CanoR_1	113	119	PF00244	0.479
LIG_14-3-3_CanoR_1	13	21	PF00244	0.453
LIG_14-3-3_CanoR_1	478	486	PF00244	0.519
LIG_APCC_ABBA_1	21	26	PF00400	0.490
LIG_APCC_ABBA_1	48	53	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_BRCT_BRCA1_1	42	46	PF00533	0.450
LIG_EVH1_2	326	330	PF00568	0.547
LIG_FHA_1	253	259	PF00498	0.616
LIG_FHA_1	347	353	PF00498	0.506
LIG_FHA_1	365	371	PF00498	0.455
LIG_FHA_1	438	444	PF00498	0.539
LIG_FHA_1	468	474	PF00498	0.516
LIG_FHA_1	75	81	PF00498	0.439
LIG_FHA_2	142	148	PF00498	0.517
LIG_FHA_2	304	310	PF00498	0.549
LIG_LIR_Apic_2	128	134	PF02991	0.484
LIG_LIR_Apic_2	287	293	PF02991	0.617
LIG_LIR_Apic_2	389	394	PF02991	0.610
LIG_LIR_Apic_2	436	442	PF02991	0.567
LIG_LIR_Gen_1	141	148	PF02991	0.490
LIG_LIR_Gen_1	75	82	PF02991	0.526
LIG_LIR_Nem_3	117	121	PF02991	0.515
LIG_LIR_Nem_3	141	145	PF02991	0.516
LIG_LIR_Nem_3	43	49	PF02991	0.504
LIG_LIR_Nem_3	75	79	PF02991	0.487
LIG_MYND_1	263	267	PF01753	0.650
LIG_PCNA_PIPBox_1	108	117	PF02747	0.490
LIG_PCNA_yPIPBox_3	108	116	PF02747	0.490
LIG_Pex14_2	114	118	PF04695	0.490
LIG_PTB_Apo_2	117	124	PF02174	0.490
LIG_PTB_Phospho_1	117	123	PF10480	0.490
LIG_SH2_CRK	131	135	PF00017	0.503
LIG_SH2_CRK	61	65	PF00017	0.486
LIG_SH2_GRB2like	420	423	PF00017	0.553
LIG_SH2_NCK_1	142	146	PF00017	0.490
LIG_SH2_STAT5	123	126	PF00017	0.450
LIG_SH2_STAT5	161	164	PF00017	0.462
LIG_SH2_STAT5	303	306	PF00017	0.534
LIG_SH2_STAT5	420	423	PF00017	0.586
LIG_SH2_STAT5	439	442	PF00017	0.432
LIG_SH2_STAT5	98	101	PF00017	0.450
LIG_SH3_3	270	276	PF00018	0.608
LIG_SH3_3	349	355	PF00018	0.501
LIG_SH3_3	76	82	PF00018	0.365
LIG_SUMO_SIM_anti_2	367	372	PF11976	0.502
LIG_SUMO_SIM_par_1	366	372	PF11976	0.506
LIG_TRAF2_2	345	350	PF00917	0.561
LIG_TRFH_1	377	381	PF08558	0.523
LIG_WRC_WIRS_1	115	120	PF05994	0.482
LIG_WRC_WIRS_1	428	433	PF05994	0.527
MOD_CK1_1	212	218	PF00069	0.644
MOD_CK1_1	221	227	PF00069	0.668
MOD_CK1_1	234	240	PF00069	0.663
MOD_CK1_1	243	249	PF00069	0.688
MOD_CK1_1	319	325	PF00069	0.566
MOD_CK1_1	392	398	PF00069	0.608
MOD_CK1_1	416	422	PF00069	0.669
MOD_CK1_1	424	430	PF00069	0.588
MOD_CK1_1	484	490	PF00069	0.561
MOD_CK2_1	202	208	PF00069	0.748
MOD_CK2_1	22	28	PF00069	0.409
MOD_CK2_1	303	309	PF00069	0.547
MOD_GlcNHglycan	195	198	PF01048	0.645
MOD_GlcNHglycan	208	212	PF01048	0.615
MOD_GlcNHglycan	227	230	PF01048	0.736
MOD_GlcNHglycan	252	255	PF01048	0.622
MOD_GlcNHglycan	268	271	PF01048	0.593
MOD_GlcNHglycan	30	33	PF01048	0.313
MOD_GlcNHglycan	309	312	PF01048	0.550
MOD_GlcNHglycan	335	338	PF01048	0.651
