C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania major

UniProt:

Q4Q773_LEIMA

TriTrypDb:

LmjF.30.2200 , LMJLV39_300029200 , LMJSD75_300028900

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q773

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q773

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	151	153	PF00082	0.584
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.638
CLV_PCSK_SKI1_1	113	117	PF00082	0.630
CLV_PCSK_SKI1_1	45	49	PF00082	0.474
DEG_APCC_DBOX_1	44	52	PF00400	0.438
DEG_Nend_UBRbox_3	1	3	PF02207	0.626
DOC_CKS1_1	143	148	PF01111	0.702
DOC_MAPK_gen_1	42	51	PF00069	0.500
DOC_PP1_RVXF_1	111	117	PF00149	0.664
DOC_PP4_FxxP_1	116	119	PF00568	0.649
DOC_USP7_MATH_1	78	82	PF00917	0.716
DOC_USP7_UBL2_3	38	42	PF12436	0.429
DOC_WW_Pin1_4	142	147	PF00397	0.690
DOC_WW_Pin1_4	19	24	PF00397	0.585
DOC_WW_Pin1_4	65	70	PF00397	0.654
LIG_BIR_III_4	105	109	PF00653	0.766
LIG_BRCT_BRCA1_1	57	61	PF00533	0.389
LIG_BRCT_BRCA1_1	83	87	PF00533	0.731
LIG_FHA_2	84	90	PF00498	0.505
LIG_LIR_Nem_3	159	165	PF02991	0.595
LIG_LIR_Nem_3	84	90	PF02991	0.718
LIG_MAD2	113	121	PF02301	0.653
LIG_SH2_NCK_1	9	13	PF00017	0.615
LIG_SH2_SRC	72	75	PF00017	0.743
LIG_SH2_SRC	9	12	PF00017	0.614
LIG_SH2_STAP1	123	127	PF00017	0.601
LIG_SH2_STAP1	158	162	PF00017	0.596
LIG_SH2_STAP1	165	169	PF00017	0.621
LIG_SH2_STAT5	46	49	PF00017	0.405
LIG_SH3_2	147	152	PF14604	0.576
LIG_SH3_3	144	150	PF00018	0.566
LIG_SH3_3	20	26	PF00018	0.703
LIG_SH3_3	48	54	PF00018	0.500
LIG_SH3_3	63	69	PF00018	0.441
LIG_TRAF2_1	139	142	PF00917	0.733
LIG_TRAF2_1	8	11	PF00917	0.572
LIG_TRFH_1	19	23	PF08558	0.624
LIG_WW_1	120	123	PF00397	0.573
LIG_WW_1	146	149	PF00397	0.575
MOD_CK1_1	22	28	PF00069	0.589
MOD_CK1_1	81	87	PF00069	0.644
MOD_CK2_1	5	11	PF00069	0.553
MOD_CK2_1	59	65	PF00069	0.376
MOD_GlcNHglycan	81	84	PF01048	0.654
MOD_GlcNHglycan	92	95	PF01048	0.499
MOD_GSK3_1	1	8	PF00069	0.634
MOD_GSK3_1	34	41	PF00069	0.506
MOD_GSK3_1	55	62	PF00069	0.429
MOD_GSK3_1	79	86	PF00069	0.633
MOD_GSK3_1	88	95	PF00069	0.660
MOD_GSK3_1	96	103	PF00069	0.518
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	49	54	PF00069	0.397
MOD_NEK2_1	55	60	PF00069	0.367
MOD_NEK2_1	90	95	PF00069	0.675
MOD_NEK2_1	98	103	PF00069	0.700
MOD_OFUCOSY	53	59	PF10250	0.429
MOD_PIKK_1	98	104	PF00454	0.661
MOD_Plk_1	10	16	PF00069	0.577
MOD_Plk_1	17	23	PF00069	0.575
MOD_ProDKin_1	142	148	PF00069	0.691
MOD_ProDKin_1	19	25	PF00069	0.579
MOD_ProDKin_1	65	71	PF00069	0.655
TRG_ENDOCYTIC_2	46	49	PF00928	0.429
TRG_NLS_MonoExtC_3	150	156	PF00514	0.620
TRG_NLS_MonoExtN_4	150	155	PF00514	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM2	Leptomonas seymouri	69%	99%
A0A0N1PGD1	Leptomonas seymouri	37%	94%
A0A3S7X3I3	Leishmania donovani	99%	100%
A4HIF2	Leishmania braziliensis	89%	100%
A4I5P9	Leishmania infantum	98%	100%
E9B0Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%