MOD_GlcNHglycan	395	398	PF01048	0.638
MOD_GlcNHglycan	423	426	PF01048	0.639
MOD_GSK3_1	212	219	PF00069	0.611
MOD_GSK3_1	221	228	PF00069	0.709
MOD_GSK3_1	230	237	PF00069	0.732
MOD_GSK3_1	239	246	PF00069	0.605
MOD_GSK3_1	284	291	PF00069	0.751
MOD_GSK3_1	303	310	PF00069	0.548
MOD_GSK3_1	316	323	PF00069	0.535
MOD_GSK3_1	389	396	PF00069	0.670
MOD_GSK3_1	402	409	PF00069	0.624
MOD_GSK3_1	412	419	PF00069	0.545
MOD_GSK3_1	477	484	PF00069	0.592
MOD_N-GLC_1	13	18	PF02516	0.255
MOD_N-GLC_1	157	162	PF02516	0.375
MOD_N-GLC_1	234	239	PF02516	0.556
MOD_N-GLC_1	355	360	PF02516	0.589
MOD_N-GLC_1	364	369	PF02516	0.556
MOD_N-GLC_1	421	426	PF02516	0.602
MOD_NEK2_1	114	119	PF00069	0.482
MOD_NEK2_1	162	167	PF00069	0.477
MOD_NEK2_1	296	301	PF00069	0.607
MOD_NEK2_1	307	312	PF00069	0.522
MOD_NEK2_1	321	326	PF00069	0.561
MOD_NEK2_1	402	407	PF00069	0.682
MOD_NEK2_1	411	416	PF00069	0.519
MOD_PIKK_1	331	337	PF00454	0.563
MOD_PIKK_1	402	408	PF00454	0.655
MOD_PIKK_1	413	419	PF00454	0.654
MOD_PKA_1	66	72	PF00069	0.464
MOD_PKA_2	250	256	PF00069	0.613
MOD_PKA_2	477	483	PF00069	0.530
MOD_Plk_1	157	163	PF00069	0.582
MOD_Plk_1	234	240	PF00069	0.632
MOD_Plk_1	355	361	PF00069	0.571
MOD_Plk_1	364	370	PF00069	0.519
MOD_Plk_1	458	464	PF00069	0.613
MOD_Plk_2-3	141	147	PF00069	0.490
MOD_Plk_4	157	163	PF00069	0.582
MOD_Plk_4	221	227	PF00069	0.514
MOD_Plk_4	364	370	PF00069	0.570
MOD_Plk_4	406	412	PF00069	0.586
MOD_Plk_4	481	487	PF00069	0.562
MOD_ProDKin_1	263	269	PF00069	0.610
MOD_ProDKin_1	282	288	PF00069	0.762
MOD_ProDKin_1	297	303	PF00069	0.438
MOD_ProDKin_1	377	383	PF00069	0.521
MOD_ProDKin_1	390	396	PF00069	0.660
MOD_SUMO_for_1	170	173	PF00179	0.385
MOD_SUMO_for_1	178	181	PF00179	0.479
MOD_SUMO_rev_2	141	151	PF00179	0.490
MOD_SUMO_rev_2	233	243	PF00179	0.638
MOD_SUMO_rev_2	52	58	PF00179	0.478
TRG_DiLeu_BaEn_4	92	98	PF01217	0.425
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.657
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.583
TRG_ENDOCYTIC_2	123	126	PF00928	0.472
TRG_ENDOCYTIC_2	142	145	PF00928	0.454
TRG_ENDOCYTIC_2	398	401	PF00928	0.499
TRG_ENDOCYTIC_2	61	64	PF00928	0.450
TRG_ER_diArg_1	182	185	PF00400	0.562
TRG_ER_diArg_1	250	252	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q0	Leptomonas seymouri	62%	100%
A0A3Q8IAX1	Leishmania donovani	26%	100%
A0A3Q8II02	Leishmania donovani	88%	99%
A4HIF1	Leishmania braziliensis	67%	100%
A4HXP3	Leishmania infantum	26%	100%
A4I5P8	Leishmania infantum	88%	99%
C9ZR15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QE25	Leishmania major	25%	100%